2IU1,2FUL


Conserved Protein Domain Family
W2_eIF5
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cd11561: W2_eIF5 
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C-terminal W2 domain of eukaryotic translation initiation factor 5
eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Links
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Statistics
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PSSM-Id: 211399
Aligned: 83 rows
Threshold Bit Score: 96.5313
Created: 8-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2IU1_A         2 ERTIEERVNILFDFVKKKKEegvi--------dssDKEIVAEAERLDv---KAMGPLVLTEVLfn---ekIREQIKKYRR 67  human
XP_001317046 219 EAEENAYFEKFGKQLVGEETda-----------eiFEEFNSMAERGGw--nSPTRCAIIFEYLfrgepteILNSIEDRRG 285 Trichomonas vag...
XP_002288103 240 ANAMALAVEAMKKFLADNPDasp----------saIAEKVVNEQMASglksQDKIHIFVQSVFtpd--fyKQKQVEKHAP 307 Thalassiosira p...
XP_002181337 249 QGALLLAVEATKKYIAENSDvsd----------keLSEVVTNQQMASalksHDKVHIIVRAALsaq--ffKNKEIEKYSS 316 Phaeodactylum t...
EGB10079     243 SGAMESAVKGIRDYIAGGKQps------------eVVSELRAVQTFCalprSERGFILAAAAFdd----gLLEQLDGKAD 306 Aureococcus ano...
XP_001021564 202 SEELAKKIQLLTESINSQKQengeftetdisqtniVKEIKDMNIQKGl---ESQVAHILFQSLfs---vnIAHEVQNNAE 275 Tetrahymena the...
EGR30622     209 SENLKNKVEQLTECIKGQRNqa-----------niIKEIKDFQINKGl---ENQISHIVFQSIft---vnIAHEVDCNAE 271 Ichthyophthiriu...
Q38LF2       258 SPELKDVIERLRNVVTRSETvdlaa------ffheMRMLQVSQDFDS----KCRIYVTLAAIFnd---dmTPTSLEARMP 324 Toxoplasma gondii
XP_667053    216 SPEIVDVIERLTNFMQKNEEvsped------ffseLRVLQVSQDFDE----FMRFSVLLTVLFglk-dpiDPKVFKLRIP 284 Cryptosporidium...
XP_001611244 216 SPEIQDAIERITSSLKGGKFqqpae------faeeLHMLQLSQDFDN----ICKVYVALCAIFsd---kfDVQELEDKIN 282 Babesia bovis T2Bo

2IU1_A        68 HFLRFCh--nNKKAQRYLLHGLECVVAmh---qaQLISKIPHILKEMYDADLLEEEVIISWSekas---------kkyvS 133 human
XP_001317046 286 FIIRVLn---EDGIQKDFQTAMASFIEkk---vpELFTSAPVIWHCMYNNEIIEDSAFLAWYtarps--------krfeD 351 Trichomonas vag...
XP_002288103 308 AIAKITq--gKNVMERHLIASFEGLCV-------DEPKKFAVVLKQLFDEEVLEEDTILEWAgegrtd-----ytlesvD 373 Thalassiosira p...
XP_002181337 317 AIYSITs--gNKIMERHLIASLEALCI-------DKPKNFPVMIKQFYDEDALAEETILEWAdegrse-----ftlpevD 382 Phaeodactylum t...
EGB10079     307 LLRAFV----KDAGAPSLLGGLEKFALvs---spALAPKFALVLKQLYDSDVLEEDALVAWHdagaappdaaihvpdacD 379 Aureococcus ano...
XP_001021564 276 VLSKTFsklkIPNPELETIMNISYLLFktynekqDFTPYVPTILKYFYDADLLSEDFLKNYAeskinl-----sehylyD 350 Tetrahymena the...
EGR30622     272 LLQKLYsklkIQKMEDDILLNLQYFFYkty-qnqDFTQYIPTILKIFYDNNLISEQIIVDWAdnkidl-----kdhflyN 345 Ichthyophthiriu...
Q38LF2       325 YILKVLd---TSVSASDVLDAFGFYCQek---ggTAMTSFPYCLQKLYNAEALEAEDILKYYaa-------------dkE 385 Toxoplasma gondii
XP_667053    285 YISKAVe---GSLRSNAIISIFESYCVek---npSTLATYPYLIQQLYDADILSEKVILKYYqkdapts----wvsgcsT 354 Cryptosporidium...
XP_001611244 283 LLIPLLe---YGVQPKDVLTSMAVFVVkl---ypQQLDDYPYICRALYASDLADGGDICRFYakstr--------fdgsL 348 Babesia bovis T2Bo

2IU1_A       134 KELAKEIRVKAEPFIKWLKEAEEESS 159 human
XP_001317046 352 PEKAKKLREMLAPFKTWIETAEIEPE 377 Trichomonas vaginalis G3
XP_002288103 374 EDQRAALRGEAEPVVVWLQEDDSSDE 399 Thalassiosira pseudonana CCMP1335
XP_002181337 383 EDVRATLRGEAEPVVVWLQEADSEDD 408 Phaeodactylum tricornutum CCAP 1055/1
EGB10079     380 VESRAKLLAFAEPFITWLKEAEEDET 405 Aureococcus anophagefferens
XP_001021564 351 AERIKKFAEAAQPFLDWILNAEEDED 376 Tetrahymena thermophila
EGR30622     346 EIFNNKFKEDTNQIVEWLRNADYDEQ 371 Ichthyophthirius multifiliis
Q38LF2       386 DPVFSACKKQAEPFLQWLAEDDGSSE 411 Toxoplasma gondii
XP_667053    355 QDTFEKAKKSCEPFVDWLLDGSNDES 380 Cryptosporidium hominis TU502
XP_001611244 349 AEAYIRTKEKAEPFVAWLQEDDGDDD 374 Babesia bovis T2Bo
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