2D8R,2JTG


Conserved Protein Domain Family
THAP

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pfam05485: THAP 
THAP domain
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.
Statistics
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PSSM-Id: 461662
Aligned: 459 rows
Threshold Bit Score: 35.2021
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2D8R_A        12 CAAAGCATT----YNKHINi--------------------SFHRFP-----LDPKRRKEW-----V-RLVRRKNFVPgkh 56 
XP_420555    348 ARALGVRI-------NPQRir------------------cAFHHPP-----SSAHCIAYF-----F-DVCH--------- 382
XP_016662398  10 CIF--CLDspyk------------------------npkiSLHTFP-----KDQSKRYLW-----L-TACGLTEEDYkps 52 
XP_008182618   5 CCFf-CQTsalk------------------------vpglILHNFP-----KDLSLRNIW-----L-KRCGYTEEEFfpy 48 
XP_016663829  10 CCIl-CLKsphk------------------------vpylRLHIFP-----KNEYQRNLW-----L-NACGLQADEClps 53 
EKC27398       7 CVAYGCNHH----RADGATc--------------------TFITFP-----EDPEYFQRW-----T-NACKREVVYEsgk 51 
XP_002414956 317 CIALGCNSIrygyDDAKLR----------------------YFRLPpd-enRRN----QW-----L-TNCGREDLKShpv 363
XP_003723332   4 CAAFNCTN----------Rlkkg--------------sgiTFHRFPk----SGSALLKEW-----L-IKMRRD---Kwip 46 
XP_002130150  12 CVAYGCRKR----KFPKTRprsnssgsedeesemkrkhprTFHSFP-----KDVQKRKQWevklrL-PKLKLTNCSL--- 78 
EFN66190       4 CVAIGCYNK----SYRKAKgqknve----------qdveiTFHRFPkdearKLT-----------RiKNMGLRDECLpks 58 
2D8R_A        57 ---------tfLCSKHFeascfd-ltgqtrRLKMDAVPTIF 87 
XP_420555    383 -------------ALHLir------------------nTLQ 392
XP_016662398  53 ---------rkLCSKHFekdcfk-tgtnlnILLPNSVPTKI 83 
XP_008182618  49 ---------nkLCSLHFdgnsyk-ntklrkLLKNNAIPTKF 79 
XP_016663829  54 ---------rlLCSRHFedtcy---tkcgyRLKSNAIPTKF 82 
EKC27398      52 rtkwtpseyqkLCCCHFendrcp-dpksrkPGNKNKIPTYF 91 
XP_002414956 364 ks----lvtkvLCQLHFhdsqfm-nahnyqRLVWNALPTLF 399
XP_003723332  47 n------kystMCSVHFeevcfdr-tgqttrLREGSIPTIF 80 
XP_002130150  79 -----------ICSDHFyerdii-rssknvMLRADAIPRRF 107
EFN66190      59 ---------phLCSLHFsessfdrsflmrpRLKENAIPIFK 90 
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