Conserved Protein Domain Family
PLN02577

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PLN02577: PLN02577 
hydroxymethylglutaryl-CoA synthase
Statistics
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PSSM-Id: 178189
Aligned: 21 rows
Threshold Bit Score: 694.566
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
15234313    1 MAKNVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVTSLFEKYKIDPNQIGRLEV 80 
168040564   4 RPQNVGILAMDVYFPASYVHQEALEEHDGVSKGKYTIGLGQDRLAFCTDLEDVISMSLTVVKSLLEKYGIAPESIGRLEV 83 
168044424   4 RPQNVGILAMDVYFPASYVSQEELEEHDGVSKGKYTIGLGQDRLAFCTDLEDVISMSLTVVKSLLEKYEIPADRIGRLEV 83 
225468564   4 SPKNVGILAMEIYFPRTCVQQEALEAHDGASKGKYTIGLGQDCTAFCTEVEDVISMSLTAVASLLEKYEIDPKQIGRLEV 83 
219129756   1 --KHVGILAVEVYFPRAYVAQAALEEHVGVPQGKYTIGLGQQGLAVTGDAEDVNSLCLTVVHSLLEKYNIDPALVGRLEV 78 
223993767   1 ---NVGILAMEFYTPRSYITQAALESHSGVAAGRYTLGLGQDAMAVTGDAEDVNSLALTVTHSLLEKYDIDPNDVGRLEV 77 
302806423   1 MAKDVGILAMEVYFPGVCVNQVDLARFDKVPPKYYTEGLGQERLAFCEDTEDVISMSLTVVKSLLENYNISPSSIGRLEV 80 
302802325   4 CPGDVGILALEVYFPPSCVRQDELEKHDGVSAGKYTAGLGQERLAFCTDVEDVISMSLTVVKNLLEKYSIAPEKVGRLEV 83 
302800361   4 RPGDVGILALEVYFPPSCVRQDELEKHDGVSAGKYTAGLGQERLAFCTDVEDVISMSLTVVKNLLEKYSIAPEKVGRLEV 83 
302808907   1 MAKDVGILAMEVYFPGVCVNQVDLAKFDKVPPKYYTEGLGQERLAFCEDTEDVISMSLTVVKSLLENYNISPSSIGRLEV 80 
15234313   81 GSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTG 160
168040564  84 GSETVIDKSKAIKTCLMQLFEESGNGDIEGVDSTNACYGGTAALQNSLNWVESSAWDGRYAIVVAADSAVYAEGAARPTG 163
168044424  84 GSETVIDKSKAIKTSLMQLFEDSGNGDIEGVDSTNACYGGTAALQNCLNWVESSAWDGRYAIVVAADSAVYAEGPARPTG 163
225468564  84 GSETVIDKSKSIKTFLMQIFEESGNTDIEGVDSTNACYGGTAALFNCINWVESSSWDGRHGLVVCTDNAVYAEGPARPTG 163
219129756  79 GTETLVDKSKSTKTLLMDLFPN--NTDIEGATIINACYGGTAALLNAFLWVESDGWDGRYAIVVAADIAAYARGPARPTS 156
223993767  78 GTETLVDKSKSTKTVLMDLFPN--NTDVEGATVINACYGGTAALMNAFAWVESSAWDGRYAIVVAVDIATYARGPARPTC 155
302806423  81 GSETVIDKSKSIKSYLMPLFEE--NSGIEGVDSTNACYGGTAALFNCVNWIESRSWDGRLAIVVAADIAVYAEGTARPSG 158
302802325  84 GSETVIDKSKSIKTWLMRLFEESGNSDIQGVDSSNACYGGTAALINCLNWVESSGWDGRYGLVVAADSAVYAEGPARPSG 163
302800361  84 GSETVIDKSKSIKTWLMRLFEESGNSDIQGVDSSNACYGGTAALINCLNWVESSGWDGRYGLVVAADSAVYAEGPARPSG 163
302808907  81 GSETVIDKSKSIKSYLMPLFEE--NSGIEGVDSTNACYGGTAALFNCVNWIESRSWDGRLAIVVAADIAVYAEGAARPSG 158
15234313  161 GAAAIAMLIGPDAPIVF-ESKLRASHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFE-----KIEGK 234
168040564 164 GAGAVAMLIGPNAPIVF-ERCLSGTHMANVYDFYKPNLASEYPIVDGKLSQTCYLQALDSCYRRFCEKYE-----KHSGK 237
168044424 164 GAGAVAMLIGPDAPIVF-ERRLSGTHMANAYDFYKPNLASEYPVVDGKLSQTCYLQAVDSCYRRFCLKYE-----KFAGK 237
225468564 164 GAAAIAMLVGPGAPIAF-ESKFKGSHMSHAYDFYKPNLASEYPEL---------------IFPQLCSMFK-----THDDP 222
219129756 157 GAGAVAILVGRDAPLSF-DPRTRATHAANVWDFYKPDHTVEYPTVDGALSQVCYYQALEDVYTRFTEKVTlrdgaTHGGR 235
223993767 156 GAGAVAVLVGRNAPLAFaDPRERTTHACNVYDFFKPDHSVEYPTVDGALSQVCYYRALEDCYAKFCDRVD-----RLEGK 230
302806423 159 GAGAVAMLVGPNAPLVL-ERSYTGTYMAHVYDFYKPDLSSEYPVVDSKLSQKCYLKALDVCYKRYCERYE-----SIEAR 232
302802325 164 GAGAVAMLIGPNAPFVI-DRKYMGTHMSHTYDFYKPNLSSEYPVLDGRLSQKCYLMALDLCYNRYCQKYE-----KADGK 237
302800361 164 GAGAVAMLIGPNAPFVI-DRKYMGTHMSHTYDFYKPNLSSEYPVLDGRLSQKCYLMALDLCYNRYCQKYE-----KADGK 237
302808907 159 GAGAVAMLVGPNAPLVL-DRSYTGTYMAHVYDFYKPDLSSEYPVVDSKLSQKCYLKALDVCYKRYCERYE-----SMEAR 232
15234313  235 EFSINDADYIVFHSPYNKLVQKSFARLLYNDFLR------------NASSIDEAAKEKFTPYSSLTLDESYQSRDLEKVS 302
168040564 238 PFTLSDASYVVCHAPYNKLVQKSFARLVYNDYIR------------NASFVSEDAAALFEPFATLSPTDSLLNRDLEKVS 305
168044424 238 PFTLSDASYVICHAPYNKLVQKSFARLVYNDYLR------------NASFVDEEAGARFQPFAILSPTDSLLNRDLEKVS 305
225468564 223 GNSISDTIFTFSYINHFLLNNQRFTVYCFC----------------LISLVDEAAREKLAPFSALSKDESYQSRDLETAT 286
219129756 236 QFTAESPDYLVFHAPYNKLVQKSYARLFLMDARAqyarhsaeekkdESTSADQDEPDPLAPWLDVPIADTYNDRALDAVL 315
223993767 231 GFNAEAADYFVFHAPYNKLVQKSYGRMHLGDVAT------------KSTTGTATIAEE---YLTKPIEETYSDKALEGIL 295
302806423 233 PFTVQEADFLVFHAPFNKLVRRSFERLLWNDYQR------------DCSSLGEDG-EKLKPFQGLTADSIVSNASLKEVM 299
302802325 238 PFSLQDVNYAVFHSPYNKLVQKSFARLVYNDIQR----------------KTRPEDEKLKPFANISEDESYTNKDLEKAT 301
302800361 238 PFSLQDVNYAVFHSPYNKLVQKSFARLVYNDIQR------------KTRPEDEK----LKPFANISEDESYTNKDLEKAT 301
302808907 233 PFTVQEAHFLVFHAPFNKLVRRSFERLLWNDYQR------------DCSSLGEDG-EKLKPFQGLTADDIVSNASLKEVM 299
15234313  303 QQIAKPFYDAKVQPTTLIPKEVGNMYTASLYAAFASLIHKK--HNDL-AGKRVVMFSYGSGSTATMFSLRLNDNKPPFSI 379
168040564 306 QQVAKKQYDVKVAPTTMLPKELGNMYCASLYAGLATLVHNK--SSSL-DGQRILLFSYGSGLASSLFSCKFVEGQK---L 379
168044424 306 QEVAKKQYNEKVGPTTMLPKELGNMYCASLYAGLATLVHNK--SSSL-DGERILMFSYGSGLAASLFSCKFTGGQK---L 379
225468564 287 QQEAKHLYDAKVQPTTLLPKQVGNMYTASLYAAFASLLHNK--NDSL-AGKRVIMFSYGSGLTATMFSFQLQNGQHPFSL 363
219129756 316 KKRAATSLQARLADANVASQLVGNTYTASVFLGLASLLDQAgtRDELtPGKNIVLFSYGSGALATMYRL-----TSQFTV 390
223993767 296 KSVSKSSYSQRLSDANSASKIVGNTYTASVFLGLASLVFHAggRGDLvEGKSVVVFSYGSGALATMY--RLHASQRVFTV 373
302806423 300 KAVAEPGYDAKVSPSTLIPRRVGNTYCASLYAGLASLVHNK--ASLLdDGQSILMFSYGSGLASSLFSIRVRRVEGVHSL 377
302802325 302 QDIAKPDYNLKVVPSTLIPKQVGNMYCAALYAALASLIHNK--AEEL-LGNTILMFSYGSGLASSLFTIHVRQGDGLFRV 378
302800361 302 QDIAKPDYNLKVVPSTLIPKQVGNMYCAALYAALASLIHSK--AEEL-LGNTILMFSYGSGLASSLFTIHVRQGDGLFRV 378
302808907 300 KAVAEPGYDAKVSPSTLIPRRVGNMYCASLYAGLASLVHNK--ASLLdDGQSILMFSYGSGLASSLFSIRVRRVEGVHSL 377
15234313  380 SNIASVMDVGGKLKARHEYAPEKFVETMKLMEHRY-GAKDFVTTKEg----iIDLLAPGTYYLKEVDSLYRRFYGKKG-- 452
168040564 380 AEIAEKMDIAAKLQSRIAVTPTEFVETMHLMETRY-GAKDFIPVSS------KSTLRPMTYYITQVDNLYRRSYDRN--- 449
168044424 380 SEIAEKMDIVAKLDSRIAVTPKEFVETMHLMETRY-GAKDYTPISS------KSTLRPSTFYITQVDALYRRTYERYQa- 451
225468564 364 LNIAMVMNVSEKLKSRLEFPPEKFVKTLKLMEHRY-GAKAFVMSKD------CSLLASGTYYLTEVDSMYRRFYAKKPgd 436
219129756 391 KSMATTMNLSERLASREMVHPGELDYALETRARMHrAGAPYSPVYPt-----VGRLFPGTYYLNGIDALFRRTYSR---- 461
223993767 374 GEMVKNLDLANRLASREEVHPSELDLALETRARMHrGGAPYSPCHDylysnqRHTIQPGTYFLNGIDSKWVRTYSR---- 449
302806423 378 ENVAKTMAISEKLDSCVAVSPEKFVETMKIMESRY-GSKDFVPMGD------LATVRPGAFYLAGVDSLYRRTYERRAlt 450
302802325 379 ANIAKRMEVSSSLESRVQVSPEDFVHTMELMETRY-GAKGFTPVSD------LARLRPGTFYLTQVDDLYRRFYDR---- 447
302800361 379 ANIAKRMEVSSSLESRVQVSPEDFVHTMELMETRY-GAKGFTPVSD------LARLRPGTFYLTQVDDLYRRFYDR---- 447
302808907 378 ENVAKTMAISEKLDSCVAVSPEKFVETMKLMESRY-GSKDFVPLGD------LAPVRPGAFYLARVDSLYRRTYERRAlt 450
15234313  453 -EDGSVANGH 461
168040564 450 -LARTNENCR 458
168044424 452 kLEKVEANGV 461
225468564 437 gDNTDPMSTC 446
219129756     ----------    
223993767     ----------    
302806423     ----------    
302802325 448 -LPQATSNGA 456
302800361 448 -LPQATSNGA 456
302808907     ----------    
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