Conserved Protein Domain Family
dnaE
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PRK05673: dnaE 
DNA polymerase III subunit alpha; Validated
Links
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Statistics
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PSSM-Id: 235554
Aligned: 468 rows
Threshold Bit Score: 1541.59
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
118475097    3 DFTHLHLHTEYSLLDGANKIKVLAKRLKELNIKSCAITDHGNMYGALDFYKTMKAEGIKPIIGLEAYIHNH--------- 73  
219683289    6 DFVQLHNHTHYSLLDGASKIPDLVKYTKELGMGAVGITDHGNMHGAYEMYTEAVKQDVKPIIGIEAYVTPEtarqdksr- 84  
241196656    6 DFVQLHNHTHYSLLDGASKIPDLVKYTKELGMGAVGITDHGNMHGAYEMYTEAVKQDVKPIIGIEAYVTPEtarqdksr- 84  
241191250    6 DFVQLHNHTHYSLLDGASKIPDLVKYTKELGMGAVGITDHGNMHGAYEMYTEAVKQDVKPIIGIEAYVTPEtarqdksr- 84  
283456439    1 --MQLHNHTHYSLLDGASKIPDLVKRAKELNMPAVGITDHGNMHGAYEMWSTAVNAGIKPIIGIEAYVTPEtarqdptrv 78  
28493477     6 SFVHLHVHTDYSMLDGAARTEDLMRKAAEDKMPAIAITDHGNTFGAFDFWKTAKTYDINPIIGMEAYLTPGtnrkekv-- 83  
298346985    5 DFVHLHVHTDYSILDGAAKIKRLVAKAVENQQKAVAITDHGYLFGAFEFYQECRNAGIKPIIGLEAYVTPGtsrfdttrv 84  
283783561    7 NFVHLHNHTHYSLLDGASKIPDLVARAKELGMPAVAITDHGNMHGAYEMWSTAVKAGIKPIIGIEAYVTPEtarqdksr- 85  
297571263    5 SFAHLHVHTDYSLLDGAAKINKLVAEVARLEQPAVAITDHGYLFGAYEMYKAATAAGIKPIIGLEAYMTPGtsrfdqtr- 83  
257068282    8 DFVHLHVHTDYSLLDGAAKIDKLVAETVRQGQPAVAITDHGYLFGAYEFYKAAKDAGIKPIIGIEAYVTPGtsrhdrtrt 87  

118475097   74 -----------------EDISNKESRQRFHLCLFAKNEVGYQNLMYLSSMSYIKGYY-YHPRINKKLLREHSEGLVCSSA 135 
219683289   85 ---------vhwgteaqRRDDVSGGGLITHLTLWAEDDEGLRNLIRASSVANLEGRVmRYPRMDKEVLSTYSKGVICGSG 155 
241196656   85 ---------vhwgteaqRRDDVSGGGLITHLTLWAEDDEGLRNLIRASSVANLEGRVmRYPRMDKEVLSTYSKGVICGSG 155 
241191250   85 ---------vhwgteaqRRDDVSGGGLITHLTLWAEDDEGLRNLIRASSVANLEGRVmRYPRMDKEVLSTYSKGVICGSG 155 
283456439   79 swdtnwnpdldpnhrkrNPNDVSGGGLITHLTMWAETDEGLVNLMKASTDANLEGRVmRYPRMDKEILSKYSKGIIASSG 158 
28493477    84 ----------rkffasgGPDDVSAGGAYTHLTLLSQNNEGMHNLFKLSSLASIEGYY-FKPRIDIELLNQYSNGLIATTG 152 
298346985   85 --------qwgtleqqkAGDDVSARGAYTHMTLLSHTTEGMHNLFRLGSYASLDGQMgKWPRADRELLERYHEGLIGTAG 156 
283783561   86 ---------vhwgtedqRADDVSGGGLITHMTLWAENDTGLTNLLKASSVANLEGRVmRYPRMDKDVLSTYSKGVIASSG 156 
297571263   84 ---------qlwgtpaqRSDDVSARGAYTHMTLLSENNTGMHNLFRMNSLASLEGQMgKWPRMDRELLETYHDGLIGTAG 154 
257068282   88 --------qwgtreqqlAGDDVSARGAYTHMTLLSHSTTGMHNLFRLGSAASLEGQMgKWPRMDREILSQYSDGLIATTG 159 

118475097  136 CLAGEVNFHLNlsdrnlkrgAGGYESAKRVALEYKDIFG-DDFYLEIMRHGIGDQQRIDDDIIRLSMETGIKLIATNDAH 214 
219683289  156 CPSGIVQTRLR---------LGQFDEALRAAGELQDIYGkDNFFIELMDHNLEIERKVTKDLLEIAKKLGAPLLATNDSH 226 
241196656  156 CPSGIVQTRLR---------LGQFDEALRAAGELQDIYGkDNFFIELMDHNLEIERKVTKDLLEIAKKLGAPLLATNDSH 226 
241191250  156 CPSGIVQTRLR---------LGQFDEALRAAGELQDIYGkDNFFIELMDHNLEIERKVTKDLLEIAKKLGAPLLATNDSH 226 
283456439  159 CPSGIIQTRLL---------LGQFDEALRAAGELQDIFGrDNFYIEFMDHGLNIERQVTDGLLDIAKKLNAPLLATNDSH 229 
28493477   153 CPSGEIQTRLR---------LGQYSEARQAAAQMRDIFGpENYYCEVMDHNLEIEKAVMPDLLRLAGDLGLPLLATNDLH 223 
298346985  157 CPSGEVQTRLR---------LGQYQEAVRAAGELQDIFGkDYFYVELMDHGLSIENRVRKDLLRLAREINAPIIATNDSH 227 
283783561  157 CPSGIIQTRLR---------LGQFKEALRAAGEFQDIFGrDNFFIELMNHGLSIETRVTKDLLEIAKKLNAPLLATNDLH 227 
297571263  155 CPSGEIQTRLR---------LGQWDEALKAAGELQDIFGkDNFYVEVMDHGLDIERRVQNDLLKIARMIGAPLIATNDSH 225 
257068282  160 CPSGEVQTRLR---------LGQFDEAVKAAGEFQDIFGkEHYFVELMDHGLDIEKRVSKDLLEVAKAVGAPLLATNDLH 230 

118475097  215 YTTKDSAVAQKIFVYISANKNFDD-KVrEQVLSEFYAKSADEMSAIFADMPEVIENTNEIVEKCN--LEIKLGD---ATP 288 
219683289  227 YVHEEDAGAQDAMLCINSGSHLDDpDRfKFDGEGYYMRSAQQMRELFRDLPEACDNTIEVAERCN--VMFDDHEd-gAFM 303 
241196656  227 YVHEEDAGAQDAMLCINSGSHLDDpDRfKFDGEGYYMRSAQQMRELFRDLPEACDNTIEVAERCNvmFDDHEDG---AFM 303 
241191250  227 YVHEEDAGAQDAMLCINSGSHLDDpDRfKFDGEGYYMRSAQQMRELFRDLPEACDNTIEVAERCNvmFDDHEDG---AFM 303 
283456439  230 YVRAEDAGAQDAMLCINSGSTLDEpGRfKFDGTGYYLKSAEEMRELFKDLPEACDNTLEIAERCN--VMFDDHEd-gAFM 306 
28493477   224 YVNSEDSASHAALLCVQSGSTINDpNRfKFDSDEFYLKSSSEMRILFEDLPEACDNTLLVAERCH--INFDTQR---SFM 298 
298346985  228 YVYKEDREIQDAMLCINSGDRLSNpDRfRFDGTDYYLRPSEEMHELFAEIPEALDNTLLIAEQCN--VEFPDVKe-gTFM 304 
283783561  228 YVHEEDREAQDAMLCINSGSRLDDpDRfKFDGSGYYLKSAEQMRELFKEFPEACDNTLEIARRCN--VMFDDGEd-gAFM 304 
297571263  226 YVKREDRDIQDAMLCINSGSTLMDpDRfKFDGDGYYIKSSEEMHRQFEDLPEAIDNTLVVAERCN--VSFQTTAdgiSYM 303 
257068282  231 YVTEQDATIQDVLLCINSGSRLNDpDRfKFGGSGYYLKSAQQMRELFREMPEACDNTLRVAEMCD--VEFRTTAegaNYM 308 

118475097  289 PNFKFTQeyakergiilphpqneydlenDSFLFEYECKQGLEKRLEFIDPSKhqiyK-DRLDLEINTINNMKFPGYMLIV 367 
219683289  304 PKFPCPEgw------------------dETSLFLKKVEEGLERRYEGNVPAH----VlAQADYECGVICQMQFPGYFLVV 361 
241196656  304 PKFPCPEgw------------------dETSLFLKKVEEGLERRYEGNVPAH----VlAQADYECGVICQMQFPGYFLVV 361 
241191250  304 PKFPCPEgw------------------dETSLFLKKVEEGLERRYEGNVPAH----VlAQADYECGVICQMQFPGYFLVV 361 
283456439  307 PQFDCPEgw------------------dETSLFLKKVEEGLEKRYDGNPPIE----VlKQADYECGVICQMQFCGYFLVV 364 
28493477   299 PRFSVPEge------------------tENSWFASEVKRGIASRYPNGPSRR----ViEQAEYEIRVVQEAGYAGYFLIV 356 
298346985  305 PVFPVPAge------------------dEVSWFIKEVERGLQYRFPNGISEE----VrKRADYEVEIIVQMGFPSYFLIV 362 
283783561  305 PQFDCPEgw------------------dETSLFLKKVEEGLERRYNNNIPME----VlKQADYECGVICQMQFCGYFLVV 362 
297571263  304 PEFPVPPge------------------dETSWFINQVEAGLLKRYNGTVPAH----VrERADYEVGVITSMGFPGYFLVV 361 
257068282  309 PHFPTPPge------------------dEESWFVKEVQRGLEYRYPAGIPDD----VqKRADYEVSVILQMGFPGYFLVV 366 

118475097  368 ADFINEAKRRGIPVGPGRGSAAGSLVAYALRITDIDPLPYNLLFERFLNPERISMPDIDVDFCQNRRGEVIDYVIEKYGE 447 
219683289  362 ADYIQWAKDHGIMVGPGRGSAAGSMVAYAMGITELDPLEHGLIFERFLNPERVSLPDIDVDFDPEGRLKVIEYCGDKYGH 441 
241196656  362 ADYIQWAKDHGIMVGPGRGSAAGSMVAYAMGITELDPLEHGLIFERFLNPERVSLPDIDVDFDPEGRLKVIEYCGDKYGH 441 
241191250  362 ADYIQWAKDHGIMVGPGRGSAAGSMVAYAMGITELDPLEHGLIFERFLNPERVSLPDIDVDFDPEGRLKVIEYCGDKYGH 441 
283456439  365 ADYINWAKTHGVMVGPGRGSAAGAMVAYAMGITELDPIQHGLIFERFLNPERVSLPDIDVDFDPDGRGRVLDYVGEKYGR 444 
28493477   357 ADFINWAKLNGIRVGPGRGSGAASMAAYAMRITDLDPLEHGLIFERFLNPARISMPDFDIDFDERRRGEVIDYVTKKYGS 436 
298346985  363 SDYIQWAKDNGIRVGPGRGSGAGSMVAYAMRITDLDPIKHGLLFERFLNPERVSMPDIDVDFDDRRRQDVIDYVTRKYGK 442 
283783561  363 ADYINWAKAHGVMVGPGRGSAAGAMVAYAMGITELDPMKHGLIFERFLNPERVSLPDIDVDFDPDGRAKVLEYVGEKYGR 442 
297571263  362 SDYIKWAKKNGIRVGPGRGSGAGSMVAYALEITQLDPIKHELLFERFLNPERVSLPDIDVDFDDRRRDEVIKYVEEKYGS 441 
257068282  367 SDYIKWAKEQDIRVGPGRGSGAGSMVAYAMRITDLDPLEHGLLFERFLNPDRVSMPDFDVDFDDRRRGEVIEYVERKYGD 446 

118475097  448 YNVAQVATFGKLLAKGVIRDVARVMGMPYSEADAMAKLIPDEL--G--ITLKahknkkgdmedGAFEKEPKIGELIAKND 523 
219683289  442 DKVAQCVIYGTIKTKQALKDSARIMGYEFSMGELVTKALPPAAtgGkdVPLHdifd----pgaKRYAEAREYRELYESNP 517 
241196656  442 DKVAQCVIYGTIKTKQALKDSARIMGYEFSMGELVTKALPPAAtgGkdVPLHdifd----pgaKRYAEAREYRELYESNP 517 
241191250  442 DKVAQCVIYGTIKTKQALKDSARIMGYEFSMGELVTKALPPAAtgGkdVPLHdifd----pgaKRYAEAREYRELYESNP 517 
283456439  445 DKVAQCVIYGTIKTKQALKDSARIMGFDFSMGERVTKALPPAQtgGkdIPLHdifd----pasKRYAEAREFRELYDSDP 520 
28493477   437 DHVAQIVTFATIKAKQALKDSARVLSYPYSFGERLTKAMPPAVm-GreIPLRaifd----tthSRHREASEVRQMIESDY 511 
298346985  443 DKVSQVVTYGTIKSKQALKDAARISGADFSKGEKLTKAMPPAVm-GkdIPLSgmyn----pqhPRYKEAEEFRKVVAEDP 517 
283783561  443 DKVAQCVIYGTIKTKQALKDSARIMGYEFSVGEKITKVLPPAKn-GkdMSLHdifd----eksKRYAEAREFREMYDTDP 517 
297571263  442 DKVAQVVTYGTIKTKQALKDAARVLGMPFQMGDQLTKALPPDVqgKs-IAVKdiyn----peaARYNEAGEFREFVDSNA 516 
257068282  447 DRIAQVATYGVMKTKNSLKDAARVLDYPFSMGDRLSKALPPTVmgKd-ISVKgifd----pedKRYAEAGEFRRIHDEDP 521 

118475097  524 LAKQVWEYSCELEGLNRNPGMHAAGIVISNEELWKKAPLWKQSNAeaGHYVTQYTKDYLEDVDLIKFDFLGLKTLTVIDN 603 
219683289  518 DAKRITDEAMGIEGLIRQTGVHACATIMGSEPITDTSPLLERTDG---TVTTTFEYHTCETLGLVKMDFLGLSNLTVIGD 594 
241196656  518 DAKRITDEAMGIEGLIRQTGVHACATIMGSEPITDTSPLLERTDG---TVTTTFEYHTCETLGLVKMDFLGLSNLTVIGD 594 
241191250  518 DAKRITDEAMGIEGLIRQTGVHACATIMGSEPITDTSPLLERTDG---TVTTTFEYHTCETLGLVKMDFLGLSNLTVIGD 594 
283456439  521 DAKRVTDEAMGIEGLIRQTGVHACATIMGSEPITNTSPLLERTDG---TVTTTLEYHTCETLGLVKMDFLGLSNLTVIRD 597 
28493477   512 EMQQIFNTAKGLENLKRQWAVHAAGVIMSDAPIIDIIPIMKRESD--GHIVTQFDYASCESLGLVKMDFLGLRNLTIIDD 589 
298346985  518 FNRQIFDLAAGVEGMVRQWGVHACAVIMSRETLTDVIPMMKRPQD--GAMITQFDYPTCEHLGLLKMDFLGLKNLTIISD 595 
283783561  518 DTHRITEEAKGIEGLIRQTGVHACATIMGSEPITNTSPLLERTDG---TITTTFEYHTCETLGLVKMDFLGLSNLTVIRD 594 
297571263  517 EAKRVFDFALGLEGMTRQTGVHACAVIMSSTALTDVIPIMKRLQD--GAIITQFEYPQCEELGLVKMDFLGLSNLTVIEG 594 
257068282  522 DVQKVVEIAKGVEGLTRGWGVHACAVIMSSDPLVDIVPMMRRPSD--GQIITQFEYPTLETLGLLKMDFLGLRNLTVLSD 599 

118475097  604 AKKLIKERFgVDILWEKIDFNDQKTYETIQSGNTLGIFQIESSGMQSLAAKLRPDCFEDIIAMIALYRPGPLNsgMVDDF 683 
219683289  595 TLRNIEANGkEPIDHTKIPLDDKETYELLSRGDTLGVFQLDSDGMRALLKQLKPDNFNDISALIALYRPGPMSmdSHTNY 674 
241196656  595 TLRNIEANGkEPIDHTKIPLDDKETYELLSRGDTLGVFQLDSDGMRALLKQLKPDNFNDISALIALYRPGPMSmdSHTNY 674 
241191250  595 TLRNIEANGkEPIDHTKIPLDDKETYELLSRGDTLGVFQLDSDGMRALLKQLKPDNFNDISALIALYRPGPMSmdSHTNY 674 
283456439  598 TLNNIEANGkDRIDHTRIPLDDKATYELLSRGDTLGVFQLDSDGMRSLLKTLKPSNFNDISALIALYRPGPMDmdSHTNY 677 
28493477   590 ALANIRQNKnTKVDLENLPLDDPEVYKLLRRADTLGVFQLDSGPIRQLLELMQPDSFDDISAAIALYRPGPMGarSHTNY 669 
298346985  596 ALDNIKINGkTPPDLERLDVDDKATYELLSTGETLGVFQLDGGGMRTLLKQLRPTEFDDISALVALYRPGPMGanSHTNY 675 
283783561  595 TLRNIENNGkDPIDYTKIPLDDKATYQLLSRGDTLGVFQLDSDGMRALLRTLKPDNFNDISALIALYRPGPMDmdSHTNY 674 
297571263  595 ALTNIRNNGkEAPNIDEIPLDDVETYELLARAETLGIFQLDSPGMRQLLKQMKPDTFADISAVSALYRPGPMGanSHTNY 674 
257068282  600 AVANMARNGkTPPDLETLPFDDPATYELLQKGDTLGVFQLDGSGMRTLLRQMKPDQFGDITAVSALYRPGPMGmgSHTNY 679 

118475097  684 IDIKHGKKKIEYAFAA----LKPILEPTYGVIVYQEQVMQVVQTVGGFSLGGADLVRRAMSKKKEDEMLHLKTQYLEGAK 759 
219683289  675 AKRKNGLQKIEPIHPElaepLKEVLDETYGLIIYQEQVQSAARILAGYSLGKADVLRRAMGKKKPEVLAKEQVPFFEGMK 754 
241196656  675 AKRKNGLQKIEPIHPElaepLKEVLDETYGLIIYQEQVQSAARILAGYSLGKADVLRRAMGKKKPEVLAKEQVPFFEGMK 754 
241191250  675 AKRKNGLQKIEPIHPElaepLKEVLDETYGLIIYQEQVQSAARILAGYSLGKADVLRRAMGKKKPEVLAKEQVPFFEGMK 754 
283456439  678 AKRKNGLQKITPIHPEvaepLKEVLDETYGLIVYQEQVQSAARILAGYSLGKADVLRRAMGKKKPEVLAKEKIPFFAGMK 757 
28493477   670 ALRKNRKQEIDHIHPEltkdLSVLLSSTYGLIVYQEQVIGIAQKLAGFTLEEADVLRWAMGKKKKDELDRQYNKFANGMR 749 
298346985  676 AFRKNGLQKIEPIHSEleepLKDILGYTYGLIIYQEQVMAIAQKVAGFTLGQADILRKAMGKKKKDVLDKQYVKFHDGMI 755 
283783561  675 AKRKNGLQDIIPIHPEvaepLKEVLDETYGLIVYQEQVQSAARILAGYSLGKADVLRRAMGKKKPEVLAKEQVPFFEGMK 754 
297571263  675 ALRKNGLQEKTPIHPElataLEDILGNTHGLIVFQEQVMRIAQKLAGFTLGQADILRKAMGKKKADVLQKQFKGFAQGMR 754 
257068282  680 ALRKNGLQEITPIHPEleepLAEILDETYGVLVYQEQVMQTAQKVAGYSLGEADILRRAMGKKKKAELDKQYVSFEAGMK 759 

118475097  760 RNGFDEGKADALFELIMKFAEYGFNKSHSAAYALITFQTAYLKTYYPAEFMAALLTSEENNIDKIIKYIDEIKRLNIKLL 839 
219683289  755 EHGYSREAAQAVWDVLVPFSGYAFNKAHSAAYGLISYWTAYLKTHYPAEFMAALLQGASTNKDKTALYLGEARRMGIKVL 834 
241196656  755 EHGYSREAAQAVWDVLVPFSGYAFNKAHSAAYGLISYWTAYLKTHYPAEFMAALLQGASTNKDKTALYLGEARRMGIKVL 834 
241191250  755 EHGYSREAAQAVWDVLVPFSGYAFNKAHSAAYGLISYWTAYLKTHYPAEFMAALLQGASTNKDKTALYLGEARRMGIKVL 834 
283456439  758 EHGYSQEAAQAVWDILVPFSGYAFNKAHSAAYGLISYWTAYLKTHYPVEFMAALLQGASTNKDKTALYLGEARRMGIQVL 837 
28493477   750 KAGYSDGATEALWNVLLPFSDYAFNKAHATAYGLISYWTAYLKAHYPTEYMAALLTSVETSRDKLGLYLQECRHMCIKVL 829 
298346985  756 EHGYSEDCCETLWGILVPFADYAFNKSHSAAYGLIAYWTAYLKANFPTEYMAAVLTTQTDK-DKLGMYLNEVRRMGIKVL 834 
283783561  755 AHGYSEEAAQAVWDVLVPFSGYAFNKAHSAAYGLISYWTAYLKTHYPVEFMAALLQNERTNKDKTALYLGEARRMGIQVL 834 
297571263  755 DHGYSDECINTLWDILVPFAQYAFNKSHSEAYALVTYQTAYLKAHYPSEYMASLLTSNQNNKTKVATYLADTRRMGIRVN 834 
257068282  760 SNGYSDAAVQALWETLLPFADYAFNKSHSAAYGVVSYWTAYLKANHPTEYMAALLTSTQENRDRLGLYLGDCRHRGITVL 839 

118475097  840 PPNVNYSVREFSViqkdGSD-SIIYGMAAIKGVGVGAVEDIIKAR-ED--G----PFESVDSFISKTDCTTVNRRVFESL 911 
219683289  835 SPDVNESVYAYSA-----VGdVVRFGLGAIRNVGEKAVADIIAER-QGshG----RYVNFMDFIRRVPLTALNRRLVESL 904 
241196656  835 SPDVNESVYAYSA-----VGdVVRFGLGAIRNVGEKAVADIIAER-QGshG----RYVNFMDFIRRVPLTALNRRLVESL 904 
241191250  835 SPDVNESVYAYSA-----VGdVVRFGLGAIRNVGEKAVADIIAER-QGshG----RYVNFMDFIRRVPLTALNRRLVESL 904 
283456439  838 SPDVNESVFEYSA----VGD-VVRFGLGAIRNVGRNAVDDIIKER-----EsghgKYVNFPDFVRRVPLSALNRRLVESL 907 
28493477   830 LPDINVSRSGFTP----SGE-NILFGLGAIKNVGANLIDDILEVR-ED--G----PFVSLIDFVQRMPHSVLNRRSVMSL 897 
298346985  835 PPDVNQSYGVFAP-----DGnDIRFGLASIRNVGENVVAEIIKARqEK--G----AYTSFSDFLKKVPAEVCNKRTIGSL 903 
283783561  835 QPDVNESVLEYSA----VGD-VVRFGLGAIRNVGDKAVNDIITER-----EgergRFVNFMDFVQRVPISALNRRLVESL 904 
297571263  835 VPDVNKSMDVYSA----VGN-EVRVGLSSVRNVGKNVVDGIIETR-KE--Kg---EYTSFQDFLDKVPAAVLNKRAVECL 903 
257068282  840 PPDVNESDLYFSA----VGE-DIRFGLSAIRNVGAHVVEEIIKTR-EE--Kg---AFTSFTDFLDKVPLSVCNKRTIESL 908 

118475097  912 IKSGAFDDFGFTRKMLIHNLETIIENSKRISdiKKNATNS--LFs---------dDDSMSEI------SVDLVNi----k 970 
219683289  905 IKAGAFDSIDPNRRALYQIHEAAIDSVTDLK--RKQATGQfdLFadldagaddgeaealgDV------SISVPDv----- 971 
241196656  905 IKAGAFDSIDPNRRALYQIHEAAIDSVTDLK--RKQATGQfdLFadldagaddgeaealgDV------SISVPDv----- 971 
241191250  905 IKAGAFDSIDPNRRALYQIHEAAIDSVTDLK--RKQATGQfdLFadldagaddgeaealgDV------SISVPDv----- 971 
283456439  908 IKAGAFDSVDPNRRALFTIHEAAINSVVGIK--RKQAEGQfdLFsdlddsa---eqdgmgDA------MVSVPDv----- 971 
28493477   898 IQAGAFDSIHPNRRSLMDIHRSVLENCQANA--RRSDVSLl------------------dGL------LDEYEGfsppdi 951 
298346985  904 IKAGAFDAFGAPRSALTAIHEQAVEAVVSTK--RQESNGQfdLFaalemegtespdnllgSA------SIDIPDi----- 970 
283783561  905 IKAGAFDSIDSNRRALFQICDPAIDSVIALK--RKQAEGQfdLFadldsssdsddDNGMGDM------QITVPDv----- 971 
297571263  904 IKAGAFDSLGYSRRALVSIHEEAIEAVLPVK--RNEAGGQfdLFggl-----genNPIAQSF------NVEIPDl----- 965 
257068282  909 IKGGAFDELGANRRSLVLIHEDAVDSVVDVK--RKEAQGQydLFadmf---agagGDGEESMasgsaaTITVPDl----- 978 

118475097  971 DEFDKKEILKFEQEILGVYVSGHPLDEYRDKIDKINYTVSSEFE-N---VEDGSE--ILVVGKIEDTTTKITKT-GKKMA 1043
219683289  972 EEWDKKTKLNFEREMLGLYVSDHPLSGMQSVLASLRDMSIAQLI-Draptm-persqVMVAGLITNVDSRVSKK-GNRWA 1048
241196656  972 EEWDKKTKLNFEREMLGLYVSDHPLSGMQSVLASLRDMSIAQLI-DraptmpeRSq-VMVAGLITNVDSRVSKK-GNRWA 1048
241191250  972 EEWDKKTKLNFEREMLGLYVSDHPLSGMQSVLASLRDMSIAQLI-DraptmpeRSq-VMVAGLITNVDSRVSKK-GNRWA 1048
283456439  972 EEWDKKTKLNFEREMLGLYVSDHPLSGMQSVLSSLREMSIAHLidragtMPDGQQ--VTVAGLITNVDRRVSKK-GNPWA 1048
28493477   952 PDWDNRERLKYEREMLGMYVSSHPLDGLEDSLLKFRDCSIAECI-S---RKPQDV--IRVAGLITSVEHKVARRtGMRYA 1025
298346985  971 SEWPKNELLAFEREMLGMYVSDHPLSGMNRVLEGLAEDRIVDLT-Sde--gkGNDspVKIAGLVTAVNVKISKRsGQQWA 1047
283783561  972 EEWDKKTKLNFEREMLGLYVSDHPLSGLSAVLADLREMSIAQLidrartMSDGQQ--VTIAGLVTSVDRRVSRK-GNAWA 1048
297571263  966 PEWDKKEKLNIERDMLGLYVSDHPLSGLEAFLDRVADHTVLGIQ-NdenPVDGQM--VTVAGLITSVQTRISQKnGKTWA 1042
257068282  979 PEWDRKEKLAFERNMLGLYVSDHPLYGLEHVIAQNSSTSISALA-DdgaVQDGTM--VTIAGLITSLQRKTTKK-GDMWA 1054

118475097 1044 IINILD-IHGNIEATAF-DEYKKIESMsqneldephafkiilnkdgqqfklkindiislddalykrftlksskltddevf 1121
219683289 1049 IVTIEDmESS-IQCLLFgKVYEAHAAE----------------------------------------------------- 1074
241196656 1049 IVTIED-MESSIQCLLFgKVYEAHAAE----------------------------------------------------- 1074
241191250 1049 IVTIED-MESSIQCLLFgKVYEAHAAE----------------------------------------------------- 1074
283456439 1049 IVTIED-LESSIQCMFFgKVYEAAAPE----------------------------------------------------- 1074
28493477  1026 HAILED-TSGEIQIMLSgQNYNNFSEQ----------------------------------------------------- 1051
298346985 1048 IAKIED-MTGSVEVLFFaKTYENIAGD----------------------------------------------------- 1073
283783561 1049 IVTVED-MESSIQCMFFgKVYEASAQE----------------------------------------------------- 1074
297571263 1043 TATIED-FTGSIEVNFFpATYQSVSHF----------------------------------------------------- 1068
257068282 1055 IATVED-LEGSIDCLLFpSTYQTVATE----------------------------------------------------- 1080

118475097 1122 kfqnyfdtikhatikdipnLTKESEILIIGKMSHINirttkSGMEMAIL--NIVDISGnsemiafdstskfianmsedeq 1199
219683289 1075 -------------------LAIDTIVQVRGMVEARD-----ETISLRAT--DLMVPvie--------------------- 1107
241196656 1075 -------------------LAIDTIVQVRGMVEARD-----ETISLRAT--DLMVPvie--------------------- 1107
241191250 1075 -------------------LAIDTIVQVRGMVEARD-----ETISLRAT--DLMVPvie--------------------- 1107
283456439 1075 -------------------LAVDTVVQIRGQVERRD-----ETVSLRATefQVPTL------------------------ 1106
28493477  1052 -------------------LVTDSIVSVTGRISFRD-----DATTLYCD--SIKDV------------------------ 1081
298346985 1074 -------------------LVQDNIVVVGGRLRRED-----ESVSIYAS--DLSVP------------------------ 1103
283783561 1075 -------------------LAIDQVVRIRGQVEVRDetvsmRATEFEIP--TLESVDE---------------------- 1111
297571263 1069 -------------------LIPDTVVTIKARMSVRD-----SGVQLNAMemTVPQLAG---------------------- 1102
257068282 1081 -------------------LAEDLIVSMKGRVDSSK-----GMPELRVM--EMMIPETg--------------------- 1113

118475097 1200 dtiyafkvapnkdaqskpiinqiislDDAKdgnftlktnrrryesrvneqsasatiIgkLEVDIDIIslDKQK----INY 1275
219683289 1108 -----------------------------------------------------ageD--RPVFVQLP--AHALdmqrLEQ 1130
241196656 1108 -----------------------------------------------------ageD--RPVFVQLP--AHALdmqrLEQ 1130
241191250 1108 -----------------------------------------------------ageD--RPVFVQLP--AHALdmqrLEQ 1130
283456439 1107 --------------------------EAEDe----------------------------RPLVITLP--QVALnrdhVMR 1130
28493477  1082 --------------------------LPVK-----------------------------KEARLRLKcsEGFLtqnvFIA 1106
298346985 1104 --------------------------KMSLhld------------------------hlDEVELLLP--AERCtkenMRA 1131
283783561 1112 -----------------------------------------------------------RPLTVVIP--RKVLdkgrVAQ 1130
297571263 1103 --------------------------VAED-----------------------------TPLDIQIP--ERMLtqdmMQR 1125
257068282 1114 --------------------------GGAD-----------------------------GPVVIALP--AMRAnervVQD 1136

118475097 1276 IYQLAHSYHqknGNK--RLLL-RITNNydKEVMIFSTEFIVsdeFKSELDAiLNEAKAG 1331
219683289 1131 FSQILSNHP---GACevRLAI-VDDNGg-VTLMTLGDRFRVr-rETGLFAD-IKVLFGA 1182
241196656 1131 FSQILSNHP---GACevRLAIvDDNGG--VTLMTLGDRFRVr-rETGLFAD-IKVLFGA 1182
241191250 1131 FSQILSNHP---GACevRLAIvDDNGG--VTLMTLGDRFRVr-rETGLFAD-IKVLFGA 1182
283456439 1131 LGRILNDHP---GYCevRLAImDDQGN--AKVLTFGDRFRVk-rDTSLFAE-IKILFGP 1182
28493477  1107 LDDVLRKYP---GDTpvTMEV-IITDNsvVKSKTFELSRCVe-iSNDLIAE-VKGILGI 1159
298346985 1132 FGALLERFP---GQApvRLHI-LEEGE--LQVLDLGPERRVn-aGPDFLGE-LRAMLGY 1182
283783561 1131 LSNILSRHP---GCCevRLAL--VDDTgkAQVLTFGDRFRVk-rDTSLFAE-MKIVFGS 1182
297571263 1126 LSDVLTQYP---GKApiRIHV-RQLGK--TTVVQLHNSYKVn-vNPSLLSN-LRVLLGK 1176
257068282 1137 LRGVLEDNP---GGSevRLRL-QEPGR--TTLMQLDKRLSVt-pSAALYAS-LKTLLGP 1187
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