2JO1


Conserved Protein Domain Family
FXYD1
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cd20317: FXYD1 
FXYD domain-containing ion transport regulator 1
FXYD domain-containing ion transport regulator 1 (FXYD1), also known as phospholemman (PLM), or sodium/potassium-transporting ATPase subunit FXYD1, associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na+ out of the cell and K+ into the cell. It is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature.
Links
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Statistics
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PSSM-Id: 410556
Aligned: 18 rows
Threshold Bit Score: 78.9066
Created: 8-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative trimer
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:putative trimer interface [polypeptide binding site]
Evidence:
  • Comment:based on structures of the Na+/K+ ATPase heterotrimer, composed of alpha, beta, and gamma (FXYD2 or phospholemman-like protein) subunits
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # # #  ##  ## ##  #  ### ## #                                             
2JO1_A         3 PKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRCRCKFNQQQRTGe---------------------pDEEEGTFR 61  human
NP_001086393  26 QAEKDPFHYDYHTLRIGGLVFAGVLFILGILIILSRKCRCKFNQHQRTGe---------------------pLEEEGTLR 84  African clawed ...
EPQ05367      23 PQEHDPFTYDYQSLRIGGLVIAGVLFILGILIVFSEYPHCLQPVPAPPHpafn---------------palfPPSARPVP 87  Brandt's bat
XP_023419462  49 PQEHDPFTYDYKSLRIGGLTVAGILFILGILIILSKRCRCKFNQQQKCKitkcddtkmqgkskllrneitsrVAQFSSQF 128 domestic guinea...
XP_029432188  35 KNERDPFTYDYKTLRIGGLVFAGVLFILGIMIILSRKCRCKFNQHQRIGe---------------------pIIEEGSLR 93  two-lined caeci...
I3LMB3        23 PQEHDPFTYDYQSLRIGGLIIAGILFILGILIVLSRRCRCKFNQQQSLGkm--------------------rSPHLAAQF 82  pig
XP_019278776  23 PQEHDPFTYDYKTLRIGGLIIAGILFILGILIVLSRRCRCKFNQQQRLSpgrlss-----------spsaipPPPTSSLF 91  leopard
XP_027833241  23 PQEHDPFTYDYQSLRIGGLIIAGILFILGILIVLSESPYPAFSRFRCLPqa--------------------cPTSRSAFN 82  sheep
XP_015352725  23 PQEHDPFTYDYQSLRIGGLTIAGILFILGILIILSKRCRCKFNQQQSLLph-------------------klLPGAPPFR 83  Alpine marmot
KAE8594478    14 ISSVISAAIDYRTLRIGGLVFAGVLFILGILIILSRKCRCKFNQHQRTGe---------------------pLEEEGTLR 72  tropical clawed...

Feature 1             
2JO1_A        62 SSIRR 66  human
NP_001086393  85 ASIRR 89  African clawed frog
EPQ05367      88 APPRH 92  Brandt's bat
XP_023419462 129 SSWRV 133 domestic guinea pig
XP_029432188  94 ASIRR 98  two-lined caecilian
I3LMB3        83 SSESC 87  pig
XP_019278776  92 PSTPG 96  leopard
XP_027833241  83 PAPSV 87  sheep
XP_015352725  84 RRTPS 88  Alpine marmot
KAE8594478    73 ASIRR 77  tropical clawed frog

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