Conserved Protein Domain Family
Zn_dep_PLPC
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smart00770: Zn_dep_PLPC 
Zinc dependent phospholipase C (alpha toxin)
This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.
Links
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Statistics
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PSSM-Id: 214813
Aligned: 16 rows
Threshold Bit Score: 142.169
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
tigr:CHY_0741   1 MVEKALKIISPL------------------------------------------QGFLDNVePTHGFLLNKALIQLQEKN 38  Carboxydotherm...
Q8VUZ6          1 MKRKFTKTVLNAvfvlglcsi-------------------------mggtsyawDGKKDGT-GTHALIAEHGLTMLNNDL 54  Clostridium so...
ZP_05269984     1 MKFKKVVLGMCLtasvlvfpvtikanaccdeylqtpaaphdidsklphklswsaDNPTNTDvNTHYWLFKQAEKILAKDV 80  Listeria monoc...
YP_003463430    1 MKIKGILMGLCLsasivalsgadeasacgdesvkdqiaphdiqnklpsklgwsaEHPSKNEiNTHLWLFNQAEKILAKDV 80  Listeria seeli...
CAC84227        1 MRINKISLGIYVfifaltaslmkvnacsddhl--mqpqtpniehklphklswsaERPLDEKaNTHLWLFKQARKILAKEN 78  Listeria ivanovii
AAO40751        1 MKKKVLALAAAItlvaplqnvafahen-------------dggskikivhrwsaEDKHKEGvNSHLWIVNRAIDIMSRNK 67  Bacillus cereus
NP_149311       1 MKNVFKKITTAIiassltltfsfttfaealp----qktqstyqelqnttnrriyDFTSDGAkGTHEFITVQAMTILGNDK 76  Clostridium ac...
NP_347655       1 MKKKFESTYGKTirgiff------------------------------vinpvkKKVIKTTcIIHKYINSLAVEILKNKR 50  Clostridium ac...
NP_781640       1 MGNRIEKTYGSAlkglfh------------------------------avnplkKKFLKTYcTVHKFIMLQSLDILKNSE 50  Clostridium te...
NP_561628       1 MDNMKKILKKMPkv---------------------------------------mKKSFKKS-NTHDVLLEQANRMVINDN 40  Clostridium pe...

tigr:CHY_0741  39 Y-----KTSY---------YERYYRQIY-CGLYAADKGWQ-------NVT------HYFNPRTKKG-L---------FI- 79  Carboxydotherm...
Q8VUZ6         55 N-----QNEPkpikqnieiLNKYLKDLK-LGSTFPDYDPN-------AYDlf--qdHFFDPDTGNNfTldnkwyvasPI- 118 Clostridium so...
ZP_05269984    81 N-----HMRAnlm----neLKKFDKQIA-QGIYDADHKNP-------YYDtstflsHFYNPDRDNTyL---------PG- 133 Listeria monoc...
YP_003463430   81 T-----GAQLdlv----reLKNYNKEIA-QGIFDADHKNP-------YYDkntflsHFYNPKTHKTyI---------AG- 133 Listeria seeli...
CAC84227       79 N-----GAYKell----emLNKYYKEVA-QGIFDADHKNP-------YYDcstfvsHFYNPTKDNTyL---------PG- 131 Listeria ivanovii
AAO40751       68 T-----LVKQdrv----alLNEWRTELE-NGIYAADYENP-------YYDnstfasHFYDPDNGKTyI---------PY- 120 Bacillus cereus
NP_149311      77 G-----NNFKnl-------iKNYEPTLR-QYCDKPDKDEN-------QWAfa---yHFYNPYTGLNyL---------PSi 124 Clostridium ac...
NP_347655      51 K-----AKQYk-------fFSDNIEAIN-EGTVWADQDFK-------STN------HFFDFEKGRG-L---------YG- 93  Clostridium ac...
NP_781640      51 H-----QEAYn-------fFKDNLAKLN-EGTTWADQDFK-------SSN------HFFHFSKGKG-L---------YG- 93  Clostridium te...
NP_561628      41 NlylnnKWFSkslkwcmdiLELNYNVSKsLGWIRPSYSRKpdimlrsVVTlf--sfHFYHGEDKDNyF---------GR- 108 Clostridium pe...

tigr:CHY_0741  80 -F---LSAKEAFYQELKNFHKFSEQKNPK-AFWH--FGRAAHILQDLCEPHHL--KPTf-------------LN--G--- 132 Carboxydotherm...
Q8VUZ6        119 -Y---DTAETQVRKFATLAENEWKKGNYKeATFL--LGQGMHYLGDLNTPYHAanVTA--------------VDspG--- 175 Clostridium so...
ZP_05269984   134 -F---ANAKITGAKYFNQSVTDYREGKFDtAFYK--LGLAIHYYTDISQPMHAnnFTA--------------ISypPg-- 191 Listeria monoc...
YP_003463430  134 -F---PNAKDTGTKYFNISIEEYQDGNFEkAFYN--LGLAIHYYTDISQPMHAnnFTA--------------LShpVg-- 191 Listeria seeli...
CAC84227      132 -F---KNAKQTCGKYFKQALQDYKEDKLNtAFYK--LGLSIHYFTDCSQPMHAnnFTA--------------VSnpIg-- 189 Listeria ivanovii
AAO40751      121 -A---KQAKETGAKYFKLAGESYKNKDMKqAFFY--LGLSLHYLGDVNQPMHAanFTN--------------LSypQg-- 178 Bacillus cereus
NP_149311     125 lP---QSKTTALTKFEEHAANAVSSYRTDrTYSMqeLGRACHFLEDVNVPYHSanLIA--------------VLs----- 182 Clostridium ac...
NP_347655      94 -F---SNLVDEAQKYYNMSLNYLRAGDKKkSLFY--LGAACHIIQDSTVPQHVnnRLLn-----------------S--- 147 Clostridium ac...
NP_781640      94 -F---SNALLECKKYYDKSLENLEKGDLDkAMFF--LGAACHLIQDVTVPQHVnnKLLk-----------------S--- 147 Clostridium te...
NP_561628     109 -IgkgKTAMCKFIFFGRKALKYRDKGKRRkCMKY--LSYSCHYLADMSEPHHVthHIAspnekimnvlkrfdINkiGkgn 185 Clostridium pe...

tigr:CHY_0741 133 ---HKKFERW-V-----------------GD-----------------NikiiirklYLPPALrPWltleiesfsSKILd 174 Carboxydotherm...
Q8VUZ6        176 ---HVKYETF-Ven--------------rKE-----------------N--------YALNTA-GNdttq--giyKDAV- 208 Clostridium so...
ZP_05269984   192 --yHCAYENY-Vdt--------------iKH-----------------N--------YQATED-MV---------AKRF- 218 Listeria monoc...
YP_003463430  192 --yHCAYENY-Vdt--------------fKQ-----------------I--------FQASAE-SE---------AKWF- 218 Listeria seeli...
CAC84227      190 --fHSVYENY-Vds--------------iKC-----------------N--------YQATES-ME---------VKKF- 216 Listeria ivanovii
AAO40751      179 --fHSKYENF-Vdt--------------iKD-----------------N--------YKVTDG-NG---------YWNW- 205 Bacillus cereus
NP_149311     183 --tHSQYEQF-Vqd--------------hQT-----------------S--------YALNST-DK---------YGNY- 209 Clostridium ac...
NP_347655     148 ---HRNFEMWiIqk--------------fLS-----------------G--------YRFMKA-DE-----------II- 172 Clostridium ac...
NP_781640     148 ---HRRFELWiIsr--------------lLN-----------------D--------YSFMAE-HE---------IVRY- 174 Clostridium te...
NP_561628     186 fsnHRRFENL-AqawikgdeditllldknKDkdenillkgvptkgeifS--------YILKDE-GI---------KVFN- 245 Clostridium pe...

tigr:CHY_0741 175 yyE---------------------L-------------V-------G---------EK---------------------- 182 Carboxydotherm...
Q8VUZ6        209 --A---------------------NkdfdqwmtqnsvkY-------A---------KK---------------------- 227 Clostridium so...
ZP_05269984   219 --CsddvkdwlyenakrakadypkI-------------V-------N---------AK---------------------- 245 Listeria monoc...
YP_003463430  219 --CtddvsewfhenakraqadypkI-------------V-------N---------TI---------------------- 245 Listeria seeli...
CAC84227      217 --CvdtpeewlrenakraqadydkI-------------V-------N---------AN---------------------- 243 Listeria ivanovii
AAO40751      206 --KgtnpedwihgaavvakqdyagI-------------V-------N---------DN---------------------- 232 Bacillus cereus
NP_149311     210 --Ysenfn-----------dycydI-------------L-------N---------DC---------------------- 225 Clostridium ac...
NP_347655     173 --R---------------------S-------------D-------NtrdyirknaKV---------------------- 187 Clostridium ac...
NP_781640     175 --S---------------------N-------------LdeyivnnA---------FL---------------------- 187 Clostridium te...
NP_561628     246 --E---------------------D-------------D-------K---------KKvldiyyknsnldfddycrylgn 273 Clostridium pe...

tigr:CHY_0741 183 -----AGD------IS----------------YFRAAQELLAAAVKLTMDlFL---ENEIYF 214 Carboxydothermus hydrogenoforman...
Q8VUZ6        228 -----AKA------LYyshstm----khnwddWDYSGREAIKNSQVCTAG-FLyrfINEVSE 273 Clostridium sordellii
ZP_05269984   246 -----TKK------SYlvgns------ewkkdTVEPTGARLRDSQQTLAG-FLefwSKKTNE 289 Listeria monocytogenes F6900
YP_003463430  246 -----IKK------SYiqglsdsqkdrtwkkaVRAATGKRLRDSQETLAG-LLefwYTKTNE 295 Listeria seeligeri serovar 1/2b ...
CAC84227      244 -----TKK------SYlegns------kwkkdIDKPTGERLQDSMQTLAG-FIdfwYKKADQ 287 Listeria ivanovii
AAO40751      233 -----TKDwfvraaVSqeyad------kwraeVTPMTGKRLMDAQRVTAG-YIqlwFDTYGD 282 Bacillus cereus
NP_149311     226 -----AKY------SYsfkdev----qksessWDSVANVTVKYAEGYVAA-FFyrfLHEVGE 271 Clostridium acetobutylicum ATCC 824
NP_347655     188 -----ANK------IYnkcfti----kdkearYDAISNYIICQAQMSTAG-LMmdyYEKYEv 233 Clostridium acetobutylicum ATCC 824
NP_781640     188 -----ANN------TYikymnv----enreekYSKIASIVLKEAQKTTAG-FLldyYENVKN 233 Clostridium tetani E88
NP_561628     274 esseyAKE------LIhdafk------ddtreQALAAIRALNMAEIQLAR-FLyyfCNYNLK 322 Clostridium perfringens str. 13
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