1TGS,1CGJ,1PCE,1R0T


Conserved Protein Domain Family
KAZAL_PSTI
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cd01327: KAZAL_PSTI 
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Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the superfamily of kazal-type proteinase inhibitors and follistatin-like proteins.
Links
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Statistics
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PSSM-Id: 238648
Aligned: 18 rows
Threshold Bit Score: 64.9978
Created: 16-Jun-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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proteaseprotease
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:protease interaction site
Evidence:
  • Comment:KAZAL type inhibitors bind to active site mimicking the substrate
  • Structure:1TGS_I; Porcine PSTI binds trypsinogen
  • Structure:1CGJ_I; Human PSTI variant 4 binds chymotrypsinogen
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #                                            
1TGS_I      12 EVSGCPKIYN-----PVCGTDGITYSNECVLCSENkkr-qtpVLIQKSGPC 56   pig
P11706      17 AMHACPMNFA-----PVCGTDGNTYPNECSLCFQRqnt-ktdILITKDDRC 61   European eel
P58062      41 VAIPCPITYL-----PVCGSDYITYGNECHLCTESlks-ngrVQFLHDGSC 85   human
Q9NQ38    1002 IGYLCPKDLK-----PVCGDDGQTYNNPCMLCHENlir-qtnTHIRSTGKC 1046 human
Q9NQ38     107 GDFICPDYYE-----AVCGTDGKTYDNRCALCAENakt-gsqIGVKSEGEC 151  human
Q9PSM2      19 LKKGCAKIFD-----PVCGTDNILYSNECLLCFQNlqr-ktnVRIKRRGTC 63   ostrich
P83039      18 ELLACPLVNL-----PVCGTDGNTYANECLLCVQKmkt-rqdIRILNNGRC 62   Muscovy duck
BAC29153   108 GDFICPSDTS-----SVCGTDGKTYRSRCELCAENaks-qnhVDVKSEGEC 152  house mouse
BAB32081    60 DGKSCPKTHK-----PVCGTDGKTYQNRCAFCQTAmerslgkLGFKHEGKC 105  house mouse
XP_217268   47 NVQMCWILTYfklsePICGSNQVTYNGECHLCSEIlfe-drtIIKVHDGPC 96   Norway rat

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