2PTU


Conserved Protein Domain Family
Receptor_2B4
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pfam11465: Receptor_2B4 
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Natural killer cell receptor 2B4
2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.
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Statistics
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PSSM-Id: 288342
Aligned: 3 rows
Threshold Bit Score: 185.167
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2PTU_D   5 CPDSSEEVVGVSGKPVQLRPSNIQTKDVSVQWKKTEQgSHRKIE-ILNWYNDGPSWSNvsFSDIYGFDYGDFALSIKSAK 83  house mouse
Q9BZW8  22 CQGSADHVVSISGVPLQLQPNSIQTKVDSIAWKKLLP-SQNGFHhILKWENGSLPSNT--SNDRFSFIVKNLSLLIKAAQ 98  human
Q9JLM2  22 CADSSEEVLGVSGKPVRLRPSNIQAKHVSIEWKKKT--GHQQTPqIVTWDTTDNKNFNmcCSDIYGFESENFALSIKSAK 99  Norway rat

2PTU_D  84 LQDSGHYLLEITNTGGKVCNKNFQLLILD 112 house mouse
Q9BZW8  99 QQDSGLYCLEVTSISGKVQTATFQVFVFE 127 human
Q9JLM2 100 LNDSGHYLLEITNQRGIVCTKNFQMLIFD 128 Norway rat
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