2JTG,2D8R


Conserved Protein Domain Family
THAP
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smart00980: THAP 
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The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion.
It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.
Links
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Statistics
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PSSM-Id: 214951
Aligned: 139 rows
Threshold Bit Score: 35.1034
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2JTG_A          4 SCSAYGCKNr--yDKDK-----PVSFH--KFPLTRPSLCKEWEAAVRR--Knf-------kPTKYSSICSEHFTPDCFKR 65   human
XP_001663350    3 HCCIKYCDTd--eNVVNc---tSVFFV--SFPSDIILRLE-WLNVLNQ--Ndall--pdveVTVATRICSCHFSEDAFGK 70   yellow fever ...
XP_316583       2 KCFVSGCDTd--dNVVS-----YTSVFyvNCPT-DPTIQQQWFTLLEVtdPdam----ralVDGRSKVCSCHFTEDCFGH 69   Anopheles gam...
XP_001663211    4 lCCIPICPNs---KTNR-----GTPCY--PFPAADPVLRGKWIEFIGT--Esh------rfRWRSKYICAEHFHQLDLVE 65   yellow fever ...
XP_001663215    4 LCCIALCPSa---KADR-----GVACF--PFP-PNEELRNQWIEFVGG--Dps------rfRWKTKYVCADHFLELELVE 64   yellow fever ...
XP_001662339    4 RCCAASCYNs--vATNR-----SVEYF--GFPK-SNEYAAAWAKAAGR--Edlle--kslcNIIKYYLCSEHFSDDCFQD 69   yellow fever ...
XP_002121651    3 RCTAYNCTHitrrANAGdn--gGVSLF--KFPK-KEKLCQLWIQALGR--DdlneftssqlKSLGLRVCQLHFKKDDVYE 75   Ciona intesti...
NP_524224       5 SCAYKDCEYy--yVGHEnaltkGRTLF--AFPK-QPQRARIWHENGQV--Hpk-------ipHSQLFMCSLHFDRKFISS 70   fruit fly
NP_495084     953 QCCY--CLEv--yEKR--------YMT--QVPk-TEQRIARWVAILG---Eqfri---rlrMKPANYMCRKHFPQADFSS 1011 nematode
NP_510587    1138 VCCF--CSKr--gDRG--------GML--RVPr-SEERLARWVDKLG---Pefea---rlhTNTENLICRSHFPDAAFSS 1196 nematode

2JTG_A         66 ecN--N----KLLKENAVPTIFL 82   human
XP_001663350   71 --H--PvhgyRFLLPTAVPSIFP 89   yellow fever mosquito
XP_316583      70 --H--PvygyRYLLATALPTVFP 88   Anopheles gambiae str. PEST
XP_001663211   66 --D--Gsg-qRLPADGAIPTIYS 83   yellow fever mosquito
XP_001663215   65 --IdgQ----KQLLEGAVPMVYS 81   yellow fever mosquito
XP_001662339   70 --PphN----RKLRKTSRPVVVP 86   yellow fever mosquito
XP_002121651   76 --KesK----HFLRKNAVPITTS 92   Ciona intestinalis
NP_524224      71 sk--nR----TLLVGEAVPFPYE 87   fruit fly
NP_495084    1012 -----R----GRLLKTAVPNVVS 1025 nematode
NP_510587    1197 -----R----GRLLKGMIPDAAP 1210 nematode
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