1G4T,1G67,1XI3,1YAD


Conserved Protein Domain Family
TMP_TenI

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cd00564: TMP_TenI 
Click on image for an interactive view with Cn3D
Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl) thiazole phosphate to yield thiamine phosphate. TenI is a enzymatically inactive regulatory protein involved in the regulation of several extracellular enzymes. This superfamily also contains other enzymatically inactive proteins with unknown functions.
Statistics
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PSSM-Id: 238317
Aligned: 279 rows
Threshold Bit Score: 59.8395
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1G67; B. subtilis thiamin synthase with reaction intermediates

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     # # #                              ##             
1G4T_B       20 VYFIMGsnnt-kadpVTVVQKALkggATLYQFREKggdaltgEARIKFAEKAQAacreagvPFIVNDDVELALNLKAdGI 98  Bacillus subtilis
1G67_A       18 VYFIMGsnnt-kadpVTVVQKALkggATLYQFREKggdaltgEARIKFAEKAQAacreagvPFIVNDDVELALNLKAdGI 96  Bacillus subtilis
AAR33936     24 LYLVTDhdd----nlIPRVEAAIdggARVVQYRNKnq---drESRLALGLELRElcrrrsiPFIVNDDLEMAVSLKAdGL 96  Geobacter sulfur...
AAT43873      6 LYLVTKdyyn--gnfFNIVEESLsagVNILQYRDKtn---pyNIKIEAGRRLKNlaykynvPFIVDDSPVLLDILDAdGI 80  Picrophilus torr...
AAW39920    150 YVAIDAdyla-grdiPAVTREALeggCRLIQLRAKta---stRKFLALAVNLKEicleygaLFIVNDRLDIALACGAdGL 225 Dehalococcoides ...
EAM93487     19 LYLVTPdysg--dwiINATERAIksgVDILQYRDKts---tfRDKLAIGKKLASichdysvPFIVDDDPVLMDILGAdGI 93  Ferroplasma acid...
YP_355772     9 VYLITEsvp----dmLERVRIALangVKVVQYRGKnd---peAKRLPMANRLRClcgeygaFFIVNDDPGLALACRAdGV 81  Pelobacter carbi...
YP_357644     9 LYLITDdsrg--dqlQAKLVAALkggTRIVQYRGKhl---peDVRHREARMVHSlckqagaLFIVNDDPHLALACQAdGV 83  Pelobacter carbi...
YP_462028    23 LYLVLSeeygagrsvMSIAEEAVaggIDILQMREKhk---srEDLLRLGSALGElcrknkvTFIVNDDPLLAAELDAdGV 99  Syntrophus acidi...
ZP_01143064  24 VYLITDhad----hlTERVRGALsggVTVLQYRNKmg---daEDKFTVGMELKTicaeagiTFIVNDDLELARELDAdGL 96  Geobacter uraniu...
Feature 1               #                  #                          # ##                      
1G4T_B       99 HIGq---eDANAKEVRAaig-dmILGVSAHtm-sEVKQAEEDgADYVGLGPiypTETKKdtraVQGVSLIEAVRrqgiSI 173 Bacillus subtilis
1G67_A       97 HIGq---eDANAKEVRAaig-dmILGVAAHtm-sEVKQAEEDgADYVGLGPiypTETKKdtraVQGVSLIEAVRrqgiSI 171 Bacillus subtilis
AAR33936     97 HLGq---gDGDPREARRvlgpgkIIGVSTHtl-sEALEAQAAgVDYIGLGAmfpSRSKEve-hVAGSELLAAIRss-iSI 170 Geobacter sulfur...
AAT43873     81 HIGk---dDPPFEYIKErfp-gkIIGVSTYgdinLGIKYERLgADYIAFGSffkTSTKDda-eMCDINILNNASk--fNI 153 Picrophilus torr...
AAW39920    226 HLGq---tDMPLSQARRflppdsIIGISADtp-eQAVSAQNEgADYVAAGAvfpTQTKPdv-lFGGLSGLKAIHqv-vKI 299 Dehalococcoides ...
EAM93487     94 HIGk---dDVPFDYVKSkyp-dhIIGVSTYgsikDALLYQKLgADYVAFGSffpTKTKDda-tICDINVLKGIGp--iNI 166 Ferroplasma acid...
YP_355772    82 HLGq---gDGSVMQARQmlgeaaLIGVSTHsl-sEAEQAQRQgADYIGFGClfaTASKRdt-vSASLDELRLVRhv-vSL 155 Pelobacter carbi...
YP_357644    84 HLGq---qDMHIAEARAllgpdkIIGTSNRtv-eQAVNSQKAgADYVAAGSvypTGSKQda-vHIGLDVLHDIRqa-vDI 157 Pelobacter carbi...
YP_462028   100 HMGqkdlqRCPLDEVRRiigidrIIGLSTHsl-eQFQRANTLdVDYLAFGPifpTQTKDy--sIGTADIRETLRv--aLK 174 Syntrophus acidi...
ZP_01143064  97 HLGq---eDGDPIGARKllgprkIIGVSTHnl-eEALRAEAAgADYIGFGAmypTGSKDie-hLPGPDMLVEVKak-vKI 170 Geobacter uraniu...
Feature 1             #                   ##                 
1G4T_B      174 PIVGIGGITiDNAAPVIqagaDGVSMISAISqaeDPESAARKFRE 218 Bacillus subtilis
1G67_A      172 PIVGIGGITiDNAAPVIqagaDGVSMISAISqaeDPESAARKFRE 216 Bacillus subtilis
AAR33936    171 PIVAIGGITrDNGASVIdagaDAVAVISAVLshpDPALAATEIAL 215 Geobacter sulfurreducens PCA
AAT43873    154 PVFAIGGINtRNVDELLkykiSGIAVVSAIFdaaNPGEATRTFLE 198 Picrophilus torridus DSM 9790
AAW39920    300 PLVAIGGINkSNFYEAMqagaDSLCLISAVLgapDIKKATSEFIT 344 Dehalococcoides ethenogenes 195
EAM93487    167 PVFVIGGISrENIDLVLkygiSGIAVVSAIYshnDIEDQVSYFKS 211 Ferroplasma acidarmanus Fer1
YP_355772   156 PIVAIGGIHiGNAALAVqagaDAVAVISAVMqadDCKSTVCELDR 200 Pelobacter carbinolicus DSM 2380
YP_357644   158 PLVAIGGINrDNTSEVIhagaDAIALISAVMadpSPALAAREISL 202 Pelobacter carbinolicus DSM 2380
YP_462028   175 PVVFIGGVNtANLGILLkegaASMALIRDIMqadDVASRTAWYKS 219 Syntrophus aciditrophicus SB
ZP_01143064 171 PVVAIGGINrDNGARVIdngaDAVAVISGILgsrEPGLAAAELSL 215 Geobacter uraniumreducens Rf4

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