2ZIY,2Z73


Conserved Protein Domain Family
7tmA_Opsin_Gq_invertebrates
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cd15337: 7tmA_Opsin_Gq_invertebrates 
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invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors
The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.
Links
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Statistics
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PSSM-Id: 320459
Aligned: 12 rows
Threshold Bit Score: 420.959
Created: 24-Jul-2013
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2ZIY: Todarodes pacificus rhodopsin binds retinal, contacts at 4A.
  • Structure:2Z73: Todarodes pacificus rhodopsin binds retinal, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                          #                       #  
2ZIY_A     34 YSLGIFIGICGIIGCGGNGIVIYLFTKTKSlq-tpANMFIINLAFSDFTFSLVNGFPLMTISCFLkkWIFGfaaCKVYGF 112 Japanese flying squid
2Z73_A     35 YSLGIFIGICGIIGCGGNGIVIYLFTKTKSlq-tpANMFIINLAFSDFTFSLVNGFPLMTISCFLkkWIFGfaaCKVYGF 113 Japanese flying squid
O15973     52 YIIGVYITIVGLLGIMGNTTVVYIFSNTKSlr-spSNLFVVNLAVSDLIFSAVNGFPLLTVSSFHqkWIFGslfCQLYGF 130 Yesso scallop
AAF73286   37 YLVGIYIGIVGILAVMGNSLVITLFLLCKQlr-tpPNMLIVSLAISDFSFALINGFPLKTIAAFNhrWGWGklaCELYGF 115 Schistosoma mansoni
CAC86665   52 YAVAAWMTFFGILGVSGNLLVVWTFLKTKSlr-taPNMLLVNLAIGDMAFSAINGFPLLTISSINkrWVWGklwRELYAF 130 Dumeril's clam worm
EKC23688   49 YAIGVFISIVGIIGIFGNATVIYIFSTTKNlk-tpSNMFIVNLALSDMIFSLVMGFPLLTISAFNkkWIWGntaCELYGL 127 Pacific oyster
AGL94564   56 WVIGVYIAIVGMIGVIGNFLVIFFFSTTRSlr-tpSNLFVINLAISDLGFSAVNGFPLMTISSFMrkWYFGniaCTLYGF 134 Dumeril's clam worm
AGJ70280   47 ILFGTYISIIGLLAVFGNGLILGVFKRCKAlrlrpSSVLTISLLASDMAFSAVNGFPILTFTSYYkkWIFGstgCQLYAF 126 Terebratalia trans...
CAX73070   37 YAIGLFIAVVGITGMCLNLLVIVFFTMFKAlr-tpSNILVINLAISDFGFSAVIGFPLKTMAAFNnfWPWGktaCTIYGL 115 Schistosoma japonicum
ELU01272   47 YGLGLYMAVVGIVGTLGNLVVITLFIKTRSlr-tpPNMFIINLALSDMGFCATNGFPLMTVASFQklWRWGpvaCELYAL 125 Capitella sp. I Gr...
CCD82678   48 YLVAIFVALIGIFGTITNLLVIFVFLTPKSsi-slQCALIINLAISDFGFSAVIGFPLKTIAAFNqyWPWGsvaCQLYGF 126 Schistosoma mansoni
GAA35102   56 YLFGAYASIVGVSSIALNSFIILAFSLNGFvr-ktRHWFTVNLAVADLGLTISCCFPLKAISLFRgkWIWGkvgCDFYGF 134 Clonorchis sinensis

Feature 1       #   #                                                                  ###    
2ZIY_A    113 IGGIFGFMSIMTMAMISIDRYNVIGRPmaaskkmsHRRAFIMIIFVWLWSVLWAIGPI--FGWGAYTLEGVLCNCSFDYI 190 Japanese flying squid
2Z73_A    114 IGGIFGFMSIMTMAMISIDRYNVIGRPmaaskkmsHRRAFIMIIFVWLWSVLWAIGPI--FGWGAYTLEGVLCNCSFDYI 191 Japanese flying squid
O15973    131 VGGVFGLMSINTLTAISIDRYVVITKPlqasqtmtRRKVHLMIVIVWVLSILLSIPPF--FGWGAYIPEGFQTSCTFDYL 208 Yesso scallop
AAF73286  116 AGSIFGFISLTTMAFIALDRYLVIVQPfetfsritYGKVIVMIFITWIWSALWSIPPF--FGYGSYIPEGFHTSCTFDYL 193 Schistosoma mansoni
CAC86665  131 VGGIFGLMSINTLAWIAIDRFYVITNPlgaaqtmtKKRAFIILTIIWANASLWALAPF--FGWGAYIPEGFQTSCTYDYL 208 Dumeril's clam worm
EKC23688  128 VGGIFGLMSITTLSAISVDRYYAIAHPlraarnmtRKKAFMMICIVWVWSLCASLPPL--FGWGRYVAEGFQTSCTFDYL 205 Pacific oyster
AGL94564  135 LGGIFGFNSIGSLMFISLDRYYVIAKPleamrkatKKRAFLQIIVIWIWALIWSGPPL--IGFGSYIPEGLQTSCSFDYL 212 Dumeril's clam worm
AGJ70280  127 LGSLFGITSINTMALMAIERYLTIKTNlylmhsgtFKRNLVFVAIAWLWALLIALMPV--LGWGRYVLEGFQTTCSFDYL 204 Terebratalia trans...
CAX73070  116 GGGLFGFVSLSTIAAIAFDRYLVIATPfesvfqttPKRTILIMLFLWLWSLIWTIPPI--FGFGRYVTEGFQTSCTFDYI 193 Schistosoma japonicum
ELU01272  126 AGSITGFNSIATLALISMDRYMVIAKPfyamkhvsHKRSLIQIILAWTWAFIWSAPPLlrMGYGRYIPEGFQVSCTFDYL 205 Capitella sp. I Gr...
CCD82678  127 ISATFGFLSLTTIAAISFDRYLVIVKDhkt---tnFRVICTVIGFLWIWSIIWTIPPF--FGFGRYVLEGYQTSCTFDYI 201 Schistosoma mansoni
GAA35102  135 AGGLFGFTSITTLAAVAYLRYWTIAHVqpwpyaltNRNATYVLLLIWLWSALWTILPF--FGIGRYVMEGFLTGCAFDYL 212 Clonorchis sinensis

Feature 1                 ##   #                                                              
2ZIY_A    191 SrdstTRSNILCMFILGFFGPILIIFFCYFNIVMSVsnhekemaamakr---------------lnakelrkaqagaNAE 255 Japanese flying squid
2Z73_A    192 SrdstTRSNILCMFILGFFGPILIIFFCYFNIVMSVsnhekemaamakr---------------lnakelrkaqagaNAE 256 Japanese flying squid
O15973    209 TktarTRTYIVVLYLFGFLIPLIIIGVCYVLIIRGVrrhdqkmltitrs---------------mktedarannkraRSE 273 Yesso scallop
AAF73286  194 StdlpNLIFNAGLYILGFLCPVFIIIFSYYQIVKTVrlnelelmkmaqsl--------------dlqnpsamktgdkKAD 259 Schistosoma mansoni
CAC86665  209 TqdmnNYTYVLGMYLFGFIFPVAIIFFCYLGIVRAIfahhaemmatakr----------------mgantgkadadkKSE 272 Dumeril's clam worm
EKC23688  206 TttpnNRTYIFFLYLFGFAAPLLVIALSYILIIRALkkherkmqqmaak---------------mkvddikanqektKAE 270 Pacific oyster
AGL94564  213 TrsptNIAFNMGLFGMGFCFPLLIIIACYVQIIAAVsrqaremqktaek----------------mgaktasddrkkQQE 276 Dumeril's clam worm
AGJ70280  205 TksanNLSYIMFLMILGFCTPLACITTSYAAIFKKVfsnykvltqaatsngc----------gaglrsgreieekayRTE 274 Terebratalia trans...
CAX73070  194 StdlkNRLFNIGMFGFGFLCPLFLSVFCYARIILIVrsrgkdfiemaassk------------agnqkdksanvsstKSD 261 Schistosoma japonicum
ELU01272  206 SrdlkNLIFVWCLFVFGFFIPVLAIACSYVGIIRAVgaqskemrktaek----------------mgaktgksdkekKQD 269 Capitella sp. I Gr...
CCD82678  202 SndmpSLLFSGGMYIFGFMFPVLLCIYCYVNLLKIVrnnervvlislsnd--------------gaskqresvrnrkRLD 267 Schistosoma mansoni
GAA35102  213 SndwsSILFSSCLFLGGFVCPFTLICFSYARILWLIrkskqsltqtekvdrkicgnptgqtvidvppsisflqaayrKVS 292 Clonorchis sinensis

Feature 1                      #   #                            #                     
2ZIY_A    256 MRLAKISIVIVSQFLLSWSPYAVVALLAqfgp--lewvTPYAAQLPVMFAKASAIHNPMIYSVSHpkFREAI 325 Japanese flying squid
2Z73_A    257 MRLAKISIVIVSQFLLSWSPYAVVALLAqfgp--lewvTPYAAQLPVMFAKASAIHNPMIYSVSHpkFREAI 326 Japanese flying squid
O15973    274 LRISKIAMTVTCLFIISWSPYAIIALIAqfgp--ahwiTPLVSELPMMLAKSSSMHNPVVYALSHpkFRKAL 343 Yesso scallop
AAF73286  260 IEAAKTSIILVLLYLMSWSPYAIVCLMTligs--rdslTPFHSELPVLFAKTSAVYNPIVYAVKHpkFRMEI 329 Schistosoma mansoni
CAC86665  273 IQIAKVAAMTIGTFMLSWTPYAVVGVFGmikphsemfiHPLLAEIPVMMAKASARYNPIIYALSHpkFRAEI 344 Dumeril's clam worm
EKC23688  271 VKVAKVAIIIVFFYMLSWSPYATVALIGqfgp--aewvTPFLSELPVMLAKASAMHNPIVYALSHpkFREAL 340 Pacific oyster
AGL94564  277 IQLAKVAAGTISLFCISWIPYALVAQFGiwgl--rqfvNPITCVVPVLFAKASAMWNPILYALSHprFRAVL 346 Dumeril's clam worm
AGJ70280  275 LKIIKTAFVVTLAFLLSWLPYTIVAMLGltry--dyliSPYVSQIPVMVAKTSAIYNPIIHVFLYpkLRKAL 344 Terebratalia transversa
CAX73070  262 TFVLKSSAILLGVFLLCWTPYAAICLMAligy--adyiTTTMVELPCLCAKTAAVWDPCIYAFRYprFRAIF 331 Schistosoma japonicum
ELU01272  270 IAMAKVAAGTIGLFLMSWTPYAAVSMIGiagn--rswiTPYVSQIPVMFAKASAMWNPILYALSHpkFRAAL 339 Capitella sp. I Grassle & ...
CCD82678  268 IEATKSVILSLLFYLMSWTPYAMVCLISilgq--syflTPTIAEMPHIFAKMAAIYNPILYAFTNrkFKNAL 337 Schistosoma mansoni
GAA35102  293 FRTVKTTSILISMYLVAWGPYAVVTLLSvfgy--hnhlTPMGTELPGLFAKTSALYNPIVYMIRNgsFRRTV 362 Clonorchis sinensis

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