1I5S,1IA0,1I6I,4UXO,1VFV,2OWM


Conserved Protein Domain Family
KISc_KIF1A_KIF1B
?
cd01365: KISc_KIF1A_KIF1B 
Click on image for an interactive view with Cn3D
Kinesin motor domain, KIF1_like proteins
Kinesin motor domain, KIF1_like proteins. KIF1A (Unc104) transports synaptic vesicles to the nerve terminal, KIF1B has been implicated in transport of mitochondria. Both proteins are expressed in neurons. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. In most kinesins, the motor domain is found at the N-terminus (N-type). N-type kinesins are (+) end-directed motors, i.e. they transport cargo towards the (+) end of the microtubule. In contrast to the majority of dimeric kinesins, most KIF1A/Unc104 kinesins are monomeric motors. A lysine-rich loop in KIF1A binds to the negatively charged C-terminus of tubulin and compensates for the lack of a second motor domain, allowing KIF1A to move processively.
Links
?
Statistics
?
PSSM-Id: 276816
Aligned: 17 rows
Threshold Bit Score: 527.306
Created: 5-Feb-2015
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
ATP bindingmicrotubule
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:1I5S: Mouse KIF1A Motor domain bound to Mg-ADP
  • Comment:interaction site for Mg ADP, ATP hydrolysis drives motor function
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                                                                      
1I5S_A       4 ASVKVAVRVRPFNSREMSRds--kCIIQMSG--STTTIVnpkq------------pketPKSFSFDYSYWShtspe---- 63   house mouse
AAB50404     4 DKIKVAVRVRPFNRREIELdt--kCIVEMEK--QQTILQnppple--------kierkqPKTFAFDHCFYSlnpe----- 66   fruit fly
CAC28851    67 ANVRVVVRVRAFLPRELERna--kCIVEMDPatERTSLLvpqetdfanargarsrrvleEKSFTFDKSFWShnte----- 139  Neurospora crassa
AAF63384     1 MNVQVAVRVRPFNSREKERna--eLIVQMNN--KSTILTrpsalranp---laaptaddEKSFSFDYSYWSydsn----- 68   Dictyostelium di...
Q15058     357 SQVTVAVRVRPFTKREKIEka--sQVVFMSG--KEITVEhpd--------------tkqVYNFIYDVSFWSfdec----- 413  human
AAL87137     5 GNIKVVVRCRPMNSRERNRga--sNLIEFVDq-HQLILSppneadtke---nskatkkkSMPFSFDRAYDEh-------- 70   Ustilago maydis
NP_498069    5 DSIIVAVRVRPFNDREKTRnc--kLVIEMPD--EETTVIrdpk-------------tndEKRFTYDHSYWShdgfsekkn 67   roundworm
NP_476817  119 SNMIVAVRVRPLNALECTRgq-vtNVVQVHGnsNELTVQagssad---------asagvTHFFSYDQVYYScdpe----- 183  fruit fly
CAC14732     2 ANVKVALRVRPPSKRETAEgs--rIILNVDE--KVARIKnirldhkpd---gcedtrerLIEFGFDSCYWSvdpe----- 69   African clawed frog
P46865      11 ERVKVSVRVRPLNERENNApegtkVTVAAKQaaAVVTVKvlggsnnsgaaesmgtarrvAQDFQFDHVFWSvetpda--- 87   Leishmania donov...

Feature 1                                             #  # ####                                
1I5S_A      64 ------dinyASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGkqek-----------dqqGIIPQLCEDL 126  house mouse
AAB50404    67 ------denfASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGtqe-------------skGIIPRLCDQL 127  fruit fly
CAC28851   140 ------dehyATQEHVYDSLGEEFLDHNFEGYHTCIFAYGQTGSGKSYTMMGtpd-------------qpGLIPRTCEDL 200  Neurospora crassa
AAF63384    69 ------dphfASQSTVYNDLGKEVLKNAWDGFNCSIFAYGQTGSGKSYSMMGyge-------------ekGIIPLICEEL 129  Dictyostelium di...
Q15058     414 ------hphyASQTTVYEKLAAPLLERAFEGFNTCLFAYGQTGSGKSYTMMGfse-------------epGIIPRFCEDL 474  human
AAL87137    71 ----------TEQDDLFQYIGVELLQHAFNGFNTCVFAYGQTGSGKSHSMVGyaq-------------akGIIPLTCARL 127  Ustilago maydis
NP_498069   68 gyleptdphyADQRRVFEDLGRGVLANAWAGYNCSLFAYGQTGSGKSYSIVGfkn-------------nkGIVPIVCEEL 134  roundworm
NP_476817  184 ------rknfACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGiealddaaldggpphdeaGIIPRFCHEL 257  fruit fly
CAC14732    70 ------dpkyASQEMVFQDLGTLVLSEAISGYNVCLFAYGQTGSGKTYTMMGtpa-------------siGLTPRICEGL 130  African clawed frog
P46865      88 -----cgatpATQADVFRTIGYPLVQHAFDGFNSCLFAYGQTGSGKTYTMMGadvsal-------sgegnGVTPRICLEI 155  Leishmania donov...

Feature 1                                                                                      
1I5S_A     127 FSRINDTTNd---NMSYSVEVSYMEIYCERVRDLLnpk------------------nkgNLRVREHPLLGPYVEDLSKLA 185  house mouse
AAB50404   128 FSAIANKSTp---ELMYKVEVSYMEIYNEKVHDLLdpkp-----------------nkqSLKVREHNVMGPYVDGLSQLA 187  fruit fly
CAC28851   201 FQRIASAQDet-pNISYNVKVSYFEVYNEHVRDLLapvvp--------------nkppyYLKVRESPTEGPYVKDLTEVP 265  Neurospora crassa
AAF63384   130 FQRIQSTPSnsneQTIYKTTVSYMEIYNEKVKDLLnpnn----------------nktgGLKVRNNPSTGPYVEDLSKLA 193  Dictyostelium di...
Q15058     475 FSQVARKQTq---EVSYHIEMSFFEVYNEKIHDLLvckden-------------gqrkqPLRVREHPVYGPYVEALSMNI 538  human
AAL87137   128 FEDINQKTAad-pNLKISVEVSYIEIYNEKVRDLLnpk------------------nkgNLKVREHPSLGPYVEDLSKLV 188  Ustilago maydis
NP_498069  135 FKQIADNKKk---NMQFEVFVSMMEIYCEKVRDLLsstp----------------ppkgGLKVREHPKNGFYVENLTTVP 195  roundworm
NP_476817  258 FRRIEAVKSq--qQLQVEVEVSYFEIYNEKIHDLLsvqhaaaatgestpiqqqqqqqrpALKVREHPIFGPYVVDLSAHS 335  fruit fly
CAC14732   131 FSYDEGSPEt---PNSFRVEVSFLEIYNERVRDLLhksee---------------kkpyTLRVREHPERGPYVQGLSQHV 192  African clawed frog
P46865     156 FARKASVEAq--gHSRWIVELGYVEVYNERVSDLLgkrkkgv----------kgggeevYVDVREHPSRGVFLEGQRLVE 223  Leishmania donov...

Feature 1                                                                                #     
1I5S_A     186 VTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHdae------------tniTTEKVSKISLVDLAGSE 253  house mouse
AAB50404   188 VTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTdqa------------tgvSGEKVSRMSLVDLAGSE 255  fruit fly
CAC28851   266 VRGLEEIIRWMRIGDRSRTVASTKMNDTSSRSHAVFTIMLKQIHHdle------------tddTTERSSRIRLVDLAGSE 333  Neurospora crassa
AAF63384   194 VKSFSEIDMLMDEGSKARTVASTNMNATSSRSHAVFTIVFTQSKIdkt------------rgtAIDRVSKISLVDLAGSE 261  Dictyostelium di...
Q15058     539 VSSYADIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTefve----------geehDHRITSRINLIDLAGSE 608  human
AAL87137   189 VASYPDIMNLMDEGNKARTVAATNMNETSSRSHAVFTLVLTQKRFdvq------------tklEAEKVSRISMVDLAGSE 256  Ustilago maydis
NP_498069  196 VNSFKEIEAKIEEGTKSRTIAATQMNATSSRAHTIVKITFNQKSSkqa-------------ggTSMKKSEINLVDLAGSE 262  roundworm
NP_476817  336 VDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLssddglssdtdsstasslRQTRRSKISLVDLAGSE 415  fruit fly
CAC14732   193 VTSYEQVVALLEEGMENRITAATHIHDASSRSHAIFTIQYTQAMLed--------------nlPTEITSKINLVDLAGSE 258  African clawed frog
P46865     224 VGSLDDVVRLIEIGNGVRHTASTKMNDRSSRSHAIIMLLLREERTmttks--------getirTAGKSSRMNLVDLAGSE 295  Leishmania donov...

Feature 1                                                                                      
1I5S_A     254 RADStgaKGTRLKEGANINKSLTTLGKVISALAEmdsgpnkn--------------------kkkkktdFIPYRDSVLTW 313  house mouse
AAB50404   256 RAVKtgaVGDRLKEGSNINKSLTTLGLVISKLADqsngkk------------------------sgndkFVPYRDSVLTW 311  fruit fly
CAC28851   334 RAKSteaTGQRLREGSNINKSLTTLGRVIAALADpkssasrpsspvk----------sgrgrtpgpansVVPYRDSVLTW 403  Neurospora crassa
AAF63384   262 RANStgaTGVRLKEGANINKSLSTLGKVISALAEnsts---------------------------kkavFVPYRDSVLTY 314  Dictyostelium di...
Q15058     609 RCSTahtNGDRLKEGVSINKSLLTLGKVISALSEqanq----------------------------rsvFIPYRESVLTW 660  human
AAL87137   257 RANStgaTGARLKEGANINRSLTTLGKVIAALAIassavepvkga--------------kkpktasldsFVPYRDSVLTW 322  Ustilago maydis
NP_498069  263 RQSAagtEGDRLKEGIVINQSLTTLGRVIKALHDsqkak-------------------------sgkktQIPYRDSVLTC 317  roundworm
NP_476817  416 RISVsgsNGERIREGVSINKSLLTLGKVIAALADsrkaiangp------------------lgsgtpstFVPYRESVLTW 477  fruit fly
CAC14732   259 RASPe-yCKDRLTEGSNINRSLVTLGIVISTLAQnsqmtsscqsinsiasdgdsgspsggstngskrqpYVPYRDSILTW 337  African clawed frog
P46865     296 RVAQsqvEGQQFKEATHINLSLTTLGRVIDVLADmatkga------------------------kaqysVAPFRDSKLTF 351  Leishmania donov...

Feature 1                                                      
1I5S_A     314 LLRENLGGNSRTAMVAALSPAdiNYDETLSTLRYADRAKQIRNTVSVN 361  house mouse
AAB50404   312 LLKDNLGGNSRTVMVATISPSadNYEETLSTLRYADRAKRIVNHAVVN 359  fruit fly
CAC28851   404 LLKDSLGGNSKTAMIACISPT--DYDETLSTLRYADQAKRIRTRAVVN 449  Neurospora crassa
AAF63384   315 LLKETLGGNSKTIMIAAISPAdiNYEESLSTLRYADSAKKIKTVAVVN 362  Dictyostelium discoideum
Q15058     661 LLKESLGGNSKTAMIATISPAasNIEETLSTLRYANQARLIVNIAKVN 708  human
AAL87137   323 LLKDSLGGNSKTAMIAAISPA--DYEETLSTLRYADQAKKIKNKAVVN 368  Ustilago maydis
NP_498069  318 LLKNALGGNSKTIMIAAISPAdiNFEETLSTLRFADRAKSIKTNAVVN 365  roundworm
NP_476817  478 LLRENLGGNSKTVMLATISPAsiHADETLATLRYACKARSIVNRVKVN 525  fruit fly
CAC14732   338 LLKDSLGGNSKTIMIATVSPAssSYNETMSTLRYASHAKNIVNKPRVN 385  African clawed frog
P46865     352 ILKDSLGGNSKTFMIATVSPSalNYEETLSTLRYASRARDIVNVAQVN 399  Leishmania donovani chagasi

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap