3D34,3Q13


Conserved Protein Domain Family
Spond_N

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pfam06468: Spond_N 
Spondin_N
This conserved region is found at the in the N-terminal half of several Spondin proteins. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells.
Statistics
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PSSM-Id: 461924
Aligned: 50 rows
Threshold Bit Score: 234.787
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3D34_A        15 AKYSITFTGKWSQTA----FPKQYPLFRPpaQWSSLLGAAHSSDYSMWRKNQYVSNGLRDFAERGEA---WALMKEIEA- 86 
EDO49895       8 ATYKLTFKGKWSQET----HARHHPGPMA--RWSPLIGCSHSNKYVMWRYGGIASRAVQMMSEWGAT---EYLDEEMRN- 77 
EDV29855      32 ATYTVVFTGLWANNNnypnYPTNFP------HWSPLIGAIHSPAVTVYAYGQYASTQVKSVAENGNAvplKALLEPMTN- 104
EDV29856     291 ATYELTFEGIWVNSSaypfYPSNFP------HWSTFIGAIHSPALTVYSYGQYASPEVESVAEAGNAgplKNLLTPMTD- 363
XP_002117808  29 ATYSMKFKGIWNKET----HPKDFPT-RSfpRWGNLIGATHSQTFYLYHYNTIVSTFMKEAAEWDFA---AKLLRDIISn 100
EFX74609       1 MVYKVTLATHWSRTL----FPKQYPEWRPpaQWSKVIGRSHDSSYTLFRISQASTEGFKEFTETGRS---DTLDAQSQGe 73 
EFX74998      15 TVYRVTLNTFWNPRN----FPKHYPQWRPpaQWSKLVGRSHNKSYTLYRLHQKATEGLKLFAENGRS---DYLDTQSQGe 87 
OWR42007       2 TVYRMVLHTYWTREK----FPKHYPDWRPpaQWSKVYGVSHSRSYVLFRLGRRVSPSVRQFAESGRS---DTLGAAP--- 71 
XP_001960760 156 AVYKVVLHTYWTREL----FPKHYPDWRPtaQWTKTLGRTHNANYALYHIGQPATAAVKQFAETGRT---DLLDSNVGE- 227
ETN64481      46 VFYRIKLVTSWSKKL----FPKHYPEFRPppHWSMTFGQTHNASFRLYEMKQAASVPVATFAETGQI---APLEESLAQq 118
3D34_A        87 -AGealQ-----------------------------------------SVHEVFSAPAV-PSGTGQTSAELEVQRRHSLV 123
EDO49895      78 -QQ---E-----------------------------------------NVMSIIQTPSLwYGVG-ESSAVFRVDSTRHLL 111
EDV29855     105 ------------------------------------------------NVKQVFVSTGSsLQPTATYSVTVNVDNNFNLL 136
EDV29856     364 ------------------------------------------------KVKKVFVSPGAyLGPTAKYTVTVDVNKNFNLL 395
XP_002117808 101 kNR---------------------------------------------RVFDYFTIRSNf-DIHQTEAVSFTVDQMHHLV 134
EFX74609      74 -----------------------------------------------gGIFDEFNAPPVt-AGEGKTEAEFFVDSNHSRV 105
EFX74998      88 -----------------------------------------------gGIYDEFNAPPIt-SGEGKTEAEFFVDGNHSRV 119
OWR42007      72 ------------------------------------------------GTLDVFGGAAIg-QGLGRAEADFFVDGNHSRV 102
XP_001960760 228 -QQ---QqqmqaqaqaqiqmprqtgksplgatartatgpserssnnerSVFDEFSMPAIq-MGAGRSEAKVFVDSNHSLV 302
ETN64481     119 qD----------------------------------------------VLFDEFRLPKIr-KGKGASEATFFVDGQHSSV 151
3D34_A       124 SFVVRIVPSPDWFVGVDSLDLCD-GDRWREQAALDLYPYDAGTDSGFTFSSPNFATIPQDTVTEITSSSPSHPANSFYYP 202
EDO49895     112 SMISRMIPSPDWNVGVDRVNLCTtNCTWKHEETIDLIPWDAGTDDGITFKSPNARSTPKQPISRITTRLHDHPRASFYLN 191
EDV29855     137 SALTMIAPSPDWCVGVDRVNFCTsSCGFIASKTIDLYLWDAGTKAAATEQYSYTGSLTRVPIYQIKTS--NQSASVFYRA 214
EDV29856     396 SALTMIAPSPDWCVGVSRVNFCTkQCGFIGNTTLDLYLWDAGTKAGPTEQYTYAGSATNRTIYQLKST--NDSSSVFYRA 473
XP_002117808 135 SFVRKISPSPDWFVGMDSLDLCKsDCNWRDSLIVNLTLLDAGTDDGISYTSPNHPTEPQKTVQKITALFSNNSSSPFYVN 214
EFX74609     106 SLASRIVPSPDWFVGLDSFNLCi-DGQWVDSVAIKVGPMDGGTDNGFTFTSPNWPSDPTEKIFRITSNMPNHPANSFYYP 184
EFX74998     120 SLISKLVPSPDWFIGIDSLDLCv-NSKWLDSISIEVGVVDAGTDNGFSFTSPNWPTEPQEMIRHLTSNFPNHPASAFFYP 198
OWR42007     103 SVMTKMIPSPDWFIGVDSFDLCv-DGNWLDSITIEVDPLDAGTDNGFTFTAPNWPTAPQGVAYRITSKYPSHPAGSFFYP 181
XP_001960760 303 SLMTRIVPSPDWFIGVDSFELCv-GGSWIDTVTVELDPLDAGTDNGFTFTAPNWPTAPQGVIYRITSRYPAHPAGSFYYP 381
ETN64481     152 SFMTKIVPSPDWFVGLDSFNLCs-RGRWIDRMTVPLHPLDAGTSSGLTFTSPKWPTNPPGMIEQITARYPLHFASSFFYP 230
3D34_A       203 RLKALPP 209
EDO49895     192 TNDQIRP 198
EDV29855     215 NGQSLLP 221
EDV29856     474 NGTSLPP 480
XP_002117808 215 GAHSSIP 221
EFX74609     185 DLNDLPP 191
EFX74998     199 GVHKLPT 205
OWR42007     182 HLRRLPP 188
XP_001960760 382 KSKRLPP 388
ETN64481     231 EVKHLPP 237
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