Conserved Protein Domain Family
PRK09419
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PRK09419: PRK09419 
multifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase/5'-nucleotidase
Links
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Statistics
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PSSM-Id: 236505
Aligned: 13 rows
Threshold Bit Score: 1400.71
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
294499457    1 MKKNKSSKTKKILSTSLALSLLSMPLLTTQAGAEEHHPgqssqqskhqghnkkdalVNIRLMETTDVHTNLLNYDYFKDA 80  
154685257    5 KRRCSVNMTLRILLPLVMILSLILPTSPIKAEENKSSS------------------VNLSILATTDVHANMMDYDYYSDK 66  
52784613     6 KRRFSRKNILRILLTSVMILSLLMPNTQTYAEEQNEHPl-----------------ISLSILGTTDIHAHMMDYDYYADK 68  
163119295    6 KRRFSRKNILRILLTSVMILSLLMPNTQTYAEEQNEHPl-----------------ISLSILGTTDIHAHMMDYDYYADK 68  
295704807    1 MKKNTRSKTKKILSTSLALSLLSMPLLTTQAGAEERHPgqssqqskhqghnkkdalVNIRLMETTDVHTNLLNYDYFKDA 80  
157691516    1 -----------------MMISLILPAVPIHAETESGKA------------------VKVSILATTDVHANMMNYDYYSDK 45  
305673487    1 -------------------------------------------------------------MATTDIHANMMDYDYYSDK 19  
16077851     5 KRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQ------------------VHLSILATTDIHANMMDYDYYSDK 66  
302875304    1 -MNKMLKGFISKVAAVAMFATILTPINLSTVIANAETEt-----------------VNIQILATSDLHGKFMPYDYALNA 62  
110799312    2 LKKVRDKKFTALAVATSMIFGIATPLTTVKATENLAPEnlekkgee--aslekegdVTIQILGTSDLHGRFMNYEYARNQ 79  
110801297    2 LKKFSNKKITALMVVLAMVFSFILPIPVKAAEISETKNsnvtek-------tdkktVNIQILATSDLHGKFMDYDYAQGE 74  
110803262    2 LKKVRDKKFTALAVATSMIFGITTPLTTVKATENLAPEnlekkgee--aslkkegdVTIQILGTSDLHGRFMNYEYARNQ 79  
110801650    2 LKKFSNKKITALMVVLAMVFSFILPIQVKAAEISEAKNsnvtek-------tdkktVNIQILATSDLHGKFMDYDYAQGE 74  

294499457   81 SYEKVGLVKTATLIKNARKEVKNSLLVDNGDLIQGTPLGTYKAK---IDPLKKGEVHPVFKAMNQLDYDIATLGNHEFNY 157 
154685257   67 PTTEFGLARTAQLIEKHRRENPNTLLVDNGDLIQGNPLGEYAVKyekNDIISGAKTHPIIEVMNSLHYDAGTLGNHEFNY 146 
52784613    69 ETAEFGLARTAQLIEKYRSRNPNTILVDNGDLIQGNPLGEYIFKherESIISGTKTHPIIDVMNKLQYDAGTLGNHEFNY 148 
163119295   69 ETAEFGLARTAQLIEKYRSRNPNTILVDNGDLIQGNPLGEYIFKherESIISGTKTHPIIDVMNKLQYDAGTLGNHEFNY 148 
295704807   81 PYEKVGLAKTATLIKNARKEVKNSLLVDNGDLIQGTPLGTYKAK---INPLKKGEVHPVFKAMNQLDYDIATLGNHEFNY 157 
157691516   46 ETNEFGLAKTAELIDKHRSQNPNTLLVDNGDLIQGTPLGEYVYKqekDSIINQTKVHPIIHTLNKLKYDAGTLGNHEFNY 125 
305673487   20 ETTDFGLARTAQLIKKHREQNPNTLLVDNGDLIQGNPLGEYAVKyekDDIISGVKTHPIISVMNALKYDAGTLGNHEFNY 99  
16077851    67 ETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGNPLGEYAVKyqkDDIISGTKTHPIISVMNALKYDAGTLGNHEFNY 146 
302875304   63 TDTTGSLTQISTKVNQLR--NPNTILVDNGDIIQGNS----------SELSLNSNPQVMIKGFNEMGYDAITLGNHEFNY 130 
110799312   80 KSDG-GLNQISTLVNEARNENPNTIVVDNGDTIQGN-----------FNHLFKNGPNPMVMGMNAIGYDVFSLGNHEFNY 147 
110801297   75 ESVG-GLNQIATVVKEAKKENPNTLVLDNGDTIQGN-----------YNHLFMNKENPMILAMNTIGYDVFSLGNHEFNF 142 
110803262   80 KSDG-GLNQISTLVNEARKENPNTIVVDNGDTIQGN-----------FNHLFKNGPNPMVMGMNAIGYDVFSLGNHEFNY 147 
110801650   75 ESVG-GLNQIATVVKEAKKENPNTLVLDNGDTIQGN-----------YNHLFMNKENPMILAMNTIGYDVFSLGNHEFNF 142 

294499457  158 GLDFLKEAYNDA--NFPYINANVyvddhdsNPKNDKNKFTPYKIMNKKVVDENGKKRTIKVGFIGFVPPQINDWDKANLD 235 
154685257  147 GLEFLDGTIKGA--DYPIVNANV-------KTLSGENRYTPYVIKDKTVTDENGGKHQIKVGYIGFVPPQIMTWDKKNLE 217 
52784613   149 GLEFLDGTIKGA--EFPIVNANI-------KTPDGKNKYTPYHIEDRTLTDESGRKHQLKVGYIGFVPPQILTWDKKHLD 219 
163119295  149 GLEFLDGTIKGA--EFPIVNANI-------KTPDGKNKYTPYHIEDRTLTDESGRKHQLKVGYIGFVPPQILTWDKKHLD 219 
295704807  158 GLDFLTEAYNDA--NFPYINANVyvddhdnNPKNDKNKFTPYKIMNKKVVDENGKKRTIKVGFIGFVPPQINDWDKANLD 235 
157691516  126 GLSFLDGTIAGA--NFPIVNANV-------KKLNGEHRFTPYVIQDKTFKDANGTSQTVKVGYIGFVPPQIMTWDKKHLD 196 
305673487  100 GLDFLDGTIKGA--DFPIVNANV-------KTTSGDNRYTPYVIKEKTVTDENGNEQKVKVGYIGFVPPQIMTWDKKNLE 170 
16077851   147 GLDFLDGTIKGA--DFPIVNANV-------KTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLE 217 
302875304  131 GVPMLQHVMSNA--TASVLCANL-------YDMNNNRFYSPYKIIQK---------AGVRVAIIGVVTPNITRWDSEYLK 192 
110799312  148 GMDNLNDVVSQAndNLDVLCANL--------YKDGKRVYEGYTTREI---------EGVEVALIGVVSPHIMKWDSENLK 210 
110801297  143 GMDKLHNIIGQAnpNLHVLCGNL--------YRNGERVFNPYTIKDV---------DGIKVAIIGVVTPHIMQWDSQNLK 205 
110803262  148 GMDNLNNVVSQAndNLDVLCANL--------YKDGKRVYEGYTTREI---------EGVEVALIGVVSPHIMKWDSENLK 210 
110801650  143 GMDKLHNIIGQAnqNLHVLCGNL--------YRNGKRVFNPYTIKEV---------DGIKVAIIGVVTPHIMQWDSQNLK 205 

294499457  236 GKVITKGIVETANKYIPEM---KKKGADVVVAMAHSGFSSNKQ--NTEDVIYSLS-EVKGIDAITFSHTHKVFPakteaa 309 
154685257  218 GRVQVEDIVESAKKTVPKM---KAEGADIVIALAHSGIEKKAQssGAENAVFDLAtKVSGIDAIVSGHQHGLFP------ 288 
52784613   220 GKITVQDITESAKETIPKM---KQEGADVIIAIAHSGIENGEQaaGAENAVYDLAlKTEGIDAIISGHQHGLFP------ 290 
163119295  220 GKITVQDITESAKETIPKM---KQEGADVIIAIAHSGIENGEQaaGAENAVYDLAlKTEGIDAIISGHQHGLFP------ 290 
295704807  236 GKVITKGILETANKYIPEM---KKKGADVVVAMAHSGFSSNKQ--NTEDVIYSLS-EVKGIDAITFSHTHKVFPakteas 309 
157691516  197 GQVQVQDIVESANETIPEM---KEKGADVIVALAHTGIEKTASpkGSENMIFDLAtKTKGIDAIVSGHQHGTFP------ 267 
305673487  171 GQVQVQDIVESANETIPKM---KAEGADIIIALAHTGIEKQAQssGAENVVFDLAtKTKGIDAIISGHQHGLFP------ 241 
16077851   218 GQVQVQDIVESANETIPKM---KAEGADVIIALAHTGIEKQAQssGAENAVFDLAtKTKGIDAIISGHQHGLFP------ 288 
302875304  193 T-CKVTNPVDEVNAAITEL----KGKADVIVVSYHAGETAEYDyvGSG--VVDLLnSCKGVDAVIAAHEHKLVG------ 259 
110799312  211 G-YEAKNPAEEVGFVIDEIenrPEGGADVYAVVSHVGLESEY---GNGDSARAIAeMNPEVSAIVAGHSHTNVP------ 280 
110801297  206 G-YEAKNPTEEVKKIIGEIk--ANGGADVYVVTSHASLNGEY---GDGDSAAGIAeANPEVSVVVAGHSHDTVK------ 273 
110803262  211 G-YEAKNPAEEVGFVIDEIenrPEGGADVYAVVSHVGLESEY---GNGDSARAIAeMNPEVSAIVAGHSHTNVP------ 280 
110801650  206 G-YEAKNPTEEVKKIIGEIk--ANGGADVYVVTSHASLNGEY---GDGDSAAGIAeANPEVSVVVAGHSHDTVK------ 273 

294499457  310 ldglflGADKKPLPGVDNAKGTINGVPAVQAGYGGGSLGLIDLTL-KEEKGKWKVVNSQSSTretykdvkdasgKTVTQS 388 
154685257  289 ------DAEYKGADQFDVDKGTINGIPVVMSSSWGKYAGVIDLRL-EKTDSAWHVEDAKGSI------------EPIAGN 349 
52784613   291 ------GTDYPGNGVIDNQKGTINGIPVVMPKNWGSHLGIIDMQL-ELDGGKWKVKDASAKT------------EAIAGN 351 
163119295  291 ------GTDYPGNGVIDNQKGTINGIPVVMPKNWGSHLGIIDMQL-ELDGGKWKVKDASAKT------------EAIAGN 351 
295704807  310 ldglflGADKKPLPGVDNAKGTINGVPAVQAGYGGGSLGLIDLTL-KEEKGKWKVVSSQSSTretykdvkdasgKTVTQS 388 
157691516  268 ------SAEYNGVDKFNVSKGTINGIPVVMSKNWGSYLGVIDLTL-EPDGSNWKVTDGTGKI------------ESVAG- 327 
305673487  242 ------SAEYAGVSQFDVGKGTINGIPVVMPSSWGKYLGVIDLKL-EKTDGLWKVADSKSSI------------ESIAGS 302 
16077851   289 ------SAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKL-EKADGSWKVADSKGSI------------ESIAGN 349 
302875304  260 ---------------SKDNQVSYNGVKVVENLPTGQTLAQLNIKVtKQADGTFKVNDRVKDVq----------tDVISVK 314 
110799312  281 -------------------EEKINNAVISQPTSNGQMVSKIELTV-RKNGEKVEVVDKKSKL--------------LSTK 326 
110801297  274 -------------------SELRGNAIISEPASRAKYVSKFNLTV-EKDESGIKVLDKNADL--------------ISLK 319 
110803262  281 -------------------EEKINNAVISQPTSNGQMVSKIELTV-RKNGEKVEVVDKKSKL--------------LSTK 326 
110801650  274 -------------------SELRGNSIISEPASRAKYVSKFNLTV-EKNESGIKVLDKSADL--------------ISLK 319 

294499457  389 TVEPDKGVVKAVQKDHDATVKYVNTPIGK-------TTDDIHSYFSLVKDDPSI-QVVTNAQKDYVEKYVsqNKPEYKDL 460 
154685257  350 VTSENETVVNTVKKAHEGTLKYIREPVGQ-------TKADINSFFAQVKDDPSI-QIVTDAQKWYAENKM--KDTEYKDL 419 
52784613   352 VTSRNETVVSAIKDTHEKTLEYVRAPVGQ-------TEADINSFFAQVKDDPSI-QIVTDAQKWYAEDVM--KGTEYENL 421 
163119295  352 VTSRNETVVSAIKDTHEKTLEYVRAPVGQ-------TEADINSFFAQVKDDPSI-QIVTDAQKWYAEDVM--KGTEYENL 421 
295704807  389 TVEPDKGVVKAVQKDHDATVKYVNTPIGK-------TTDDIHSYFSLVQDDPSI-QVVTNAQKDYVEKYVsqNKPEYKDL 460 
157691516  328 VSSQNSTVKDAIQTTHQNTLDYVRKPVGK-------TEADINSFFAQVMDDPSI-QIVTDAQKWYAQEKM--KDTSYQNL 397 
305673487  303 VTSRNETVTNTIQQTHQNTLEYVRKPVGK-------TEADINSFFAQVKDDPSI-QIVTDAQKWYAEKEM--KDTEYKDL 372 
16077851   350 VTSRNETVTNTIQQTHQNTLEYVRKPVGK-------TEADINSFFAQVKDDPSI-QIVTDAQKWYAEKEM--KDTEYKNL 419 
302875304  315 NGVSDATLEASLKSYHDEAIADAETPIGTlkggdlvPADEIKGIPTSQTQETAMiKLINDVQKYYAGTDI---------- 384 
110799312  327 GVAEDQKINDLLSDFHNTAIADATAPVGEmvggdlaDKNEIKEIPQSLVEDQGItDFINEVQLYNSRKHLesKNINPDEV 406 
110801297  320 GVQGDPELTEKLKPFHEAAINDATAKIGElkggdlaKPDEVKGIPQSIVEDQGVtDFINEVQLYNSKKFLqtKGIDSNNV 399 
110803262  327 GVAEDQKINDLLTDFHNTAIADATAPVGEmvggnlaDKNEIKEIPQSLVEDQGItDFINEVQLYNSRKHLesKNINPDEV 406 
110801650  320 GVQGDPELTEKLKPFHEAAINDATAKIGElkggdlaKPDEVKGIPQSIVEDQGVtDFINEVQLYNSKKFLqtKGIDPNNV 399 

294499457  461 PILSVGAPFKA-GRNGVDEYTEIKKGDLTIRSAGDLYLYDNTLKAVKVKGSVIKDWIDMSAGKFNQITPNKTEEQELLNP 539 
154685257  420 PILSAGAPFKAgGRNGSNYYTNISAGDLAIKNIGDLYLYDNTVQIVKLNGSEVKDWLEMSAGQFNQIDQAKGGSQALLND 499 
52784613   422 PILSAGAPFKAgGRNGADYYTNIKAGNLAIKNIGDLYLYDNTLYIVKLTGSEVKDWIEMSAGQFNQIDPSKSGEQALLNP 501 
163119295  422 PILSAGAPFKAgGRNGADYYTNIKAGNLAIKNIGDLYLYDNTLYIVKLTGSEVKDWIEMSAGQFNQIDPSKSGEQALLNP 501 
295704807  461 PILSVGAPFKA-GRNSVDEYTEIKKGDLTIRSAGDLYLYDNTLKAVKVKGSVVKDWIDMSAGKFNQITPNKTEEQELLNP 539 
157691516  398 PILSAGAPFKAgGRNGVNYYTNIAKGDLAIKNIGDLYLYDNTVQIVKLKGSEVKDWLEMSAGQFNQIKPNDAKEQPILNE 477 
305673487  373 PILSAGAPFKAgGRNGANYYTNIPAGDLAIKNVGDLYLYDNTVQIVKLTGSEVKDWLDMSAGQFNQIDPSKGGDQALLNE 452 
16077851   420 PILSAGAPFKAgGRNGANYYTNIPAGDLAIKNVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNE 499 
302875304  385 ---SAAAAFSS--------TANIKEGTIRKCDTSLIYKYANTLYKLEMTGKQLKQYMEWSAQFYNTYK--DGDLTLSFNE 451 
110799312  407 YMVSGAALFSA--------SSNLYEGNISKADISNIYRYDNKLYTIKTNGKQLKKYMEKNAEYYNTYK--DGDLTVSFNE 476 
110801297  400 YMVSSAALFSP--------KANLKEGPISKADVSNIYKFDNKLYVIKTNGKQLKKYMEENSKFFNKYK--DGDLTISFDE 469 
110803262  407 YMVSGAALFSA--------SSNLYEGNISKADISNIYRYDNKLYTIKTNGKQLKKYMEKNAEYYNTYK--DGDLTVSFNE 476 
110801650  400 YMVSSAALFSP--------KANLKEGPISKADVSNIYKFDNKLYVIKTNGKQLKKYMEENSKFFNKYK--DGDLTISFDE 469 

294499457  540 SFPVYNFDVIDGVQYQIDVTKPAKYDVNGNVIHADSSRVVNLTY--NGKPVDPNQEFIVVTNNYRAGG-------GGNFP 610 
154685257  500 AYRSYNFDVIDGVTYQVDVTKPAKYNENGTVIHPDASRIVNLSY--QGKPVSAKQEFLIVTNNYRASG-------GGGFP 570 
52784613   502 DFRSYNFDVIDGVTYQIDVTQPAKYNASGGVKNPQANRVKQLSY--NGKPVRDDQEFLVVTNNYRASG-------GGGFP 572 
163119295  502 DFRSYNFDVIDGVTYQIDVTQPAKYNASGGVKNPQANRVKQLSY--NGKPVRDDQEFLVVTNNYRASG-------GGGFP 572 
295704807  540 SFPVYNFDVIDGVQYQIDVTKPAKYDVNGNVIHGDSSRVVNLTY--NGKPVDPNQEFIVVTNNYRAGG-------GGNFP 610 
157691516  478 EYRSYNFDVIDGVTYQVDVTQPAKYSTTGTLVNANANRIKNLSY--NGKPVSDNQEFLVVTNNYRASG-------GGGFP 548 
305673487  453 NFRSYNFDVIDGVTYQVDVTKPAKYDENGKVINADSSRIINLSY--EGKPISLNQEFLVVTNNYRASG-------GGGFP 523 
16077851   500 NFRSYNFDVIDGVTYQVDVTKPAKYNENGKVINADSSRIINLSY--EGKPISPSQEFLVVTNNYRASG-------GGGFP 570 
302875304  452 KIRGYNYDMFSGVNYDVDVTKPL------------GERIVNLKKa-DGTAINDGDKFTIAVNNYRATSqlssfgsIDPIT 518 
110799312  477 DVRMYLYDMFDGVSYEINISKEP------------GQRIENLKFekDGKPVEDSDVVYLTVNDYRYNSg-----lAAGIM 539 
110801297  470 NVRMYKYDMFEGVNYEINIAKDP------------GERIENLKFskDGKPVEDSDVVYLSVNDYRYNSg-----lAAGIM 532 
110803262  477 DVRMYLYDMFDGISYEINISKEP------------GQRIENLKFekDGKPVEDSDVVYLTVNDYRYNSg-----lAAGIM 539 
110801650  470 NVRMYKYDMFEGVNYEINIAKDP------------GERIENLKFskDGKPVEDSDVVYLSVNDYRYNSg-----lAAGIM 532 

294499457  611 GLKGS-----------ELVVDSADEN----RQILMDYITEQK--EITPTADDNWSIAPINGTAnVTFTSSPRGESYLTEG 673 
154685257  571 HLSND-----------KIVYSSADEN----RQVLMDYIIQQK--TINPQADHNWSILPVKGTN-LTFESSLAAKPFADRA 632 
52784613   573 HLTQD-----------KVVYAAADEN----RQVLMNYIMEKK--TVNPAADNNWSIAPIKGAD-VTFESSLLAKPFAEKA 634 
163119295  573 HLTQD-----------KVVYAAADEN----RQVLMNYIMEKK--TVNPAADNNWSIAPIKGAD-VTFESSLLAKPFAEKA 634 
295704807  611 GLKGS-----------ELVVDSADEN----RQILMDYITEQK--EITPTADDNWSIAPINGTAnVTFTSSPRGESYLTQG 673 
157691516  549 HLTQD-----------KVVLASADEN----RQVLMDYIIEQK--TINPSADQNWSIAPIKGAT-VTFESSLLAKPFAEKS 610 
305673487  524 HLTSD-----------KIVHGSAVEN----RQVLMDYIIEQK--TVNPKADNNWSIAPVSGTN-LTFESSLLAKPFADKA 585 
16077851   571 HLTSD-----------KIVHGSAVEN----RQVLMDYIIEQK--TVNPKADNNWSIAPVSGTN-LTFESSLLAKPFADKA 632 
302875304  519 GLKSTpytdpvndtlpTILAKDVKIEiggvRELIGDYVKNVKggTITPELENNWKVI---GANwNPVFRAEAVKAINAGK 595 
110799312  540 DQGEH-----------EKIYDTNNDQisdmRDLIVDYIQNVKggKITKNIDNNWKIT---GNDwDSEQRELAVKLINEGK 605 
110801297  533 DPGEH-----------EKIYDTVNDDisaiRDLISDYIINVKhgVINRNVDGNWKIT---GNNwNPEQRALAVKLINEGK 598 
110803262  540 DQGEH-----------EKIYDTNNDQisdmRDLIVDYIQNVKggKITKKVNNNWKIT---GNDwDSEQRELAVKLVNEGK 605 
110801650  533 DSGEH-----------EKIYDTVNDDisaiRDLISDYIINVKhgVINRNVDGNWKIT---GNNwNPEQRALAVKLINEGK 598 

294499457  674 SNITYTNKTDDKGFGIYKINL-------NGESKDNTKVQLLGMNDLHGQL--------DTDTKitsngqslvagnmkyTA 738 
154685257  633 DDVAYIGESQNAGYGQYKLQFkddepgtDPPKDDAWKLTVMHTNDTHAHL--------DNAAR---------------RM 689 
52784613   635 NDIDFVRESENKGYGVYKLNFdg---sePPVDDENWTLTVMHTNDTHAHL--------DGAAR---------------RA 688 
163119295  635 NDIDFVRESENKGYGVYKLNFdg---sePPVDDENWTLTVMHTNDTHAHL--------DGAAR---------------RA 688 
295704807  674 SNITYTNKTDDKGFGIYKINL-------NGESKDNTKVQLLGMNDLHGQL--------DTDTKinsngqallagnmkyTA 738 
157691516  611 SNVDFIRNASTDGLGVYKLAFkdd-gttEPPASDNWNLTVMHTNDTHAHL--------DDAAR---------------RA 666 
305673487  586 DDVAFVGESTNEGYGLYKLQFddd-snpEPPKDGLWDLTVMHTNDTHAHL--------DDAAR---------------RM 641 
16077851   633 DDVAYVGKSANEGYGVYKLQFddd-snpDPPKDGLWDLTVMHTNDTHAHL--------DDAAR---------------RM 688 
302875304  596 INIPTSVDGRTANVAAVTYNM-------LATVNNYKNVDILSINDFHGTLledpkgknVGASK---------------LV 653 
110799312  606 IKIPVSEDGRTPNVKAVTWNDv-----lEALGTKEVEIPIVTFNDFHGSLaes--ksdVGAAK---------------LV 663 
110801297  599 IKLPTSSNGRTPNVKSVTWDEvskfaeaLPEEKKEVEIPILTFNDFHGSLkes--ggnPGAAK---------------FV 661 
110803262  606 IKIPVSEDGRTPNVKAVTWNDv-----lEALGTKEVEIPIVTFNDFHGSLaes--ksdVGAAK---------------LV 663 
110801650  599 IKLPTSSNGRTPNVKSVTWDEvskfaeaLPEEKKEVEIPILTFNDFHGSLkes--ggnPGAAK---------------FV 661 

294499457  739 AAIRKQEAENPNTLLVHAGDMIGGSpLVSALFQDEPTVEVMESLGFDVGTLGNHEFDEGIAELHRMIEGGD---HPKGTK 815 
154685257  690 TKIKEIRSETDRSILLDAGDVFSGD-LYFTKWQGLADLKLMNSMGYDAMTFGNHEFDKGPGALASFLSGNGsaaDPSGKY 768 
52784613   689 AKVKEIRSETENNVLLDAGDVFSGD-LYFTKWNGLADLKLMNMMGYDAMTFGNHEFDKGPKVLADFLSGNYtavDPLNRH 767 
163119295  689 AKVKEIRSETENNVLLDAGDVFSGD-LYFTKWNGLADLKLMNMMGYDAMTFGNHEFDKGPKVLADFLSGNYtavDPLNRH 767 
295704807  739 AAIRKQEAENPNTLLVHAGDMIGGSpLVSALFQDEPTVEVMESLGFDVGTLGNHEFDEGIAELHRMIEGGD---HPKGTK 815 
157691516  667 TKIKEVRAENKNNILLDAGDVFSGD-LYFTKWQGLADLKLMNLMKYDAMTFGNHEFDKGPSVLRQFLTGDAsdvDPKNRH 745 
305673487  642 TKINEVRSETDHNILLDAGDVFSGD-LYFTKWNGLADLKLMNMMGYDAMTFGNHEFDKGPTVLSDFLSGNSttvDPANHY 720 
16077851   689 TKINEVRSETNHNILLDAGDVFSGD-LYFTKWNGLADLKMMNMMGYDAMTFGNHEFDKGPTVLSDFLSGNSatvDPANRY 767 
302875304  654 TAVKEYKTANPNTVVVSAGDNYQGS-ALSNLLKGKPVSDMLKEMGVEVSAIGNHEYDWGTDLFSQWEKDGN--------- 723 
110799312  664 GEIKRVKEENPNTVVVTGGDIYQGS-AMSNLLKGEPVTAMLKEMGLEFSAVGNHEFDWGYEYIPDWAKAGE--------- 733 
110801297  662 GELKKVKEKNPNTIVVSGGDMYQGS-ALSNLLKGKPVSDMNKALGVQFSSVGNHEFDWGYDLIPGWAKDGG--------- 731 
110803262  664 GEIKRVKEENPNTVVVTGGDIYQGS-AMSNLLKGEPVTAMLKEMGLEFSAVGNHEFDWGYEYIPDWAKAGE--------- 733 
110801650  662 GELKKVKEKNPNTIVVSGGDMYQGS-ALSNLLKGKPVSDMNKALGVQFSSVGNHEFDWGYDLIPGWAKDGG--------- 731 

294499457  816 GYDGMNFPVIAANAYDTSTNKLITE------------------PYAIKEVGGKKIGFIGVVTQETPSMIVRKgnENLKIT 877 
154685257  769 NFQAPDFPLVSSNVDVSKESKLRPFmkkadtftagkkkkagiyPYILLDVNGEKVAVFGLTTEDTSVTSSPG--KSIVFH 846 
52784613   768 QLEKPDFPIVSSNVDVSKEPKLRSFqkepavlaagkkkesgiyPYILLDVNGEQVGVFGLTTEDTSYTSSPG--PNIAFH 845 
163119295  768 QLEKPDFPIVSSNVDVSKEPKLRSFqkepavlaagkkkesgiyPYILLDVNGEQVGVFGLTTEDTSYTSSPG--PNIAFH 845 
295704807  816 GYDGMNFPVVAANAYDTSTDKLITE------------------PYAIKEVGGKKIGFIGVVTQETPSMIVRKgnENLKIT 877 
157691516  746 QFEKPRFPVVSSNVDVSKEKQLSDLvkkpasfkagekkeagiyPYILLDVNGEKVAVFGLTTEDTAITSSSG--PNIQFK 823 
305673487  721 HFEAPEFPIVSANVDVSNEPKLTSFvkkpqtftagekkepgihPYILLDVDGEKVAVFGLTTEDTATTSSPG--KSIVFH 798 
16077851   768 HFEAPEFPIVSANVDVSNEPKLKSFvkkpqtftagekkeagihPYILLDVDGEKVAVFGLTTEDTATTSSPG--KSIVFN 845 
302875304  724 ------LEFLASNIYDKTTGAPVSYa----------------kPYKIVAVNGLKIAFIGLTTPETAFKTKPEnvSNLDFK 781 
110799312  734 ------FDFLASNIYEKETGKPVEWa----------------kPYGVVEREGKKVGFIGLATPETAYKTKPDnvAHLEFK 791 
110801297  732 ------FEFLASNIYEKSTGEPVKWa----------------kPYGVVEKGGKKIGFIGLATPETAYKTNPDnvKDLEFR 789 
110803262  734 ------FDFLASNIYEKETGEPVEWa----------------kPYGVVEREGKKVGFIGLATPETAYKTKPDnvSHLEFK 791 
110801650  732 ------FEFLASNIYEKATGEPVKWa----------------kPYGVVEKGGKKIGFIGLATPETAYKTNPDnvKDLEFR 789 

294499457  878 DEAEAIDKYTAELK----KKGIKAIVVLAHNPSNQNgtst--efdaADIAKKIDDeVDVIFSAHNHVYNNKVV-----DN 946 
154685257  847 DAFQSAQDTVKEIQn---KEHVNKIIALTHIGHQRD----------LDLAKKVKG-IDLIVGGHTHTLVDKMEvvkneEP 912 
52784613   846 DAYQSAEKTVKELKe---KEKVNKIIALTHLGYNRD----------LELAKKVKG-IDLIIGGHTHTLVDHLKvveneEP 911 
163119295  846 DAYQSAEKTVKELKe---KEKVNKIIALTHLGYNRD----------LELAKKVKG-IDLIIGGHTHTLVDHLKvveneEP 911 
295704807  878 DEAAAIDKYTEELK----KQGIKAIVVLAHNPSNQNgtst--efdaADIAKKVDDeVDVIFSAHNHVYNNKVV-----DN 946 
157691516  824 DAYKKAKETVNTIQt---EEKINKIIALTHIGYNRD----------LELAQKVDG-IDLIIGGHTHTLVEKLKvinkkEP 889 
305673487  799 DAFETAQNTVKTIQe---EEKVNKIIALTHLGHNRD----------LELAKKVKG-IDLIIGGHTHTLVDKMEvvnneEP 864 
16077851   846 DAFETAQNTVKAIQe---EEKVNKIIALTHIGHNRD----------LELAKKVKG-IDLIIGGHTHTLVDKMEvvnneEP 911 
302875304  782 DPAVSAKYWTEYLKsgkaGETVDAVVALTHLGSFQNsttkaitgeaADLANANTG-VDAIISAHTHNTVAGVV-----NG 855 
110799312  792 DPVEATKTWVDYLEn---KENVDAVVVLSHLGSEQNretgeitgeiVEVAE-VPG-VDAIISAHSHQKVEGKV-----NG 861 
110801297  790 DPNTEAEKWVKHLRe---VEKVDAVIALTHIGSQQDrktgeitgevVNLTK-VTG-LDAIVSAHSHMPVKGTV-----NG 859 
110803262  792 DPVEATKIWVDYLEn---EENVDAVVVLSHLGSEQNretgeitgeiVEVAE-VPG-VDAIISAHSHQKVEGKV-----NG 861 
110801650  790 DPNTEAEKWVKHLRe---VEKVDAVIALTHIGSQQDretgeitgevVNLTK-VPG-LDAIVSAHSHMPVKGTV-----NG 859 

294499457  947 KLIVQAYSYGSAFSDVDVEIDNTGDIVKKDAKI--VTVYQKDYTPDPEVSSIMKKYEDLAAPIKAEVVGNSSTALaKGYP 1024
154685257  913 TIVAQAKEYGEYLGRADVAFDKNGVVLPEQSSLq-AIPVNEQTKEDPDLKKELDPFKKELVSVKNEKVGSTKVAL-DGQR 990 
52784613   912 TIVAQVKDYGQFLGRVDVVFDENGVVQTDQSRFn-LIAIDDKVDEDPPGKEVLDGFKEDIDELKKKKVGYADVPL-DGKR 989 
163119295  912 TIVAQVKDYGQFLGRVDVVFDENGVVQTDQSRFn-LIAIDDKVDEDPPGKEVLDGFKEDIDELKKKKVGYADVPL-DGKR 989 
295704807  947 KLIVQAYSYGSAFSDVDVEIDNTGDIVKKDAKI--VTVYQKDYTPDPEVSSIMKKYEDLAAPIKAEVVGKSSTDLaKGYP 1024
157691516  890 TIVAQVKDYGQFLGKVDVAFDKKGVVQPKESSFd-LIPIDDSVKEDAEAKAILDGYKADIQDLKTEKVGHTDVLL-DGQR 967 
305673487  865 TIVAQAKEYGQFLGRVDVVFDENGVVQTDKSNLn-VLPIDEHTEENAEAKKELDQFKNELEDVKNEKVGYTDVAL-DGQR 942 
16077851   912 TIVAQAKEYGQFLGRVDVAFDEKGVVQTDKSNLs-VLPIDEHTEENPEAKQELDQFKNELEDVKNEKVGYTDVAL-DGQR 989 
302875304  856 TPIVQGYYNGRNLAKLSFVFDSSNKIVAVTPTIdnLAARKATIAEDTTIKTVVDKYNTELQPILGEKIGYTDIEL---SH 932 
110799312  862 VPVIQAYKNGRNLGYVNLKFDYKDELVVTTKLDd-ISKRKDTLPVDKNMEDILAKFEADLAPIMNEKVADLSVDL----P 936 
110801297  860 VPIVQAYKNGRAIGLIDLKFDKDGKLSVEAQRMd-ISKNIKDLPVDKEMEETLGKYEKELSPILDVKVADLSEDL----P 934 
110803262  862 VPVIQAYKNGRNLGYVNLKFDYKDELVVTTKLDd-ISKRKDTLPVDKNMKDILANFEADLAPIMNEKVADLSVDL----P 936 
110801650  860 VPIVQAYKNGRAIGLIDLKFDKDGKLSVEAQRMd-ISKNIKDLPVDKEMEETLGKYEKELSPILDVKVADLSEDL----P 934 

294499457 1025 SSGATGDIALGNLIADGM----KAEMKADFALMNGGGVRSQLDSGDVTYGDLFAIQPFGNVLNKVKLSGADLETVLNNQI 1100
154685257  991 EHVRSKETNLGNFIADGMlqkaKEAAGAQIAITNGGGIRAGIDKGEITLGDVLNVMPFGNTLYVADLTGKQIKQALEQGL 1070
52784613   990 EHVRSKETNLGNFIADGMlkkaKQAGGADIAITNGGGIRSGIAKGEITLGDVLTVMPFGNTLYAADLTGAQIKEALEHGV 1069
163119295  990 EHVRSKETNLGNFIADGMlkkaKQAGGADIAITNGGGIRSGIAKGEITLGDVLTVMPFGNTLYAADLTGAQIKEALEHGV 1069
295704807 1025 SNGATGDIALGNLIADGM----KAEMNADFALMNGGGVRSQLDAGDVTYGDLFAIQPFGNVLNKVKLSGADLETVLNNQI 1100
157691516  968 EHVRAKETNLGNFIADGMlqkaQESAGADLAITNGGGIRGSIEKGDITLGDILTVMPFGNTLYVADLKGSQIKKALEQGL 1047
305673487  943 EHVRTKETNLGNFIADGMlakaKEAAGARIAITNGGGIRAGIDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGL 1022
16077851   990 EHVRTKETNLGNFIADGMlakaKEAAGARIAITNGGGIRAGIDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGL 1069
302875304  933 DKIKEGVSVLGKWTTDIM----RKITNTQIAITNGGGLRAPIAQGDITVGDLYTVMPFDNTFVNMKLTGAGIKKALENGI 1008
110799312  937 HDRDTGVSPMGATVAETM----RRIVDADIAITNGGGVRAPLMAGTVTVGDMYTILPFDNTLVTMEMKGSDIIKVLEHGI 1012
110801297  935 HNRDAGVSPMGATVTETM----RKIVDADIAINNGGGVRAPLKKGVITVGDMYTILPFDNTIVTMDMKGSDIIKVLEHGI 1010
110803262  937 HDRDTGVSPMGATVTETM----RRIVDADIAITNGGGVRAPLMAGTVTVGDMYTILPFDNTLITMEMKGSDIIKVLEHGI 1012
110801650  935 HNRDVGVSPMGATVTETM----RKIVDADIAINNGGGVRAPLKKGVITVGDMYTILPFDNTIVTMDMKGSDIIKVLEHGI 1010

294499457 1101 TS----SGLDFHIAGFNYTWDGST---NKVVDIRLPDGS----KIDKEKEYTVVVNNYM-YGNEKYG-IGALSSDMEVGP 1167
154685257 1071 SGieaqGGAFPQVAGLTYTFTLNKkpgHRVLQAAAVQDDgsvkPISDKKTYRVATSNFVgEGGDGYSvFNEASHKEDLGF 1150
52784613  1070 SQveegGGAFPHVSGLSFTFTLSKpkgERILDVNLVNDKgdavPLDLDKTYRVATNNFMgGGGDGYSvFKEAKNGVDLGF 1149
163119295 1070 SQveegGGAFPHVSGLSFTFTLSKpkgERILDVNLVNDKgdavPLDLDKTYRVATNNFMgGGGDGYSvFKEAKNGVDLGF 1149
295704807 1101 TS----SGLDFHIAGFNYTWDSST---NKVVDITLSDGS----KIDKEKEYTVVVNNYM-YGNEKYG-IGALSSDMEVGP 1167
157691516 1048 SGieegGGAFPHVAGIEYTFTLSKpagSRLINVKLKDQKgqltDIDDEKTYRVATNAFVgTGGDGYSvFTEASHGEDLGY 1127
305673487 1023 SNvengGGAFPQVAGIEYTFTLNNepgHRVLDVKFESPNgdkvDLNTDDTYRVATNNFVgAGGDGYSvFTEASHGEDLGY 1102
16077851  1070 SNvengGGAFPQVAGIEYTFTLNNkpgHRVLEVKIESPNgdkvAINTDDTYRVATNNFVgAGGDGYSvFTEASHGEDLGY 1149
302875304 1009 GNtsigSV---QYSGVIATVDLTRpfgDRITALTLEDGT----PLDMAKEYTVTTNDFMfTGGDGYN-FSGATGAVDTGL 1080
110799312 1013 EPdnfgWG---QHAGVKLWYTPGAergEKITSVRLADGT----KLENDKYYTVVTNDFMaVGGDSYD-FSAAKNVVDTNL 1084
110801297 1011 APkdfgWG---QHAGLKFWYNPDAepgNRITSVRLLDGS----KLDPNKYYKLATNDFMaAGGDGYD-FSAAKNIKDTNK 1082
110803262 1013 EPdnfgWG---QHAGVKLWYTPGAergEKITSVRLADGT----KLENDKYYKVVTNDFMaVGGDSYD-FSAAKNVVDTNL 1084
110801650 1011 APkdfgWG---QHAGLKFWYNPDAepgNRITSVRLLDGS----KLDPNKYYKLATNDFMaAGGDGYD-FSAAKNIKDTNK 1082

294499457 1168 EDLQATVNYIKTLNSPFEYKAEGRIQNVAAAKTAEQQEPTLKIAQ 1212
154685257 1151 VDYEVFTEQLEKAGKAVEPKVDGRAQEVYLPTKQKNGSWTLEDDS 1195
52784613  1150 TDYDIFTEQL-ALYDSVSPNIENRITEVFLPDRQADGSWTLAEKP 1193
163119295 1150 TDYDIFTEQL-ALYDSVSPNIENRITEVFLPDRQADGSWTLAEKP 1193
295704807 1168 EDLQATVNYIKTLNSPFEYKAEGRIQNVAAAKTAEQKEPTLKIAQ 1212
157691516 1128 VDYEIFKEQIEKADGQISPVIDHRVKEVFLPRAKGKGAYDIQDDE 1172
305673487 1103 VDYEIFTEQLKKLGNKVSPKIEGRIKEVFLPTKQKDGSWTLDEDK 1147
16077851  1150 VDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDK 1194
302875304 1081 AIRDGIISYLRAQLNPIKIDDEHNggngngvvvgggngstitesl 1125
110799312 1085 VIRDEMANYWREngidpitdlstlleagedttvdsekpenpenpg 1129
110801297 1083 VLREGISDYWKNhginpitnlatliepgedkgeavkpvepenpsv 1127
110803262 1085 VIRDEMANYWKEngidpitdlatlleagedttvdlekpenpgnpe 1129
110801650 1083 VLREGISDYWKNhgispitnlatliepgedkseaikpveqekpsi 1127
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