Conserved Protein Domain Family
RhoGAP-FF1
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pfam16512: RhoGAP-FF1 
p190-A and -B Rho GAPs FF domain
RhoGAP-FF1 is the FF domain of the Rho GTPase activating proteins (GAPs). These are the key proteins that make the switch between the active guanosine-triphosphate-bound form of Rho guanosine triphosphatases (GTPases) and the inactive guanosine-diphosphate-bound form. Rho guanosine triphosphatases (GTPases) are a family of proteins with key roles in the regulation of actin cytoskeleton dynamics. The RhoGAP-FF1 region contains the FF domain that has been implicated in binding to the transcription factor TFII-I; and phosphorylation of Tyr308 within the first FF domain inhibits this interaction. The RhoGAPFF1 domain constitutes the first solved structure of an FF domain that lacks the first of the two highly conserved Phe residues, but the substitution of Phe by Tyr does not affect the domain fold.
Links
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Statistics
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PSSM-Id: 465153
Aligned: 23 rows
Threshold Bit Score: 104.592
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_009018707  269 DAHRVVMETKEITENAFMSLIKSHVgTDYKALWIPIHQQLQSNADFLSYIQLFGTDQAGRVFRKYLITVKEEYIKMKQKK 348 
XP_018670541  262 DAAQVRKELLKDAKKKLETLLAHTV-VKYDESWTTARKTLENELDYQRFVDLEGKNAASKIFRKHVNRLRDEYRSELQSK 340 
XP_007261046  260 EALKHQSQLIASAKDRYEWLVNHIV-KNHNETWPNISRRMQPSPEYKEYVFLEGTAKAKKLFQQHIHRLKQEHIERRRKG 338 
XP_004917008  261 EALKQQSQLIAAAKDKYEWLVSRVV-KSHNETWINQSRRMQSNIEYQDYVHLEGTDKAKKLFHQHVLRLKQEHIERRRRN 339 
XP_001510691  261 EALKQQSQQIAAAKDRYEWLVSRLV-KSHQDSWPGASRQLQAAPEFQDYVYLEGTPKAKKLFAQHTLRLRHEHVERRRRL 339 
XP_016161095  261 EALKQQSQQIAAAKDKYEWLVSRIV-KSHHEVWANVSRKMQPAPEYQDYVYLEGTSKAKKLFLQHVQRLKQEHIERRRKL 339 
XP_012824567  260 EAFKIHRQIVISASDKFDKLIVQTV-RDYHAVWKTVSNKLKNHSDYEDYINLEGTVKAKKTFSKHIDQLKQEHIRKRKEE 338 
XP_001336016  258 EAYKSQRQLVASVSDKFEKLIVQTV-RDYHTSWKIVSNKLKSHPDYEEYINLEGTKKARNTFSKHIEQLRQEHIKRRRED 336 
XP_011489049  259 EAFKVQRQLVASATDKFEKMILNTV-RDYHTTWKTVTNILKGQTDYEEFITLEGSRKAHNMFTKHIAQLRQEHIRKRREE 337 
XP_006006418  268 DAYKTQRQLVATAADKFEKLIGQTV-RDFHATWKTVSNKLKNHPDYEEYINLEGTKKAKNIFSKHIEQLKQEHIRKRRDE 346 

XP_009018707  349 Y 349 
XP_018670541  341 Y 341 
XP_007261046  339 Y 339 
XP_004917008  340 Y 340 
XP_001510691  340 Y 340 
XP_016161095  340 Y 340 
XP_012824567  339 Y 339 
XP_001336016  337 Y 337 
XP_011489049  338 Y 338 
XP_006006418  347 Y 347
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