Conserved Protein Domain Family
leuS

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PRK12300: leuS 
leucyl-tRNA synthetase; Reviewed
Links
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Statistics
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PSSM-Id: 237049
Aligned: 82 rows
Threshold Bit Score: 1052.54
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
124028098   1 MHLGHSRTYTITDAYARFKRMQGYNVLFPMGFHYTGTPILTMAESIAAGDKELIDLMINVYDV-------PPEDIEKLKD 73  
218883935  51 LHIGHGRTYTIGDIIARYKRLKGYNVLYPMAFHITGTPVLAVSEMIARGDERVVNMYKSYIRYyvsdegkVNEILESFKN 130 
126465030  51 LHIGHGRTYTIGDIIARYKRLRGYNVLFPMAFHITGTPIIAISERISRGEEEIINRYKSYIAKyvkdpveIEKIIESFKD 130 
297526696  51 LHIGHGRTYTIGDIIARYKRLRGYNVLFPMAFHITGTPIIAISERISRGEEEIINRYRNYVAKyvkdpveIEKIIESFKD 130 
227827868  47 MHVGHGRTYVTADVYARYLRMRGYNVLFPFAFQFTGTPVLAIADSIRRGDVDMIEFFKSVYGV-------PEDKIKELGD 119 
229585136  47 MHVGHGRTYVTADVYARYLRMRGYNVLFPFAFQFTGTPVLAIADSIRRGDVDMIEFFKSVYGV-------PEDKIKELGD 119 
16081844   56 LHVGHGRTYTLGDIIARYKRSRNYNVLFPMGFHQSGTPILAFSERIRAGDRSTIDLYTSYLKEyge--kdIDALIESFKD 133 
13541592   56 LHVGHGRTYTLGDIIARYKRSRNYNVLFPMGFHQSGTPILAFSERIRAGDASTIALYRSYLSEyge--kdIDGWLEKFKD 133 
48478263   42 LHVGHGRTYTLGDIVARYKRLEGYNVLFPMGFHESGTPILAFSERLRENDPETIKLYRSYLEEyen-kenIDKLIESFKE 120 
296242280  54 LHIGHGRTYTIGDIIARFKRLTGYNVLFPMAFHITGTPIIAISERIANKDAKTLDMYRSYISYyiedrekVEEILESFKD 133 
124028098  74 PLSLARYFHNDAKQAMMEIGYSIDWRREFTSIDEEFKQFVVWQFMKLKEKGLLKKGTHPVGWCPKHNMPVGMHDTKGD-V 152 
218883935 131 PLNLAVFFAERIQSDFDALGYSIDWRRKFHTGEPIYNKFVTWQYHKLNEKGLITIGDHIVTYCLLHKQPEGEDDIQDAdV 210 
126465030 131 PLNLAVFFAERVHMDFDALGYSIDWRRRFHTGEPIYNAFVTWQFLKLREKGLIKRGDHVVTYCLLHKQPEGEDDIQDAdV 210 
297526696 131 PLNLAVFFAERVHMDFDALGYSIDWRRRFHTGEPIYNAFVTWQFHKLHEKGVIKRGDHIVTYCLLHKQPEGEDDIQDAdV 210 
227827868 120 PYKLAEYFKEEMKNTAKSIGMSIDWRRSFTTTDTRFEKFIHWQLRKLKELGYLVTEDDVVGYCPNDNFPVGMHDTRGD-I 198 
229585136 120 PYKLAEYFKEEMKNTAKSIGMSIDWRRSFTTTDTRFEKFIHWQLRKLKELGYLVTEDDVVGYCPNDNFPVGMHDTRGD-I 198 
16081844  134 PKNIADYFSNAIINDFKHLGYSIDWTRRFTSADEFYQKFVQWQFRRLNEKGLVKQGRYPILYSLEDDNAVGEDDIKDGdT 213 
13541592  134 PRNIADYFSNAIINDFKHLGYSIDWTRKFTSADEFYQNVVKWQFHKLNEKGLIKQDKYPILYSIDDDNAVGEDDIKDGdT 213 
48478263  121 PENIANYFADKIIKDFTSLGYSIDWTRRFTSADPDYQEIVKWQFNKLKELKLIKQGNYPILYSVKDENAVGEDDIKDGdV 200 
296242280 134 PLKLATFFAEKVQSDFEALGYSIDWRRKFHTGEPIYNAFVTWQYNRLRQLGVVAKGEHMVTYCLLHKQPEGEDDIQDAdV 213 
124028098 153 EP-EIGEFTLILFk-lENE-DVYLPAATLRPETVFGVTNIWLNPEAEYVLVEVDGRKYIMSKRAVFKLRFQ--RDNVREV 227 
218883935 211 NPvEILEYTAVKFl--DPEwKVYLAAATLRPETIYGVTNLWVNPNAKYLEISFGDEVLIVSEKAYVKLVHQhpEKEIRVL 288 
126465030 211 NPvEILEFTAIKFkllGEE-NTYLVAATLRPETLFGATNLWVKPDADYVVVEWRGENIIVSKEALVKLQHQhpLDEFKVV 289 
297526696 211 NPvEILEFTAIKFkllNED-NTYLVAATLRPETLFGATNIWVNPDAEYVVVKWRGEKIIVSKEALVKLQHQhpLDEFKII 289 
227827868 199 EP-EITTMNVILFe--GSE-SYNFMVATSRPELIFGVVALMVNSDANYVVVEYEGKNFIISEKAYKKLSYQ---KDMKMI 271 
229585136 199 EP-EITTMNVILFe--GSE-SYNFMVATSRPELIFGVVALMVNSDANYVVVEYEGKNFIISEKAYKKLSYQ---KDMKMI 271 
16081844  214 DKvTIEEYTAIFF---RGK-SFDLIAASLRPETIYGITNIWVNPDVKYVKVKISGRMAVVSEECSTKLKFQ--GNEIEVA 287 
13541592  214 DKvSVEEYTAVFF---ESN-SYSLIAASLRPETLFGVTNIWINPTGEYVKIKIGDKIAVVSKEAVDKLKYQ--RNDVSVI 287 
48478263  201 DKvTIEEYTGLIL---END-DFNLIAASVRPETIFGITNAWIS-NSKYSIFEYKNKYYAVSKEAYTKLSYQ---YDIKFI 272 
296242280 214 NPvEILEYTAIKFk-lEGS-ESSLLASTLRPETLLGATNIWVNPEAEYVIVEFNGERLIISKKAWVKLAHQhvESDIRIL 291 
124028098 228 REIDPGELFGKRVVNPATGRRVPILPAKFVDPATATGVVMSVPAHAPYDYVALRELLENKELLekygvnsEE---LTPIP 304 
218883935 289 REIPGKGLVGRRVVSPL-GKEVIVLPAEFVDPDNATGVVYSEPSDAPYDYVALQELKANKNVLreyglnpEIidsITPIK 367 
126465030 290 GEMKGRELVGKKVVSPL-GNELIVLPADFVDPDNATGIVYSEPSDAPYDYVALMELKKNSEKLamygvdpEVvkkIEPIK 368 
297526696 290 REIKGRELIGKKAISPL-GKELIVLPADFVDPDNATGIVYSEPSDAPYDYVALMELKKNPEKLamygidpEIvkeIEPIK 368 
227827868 272 KTISTSDIVKLYGINPVTGKKLEIIKSKHVDPSLGTGVVMSYPAHDPFHYLAIAEANKE----------------FEIIP 335 
229585136 272 KTISTSDIVKLYGINPVTGKKLEIIKSKHVDPSLGTGVVMSYPAHDPFHYLAIAEANKE----------------FEIIP 335 
16081844  288 GEASVQEIQKQTYTTPA-GKEVKVYQADFVDPDNGTGIVYSVPSHSVYDYVYYRKKRG-----------------KDFPV 349 
13541592  288 GPISAESIQRKKFTTPF-GKEVPVYKADFVDTDNGTGVVYSVPSHSVYDFVYYRRKKS-----------------GQTPV 349 
48478263  273 KDIEPGEITSRKFRVPLLNEYINVYIADFVDPDNATGVVYSVPGHAIYDYYYVKRLGIn----------------VKIKK 336 
296242280 292 GELKGSELIGKTVESPL-GQKLLVLPAAFVDPDNATGIVYSEPSDAPYDYVALIELKANPHLLeaygmdaRIvenINPIK 370 
124028098 305 LIEVKGYSELPARDVVERMGIRSQYERDlLDKATKELYSDEYRYGVMRSDIVELvypeapselrdlvraavkawiVGQPV 384 
218883935 368 IIDVPGLSDHHAKIIVEKIGIKSQIDER-LEEVSKEVYREQYYNGVMIVDDPLV---------------------KGLTV 425 
126465030 369 IIDVPGIKGHHAGIVVEEMGISSQFDPR-LVEATKIVYREQYYKGVMIVDDPEF---------------------KGLSV 426 
297526696 369 IIDVPGIKGHHAGVVVEEMGITSQLDPR-LVEATKIVYKEQYYKGVMIVDDPEF---------------------KGLSV 426 
227827868 336 VIETEELDEIPGESAV--LQTKNIYA---LKDFMESIYRTEYYKGYMKDTILSLvpdflkq--------yvkeniVGKQV 402 
229585136 336 VIETEELDEIPGESAV--LQTKNIYA---LKDFMESIYRTEYYKGYMKDTILSLvpdflkq--------yvkeniVGKQV 402 
16081844  350 IIEA----PMKMKDIESKYDLETEEG---REEATKDLYRNEFYYGKLVDS-GPY---------------------TGMTV 400 
13541592  350 VIEA----PLKMPEVEIKFDLNSKEG---LDEATKELYKSEFYYGKLVNS-GEY---------------------TGLTV 400 
48478263  337 VIAIDNIS-------VEKLLEKYGSDEKsLKEATQELYKSEFYNGLLINS-GDY---------------------SGLSV 387 
296242280 371 IIEVPGIADHHAKAVVEKYGITSQLDDR-LEEATREVYREQFYNGKLIVDHPDF---------------------KGLSV 428 
124028098 385 SVAREATVKWLSAIGRADKIYEIMNRPVYCRCGTEIVVKVLKDQWFVDYGNPEWKRIVLEHL-EVMRIVPEELREEFRKV 463 
218883935 426 KEAREVIRKRLIDSNQAFIFYEL-NRKAKCRSGGEIIVAKIRGQWFLNYGVKAFKERVKKYIeEELVVIPEKYRKAFLDT 504 
126465030 427 SEAKEKIKKKLLRENKGFVFYEL-NRKAYCRAGGKIIAAKIIGQWFIDYSVPWWKEEAKKYVsEKMRIIPVKYKKAMLDA 505 
297526696 427 SEAKEKIKKKLFRENKGFVFYEL-NRKAYCRAGGKIIAAKIIGQWFIDYSVPWWKEEVKKYVsEKMRIIPNKYKKALLDA 505 
227827868 403 QEARKNTIELLKSLNIYDTIYEISNGPIYCRCGAEIVPKKIKDQWFIAYDNPKWKASVLKAI-NNIELIPNLAKSELEKT 481 
229585136 403 QEARKNTIELLKSLNIYDTIYEISNGPIYCRCGAEIVPKKIKDQWFIAYDNPKWKASVLKAI-NNIELIPNLAKSELEKT 481 
16081844  401 REAREAVKRDLISSGNAFTFYE-TSRHAVTRSGSKVIVAVLPDQWFLDYSQPWLKDLGHTMI-NTMTMHPEVYRNVMNDA 478 
13541592  401 RDAREKIKKDLIGSGKAIIFYE-TSRKAVTRGGSKVIVAVLPDQWFIDYSADWLKKLSHDML-NRMMIYPEMYRNVMNDA 478 
48478263  388 QEAREKIKNDLIRSGNAIIIYE-TSRKAITRSGSKVIVAVINGQWFIDYSQPWLKERTHKMI-DAMSFYPEFYRKIMGDA 465 
296242280 429 PEAREKMKKKLISDGKAMVFYEL-NRRAFCRGGGEIIVAKIRDQWFIDYSVPWWKDRTRNLInERLEIIPPKYKKAFQDV 507 
124028098 464 VDWLRERAVARTRGLGTELPWAKGWIIESLSDSTIYMAFYTVIHKIRs----yGLKPDQLTLEFWDYVMLgkgdpKAISA 539 
218883935 505 VDWLDKRPCARKRGIGTPLPWSPDWIIESLSDSTIYMAFYTIVHKIRe----yGIKPESLTPELFDYVFLgigdpVDVSS 580 
126465030 506 IDWLERRPCARKRGLGTRLPFDPEWVIESLSDSTIYMAFYTIAHLIRk----hNIKPEQLKPQVFDYVFLgkgdpEEISE 581 
297526696 506 IDWLEKRPCARKRGLGTKLPFDPEWVIESLSDSTIYMAFYTIAHIIRk----hNVKPEQLKPQVFDYIFLgegdpEEISE 581 
227827868 482 IFNTRREPIGRSRGIGVKLPWDESQIVESLSDSTLYTVLYTIIYKMP----------VDIDNELFDFMFLgkgdtKELEK 551 
229585136 482 IFNTRREPIGRSRGIGVKLPWDESQIVESLSDSTLYTVLYTIIYKMP----------VDIDNELFDFMFLgkgdtKELEK 551 
16081844  479 IDWLKERPCARRRGLGTRLPFDDRWVIESLSDSTIYPAVYTNSIPLR---------------SLYETGKLdddaiTRIFM 543 
13541592  479 IDWLKERPCARRRGLGTKLPFDDRWVIESLSDSTIYPAVYTTSIQMR---------------KLYENGKLdenaiERIFD 543 
48478263  466 IDWLRERPCARRRGIGTRLPFDENWVIESLSDSTIYMVGYTNLKYLRniynelKCIPD----DVLDFVYLnkdfpENYKK 541 
296242280 508 LEWVEKRPCARKRGLGTKLPWEPDWIIESLSDSTIYMAFYTIAHKIRe----yRIPPEKLIPAFFDYVFLgegcaEEISK 583 
124028098 540 KIGVPVKVLEELRSEFEYWYPLDSRHSGRDLVPNHLTFFIFNHVAIFPRDKWPRQIVVNGFVMLEGKKMSKSLRNIIPLR 619 
218883935 581 KTSVPLKVLEEMRSEFMYWYPVDHRHTSIPHISNHLSFYIFHHVVIFPREHWPRMITLNETVIREGAKMSKSKGNVIPLR 660 
126465030 582 DTGIPLKALEEMRQEFNYWYPVDQRHTGIAHISNHLSFFIYHHIAIFPRKHWPKMITLNEMVIREGTKMSKSKGNVILLR 661 
297526696 582 DTGIPLKILEEMRQEFNYWYPVDQRHTGIAHISNHLSFFIYHHIAIFPRKHWPKMITLNEMVIREGAKMSKSKGNVILLR 661 
227827868 552 KYG---ADLVQLREEFLYWYPVDQRHTGRDLIQNHIPFYIYNHLAIFGEKYLPKRIVINGFVRVGGRKMSKSLKNIYTLS 628 
229585136 552 KYG---ADLVQLREEFLYWYPVDQRHTGRDLIQNHIPFYIYNHLAIFGEKYLPKRIVINGFVRVGGRKMSKSLKNIYTLS 628 
16081844  544 NGEPKNEDESEAKRQFEYWYPVDIRLTAIPHISNHLSFYVLNHAAIFPKEKWPAGLIISGLVVSNGAKISKSKGNVVSLL 623 
13541592  544 GGEVQNDEERTARNEFSYWYPVDIRLTAVPHISNHLSFYVMNHAAIFPPEKWPSGLIISGLVVSNGAKISKSKGNVVSLL 623 
48478263  542 ----FKNDIEMARNEFNYWYGVDLRITAPPHISNHLSFYLMNHAAIFDEEKYPKGLMISGLVISNGAKISKSKGNVISLL 617 
296242280 584 ETGIPVELIEEMRKEFNYWYPVDHRHTGIPHISNHLTFYLFHHTAIFPEDKWPRIISLNETVIREGAKMSKSKGNVIPLR 663 
124028098 620 RALRIYGPDTVRAAILAAAELLQDADFSDALARSVMGQLAKFESIAAKALEHDDR----VDLVDRWLLSKLQESIEYVTK 695 
218883935 661 DIARLYSADLFRLYISWAAGLDSVLDWREKEVAIVIDSLKRFVELAENAVGAECRdnagDDAASRWFMDKFHQLISDASS 740 
126465030 662 DIAEKYSADLFRLYIAGAANLDTVLDWREKEVERVIDSLKKFTAIAEKAIRTKCGtyshDKYIDKWFLSKFNRLLAEATN 741 
297526696 662 DIAEKYSADLFRLYIAGAANLDTVLDWREKEVERVIDSLRKFTVIAEKAIRTKCEkyghDKYIDKWFLSRFNRLLVEATN 741 
227827868 629 KAIKEFGVDPVRITLTSTSDLLQDLDFNENLVNPIAEQLKKVYDLIDRLLSINTEik-gLRTADEWLSSKIREIVEKVKN 707 
229585136 629 KAIKEFGVDPVRITLTSTSDLLQDLDFNENLVNPIAEQLKKVYDLIDRLLSINTEik-gLRTADEWLSSKIREIVEKVKN 707 
16081844  624 EIAKKYSADIYRLYVAVQADISSTMDWNETDLASITRRFNEFKDLMAGFKQDTSD----LTFEEAWFVARFSVRLRQFME 699 
13541592  624 EITKKYSADIYRLYVAVQADVSSTMDWNENDLSNIVRRFNEFKTIMDSFKPDTSE----LNFEETWFVSRFAERLKQFMD 699 
48478263  618 KIKEKYSADIYRLFVAVGADISSLLDWNEKDLSAVIKRYESFIDIMNKFEFKNG-----DGFIYKWFLSRFYSNLNDYFN 692 
296242280 664 DIARNYSADLFRFYIASAASLDSVLDWKQKEIELVLDGLYRFTNIMLQARSIGGEi--pSDFYGRWFASKFRRIISDSRK 741 
124028098 696 AMEELRVRSATIHVLYEMENMASKYLELRGG-KPGPALLEYVKTWTKMLAPVAPHLAEEVWHR-LGGES-FVSIEKWPSS 772 
218883935 741 NIEHMEIREYVQNAFFNVLSLIDKYRDIVGD-RYLCSIKQVLRDWITVVNPVIPHVTEEINEL-MGGKG-FLSKGSWPTS 817 
126465030 742 ALDNMEIRDYVQKMFYDVMVSIDHYRERTSNeETICMIKRILSKWLKSLNPVIPHLTEEIWSW-MGKEE-FLSLEKWPEI 819 
297526696 742 ALDNMEVRDYIQKIFYDVMVSIDHYRERTNNeETICMVKRILSKWLKALNPVIPHLTEEIWSW-MGKKE-FLSLEKWPEA 819 
227827868 708 DITSFEFRDAVNLLLYEMYDVLRDYFDLIEI-PNQEVIRKISSIWIRALAPFAPHIAEELWHKiSST---FVSLEKYPDP 783 
229585136 708 DITSFEFRDAVNLLLYEMYDVLRDYFDLIEI-PNQEVIRKISSIWIRALAPFAPHIAEELWHKiSST---FVSLEKYPDP 783 
16081844  700 SMDRYQIRDAYINIFYGVLNDLRYLSSRGGD--VNRALTPVIADWLRALMPVIPHHAEEYWHS-YVSDT-YVSVDPFDEN 775 
13541592  700 QMDGFQIRDAYINIFYGTLNDLKYAVNRGAS--QNRSLASIIADWLRALMPVISHHAEEYWHRyVSNt--YVSINPFDDN 775 
48478263  693 LMSSYKIRDAYISIFYNVLNDIKHLELRHGD--VNTAVSMIIRDWLIALSPVIPHTCEEYWHRyI--EDsFVSLKTINKD 768 
296242280 742 SMELLEVRDYVQKAFYHVMNLIEQYRDLVGE-NYLKAVKYISKDWLIMLNPVIPHLTEELNEL-LGGSG-FLSTSEWPTG 818 
124028098 773 DKTKID----------YEAELAIEYLDKVIEDVKSILRIFKG-KPR-RLIIAVAGREYWSYARIAA-----EVLLARQQL 835 
218883935 818 REARy-----------PEITTAIDNALALQEDIREILGLVKG-VPG-KIYIIVAPEWKREIAVKTLdgiqlREIMDYMRS 884 
126465030 820 DYKAIN----------EEVEYLEEAIEALIEDIKNVLNILSP-KPK-HAYIVVASPWKREVIEMIEkgmdrREIIRTIRD 887 
297526696 820 DYNAIN----------EEVEILEEAIESLIDDIKNVLNILSP-KPK-HAYIVVASPWKREVIEMIEkgmdrREIIRTIRD 887 
227827868 784 NELDLY----------PDAILEISYINEIIENVRELEDLVHK-KAE-KVVIYINESKKVKELM--------KNAISAIND 843 
229585136 784 NELDLY----------PDAILEISYINEIIENVRELEDLVHK-KAE-KVVIYINESKKVKELM--------KNAISAIND 843 
16081844  776 FQDRYErtvrrfgmtcDQMYSAMDYVEKVLQDVKNIMQVTGI-EPK-SVEITVANADVVRAA---------QEFLNNSVS 844 
13541592  776 FAEKYErlakvyglstSEFYQVMDYVEHIIQDINNIISVTGI-EPK-SVEITVANEDVIKAS---------REFLSNSVS 844 
48478263  769 IKEKID----------NYIIESENYLENIINDIREIQRAARIsGKTaLITVYGDEQAYF--------------------- 817 
296242280 819 SRYWED----------EESEILVDSLFALVEDVKKILEVLK--KPAtKAVIIVAPEWKREALKLYRegkgiKSIIEELKS 886 
124028098 836 RTLIQRfveagisdRKQAAQLAQKISRVFSELSPETlkrismveEFDEKAVLEKFKDYVASRLGMeEVVIVTAEEAEHKE 915 
218883935 885 RYGLKGre----veIAEVYNYFKKQPNEKVKLIS----------SSTEFNTYMYMAQYYSRKFNV-DVEVLWEDDARAKR 949 
126465030 888 KYGLKGr-------EKEIVYVIQEC-------SRTPckralkidPIHEYEAYNEARQYIAKKTGL-HIEVYWEEEAKAKN 952 
297526696 888 KYGLKGr-------EKEIVYVIQEC-------SRLPckralktdPLHEYEAYNEARHYIAKKTGL-NIEVYWEEEARTKN 952 
227827868 844 GISLREf------vMKTGDKIAEKVYVVVSKLDKSIrdyl-lknEVDEEQIIVKNMNFLLKRLAVsEIVIYNAEDPTVPD 916 
229585136 844 GISLREf------vMKTGDKIAEKVYVVVSKLDKSIrdyl-lknEVDEEQIIVKNMNFLLKRLAVsEIVIYNAEDPTVPD 916 
16081844  845 GQSKKYmq----ylAKRRKDIMIY--------------------GFDEYDVLQRNQVYLSKQIGC-PVRIERGDVINGKI 899 
13541592  845 ERSKRY--------LQYLAKRRKDIVVY----------------PFNEIDILRRNSSYISRQVKA-DVSINTGDIINGKI 899 
48478263  818 --------------IKNYSNLTGKFKMAIPDYMRNKqri--mntMINEYSVIKENIDYIEEMTSL-KIVVDVSKGIDKKN 880 
296242280 887 KYNLRG--------------RELEIVETVQTFSKNPnedvfktsSKREYEVLEYSVNFLERKTGL-KIEVLWEDEARARG 951 
124028098 916 LvpPTKlaqAVPMRPAILVE 935 
218883935 950 IpkSEK---ALPLKPSIYVE 966 
126465030 953 I--PKAe-kTLPLKPSFYLY 969 
297526696 953 I--PKAe-kTLPLKPSFYLH 969 
227827868 917 V--KGKksqALPLSPAIVIE 934 
229585136 917 V--KGKksqALPLSPAIVIE 934 
16081844  900 ---------ALPGKPVIYIS 910 
13541592  900 ---------AVPGKPVIHIT 910 
48478263  881 ---------PWPGRPLIKII 891 
296242280 952 IprSEK---AQPLKPAIYVD 968 
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