3KTF,3PA6,2WT8


Conserved Protein Domain Family
BRCT_microcephalin_rpt1
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cd17716: BRCT_microcephalin_rpt1 
first (N-terminal) BRCT domain of microcephalin and similar proteins
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the first repeat.
Links
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Statistics
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PSSM-Id: 349348
Aligned: 53 rows
Threshold Bit Score: 70.3006
Created: 4-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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BRCT sequence
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: BRCT sequence motif, 2 residue positions
Conserved feature residue pattern:W [SC]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
3KTF_A        10 DVVAYVEVWSSngt--enySKTFTTQLVDxGAKVSKTfnk----qvTHVIFKDGyQSTWDKAQKRg-------------- 69  human
XP_003385325  38 GIVAFVDVRSGskst-intGNSLEECLEGlGATVVTRlnk----dvTHIVYKAGkTNLDRVNKKE--------------- 97  Amphimedon quee...
KPJ01275      90 GVVALVDVGAGs------rALALRAALSAlGATVVPAwnh----lvTHLVWSHDgCRNVRGRARAl-------------a 146 Papilio xuthus
CDJ93841     130 GCRIIVEMGCCae-----sSEDVRSRLRRmGAVVSRRftr----ttTHVVFSFGgRAAILRCAFAlp-----------kk 189 barber pole worm
XP_001420200   7 GVSAYVDVTLTgnv---daSAPFRAKLVAkGAKVTVNicp----ttTHVIFRAA-DAARGVALHRklaem-----klask 73  Ostreococcus lu...
CEF99468       8 GVRAFVAVRTNdgv---dcSGVFASKLVKmGAKTFKDrlt---nslTHIVFRAGnDAEGLPRLRRrmkda------gces 75  Ostreococcus tauri
OQR97664      10 GLRVVVDVRMSmggadvdcSAEIGRKLSSlGARVCKRigk----etTHVVWLNGsRAIRDATLKRn-------------d 72  Achlya hypogyna
O74389       163 SVHAYVEIGEGmf-----sMEIVTEQLRLlGATVHASlqmteenpvSHAVLYDCsQETLKKISSAq-------------- 223 Schizosaccharom...
CEG35334      46 GVVAIVDVRVGgeaq-idcSDVVSRKLREmGASTVKRltp----kiTHVVLSHFtPAWKTKILKWqgsggsmaaaaaryg 120 Plasmopara hals...
CCI49677      19 RICAMVNVRIGddat-idcSRVIASKLESlGATIVKRftp----klTHLVIHDYnSDWKARIVKWqqiiks----ksiln 89  Albugo candida

Feature 1                 #   #       
3KTF_A        70 VKLVSV--LWVEKCRTAGAHI 88  human
XP_003385325  98 VFLVNP--LWLDACKRCNERV 116 Amphimedon queenslandica
KPJ01275     147 CRVVSP--LWVEACAASGRRL 165 Papilio xuthus
CDJ93841     190 PFLVDP--QWVYECFNTRTRV 208 barber pole worm
XP_001420200  74 VKVVSP--LWITNSERRGEMV 92  Ostreococcus lucimarinus CCE9901
CEF99468      76 AFIVTP--SWITACERAGSRA 94  Ostreococcus tauri
OQR97664      73 VILVGP--SWVEACVKTTSRV 91  Achlya hypogyna
O74389       224 VPIVCVspKWVLACYSSKYLV 244 Schizosaccharomyces pombe 972h-
CEG35334     121 LKIVSQ--LWVNACFVSKRCM 139 Plasmopara halstedii
CCI49677      90 LHIVSP--LWVQACLTSNSHE 108 Albugo candida

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