1Q7X,1VJ6,5ZDS


Conserved Protein Domain Family
PDZ2-PTPN13_FRMPD2-like
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cd06792: PDZ2-PTPN13_FRMPD2-like 
PDZ domain 2 of tyrosine kinase PTPN13, FERM and PDZ domain-containing protein 2 (FRMPD2), and similar domains
PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 2 of human PTPN13, and related domains. PTPN13, also known as Fas-associated protein-tyrosine phosphatase 1 (FAP-1), protein-tyrosine phosphatase 1E (PTP-E1), and protein-tyrosine phosphatase (PTPL1), negatively regulates FAS-mediated apoptosis and NGFR-mediated pro-apoptotic signaling, and may also regulate phosphoinositide 3-kinase (PI3K) signaling. It contains 5 PDZ domains; interaction partners of its second PDZ domain (PDZ2) include the Fas receptor (TNFRSF6) and thyroid receptor-interacting protein 6 (TRIP6). The second PDZ (PDZ2) domain, but not PDZ1 or PDZ3, of FRMPD2 binds to GluN2A and GluN2B, two subunits of N-methyl-d-aspartic acid (NMDA) receptors. Other binding partners of the FRMPDZ2 PDZ2 domain include NOD2, and catenin family members, delta catenin (CTNND2), armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF) and p0071 (also known as plakophilin 4; PKP4). PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This PTPN13-like family PDZ2 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Links
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Statistics
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PSSM-Id: 467254
Aligned: 28 rows
Threshold Bit Score: 118.853
Created: 19-Jun-2007
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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peptide binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on canonical PDZ domains with structure
  • Comment:PDZ domains specifically recognize and bind to short C-terminal peptide motifs, but can also recognize internal peptide motifs and certain lipids
  • Structure:1VJ6: PDZ domain 2 of Mus musculus protein-tyrosine-phosphatase (nonreceptor type 13) binds the C-terminal ligand of adenomatous polyposis coli (APC) protein, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #######                   #  #                             #   #  #
1Q7X_A          9 DIFEVELAKn-dNSLGISVTVLfdkggvntsvrhGGIYVKAVIPQGAAESDGrIHKGDRVLAVNGVSLEGaTHKQAVETL 87   human
1VJ6_A         12 DTFEVELAKt-dGSLGISVTGGvnts-----vrhGGIYVKAIIPKGAAESDGrIHKGDRVLAVNGVSLEGaTHKQAVETL 85   house mouse
XP_006812581 1240 DVFEMRLSRi-dGSLGLSVTGGvnts-----vkhGGIYVKCVFENGAAELDGrIKVGDRVLEVNEVQLVGvTHKQAVETL 1313 Saccoglossus ...
ELT89391     1050 EVYEVKLRKi-nNSLGLNVAGGvnt-------smGGIFVKSLADRGAAGQNGrILIGDRVLEVNGVSLVGvTHNQAVETL 1121 Capitella teleta
XP_012555547  953 EEIEVEIEKvkkQSFGISIVGGidst-----lplGGIFVKSLLFGSPAQLTGkIREGDRILSVNGTSLENmTHLEAVEIL 1027 Hydra vulgaris
XP_012561741 1117 VLTVVKLTKs-vSGFGISLTGGpe---------iGGIFVKALMPGGCAENDGhILIGDRLVEINGQSFDNlTRQQATDLL 1186 Hydra vulgaris
XP_029658474 1130 KFFECVLTKi-qGSFGLNIIGGidtk-----tdlGGVYVKSLQPGGAAQQNGtIQKNDRILSINDVSLQDkYHQQAVRIL 1203 Octopus vulgaris
XP_012561741  560 NFISITLNKk-nDSLGFSITGGld---------lGGIFVKYLNPNGPAACDKrLEIGDRVVGVNDISLETvSRQKALEIL 629  Hydra vulgaris
XP_012561741  454 DYIRVNLVKh-nNTFGIGFTGGpe---------lGGVYVKSLLPHSSAEIDGrIAVGDRLVEIDQINVENfTRKKIQDFL 523  Hydra vulgaris
XP_012561741  333 KQTTIDLIKk-dGSFGFSIVGGie---------lGGIFVKDITPGGPAALSRqINAGDRIVQINKVSFENvTRREAINTL 402  Hydra vulgaris

Feature 1         #            
1Q7X_A         88 RNTGQVVHLLLEK 100  human
1VJ6_A         86 RNTGQVVHLLLEK 98   house mouse
XP_006812581 1314 RQAPHTTSLVIER 1326 Saccoglossus kowalevskii
ELT89391     1122 RSAPQVCKLVMQR 1134 Capitella teleta
XP_012555547 1028 KHAPERTTIVIDR 1040 Hydra vulgaris
XP_012561741 1187 KNSPNNATFILER 1199 Hydra vulgaris
XP_029658474 1204 HDATDRSILVLGR 1216 Octopus vulgaris
XP_012561741  630 RNATSPVNLIIEK 642  Hydra vulgaris
XP_012561741  524 KQAQGHVSIVVER 536  Hydra vulgaris
XP_012561741  403 RNAPDKSKFVIES 415  Hydra vulgaris

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