3L2P,3W1B,2CFM


Conserved Protein Domain Family
dnl1

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TIGR00574: dnl1 
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DNA ligase I, ATP-dependent (dnl1)
All proteins in this family with known functions are ATP-dependent DNA ligases. Functions include DNA repair, DNA replication, and DNA recombination (or any process requiring ligation of two single-stranded DNA sections). This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 273147
Aligned: 15 rows
Threshold Bit Score: 519.18
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3L2P_A        64 VYNLNDKQIVKLFSRIFNCNPDDMARD-LeQGDVSETIRVFFEQSk----------SFPPAAKSLLTIQEVDEFLLRLSK 132  human
CAA82805      56 IYNINDKQLVKLFSKIFCHDADEMYKYvInIGDVAYVIGSFLKKSk---------sVVDYATESTLTLHEVDCFLTRLST 126  Fowlpox virus
P54875        60 ELGVGIKLLMKAISLVVGVSMDEIEDEiReQGDIGLASEKLFSRKtq--------tTFFSQPLTVEFVYSRLKALASASG 131  Methanothermob...
O59288        57 ELGVGEKLLIKAVSMATGVDPKEIENSvKdTGDLGESIALAIKRRkq--------kSFFSQPLTIKRVYQTLVKIAETTG 128  Pyrococcus hor...
Q57635        61 ELGIGEKLLINAVTSIG-IKKDELLEKiKeTGDIGLAIEQLKSKIkq--------aSLFFQPLTVDEVYETLKRVGEIEG 131  Methanocaldoco...
Q08387        84 IYNIKDYVLIRTICSYLKLPKNSATEQrLkDWKQRVGKGGNLSSLlve------eiAKRRAEPSSKAITIDNVNHYLDSL 157  Saccharomyces ...
P49917        81 AYGIKETMLAKLYIELLNLPRDGKDALkLlNYRTPTGTHGDAGDFamiayfvlkprCLQKGSLTIQQVNDLLDSIASNNS 160  human
WP_010880901  58 DYNFGEKLAIRALSRVLKIPALEIEKRvRqEGDLGEAGRKLYEELg----------FKPEGTLTVEEVYNGLLNIAKAVG 127  Aquifex aeolicus
AAC53003     323 VYNLNDKQIVKLFSRIFNCNPDDMARDlE-QGDVSETIRIFFEQSk----------SFPPAAKSLLTIQEVDAFLLHLSK 391  house mouse
CAA64457      83 IYFIKEVALARLLIKMYKIPKESEDYItLhDWNKSYQRSRRFSIDe---------kKIRDLPLQASRIISKRRPIVDKLE 153  Candida albicans
3L2P_A       133 LTKEDEQQQALQDIASRCTANDLKCiIRLIKHDLKMNSGAKHVLDALDPNA----------------YeAFKASRNLQDV 196  human
CAA82805     127 VTRENDQIKEIKKIIPRCTPNDLRHiIRLIKHDLRMNIGPKHVLSGLHKDAy---------------G-IFKLCNNLEQV 190  Fowlpox virus
P54875       132 DRAQSKKINILVEVLSQAKPLEARYiTRTVLEELRVGVAEGIIRDAIARAFevdp---------alvErAHMLTNDLGMV 202  Methanothermob...
O59288       129 EGSQEKKMKYLANLFMDAEPLEAKYlARTVLGTMRTGVAEGLLRDAIALAFhvkv---------elvErAYMLTSDFGFV 199  Pyrococcus hor...
Q57635       132 EGSQKKKLRLISSLFLRASPIECRYlARLILEDMRIGMNVPTILDALSVYFnvpk---------eklEkIYAITNDIGLL 202  Methanocaldoco...
Q08387       158 SGDRFASGRGFKSLVKSKPFLHCVEnMSFVELKYFFDIVLKNRVIGGQEHKllncw-------hpdaQdYLSVISDLKVV 230  Saccharomyces ...
P49917       161 AKRKDLIKKSLLQLITQSSALEQKWlIRMIIKDLKLGVSQQTIFSVFHNDA----------------AeLHNVTTDLEKV 224  human
WP_010880901 128 IGSQERKISIFASLLKKATPLEAKYlLRTITERLRLGIGDNTILEALSIAFtgssv------nrevvErAYNLTSDLGYV 201  Aquifex aeolicus
AAC53003     392 LTKEDEQQQALQDIASRCTANDLKC-IRLIKHDLKMNSGAKHVLDALDPNAy---------------E-AFKASRNLQDV 454  house mouse
CAA64457     154 EYTVPQINSSLDQLALEKVSQGQIDiLKPLFDNLSIPEVRWLIHILLNKSIltsmerfffntwhpdgYrVFSICNDLQKT 233  Candida albicans
3L2P_A       197 VERvlhnaqevekePGqRRALSVQASLMTPVQPMLAEACKSVEYAMKKCP--------------------N-GMFSEIKY 255  human
CAA82805     191 VQR-----------SL-EDNIKPLIELMVPLQPMLASACKTFSEAVKKCP--------------------N-GIIVEFKY 237  Fowlpox virus
P54875       203 AAVar-------eeGEpGLGR-LNLEPGRPVKPMLAQLASSIESAITELG----------------------RAFCETKY 252  Methanothermob...
O59288       200 AKIak-------aeGNeGLEK-VTIQLGKPIKPMLAQQAANIKEALLEMG--------------------G-EAEFEIKY 250  Pyrococcus hor...
Q57635       203 AEKll--------mGDlESEE-LKLKLFRPIKPMLAQLTPSIEEALLEMG----------------------RAQFETKY 251  Methanocaldoco...
Q08387       231 TSKly-------dpKVrLKDDDLSIKVGFAFAPQLAKKVNLSYEKICRTL--------------------HdDFLVEEKM 283  Saccharomyces ...
P49917       225 CRQl---------hDPsVGLSDISITLFSAFKPMLAAIADIEHIEKDMKH--------------------Q-SFYIETKL 274  human
WP_010880901 202 AKIla-------ekGLeGV-KQVKIQVGRPVRPMLAERMSSPILILRKLG--------------------G-KCGAEYKY 252  Aquifex aeolicus
AAC53003     455 VERvlhneqevekdPGrRRALRVQASLMTPVQPMLAEACKSIEYAMKKCP--------------------N-GMFSEIKY 513  house mouse
CAA64457     234 LQFst-------npDLrLDPSQLAIHPCFKFKPQLSERLTTSYKTLVKKLqrkhemdppyekkfqelgleN-KFYIEEKM 305  Candida albicans
3L2P_A       256 DGERVQVHK--NGDHFSYFSRSLKPVLPHKVAH-----F-----KDYIPQAFPG-GHSMILDSEVLLIDNKTGKPLPFGT 322  human
CAA82805     238 DGERIQIHK--HDKNFKYFSRSLKPITPHKVTD-----F-----EELLDRAFPS-ANNMILDGEIILIDTETNQPLPFGT 304  Fowlpox virus
P54875       253 DGIRVQIHR--CGDEVSIFTRRLENITAAVPEI-----------LEGVEEALPA-DD-YIVEGEIIVTMD--GRPASFQY 315  Methanothermob...
O59288       251 DGARVQVHK--DGEKVIIYSRRLENVTRAIPEI-----------VEAIKEAIEP-EK-VIVEGELVAIGEE-GRPLPFQY 314  Pyrococcus hor...
Q57635       252 DGARVQIHK--DGNKVKIYSRRLEDVTNALPEI-----------VEAVKNINVD-K--LIVEGECVAIDKQTGKPRPFQD 315  Methanocaldoco...
Q08387       284 DGERIQVHYmnYGESIKFFSRRGIDYTYLYGASls--sG-----TISQHLRFTDsVKECVLDGEMVTFDAKRRVILPFGL 356  Saccharomyces ...
P49917       275 DGERMQMHK--DGDVYKYFSRNGYNYTDQFGASptegsL-----TPFIHNAFKAdIQICILDGEMMAYNPNTQTFMQKGT 347  human
WP_010880901 253 DGERIQAHR--KGDEFYLFSRRLENITHQYPD------L-----IEFLKEAIPH-D--FIVELEAVVIDPASGEIRPFQE 316  Aquifex aeolicus
AAC53003     514 DGERVQVHK--KGDHFSYFSRSLKPVLPHKVAH-----F-----KDYIPKAFPG-GQSMILDSEVLLIDNNTGKPLPFGT 580  house mouse
CAA64457     306 DGDRMLLHK--DGDSFKFFSRRLKDYSYLYGES-----FqfgalTKFLAHAFAGnIQSVILDGEMVAYDYERNVILPFGT 378  Candida albicans
3L2P_A       323 LGVHk-----------KAAFQDANVCLF-VFDCIYFNDVSLMDRPLCERRKFLHDNMVEIPN----------RIMFSEMK 380  human
CAA82805     305 LGINk-----------KSMYHNACVCIF-IFDCLYFNDTVLIDKPLIERRNIIHANIKEIPN----------RILLSEVK 362  Fowlpox virus
P54875       316 ILQRvrrk-----ydvDRLTREVPLSLF-LFDVLYHRG-PLIDEPLWHRREVLESILSEIPG----------RVEASRMV 378  Methanothermob...
O59288       315 VLRRfrrk-----hniEEMMKKIPLELN-LFDVLYVDGKSFVDTKFIERRKKLEEIVKPNG-----------KIKVAENL 377  Pyrococcus hor...
Q57635       316 ILRRfrrk-----ydiGKMMKEINLRVY-LFDILYKDGVSFIDEEFEKRRKVLEEIVGYENDwrterkriekELKSDKII 389  Methanocaldoco...
Q08387       357 VKGSakea-----lsfNSINNVDFHPLYmVFDLLYLNGTSLTPLPLHQRKQYLNSILSPLKN----------IVEIVRSS 421  Saccharomyces ...
P49917       348 KFDIk----------rMVEDSDLQTCYC-VFDVLMVNNKKLGHETLRKRYEILSSIFTPIPG----------RIEIVQKT 406  human
WP_010880901 317 LMHRkvk------yvtKYHITKYPVAGF-LFDIIYLDGEDLTLKPYPERREILEKVVKRTD-----------RIGLVPRK 378  Aquifex aeolicus
AAC53003     581 LGVHk-----------KAAFQDANLCLF-VFDCIYFNDVSLMDRPLCERRKFLHDNMVEIRN----------RIMFSEMK 638  house mouse
CAA64457     379 LKSSaiqesvrqfttiDQYEQQTAYPFFlVFDILFLNGKDLTNYPLFFRKNILNRILRPIPN----------RFEVLDTR 448  Candida albicans
3L2P_A       381 RVt------KALDLADMITRVIQEGLEGLVLKDV--KGTYE-PGKRHWLKVKKDYLNEGAMADTADLVVLG-------AF 444  human
CAA82805     363 NIs------TDEELSKLLHIVLSKNIEGFVLKDA--KGVYE-PGMRRWLKIKKDYLDGCVMADKADLVVLG-------AY 426  Fowlpox virus
P54875       379 DVgp----dNLDDALWLFKESIREGHEGIMIKDT--EAPYI-PGIRGKKMLKFK-----AEPETLDLIVVG-------GT 439  Methanothermob...
O59288       378 ITk------NAEEAEKFYKRALEMGHEGLMAKRL--DAVYE-PGNRGKKWLKIK-----PTMENLDLVIIG-------AE 436  Pyrococcus hor...
Q57635       390 DIsyklvtnDAKEAREFYNWSLSIGHEGVMIKNL--KAPYT-PGSRVRTMYKFK-----PTLESLDVVITK-------AK 454  Methanocaldoco...
Q08387       422 RCy------GVESIKKSLEVAISLGSEGVVLKYY--NSSYN-VASRNNNWIKVKPEYLEEFGENLDLIVIGrdsgkkdSF 492  Saccharomyces ...
P49917       407 QAh------TKNEVIDALNEAIDKREEGIMVKQP--LSIYK-PDKRGEGWLKIKPEYVSGLMDELDILIVG-------GY 470  human
WP_010880901 379 IVd------NVEDLENFFYQAIEEGCEGLVCKSLapNSIYQ-AGKRGFLWIKYKRDYKSVLADTLDLVVVG-------GF 444  Aquifex aeolicus
AAC53003     639 QVt------KASDLADMINRVIREGLEGLVLKDV--KGTYE-PGKRHWLKVKKDYLNEGAMADTADLVVLG-------VF 702  house mouse
CAA64457     449 LGs------SSEDIERAIREVVSSRCEGLVLKNV--QSKYEiDGFRNPDWIKVKPEYLEKFGENLDLVVIGkspaiknSY 520  Candida albicans
3L2P_A       445 Y-------------------------------GQGSKGGMMSIFLMGCYDPGS-----QKWCTVTKCAGG--------HD 480  human
CAA82805     427 Y-------------------------------GKGNKSGILSSFLMGCYDTKS-----EKWCTVTKCSGG--------HT 462  Fowlpox virus
P54875       440 Y-------------------------------GRGKRAHLVGSYLLAVRDEKS-----GELKTIAHVATG--------LD 475  Methanothermob...
O59288       437 W-------------------------------GEGRRAHLFGSFILGAYDPET-----GEFLEVGKVGSG--------FT 472  Pyrococcus hor...
Q57635       455 R-------------------------------GMGKRKDWYGSFEICVRDEE------GNLYPIGHVGTG--------LT 489  Methanocaldoco...
Q08387       493 MlgllvldeeeykkhqgdsseivdhssqekhiQNSRRRVKKILSFCSIANGISq----EEFKEIDRKTRGhwkrtsevAP 568  Saccharomyces ...
P49917       471 W-------------------------------GKGSRGGMMSHFLCAVAEKPPpgekpSVFHTLSRVGSG--------CT 511  human
WP_010880901 445 Y-------------------------------GKGQRKGTFGSLLMACYDPES-----DMFKTVTKVGTG--------FT 480  Aquifex aeolicus
AAC53003     703 Li------------------------------GQGSKGGMMSIFLMGCYDPDS-----QKWCTVTKCAGG--------HD 739  house mouse
CAA64457     521 Mc------------------------------GLKSVTDGFIIVFCTCANGIEi----EEFDKIERLTHGkwiktdvsMP 566  Candida albicans
3L2P_A       481 DATLARLQNELDMVKISKDpsKIPSWLkvnkiyyP--------------------DFIVPDPKKAAVWEITGAEFSKSEA 540  human
CAA82805     463 DLELQEINDNLSVVPFDRN--AIPDWLsinkihyP--------------------DVIISDISLAPVWEIIGSEFTRSST 520  Fowlpox virus
P54875       476 DQTLQDLSERMENLKVERRgrKIR-------------------------------------VKPEIILEVAYSEIVRSPE 518  Methanothermob...
O59288       473 DDDLVEFTKMLKPLIVKEEgkRVV-------------------------------------IQPKIVIEVTYQEIQKSPK 515  Pyrococcus hor...
Q57635       490 EADLEFLKEEIDKIIIRDLgeEVE-------------------------------------VEPKIVIEVAYEEIQKSDK 532  Methanocaldoco...
Q08387       569 PASILEFGSKIPAEWIDPSesIVLEIKsrsldntEtnmqkyat-----nctlyggYCKRIRYDKEWTDCYTLNDLYESRT 643  Saccharomyces ...
P49917       512 MKELYDLGLKLAKYWKPFHrkAPPSSIlc----gTe------------------kPEVYIEPCNSVIVQIKAAEIVPSDM 569  human
WP_010880901 481 EDDFKKLEEILMPRKLNHRhpRVNSIL-----------------------------EADMWFEPYLVLEITGAELTLSPV 531  Aquifex aeolicus
AAC53003     740 DATLARLQKELVMVKISKDpsKIPSWLkinkiyyP--------------------DFIVPDPKKAAVWEITGAEFSRSEA 799  house mouse
CAA64457     567 PESLIKFGTKIPTFWIHPSdsLVLEIR-------ArsidtragtsyavgstlhnnHCRKIREDKSIDECVTLQEYTHIKA 639  Candida albicans
3L2P_A       541 HTAD------------GISIRFPRCT---------------------------------RIRDDKDWKS----------- 564  human
CAA82805     521 HTAS------------NISIRFPRCS---------------------------------RIREDKTYET----------- 544  Fowlpox virus
P54875       519 YES-------------GYSLRFPVVK---------------------------------RIRDDLSPDD----------- 541  Methanothermob...
O59288       516 YRS-------------GFALRFPRYV---------------------------------ALRDDKGPED----------- 538  Pyrococcus hor...
Q57635       533 YPC-------------GYALRFPRVV---------------------------------RFRFDKGVNE----------- 555  Methanocaldoco...
Q08387       644 VKSNpsyqaersqlglIRKKRKRVLIsdsfhqnrkql-----------pisnifagllfYVLSDYVTEDtg--------- 703  Saccharomyces ...
P49917       570 YKT-------------GCTLRFPRIEkirddkewhecmtlddleqlrgkasgklaskhlYIGGDDEPQEkkrkaapkmkk 636  human
WP_010880901 532 HTCGwgkv----spnrGIGLRFPRFTg--------------------------------RYRFDKRPED----------- 564  Aquifex aeolicus
AAC53003     800 HTAD------------GISIRFPRCT---------------------------------RIRDDKDWKS----------- 823  house mouse
CAA64457     640 NYINdlnk----aqtaLGKKREPVYSldnesklkkvk-----------vesdlfsgiefLIMSDKREADg---------- 694  Candida albicans
3L2P_A       565 ------------ATNLPQLKELYQ 576  human
CAA82805     545 ------------ANNLNDIKQLYA 556  Fowlpox virus
P54875       542 ------------IDTLGRVISLFK 553  Methanothermobacter thermautotrophicus
O59288       539 ------------ADTIERIAQLYE 550  Pyrococcus horikoshii OT3
Q57635       556 ------------INTIEDVERIYE 567  Methanocaldococcus jannaschii DSM 2661
Q08387       704 ----------irITRAELEKTIVE 717  Saccharomyces cerevisiae S288c
P49917       637 vigiiehlkapnLTNVNKISNIFE 660  human
WP_010880901 565 ------------ATTEQEIIEMYR 576  Aquifex aeolicus
AAC53003     824 ------------ATNLPQLKELYQ 835  house mouse
CAA64457     695 -----------eVTRIEEMKAMVK 707  Candida albicans
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