3AL8


Conserved Protein Domain Family
Sema_plexin_A2
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cd11272: Sema_plexin_A2 
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The Sema domain, a protein interacting module, of Plexin A2
Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Links
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Statistics
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PSSM-Id: 200533
Aligned: 8 rows
Threshold Bit Score: 1088.81
Created: 7-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Semaphorin
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:Semaphorin binding site [polypeptide binding site]
Evidence:
  • Comment:Plexins function as receptors of semaphorins.
  • Structure:3AL8; mouse Plexin A2 binds to semaphorin 6A, contacts at 4A distance.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                # ##                     
3AL8_B          8 YSTFHSENRDWTFNHLTVHRRTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKACYPPLIVQPCsEVLTLTNNVNKLL 87   house mouse
XP_002196469   38 FNTFHSEHRDWTFNHLAVHRGTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCgEVLTLTNNVNKLL 117  zebra finch
NP_001116947   41 SNTFNTEHRDWTFSHLTVHQTTGAVYVGAVNRIYKLSGNLTLLVSHNTGPGEDNKSCYPPQNVQPCsEPRTLTNNVNKLL 120  western clawe...
CBN80703       25 LNTFQSERKEWSLNHLTVHQSTGALYIGAVNRIYKLSANLTLLVSHDTGPEYDNKACYPPLIVQPCsEPLASTDNVNKLL 104  European seabass
NP_001099458   38 FSTFHSENRDWTFNHLTVHRRTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKACYPPLIVQPCsEVLTLTNNVNKLL 117  Norway rat
NP_079455      38 FSTFHSENRDWTFNHLTVHQGTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCsEVLTLTNNVNKLL 117  human
XP_003224657  106 YNTFHSENRDWTFNHLTVHQATGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCtEILTLTNNVNKLL 185  green anole
XP_417985      40 FSTFHSEHRDWTFNHLTVHRSTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCsEVLTLTNNVNKLL 119  chicken

Feature 1                                              #                                    ###   
3AL8_B         88 IIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPT 167  house mouse
XP_002196469  118 IIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPT 197  zebra finch
NP_001116947  121 IIDYAENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNETGTMYGVIVHTEGQDGKLFIGTAVDGKQDYFPT 200  western clawe...
CBN80703      105 LIDYSHNRLLACGSLYQGVCKLMRLDDLFILVEPTHKKEHYLSSDNQTGTMYGVVVPSQGQDATLYIGTAVGGKQDYFPT 184  European seabass
NP_001099458  118 IIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPT 197  Norway rat
NP_079455     118 IIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPT 197  human
XP_003224657  186 IIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPT 265  green anole
XP_417985     120 IIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPT 199  chicken

Feature 1                               ###      ###                                              
3AL8_B        168 LSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTlaLVSHFDIFYIYGFASGGFVYFLTVQPETPDGMAins--agDLF 245  house mouse
XP_002196469  198 LSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTlaLVSHFDIFYIYGFASGNFVYFLTVQPETPEGVSins--asDLF 275  zebra finch
NP_001116947  201 LSSRKLPRDPESSTMLDYELYSDFVSSLIKIPSDTlaLVSHFDIFYVYGFSSGNYVYFLTVQPETPEGISsns--anDLF 278  western clawe...
CBN80703      185 ISSRKLPRDPESSAMLDYELHTDFVSSLIKIPSDTlaLVPHFDIYYIYGFASGSFVYFMTVQPETPENGMpagsspgDLF 264  European seabass
NP_001099458  198 LSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTlaLVSHFDIFYIYGFASGGFVYFLTVQPETPEGMAins--agDLF 275  Norway rat
NP_079455     198 LSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTlaLVSHFDIFYIYGFASGGFVYFLTVQPETPEGVAins--agDLF 275  human
XP_003224657  266 LSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTlaLVSHFDIFYIYGFASGNFVYFLTVQPETPEGVSins--asDLF 343  green anole
XP_417985     200 LSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTlaLISHFDIFYIYGFASGNFVYFLTVQPDTPEGVSns---asDLF 276  chicken

Feature 1                                                                                         
3AL8_B        246 YTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGEALAQAFNISSDEDVLFAIFSKGQKQYHHPPDDSAL 325  house mouse
XP_002196469  276 YTSRIVRLCKDDPKFHSYVSLPFGCVKGDTEYRLLQAAYLSKPGEVLARALNITAQEDVLFAIFSKGQKQYHHPPDDSAL 355  zebra finch
NP_001116947  279 YTSRIVRLCKNDPKFHSYVSLPIGCTKNGVEYRLLQAAYLTKPGATLARSLKITTQDDVLFAIFSKGQKQYHHPPDDSTL 358  western clawe...
CBN80703      265 YTSRIIRLCKGDKKFHSYVSLPVGCVHRGEEYRLLQAAYLSKAGRVLAKSLNISAQEDVLFAVFSKGQKQCHDPPDHSAL 344  European seabass
NP_001099458  276 YTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGEALAQAFNISSEEDVLFAIFSKGQKQYHHPPDDSAL 355  Norway rat
NP_079455     276 YTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQYHHPPDDSAL 355  human
XP_003224657  344 YTSRIVRLCKNDPKFHSYVSLPFGCVKGDVEYRLLQAAYLSKPGEVLARSLNITAQDDVLFAIFSKGQKQYHQPPDDSAL 423  green anole
XP_417985     277 YTSRIVRLCKDDPKFHSYVSLPFGCVRGDTEYRLLQAAYLSKPGDVLAKSLNITAHEDVLFAIFSKGQKQYHQPPDDSAL 356  chicken

Feature 1                                       #  # #  #####         #  #                        
3AL8_B        326 CAFPIRAINLQIKERLQSCYHGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRLTSV 405  house mouse
XP_002196469  356 CAFPIRTVNAHIKERLRSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSVPVDGVTLFTSSRDRLTSV 435  zebra finch
NP_001116947  359 CVFPIKTINSLIKERLQSCYQGEGHLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTMVEGVTLYTESRDRMTSL 438  western clawe...
CBN80703      345 CVFTIQDINTRIKERLQSCYQGEGNLELHWLLGKDVQCTKAPVPIDDHFCGLDINQPLGGSQLVSGQTVYTESRDRLTSV 424  European seabass
NP_001099458  356 CAFPIRAINLQIKERLQSCYHGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRLTSV 435  Norway rat
NP_079455     356 CAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSV 435  human
XP_003224657  424 CIFPIRAINAQIKDRLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSVPVEGVTLYTSSRDRMTSV 503  green anole
XP_417985     357 CVFPIRAVNAQIKDRLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSVPVDGVTLFTSSRDRMTSV 436  chicken

Feature 1                                                                                         
3AL8_B        406 ASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVFkDGSPILRDMAFSINQLYLYVMSERQVTRVPVESCEQYT 485  house mouse
XP_002196469  436 ASYVYNGYSVVFVGTKTGRLKKIRADGPPQGGIQYEVVPVFkDGSPVLRDMAFSTDHKYLYVMSERQVSRVPVESCEQYT 515  zebra finch
NP_001116947  439 ASYVYNNYSVVFVGTKSGRIKKIRADGPPDGGIPYEVVNVTrDEIPLLRDMAFSTDNKYLYVMSERQVSRVEVEHCEQYS 518  western clawe...
CBN80703      425 TSYVYNGHSVVFLGTRSGRLKKIRVDGPLEGGVLYETVTVMkDSSPILRDMAFSLDRNSLYVMADNQVAQVPVEACEQYS 504  European seabass
NP_001099458  436 ASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVFkDGSPILRDMAFSINQLYLYVMSERQVTRVPVESCEQYT 515  Norway rat
NP_079455     436 ASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLkDGSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYT 515  human
XP_003224657  504 TSYVYNDYIVVFVGTKSGKLKKIRADGPPHGGIQYEMIPIFkDGSPILRDMAFSTDHNYLYVMSERQVSQVPVESCEQYT 583  green anole
XP_417985     437 ASYIYNGYSVVFVGTKNGKVKKIRADGPPHGGIQYEVVTVFkDGSPVLRDMAFSIDHKYLYVMSERQVSRVPVESCEQYT 516  chicken

Feature 1                                              
3AL8_B        486 TCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEANRF 522  house mouse
XP_002196469  516 TCQECLSSGDPHCGWCSLHHMCSPRDRCERAEEPFRF 552  zebra finch
NP_001116947  519 SCEECLSSGDPHCGWCVLHNTCSRKDKCERAHEPFRF 555  western clawed frog
CBN80703      505 TCAECLSSGDPHCGWCVLYNMCSRRDRCQRAEETFRF 541  European seabass
NP_001099458  516 TCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEANRF 552  Norway rat
NP_079455     516 TCGECLSSGDPHCGWCALHNMCSRRDKCQQAWEPNRF 552  human
XP_003224657  584 TCGECLSSGDPHCGWCALHHTCSRRDKCERADEPFRF 620  green anole
XP_417985     517 TCAECLSSGDPHCGWCTLHHTCSPRDSCERADEPHRF 553  chicken

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