"GeneDx"[submitter] AND "WT1"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 58858	GRCh38/hg38 11p14.3-12(chr11:22550115-38199159)x1	PAX6_HS3, PAX6_HS8 +334 more	Copy number loss	See cases	GPathogenic
Select item 145969	GRCh38/hg38 11p14.2-13(chr11:26368962-35252976)x1	LOC129390275, LOC129390276 +255 more	Copy number loss	See cases	GPathogenic
Select item 304410	NM_024426.6(WT1):c.*267G>C	WT1	Single nucleotide variant (3 prime UTR variant +1 more)	Meacham syndrome +5 more	GBenign
Select item 304412	NM_024426.6(WT1):c.*224A>G	WT1	Single nucleotide variant (3 prime UTR variant +1 more)	Meacham syndrome +5 more	GBenign
Select item 304416	NM_024426.6(WT1):c.*88A>G	WT1	Single nucleotide variant (3 prime UTR variant +1 more)	Wilms tumor 1 +5 more	GBenign
Select item 304417	NM_024426.6(WT1):c.*16G>T	WT1	Single nucleotide variant (3 prime UTR variant +1 more)	Meacham syndrome +5 more	GBenign/Likely benign
Select item 515922	NM_024426.6(WT1):c.1568G>A (p.Ter523=)	WT1	Single nucleotide variant (synonymous variant +1 more)	Meacham syndrome +8 more	GConflicting classifications of pathogenicity
Select item 666088	NM_024426.6(WT1):c.1562C>T (p.Ala521Val)	WT1 (A125V +14 more)	Single nucleotide variant (missense variant +1 more)	Wilms tumor 1 +8 more	GUncertain significance
Select item 261709	NM_024426.6(WT1):c.1448-49T>C	WT1	Single nucleotide variant (intron variant)	not specified +6 more	GBenign
Select item 3493	NM_024426.6(WT1):c.1447+5G>A	WT1	Single nucleotide variant (intron variant)	Wilms tumor 1 +10 more	GPathogenic
Select item 3500	NM_024426.6(WT1):c.1447+4C>T	WT1	Single nucleotide variant (intron variant)	WT1-related disorder +6 more	GPathogenic/Likely pathogenic
Select item 1678751	NM_024426.6(WT1):c.1420C>T (p.His474Tyr)	WT1 (H240Y +11 more)	Single nucleotide variant (missense variant +1 more)	not provided	GLikely pathogenic
Select item 3490	NM_024426.6(WT1):c.1405G>A (p.Asp469Asn)	WT1 (D252N +9 more)	Single nucleotide variant (missense variant +1 more)	not provided +1 more	GPathogenic
Select item 419332	NM_024426.6(WT1):c.1400G>A (p.Arg467Gln)	WT1 (R250Q +10 more)	Single nucleotide variant (missense variant +1 more)	Drash syndrome +11 more	GPathogenic/Likely pathogenic
Select item 3487	NM_024426.6(WT1):c.1399C>T (p.Arg467Trp)	WT1 (R250W +9 more)	Single nucleotide variant (missense variant +1 more)	Mesothelioma, malignant +9 more	GPathogenic/Likely pathogenic
Select item 2575789	NM_024426.6(WT1):c.1390A>G (p.Lys464Glu)	WT1 (K210E +11 more)	Single nucleotide variant (missense variant +2 more)	not provided	GUncertain significance
Select item 3494	NM_024426.6(WT1):c.1387C>T (p.Arg463Ter)	WT1 (R246* +9 more)	Single nucleotide variant (nonsense +1 more)	Drash syndrome +9 more	GPathogenic
Select item 1186419	NM_024426.6(WT1):c.1355-87G>A	WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 414077	NM_024426.6(WT1):c.1354+9G>A	WT1	Single nucleotide variant (intron variant)	Frasier syndrome +4 more	GLikely benign
Select item 453183	NM_024426.6(WT1):c.1351A>C (p.Thr451Pro)	WT1 (T234P +9 more)	Single nucleotide variant (missense variant +1 more)	not provided	GLikely pathogenic
Select item 3488	NM_024426.6(WT1):c.1316G>A (p.Arg439His)	WT1 (R222H +8 more)	Single nucleotide variant (missense variant +1 more)	Nephrotic syndrome, type 4 +8 more	GPathogenic
Select item 3497	NM_024426.6(WT1):c.1303C>T (p.Arg435Ter)	WT1 (R218* +8 more)	Single nucleotide variant (nonsense +1 more)	Drash syndrome +8 more	GPathogenic
Select item 2506710	NM_024426.6(WT1):c.1288T>C (p.Phe430Leu)	WT1 (F176L +10 more)	Single nucleotide variant (missense variant +2 more)	not provided	GUncertain significance
Select item 222890	NM_024426.6(WT1):c.1265G>T (p.Gly422Val)	WT1 (G205V +9 more)	Single nucleotide variant (missense variant +1 more)	Familial idiopathic steroid-resistant nephrotic syndrome +1 more	GLikely pathogenic
Select item 224479	NM_024426.6(WT1):c.1265-32C>A	WT1	Single nucleotide variant (intron variant)	Frasier syndrome +6 more	GBenign
Select item 1193538	NM_024426.6(WT1):c.1265-141T>G	WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1223622	NM_024426.6(WT1):c.1265-173C>T	WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1238846	NM_024426.6(WT1):c.1265-218dup	WT1	Duplication (intron variant)	not provided	GBenign
Select item 1213139	NM_024426.6(WT1):c.1265-218del	WT1	Deletion (intron variant)	not provided	GLikely benign
Select item 1186874	NM_024426.6(WT1):c.1265-249C>T	WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1224721	NM_024426.6(WT1):c.1264+277T>G	WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 677553	NM_024426.6(WT1):c.1264+134T>A	WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 406697	NM_024426.6(WT1):c.1211A>C (p.Asn404Thr)	WT1 (N187T +9 more)	Single nucleotide variant (missense variant +1 more)	Drash syndrome +4 more	GUncertain significance
Select item 1707868	NM_024426.6(WT1):c.1173T>G (p.Ser391Arg)	WT1 (S137R +9 more)	Single nucleotide variant (missense variant +2 more)	Frasier syndrome +4 more	GUncertain significance
Select item 198590	NM_024426.6(WT1):c.1131T>C (p.Pro377=)	WT1	Single nucleotide variant (synonymous variant +2 more)	not provided +8 more	GConflicting classifications of pathogenicity
Select item 198591	NM_024426.6(WT1):c.1122A>G (p.Arg374=)	WT1	Single nucleotide variant (synonymous variant +2 more)	Wilms tumor 1 +8 more	GBenign
Select item 476679	NM_024426.6(WT1):c.1121G>A (p.Arg374Gln)	WT1 (R157Q +8 more)	Single nucleotide variant (missense variant +2 more)	not provided +4 more	GUncertain significance
Select item 449416	NM_024426.6(WT1):c.1120C>T (p.Arg374Ter)	WT1 (R157* +8 more)	Single nucleotide variant (nonsense +2 more)	WT1-related Wilms tumor +7 more	GPathogenic
Select item 476678	NM_024426.6(WT1):c.1117G>A (p.Val373Met)	WT1 (V156M +8 more)	Single nucleotide variant (missense variant +2 more)	Drash syndrome +5 more	GUncertain significance
Select item 241475	NM_024426.6(WT1):c.1114-9T>C	WT1	Single nucleotide variant (intron variant)	Frasier syndrome +10 more	GBenign/Likely benign
Select item 1204199	NM_024426.6(WT1):c.1114-160G>A	WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1297436	NM_024426.6(WT1):c.1113+221G>A	WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1041007	NM_024426.6(WT1):c.1113+5G>C	WT1	Single nucleotide variant (intron variant)	Frasier syndrome +4 more	GUncertain significance
Select item 261708	NM_024426.6(WT1):c.1074A>G (p.Gln358=)	WT1	Single nucleotide variant (synonymous variant +2 more)	Nephroblastoma +9 more	GBenign
Select item 41847	NM_024426.6(WT1):c.1063T>C (p.Cys355Arg)	WT1 (C138R +7 more)	Single nucleotide variant (missense variant +2 more)	not provided +6 more	GConflicting classifications of pathogenicity
Select item 1292812	NM_024426.6(WT1):c.1016+195T>G	WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1292807	NM_024426.6(WT1):c.1016+164A>T	WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1265422	NM_024426.6(WT1):c.1016+134C>T	WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1225976	NM_024426.6(WT1):c.1016+122A>C	WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1214411	NM_024426.6(WT1):c.1016+81C>T	WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 939155	NM_024426.6(WT1):c.1013G>A (p.Ser338Asn)	WT1 (S121N +4 more)	Single nucleotide variant (missense variant +2 more)	not provided +4 more	GUncertain significance
Select item 2662441	NM_024426.6(WT1):c.1008G>T (p.Gly336=)	WT1	Single nucleotide variant (synonymous variant +2 more)	not provided	GUncertain significance
Select item 703782	NM_024426.6(WT1):c.1008G>A (p.Gly336=)	WT1	Single nucleotide variant (synonymous variant +2 more)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 403610	NM_024426.6(WT1):c.977G>C (p.Gly326Ala)	WT1 (G109A +3 more)	Single nucleotide variant (missense variant +2 more)	Drash syndrome +5 more	GUncertain significance
Select item 1257492	NM_024426.6(WT1):c.965+122A>G	WT1	Single nucleotide variant (non-coding transcript variant +1 more)	not provided	GBenign
Select item 1226513	NM_024426.6(WT1):c.965+85A>G	WT1	Single nucleotide variant (non-coding transcript variant +1 more)	not provided	GBenign
Select item 2662183	NM_024426.6(WT1):c.898T>C (p.Tyr300His)	WT1 (Y259H +4 more)	Single nucleotide variant (missense variant +1 more)	not provided	GUncertain significance
Select item 1209084	NM_024426.6(WT1):c.888-98G>A	WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1217929	NM_024426.6(WT1):c.887+229G>A	WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1231547	NM_024426.6(WT1):c.887+228C>G	WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1242813	NM_024426.6(WT1):c.887+85G>C	WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1292784	NM_024426.6(WT1):c.887+82G>T	WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 261716	NM_024426.6(WT1):c.887+16G>A	WT1	Single nucleotide variant (intron variant)	Nephrotic syndrome, type 4 +7 more	GBenign
Select item 406688	NM_024426.6(WT1):c.785G>A (p.Gly262Asp)	WT1 (G45D +3 more)	Single nucleotide variant (missense variant +1 more)	not provided +8 more	GConflicting classifications of pathogenicity
Select item 261715	NM_024426.6(WT1):c.785-20G>T	WT1	Single nucleotide variant (intron variant)	Nephrotic syndrome, type 4 +6 more	GBenign/Likely benign
Select item 1292785	NM_024426.6(WT1):c.785-57C>T	WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1199634	NM_024426.6(WT1):c.785-160T>C	WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1215298	NM_024426.6(WT1):c.785-172A>C	WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1292793	NM_024426.6(WT1):c.785-195C>A	WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 180586	NM_024426.6(WT1):c.764T>A (p.Met255Lys)	WT1 (M38K +2 more)	Single nucleotide variant (missense variant +1 more)	not provided +9 more	GConflicting classifications of pathogenicity
Select item 135453	NM_024426.6(WT1):c.760C>T (p.Pro254Ser)	WT1 (P37S +1 more)	Single nucleotide variant (missense variant +1 more)	not specified +11 more	GConflicting classifications of pathogenicity
Select item 854538	NM_024426.6(WT1):c.752A>G (p.His251Arg)	WT1 (H251R +2 more)	Single nucleotide variant (missense variant +1 more)	Wilms tumor 1 +4 more	GUncertain significance
Select item 1408301	NM_024426.6(WT1):c.718C>T (p.His240Tyr)	WT1 (H23Y +2 more)	Single nucleotide variant (missense variant +1 more)	not provided +4 more	GUncertain significance
Select item 640025	NM_024426.6(WT1):c.710C>T (p.Pro237Leu)	WT1 (P20L +2 more)	Single nucleotide variant (missense variant +1 more)	WT1-related disorder +5 more	GUncertain significance
Select item 476716	NM_024426.6(WT1):c.700G>C (p.Gly234Arg)	WT1 (G17R +1 more)	Single nucleotide variant (missense variant +1 more)	Drash syndrome +4 more	GUncertain significance
Select item 392045	NM_024426.6(WT1):c.691C>T (p.Pro231Ser)	WT1 (P14S +1 more)	Single nucleotide variant (missense variant +1 more)	Meacham syndrome +8 more	GUncertain significance
Select item 566230	NM_024426.6(WT1):c.685G>A (p.Gly229Arg)	WT1 (G12R +1 more)	Single nucleotide variant (missense variant +1 more)	Aniridia 1 +8 more	GUncertain significance
Select item 2578250	NM_024426.6(WT1):c.682G>C (p.Asp228His)	WT1 (D11H +2 more)	Single nucleotide variant (missense variant +3 more)	not provided	GUncertain significance
Select item 241486	NM_024426.6(WT1):c.662-6C>A	WT1	Single nucleotide variant (intron variant)	Drash syndrome +6 more	GConflicting classifications of pathogenicity
Select item 1178592	NM_024426.6(WT1):c.662-80dup	WT1	Duplication (intron variant)	not provided	GBenign
Select item 1203663	NM_024426.6(WT1):c.662-80del	WT1	Deletion (intron variant)	not provided	GLikely benign
Select item 1204006	NM_024426.6(WT1):c.662-211G>C	WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1265146	NM_024426.6(WT1):c.662-1755A>C	LOC107982234, WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1279947	NM_024426.6(WT1):c.662-1756C>G	LOC107982234, WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1255107	NM_024426.6(WT1):c.662-1785T>G	LOC107982234, WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1219206	NM_024426.6(WT1):c.662-1831CT[8]	LOC107982234, WT1	Microsatellite (intron variant)	not provided	GLikely benign
Select item 1269780	NM_024426.6(WT1):c.662-1829_662-1828insCC	LOC107982234, WT1	Insertion (intron variant)	not provided	GBenign
Select item 1316101	NM_024426.6(WT1):c.662-1836_662-1835dup	LOC107982234, WT1	Duplication (intron variant)	not provided	GLikely benign
Select item 1208247	NM_024426.6(WT1):c.662-1873_662-1868dup	LOC107982234, WT1	Duplication (intron variant)	not provided	GLikely benign
Select item 257619	NM_024426.6(WT1):c.662-1928_662-1927del	LOC107982234, WT1	Deletion (5 prime UTR variant +1 more)	not provided +6 more	GBenign
Select item 1291085	NM_024426.6(WT1):c.662-2076del	LOC107982234, WT1	Deletion (5 prime UTR variant +1 more)	not provided	GBenign
Select item 1182725	NM_024426.6(WT1):c.662-2173G>A	LOC107982234, WT1	Single nucleotide variant (intron variant +1 more)	not provided	GBenign
Select item 1186896	NM_024426.6(WT1):c.662-2299A>C	WT1, LOC107982234	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1201160	NM_024426.6(WT1):c.662-2310C>T	LOC107982234, WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1268404	NM_024426.6(WT1):c.662-2359C>G	LOC107982234, WT1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1200816	NM_024426.6(WT1):c.661+161G>T	LOC107982234, WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1194853	NM_024426.6(WT1):c.661+58C>T	LOC107982234, WT1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 2143668	NM_024426.6(WT1):c.661G>T (p.Gly221Cys)	LOC107982234, WT1 (G221C +1 more)	Single nucleotide variant (missense variant +1 more)	Drash syndrome +4 more	GUncertain significance
Select item 654381	NM_024426.6(WT1):c.658C>A (p.Gln220Lys)	LOC107982234, WT1 (Q220K)	Single nucleotide variant (missense variant +1 more)	not provided +8 more	GUncertain significance
Select item 935383	NM_024426.6(WT1):c.646G>A (p.Ala216Thr)	LOC107982234, WT1 (A216T)	Single nucleotide variant (missense variant +1 more)	Aniridia 1 +8 more	GUncertain significance

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