"Laboratory for Molecular Medicine, Mass General Brigham Personalized - ClinVar - NCBI

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Items: 14

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 13875	NM_004448.4(ERBB2):c.2313_2324dup (p.Tyr772_Ala775dup)	ERBB2	Duplication (inframe_insertion +2 more)	Non-small cell lung carcinoma	GLikely pathogenic
Select item 44985	NM_004448.4(ERBB2):c.2314_2325dup (p.Tyr772_Ala775dup)	ERBB2	Duplication (inframe_insertion +2 more)	Non-small cell lung carcinoma	GLikely pathogenic
Select item 179590	NM_004448.4(ERBB2):c.2324_2325insCTCCGTGATGGC (p.Ala775_Gly776insSerValMetAla)	ERBB2	Insertion (inframe_insertion +2 more)	Non-small cell lung carcinoma	GLikely pathogenic
Select item 163409	NM_004448.4(ERBB2):c.2325_2326insTCCGTGATGGCT (p.Ala775_Gly776insSerValMetAla)	ERBB2	Insertion (inframe_insertion +2 more)	Non-small cell lung carcinoma	GLikely pathogenic
Select item 44986	NM_004448.4(ERBB2):c.2320del (p.Met774fs)	ERBB2 (M744fs +18 more)	Deletion (frameshift variant +2 more)	Non-small cell lung carcinoma	GLikely pathogenic
Select item 44990	NM_004448.4(ERBB2):c.2326delinsTTAT (p.Gly776delinsLeuCys)	ERBB2	Indel (inframe_indel +2 more)	Non-small cell lung carcinoma	GLikely pathogenic
Select item 44989	NM_004448.4(ERBB2):c.2326_2327insTTT (p.Gly776delinsValCys)	ERBB2	Insertion (inframe_indel +2 more)	Non-small cell lung carcinoma	GLikely pathogenic
Select item 44988	NM_004448.4(ERBB2):c.2326_2327insTGT (p.Gly776delinsValCys)	ERBB2	Insertion (inframe_indel +2 more)	Non-small cell lung carcinoma	GLikely pathogenic
Select item 44987	NM_004448.4(ERBB2):c.2326_2327insTCT (p.Gly776delinsValCys)	ERBB2	Insertion (inframe_indel +2 more)	not specified	GUncertain significance
Select item 163410	NM_004448.4(ERBB2):c.2327G>T (p.Gly776Val)	ERBB2 (G746V +18 more)	Single nucleotide variant (missense variant +2 more)	not specified	Gnot provided
Select item 44991	NM_004448.4(ERBB2):c.2329G>T (p.Val777Leu)	ERBB2 (V777L +18 more)	Single nucleotide variant (missense variant +2 more)	not specified +1 more	GUncertain significance OOncogenic
Select item 44992	NM_004448.4(ERBB2):c.2331_2339dup (p.Gly778_Pro780dup)	ERBB2	Duplication (inframe_insertion +2 more)	Non-small cell lung carcinoma +1 more	GPathogenic OOncogenic
Select item 44993	NM_004448.4(ERBB2):c.2332_2340dup (p.Gly778_Pro780dup)	ERBB2	Duplication (inframe_insertion +2 more)	Non-small cell lung carcinoma	GLikely pathogenic
Select item 44994	NM_004448.4(ERBB2):c.2443G>A (p.Gly815Arg)	ERBB2 (G815R +18 more)	Single nucleotide variant (missense variant +2 more)	not specified +1 more	GBenign/Likely benign