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Items: 56

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
TP53
(A215D +3 more)
Single nucleotide variant
(missense variant +1 more)
Li-Fraumeni syndrome
GPathogenic
TP53
(R210* +3 more)
Single nucleotide variant
(nonsense +1 more)
Hereditary cancer-predisposing syndrome
+14 more
GPathogenic
TP53
(R205P +3 more)
Single nucleotide variant
(missense variant +1 more)
Li-Fraumeni syndrome
+2 more
GLikely pathogenic
TP53
(R337H +3 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+17 more
GPathogenic/Likely pathogenic
TP53
(S213L +3 more)
Single nucleotide variant
(missense variant +2 more)
not specified
+1 more
GConflicting classifications of pathogenicity
TP53
(Q185* +3 more)
Single nucleotide variant
(nonsense)
Li-Fraumeni syndrome 1
+4 more
GPathogenic/Likely pathogenic
OOncogenic
TP53
Single nucleotide variant
(splice acceptor variant)
Breast and/or ovarian cancer
+4 more
GPathogenic/Likely pathogenic
TP53
Single nucleotide variant
(synonymous variant)
Hereditary breast ovarian cancer syndrome
+6 more
GBenign/Likely benign
TP53
Single nucleotide variant
(synonymous variant)
not provided
+5 more
GBenign/Likely benign
TP53
(R158H +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
GBenign
TP53
(R151C +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
GLikely benign
TP53
(R282W +3 more)
Single nucleotide variant
(missense variant)
Colorectal cancer
+10 more
GPathogenic/Likely pathogenic
OOncogenic
TP53
(D149N +3 more)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+1 more
GPathogenic/Likely pathogenic
TP53
(P146S +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
+3 more
GPathogenic/Likely pathogenic
TP53
(R141L +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
+15 more
GPathogenic
OOncogenic
TP53
(R273H +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
+1 more
GPathogenic
OOncogenic
TP53
(R141C +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome 1
+5 more
GPathogenic/Likely pathogenic
OOncogenic
TP53
(V140M +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome 1
+1 more
GPathogenic
OOncogenic
TP53
(G103fs +3 more)
Insertion
(frameshift variant +1 more)
Li-Fraumeni syndrome
GLikely pathogenic
TP53
(T121N +3 more)
Single nucleotide variant
(missense variant)
not specified
+1 more
GUncertain significance
TP53
(R248Q +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
+1 more
GPathogenic
OOncogenic
TP53
(R248W +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
+1 more
GPathogenic
OOncogenic
TP53
Deletion
(inframe_deletion)
not specified
GUncertain significance
TP53
(G245S +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
GPathogenic
TP53
(G112D +3 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GPathogenic/Likely pathogenic
OOncogenic
TP53
(S109C +3 more)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+3 more
GPathogenic/Likely pathogenic
TP53
(Y104C +3 more)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+4 more
GConflicting classifications of pathogenicity
OOncogenic
TP53
(N103S +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
GBenign
TP53
Single nucleotide variant
(splice donor variant)
Li-Fraumeni syndrome
GLikely pathogenic
TP53
Single nucleotide variant
(synonymous variant)
Breast and/or ovarian cancer
+5 more
GBenign/Likely benign
TP53
(Y181C +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
+1 more
GPathogenic
OOncogenic
TP53
(V177M +3 more)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+5 more
GPathogenic/Likely pathogenic
OOncogenic
TP53
Single nucleotide variant
(synonymous variant)
not specified
+5 more
GBenign
TP53
(R174Q +3 more)
Single nucleotide variant
(missense variant)
Breast and/or ovarian cancer
+5 more
GPathogenic
TP53
(R174* +3 more)
Single nucleotide variant
(nonsense)
Squamous cell carcinoma of the head and neck
+6 more
GPathogenic
TP53
(R157* +3 more)
Single nucleotide variant
(nonsense)
not provided
+4 more
GPathogenic
TP53
(R142H +3 more)
Single nucleotide variant
(missense variant)
not provided
+5 more
GConflicting classifications of pathogenicity
TP53
(R175H +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
+1 more
GPathogenic
OOncogenic
TP53
(V134M +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
GPathogenic
TP53
(R119H +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+5 more
GPathogenic/Likely pathogenic
TP53
(P113L +2 more)
Single nucleotide variant
(missense variant +1 more)
Li-Fraumeni syndrome
+1 more
GPathogenic
OOncogenic
TP53
(K132E +1 more)
Single nucleotide variant
(missense variant +1 more)
Li-Fraumeni syndrome
+3 more
GConflicting classifications of pathogenicity
TP53
(S127F +1 more)
Single nucleotide variant
(missense variant +1 more)
not specified
+5 more
GConflicting classifications of pathogenicity
TP53
Duplication
(5 prime UTR variant +1 more)
not specified
+4 more
GConflicting classifications of pathogenicity
TP53
Single nucleotide variant
(synonymous variant)
TP53-related disorder
+7 more
GPathogenic/Likely pathogenic
OLikely oncogenic
TP53
(R110L +1 more)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+2 more
GPathogenic/Likely pathogenic
TP53
Single nucleotide variant
(synonymous variant)
Li-Fraumeni syndrome 1
+3 more
GLikely benign
TP53
(A84V +1 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GConflicting classifications of pathogenicity
TP53
Single nucleotide variant
(no sequence alteration)
not specified
GBenign
TP53
(A24G +1 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome 1
GLikely benign
TP53
(P47S +1 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
GBenign
TP53
(N30del)
Microsatellite
(inframe_deletion +1 more)
Li-Fraumeni syndrome 1
GUncertain significance
TP53
(L26fs)
Indel
(frameshift variant +1 more)
Hereditary cancer-predisposing syndrome
GPathogenic
TP53
(E11Q)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+5 more
GConflicting classifications of pathogenicity
TP53, WRAP53
(R68G)
Single nucleotide variant
(missense variant)
not specified
+4 more
GBenign
TP53, WRAP53
Single nucleotide variant
(synonymous variant)
not specified
+4 more
GBenign/Likely benign
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