"PreventionGenetics, part of Exact Sciences"[submitter] AND "HRAS"[gen - ClinVar

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Items: 41

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 137557	NM_005343.4(HRAS):c.*1C>T	HRAS, LRRC56	Single nucleotide variant (3 prime UTR variant)	HRAS-related disorder +2 more	GBenign/Likely benign
Select item 415883	NM_005343.4(HRAS):c.534C>G (p.Gly178=)	LRRC56, HRAS	Single nucleotide variant (synonymous variant +1 more)	not specified +4 more	GLikely benign
Select item 40448	NM_005343.4(HRAS):c.520C>T (p.Pro174Ser)	HRAS, LRRC56 (P174S +1 more)	Single nucleotide variant (missense variant +1 more)	RASopathy	GBenign FDA Recognized database
Select item 180856	NM_005343.4(HRAS):c.506G>A (p.Arg169Gln)	HRAS, LRRC56 (R169Q +1 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +8 more	GUncertain significance
Select item 1019189	NM_005343.4(HRAS):c.497A>G (p.His166Arg)	HRAS, LRRC56 (H166R +1 more)	Single nucleotide variant (missense variant +1 more)	HRAS-related disorder +1 more	GUncertain significance
Select item 948223	NM_005343.4(HRAS):c.491G>A (p.Arg164Gln)	HRAS, LRRC56 (R164Q +1 more)	Single nucleotide variant (missense variant +1 more)	HRAS-related disorder +2 more	GUncertain significance
Select item 40446	NM_005343.4(HRAS):c.477G>A (p.Leu159=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	RASopathy	GBenign FDA Recognized database
Select item 578573	NM_005343.4(HRAS):c.461A>T (p.Asp154Val)	LRRC56, HRAS (D154V +1 more)	Single nucleotide variant (missense variant +1 more)	Costello syndrome +1 more	GUncertain significance
Select item 379346	NM_005343.4(HRAS):c.450+174G>A	HRAS, LRRC56 (A71T)	Single nucleotide variant (missense variant +2 more)	not provided +1 more	GLikely benign
Select item 3048018	NM_005343.4(HRAS):c.450+170T>G	HRAS, LRRC56	Single nucleotide variant (synonymous variant +2 more)	HRAS-related disorder	GLikely benign
Select item 830080	NM_176795.5(HRAS):c.488_507del (p.Leu163fs)	HRAS, LRRC56 (L163fs +1 more)	Deletion (frameshift variant +1 more)	RASopathy	GBenign FDA Recognized database
Select item 3040518	NM_176795.5(HRAS):c.457C>T (p.Arg153Cys)	HRAS, LRRC56 (R153C)	Single nucleotide variant (synonymous variant +2 more)	HRAS-related disorder	GLikely benign
Select item 2037387	NM_005343.4(HRAS):c.446G>A (p.Arg149Gln)	HRAS, LRRC56 (R149Q +1 more)	Single nucleotide variant (missense variant)	Costello syndrome +1 more	GUncertain significance
Select item 3029345	NM_005343.4(HRAS):c.434C>T (p.Ser145Leu)	HRAS, LRRC56 (R39W +1 more)	Single nucleotide variant (missense variant)	HRAS-related disorder	GUncertain significance
Select item 45304	NM_005343.4(HRAS):c.412G>A (p.Gly138Ser)	HRAS, LRRC56 (G138S)	Single nucleotide variant (missense variant +1 more)	RASopathy	GUncertain significance FDA Recognized database
Select item 259747	NM_005343.4(HRAS):c.369C>T (p.Arg123=)	HRAS, LRRC56 (A17V)	Single nucleotide variant (synonymous variant +1 more)	RASopathy	GBenign FDA Recognized database
Select item 40441	NM_005343.4(HRAS):c.357C>T (p.Asp119=)	HRAS, LRRC56 (T13I)	Single nucleotide variant (synonymous variant +1 more)	RASopathy	GBenign FDA Recognized database
Select item 40440	NM_005343.4(HRAS):c.309G>A (p.Val103=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	RASopathy	GBenign FDA Recognized database
Select item 3058014	NM_005343.4(HRAS):c.306G>C (p.Arg102=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	HRAS-related disorder	GLikely benign
Select item 448926	NM_005343.4(HRAS):c.291-6T>G	HRAS, LRRC56	Single nucleotide variant (intron variant)	RASopathy	GBenign FDA Recognized database
Select item 1161396	NM_005343.4(HRAS):c.291-9del	HRAS, LRRC56	Deletion (intron variant)	HRAS-related disorder +1 more	GLikely benign
Select item 45299	NM_005343.4(HRAS):c.282C>T (p.His94=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	Cardiovascular phenotype +3 more	GLikely benign
Select item 40437	NM_005343.4(HRAS):c.257A>C (p.Asn86Thr)	HRAS, LRRC56 (N86T)	Single nucleotide variant (missense variant +1 more)	RASopathy	GBenign FDA Recognized database
Select item 45298	NM_005343.4(HRAS):c.249C>T (p.Ala83=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	HRAS-related disorder +4 more	GLikely benign
Select item 415879	NM_005343.4(HRAS):c.219C>T (p.Arg73=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	HRAS-related disorder +3 more	GLikely benign
Select item 2633786	NM_005343.4(HRAS):c.179_205dup (p.Arg68_Asp69insGlyGlnGluGluTyrSerAlaMetArg)	HRAS, LRRC56	Duplication (inframe_insertion +1 more)	HRAS-related disorder	GLikely pathogenic
Select item 1126862	NM_005343.4(HRAS):c.192C>T (p.Tyr64=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	not specified +2 more	GLikely benign
Select item 180847	NM_005343.4(HRAS):c.177C>T (p.Ala59=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +5 more	GBenign/Likely benign
Select item 259746	NM_005343.4(HRAS):c.171T>C (p.Asp57=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 378924	NM_005343.4(HRAS):c.162C>T (p.Asp54=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	Costello syndrome +2 more	GLikely benign
Select item 40432	NM_005343.4(HRAS):c.111+15G>A	HRAS, LRRC56	Single nucleotide variant (intron variant)	not specified +2 more	GBenign
Select item 40431	NM_005343.4(HRAS):c.81T>C (p.His27=)	LRRC56, HRAS	Single nucleotide variant (synonymous variant +1 more)	RASopathy	GBenign FDA Recognized database
Select item 259749	NM_005343.4(HRAS):c.57G>C (p.Leu19=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	Cardiovascular phenotype +2 more	GLikely benign
Select item 179085	NM_005343.4(HRAS):c.45C>T (p.Gly15=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	not specified +4 more	GConflicting classifications of pathogenicity
Select item 259748	NM_005343.4(HRAS):c.42G>A (p.Val14=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	not specified +3 more	GLikely benign
Select item 12604	NM_005343.4(HRAS):c.38G>A (p.Gly13Asp)	HRAS, LRRC56 (G13D)	Single nucleotide variant (missense variant +1 more)	Costello syndrome +10 more	GPathogenic
Select item 12606	NM_005343.4(HRAS):c.37G>T (p.Gly13Cys)	HRAS, LRRC56 (G13C)	Single nucleotide variant (missense variant +1 more)	Noonan syndrome	GPathogenic FDA Recognized database
Select item 222076	NM_005343.4(HRAS):c.36C>T (p.Gly12=)	HRAS, LRRC56	Single nucleotide variant (synonymous variant +1 more)	RASopathy	GLikely benign FDA Recognized database
Select item 12600	NM_005343.4(HRAS):c.35G>T (p.Gly12Val)	HRAS, LRRC56 (G12V)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GPathogenic
Select item 12602	NM_005343.4(HRAS):c.34G>A (p.Gly12Ser)	HRAS, LRRC56 (G12S)	Single nucleotide variant (missense variant +1 more)	Costello syndrome	GPathogenic FDA Recognized database
Select item 137556	NM_005343.4(HRAS):c.-10C>T	HRAS, LRRC56	Single nucleotide variant (5 prime UTR variant)	not provided +3 more	GBenign

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Items: 41