"PreventionGenetics, part of Exact Sciences"[submitter] AND "LZTR1"[ge - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 928479	NM_006767.4(LZTR1):c.-6C>T	LOC130067016, LZTR1	Single nucleotide variant (5 prime UTR variant)	not provided +3 more	GBenign
Select item 1334203	NM_006767.4(LZTR1):c.21G>A (p.Thr7=)	LOC130067016, LZTR1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +4 more	GBenign/Likely benign
Select item 1788782	NM_006767.4(LZTR1):c.108C>T (p.Asp36=)	LOC130067016, LZTR1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +3 more	GLikely benign
Select item 1095011	NM_006767.4(LZTR1):c.138G>A (p.Gly46=)	LZTR1	Single nucleotide variant (synonymous variant)	not specified +4 more	GLikely benign
Select item 1661677	NM_006767.4(LZTR1):c.180C>T (p.Cys60=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +3 more	GLikely benign
Select item 2633430	NM_006767.4(LZTR1):c.209_210delinsGA (p.Lys70Arg)	LZTR1 (K70R)	Indel (missense variant)	LZTR1-related disorder	GUncertain significance
Select item 2636997	NM_006767.4(LZTR1):c.273G>A (p.Met91Ile)	LZTR1 (M91I)	Single nucleotide variant (missense variant)	LZTR1-related disorder	GLikely pathogenic
Select item 450299	NM_006767.4(LZTR1):c.319A>G (p.Arg107Gly)	LZTR1 (R107G)	Single nucleotide variant (missense variant)	LZTR1-related disorder +1 more	GUncertain significance
Select item 929193	NM_006767.4(LZTR1):c.351C>T (p.Pro117=)	LZTR1	Single nucleotide variant (synonymous variant)	not specified +5 more	GBenign/Likely benign
Select item 101035	NM_006767.4(LZTR1):c.365C>T (p.Ser122Leu)	LZTR1 (S122L)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +4 more	GConflicting classifications of pathogenicity
Select item 704556	NM_006767.4(LZTR1):c.366G>A (p.Ser122=)	LZTR1	Single nucleotide variant (synonymous variant)	LZTR1-related disorder +4 more	GBenign/Likely benign
Select item 929196	NM_006767.4(LZTR1):c.369C>T (p.Ala123=)	LZTR1	Single nucleotide variant (synonymous variant)	not specified +4 more	GBenign/Likely benign
Select item 1370567	NM_006767.4(LZTR1):c.373G>A (p.Val125Ile)	LZTR1 (V125I)	Single nucleotide variant (missense variant)	Noonan syndrome 10 +4 more	GUncertain significance
Select item 930614	NM_006767.4(LZTR1):c.401-2_401-1del	LZTR1	Deletion (splice acceptor variant)	not provided +4 more	GPathogenic/Likely pathogenic
Select item 2629887	NM_006767.4(LZTR1):c.419T>A (p.Ile140Asn)	LZTR1 (I140N)	Single nucleotide variant (missense variant)	LZTR1-related disorder	GUncertain significance
Select item 2676406	NM_006767.4(LZTR1):c.451G>A (p.Asp151Asn)	LZTR1 (D151N)	Single nucleotide variant (missense variant)	LZTR1-related disorder +1 more	GUncertain significance
Select item 516328	NM_006767.4(LZTR1):c.453C>T (p.Asp151=)	LZTR1	Single nucleotide variant (synonymous variant)	Noonan syndrome and Noonan-related syndrome +5 more	GBenign/Likely benign
Select item 420175	NM_006767.4(LZTR1):c.509G>A (p.Arg170Gln)	LZTR1 (R170Q)	Single nucleotide variant (missense variant)	not provided +5 more	GPathogenic/Likely pathogenic
Select item 1400783	NM_006767.4(LZTR1):c.509+6A>G	LZTR1	Single nucleotide variant (intron variant)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 933177	NM_006767.4(LZTR1):c.524G>T (p.Arg175Met)	LZTR1 (R175M)	Single nucleotide variant (missense variant)	LZTR1-related disorder +1 more	GUncertain significance
Select item 3030477	NM_006767.4(LZTR1):c.525G>C (p.Arg175Ser)	LZTR1 (R175S)	Single nucleotide variant (missense variant)	LZTR1-related disorder	GUncertain significance
Select item 515168	NM_006767.4(LZTR1):c.543G>A (p.Thr181=)	LZTR1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign/Likely benign
Select item 3030989	NM_006767.4(LZTR1):c.552T>C (p.Ser184=)	LZTR1	Single nucleotide variant (synonymous variant)	LZTR1-related disorder	GLikely benign
Select item 3033089	NM_006767.4(LZTR1):c.578A>C (p.Tyr193Ser)	LZTR1 (Y193S)	Single nucleotide variant (missense variant)	LZTR1-related disorder	GLikely pathogenic
Select item 1557652	NM_006767.4(LZTR1):c.582C>T (p.Asp194=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +3 more	GLikely benign
Select item 984508	NM_006767.4(LZTR1):c.588C>T (p.Asn196=)	LZTR1	Single nucleotide variant (synonymous variant)	not specified +4 more	GLikely benign
Select item 599030	NM_006767.4(LZTR1):c.628C>T (p.Arg210Ter)	LZTR1 (R210*)	Single nucleotide variant (nonsense)	Schwannomatosis 2 +5 more	GPathogenic
Select item 218690	NM_006767.4(LZTR1):c.651+10_651+46del	LZTR1	Deletion (splice donor variant)	LZTR1-related disorder +2 more	GBenign/Likely benign
Select item 2885807	NM_006767.4(LZTR1):c.651+3G>A	LZTR1	Single nucleotide variant (intron variant)	LZTR1-related disorder +1 more	GConflicting classifications of pathogenicity
Select item 2167068	NM_006767.4(LZTR1):c.652-10C>G	LZTR1	Single nucleotide variant (intron variant)	not provided +1 more	GLikely benign
Select item 2629188	NM_006767.4(LZTR1):c.739del (p.Ser247fs)	LZTR1 (S247fs)	Deletion (frameshift variant)	LZTR1-related disorder	GPathogenic
Select item 3059420	NM_006767.4(LZTR1):c.750A>G (p.Lys250=)	LZTR1	Single nucleotide variant (synonymous variant)	LZTR1-related disorder	GLikely benign
Select item 2632668	NM_006767.4(LZTR1):c.764T>C (p.Leu255Pro)	LZTR1 (L255P)	Single nucleotide variant (missense variant)	LZTR1-related disorder +1 more	GUncertain significance
Select item 372924	NM_006767.4(LZTR1):c.774del (p.Phe258fs)	LZTR1 (F258fs)	Deletion (frameshift variant)	not provided +4 more	GPathogenic/Likely pathogenic
Select item 561683	NM_006767.4(LZTR1):c.842C>T (p.Pro281Leu)	LZTR1 (P281L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 561716	NM_006767.4(LZTR1):c.848G>A (p.Arg283Gln)	LZTR1 (R283Q)	Single nucleotide variant (missense variant)	Male infertility with azoospermia or oligozoospermia due to single gene mutation +5 more	GConflicting classifications of pathogenicity
Select item 209089	NM_006767.4(LZTR1):c.850C>T (p.Arg284Cys)	LZTR1 (R284C)	Single nucleotide variant (missense variant)	not provided +5 more	GPathogenic
Select item 1166240	NM_006767.4(LZTR1):c.855C>T (p.Tyr285=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +4 more	GBenign/Likely benign
Select item 1073645	NM_006767.4(LZTR1):c.890_891del (p.Tyr297fs)	LZTR1 (Y297fs)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome +4 more	GPathogenic/Likely pathogenic
Select item 391996	NM_006767.4(LZTR1):c.906G>A (p.Ala302=)	LZTR1	Single nucleotide variant (synonymous variant)	LZTR1-related disorder +4 more	GBenign/Likely benign
Select item 1153905	NM_006767.4(LZTR1):c.984C>T (p.Ser328=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +3 more	GLikely benign
Select item 2633921	NM_006767.4(LZTR1):c.992_993delinsTA (p.Glu331Val)	LZTR1 (E331V)	Indel (missense variant)	LZTR1-related disorder	GUncertain significance
Select item 1768685	NM_006767.4(LZTR1):c.994-1G>A	LZTR1	Single nucleotide variant (splice acceptor variant)	not provided +4 more	GLikely pathogenic
Select item 1786938	NM_006767.4(LZTR1):c.1083C>A (p.Ser361=)	LZTR1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +2 more	GLikely benign
Select item 1787227	NM_006767.4(LZTR1):c.1084C>A (p.Arg362=)	LZTR1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +2 more	GLikely benign
Select item 1731819	NM_006767.4(LZTR1):c.1143C>T (p.Ala381=)	LZTR1	Single nucleotide variant (synonymous variant)	LZTR1-related disorder +3 more	GLikely benign
Select item 1430120	NM_006767.4(LZTR1):c.1149+3A>T	LZTR1	Single nucleotide variant (intron variant)	LZTR1-related disorder +2 more	GUncertain significance
Select item 1673889	NM_006767.4(LZTR1):c.1150-12_1150-10del	LZTR1	Microsatellite (intron variant)	LZTR1-related disorder +1 more	GLikely benign
Select item 1736922	NM_006767.4(LZTR1):c.1161G>A (p.Gly387=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +3 more	GLikely benign
Select item 1623079	NM_006767.4(LZTR1):c.1173C>T (p.His391=)	LZTR1	Single nucleotide variant (synonymous variant)	not specified +4 more	GLikely benign
Select item 1208426	NM_006767.4(LZTR1):c.1194C>T (p.Asp398=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +3 more	GLikely benign
Select item 373089	NM_006767.4(LZTR1):c.1234C>T (p.Arg412Cys)	LZTR1 (R412C)	Single nucleotide variant (missense variant)	Non-immune hydrops fetalis +7 more	GConflicting classifications of pathogenicity
Select item 1305284	NM_006767.4(LZTR1):c.1260+1G>A	LZTR1	Single nucleotide variant (splice donor variant)	Schwannomatosis 2 +5 more	GConflicting classifications of pathogenicity
Select item 1769448	NM_006767.4(LZTR1):c.1302G>C (p.Gly434=)	LZTR1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +2 more	GLikely benign
Select item 706250	NM_006767.4(LZTR1):c.1377C>T (p.His459=)	LZTR1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign/Likely benign
Select item 1771461	NM_006767.4(LZTR1):c.1388T>A (p.Val463Asp)	LZTR1 (V463D)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 280342	NM_006767.4(LZTR1):c.1396C>T (p.Arg466Trp)	LZTR1 (R466W)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +5 more	GConflicting classifications of pathogenicity
Select item 997938	NM_006767.4(LZTR1):c.1416G>A (p.Arg472=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +4 more	GBenign/Likely benign
Select item 1772861	NM_006767.4(LZTR1):c.1449G>A (p.Gln483=)	LZTR1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +3 more	GConflicting classifications of pathogenicity
Select item 1164387	NM_006767.4(LZTR1):c.1449+9C>G	LZTR1	Single nucleotide variant (intron variant)	not provided +1 more	GBenign/Likely benign
Select item 1773440	NM_006767.4(LZTR1):c.1474G>A (p.Val492Ile)	LZTR1 (V492I)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +3 more	GUncertain significance
Select item 1629887	NM_006767.4(LZTR1):c.1491C>T (p.Pro497=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +3 more	GLikely benign
Select item 1351007	NM_006767.4(LZTR1):c.1520C>T (p.Pro507Leu)	LZTR1 (P507L)	Single nucleotide variant (missense variant)	LZTR1-related disorder +3 more	GUncertain significance
Select item 516186	NM_006767.4(LZTR1):c.1530C>T (p.His510=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +5 more	GConflicting classifications of pathogenicity
Select item 766850	NM_006767.4(LZTR1):c.1548C>T (p.Ala516=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +4 more	GBenign/Likely benign
Select item 839278	NM_006767.4(LZTR1):c.1570C>T (p.Leu524Phe)	LZTR1 (L524F)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 1440234	NM_006767.4(LZTR1):c.1587C>A (p.Tyr529Ter)	LZTR1 (Y529*)	Single nucleotide variant (nonsense)	LZTR1-related disorder +1 more	GPathogenic
Select item 2631069	NM_006767.4(LZTR1):c.1600A>T (p.Lys534Ter)	LZTR1 (K534*)	Single nucleotide variant (nonsense)	LZTR1-related disorder	GLikely pathogenic
Select item 997883	NM_006767.4(LZTR1):c.1615G>A (p.Gly539Ser)	LZTR1 (G539S)	Single nucleotide variant (missense variant)	Schwannomatosis 2 +5 more	GUncertain significance
Select item 2629918	NM_006767.4(LZTR1):c.1615+2T>C	LZTR1	Single nucleotide variant (splice donor variant)	LZTR1-related disorder +1 more	GPathogenic/Likely pathogenic
Select item 929197	NM_006767.4(LZTR1):c.1615+4C>T	LZTR1	Single nucleotide variant (intron variant)	not specified +4 more	GBenign/Likely benign
Select item 3061605	NM_006767.4(LZTR1):c.1616-10_1616-9del	LZTR1	Deletion (intron variant)	LZTR1-related disorder	GLikely benign
Select item 1776876	NM_006767.4(LZTR1):c.1633C>T (p.Leu545=)	LZTR1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +2 more	GLikely benign
Select item 1685373	NM_006767.4(LZTR1):c.1682G>A (p.Arg561His)	LZTR1 (R561H)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 1778265	NM_006767.4(LZTR1):c.1698C>A (p.Cys566Ter)	LZTR1 (C566*)	Single nucleotide variant (nonsense)	Cardiovascular phenotype +3 more	GPathogenic/Likely pathogenic
Select item 705547	NM_006767.4(LZTR1):c.1719C>T (p.Ser573=)	LZTR1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign/Likely benign
Select item 705680	NM_006767.4(LZTR1):c.1723G>A (p.Asp575Asn)	LZTR1 (D575N)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign/Likely benign
Select item 2631261	NM_006767.4(LZTR1):c.1742T>A (p.Val581Asp)	LZTR1 (V581D)	Single nucleotide variant (missense variant)	LZTR1-related disorder	GUncertain significance
Select item 1096286	NM_006767.4(LZTR1):c.1758C>T (p.Ala586=)	LZTR1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 1483943	NM_006767.4(LZTR1):c.1785+4T>G	LZTR1	Single nucleotide variant (intron variant)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 2630418	NM_006767.4(LZTR1):c.1885G>A (p.Val629Met)	LZTR1 (V629M)	Single nucleotide variant (missense variant)	LZTR1-related disorder	GUncertain significance
Select item 1326438	NM_006767.4(LZTR1):c.1888C>T (p.Arg630Trp)	LZTR1 (R630W)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +4 more	GUncertain significance
Select item 561963	NM_006767.4(LZTR1):c.1889G>A (p.Arg630Gln)	LZTR1 (R630Q)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 433552	NM_006767.4(LZTR1):c.1904C>T (p.Pro635Leu)	LZTR1 (P635L)	Single nucleotide variant (missense variant)	LZTR1-related disorder +5 more	GConflicting classifications of pathogenicity
Select item 3030142	NM_006767.4(LZTR1):c.1943-9T>A	LZTR1	Single nucleotide variant (intron variant)	LZTR1-related disorder	GUncertain significance
Select item 2629871	NM_006767.4(LZTR1):c.1984_1985delinsAA (p.Ala662Lys)	LZTR1 (A662K)	Indel (missense variant)	LZTR1-related disorder	GUncertain significance
Select item 595956	NM_006767.4(LZTR1):c.1990G>A (p.Ala664Thr)	LZTR1 (A664T)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 1784437	NM_006767.4(LZTR1):c.2013_2014del (p.Leu672fs)	LZTR1 (L672fs)	Deletion (frameshift variant)	Cardiovascular phenotype +2 more	GPathogenic
Select item 561796	NM_006767.4(LZTR1):c.2022C>T (p.Asp674=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +5 more	GBenign/Likely benign
Select item 993626	NM_006767.4(LZTR1):c.2058C>T (p.Ala686=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +3 more	GLikely benign
Select item 101036	NM_006767.4(LZTR1):c.2062C>T (p.Arg688Cys)	LZTR1 (R688C)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 1585558	NM_006767.4(LZTR1):c.2069+7G>T	LZTR1	Single nucleotide variant (intron variant)	not provided +1 more	GLikely benign
Select item 1785631	NM_006767.4(LZTR1):c.2085G>A (p.Met695Ile)	LZTR1 (M695I)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +3 more	GUncertain significance
Select item 3061218	NM_006767.4(LZTR1):c.2103del (p.Glu702fs)	LZTR1 (E702fs)	Deletion (frameshift variant)	LZTR1-related disorder	GLikely pathogenic
Select item 704259	NM_006767.4(LZTR1):c.2103C>G (p.Pro701=)	LZTR1	Single nucleotide variant (synonymous variant)	LZTR1-related disorder +4 more	GBenign/Likely benign
Select item 976556	NM_006767.4(LZTR1):c.2130C>T (p.Ile710=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 706636	NM_006767.4(LZTR1):c.2190C>T (p.Gly730=)	LZTR1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 1529204	NM_006767.4(LZTR1):c.2205G>A (p.Pro735=)	LZTR1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign/Likely benign
Select item 1659761	NM_006767.4(LZTR1):c.2217G>A (p.Ser739=)	LZTR1	Single nucleotide variant (synonymous variant)	not provided +3 more	GLikely benign
Select item 1656171	NM_006767.4(LZTR1):c.2220-6C>T	LZTR1	Single nucleotide variant (intron variant)	LZTR1-related disorder +1 more	GLikely benign

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