"PreventionGenetics, part of Exact Sciences"[submitter] AND "MSH2"[gen - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 1786088	NM_000251.2(MSH2):c.-210T>C	MSH2	Single nucleotide variant	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 141978	NM_000251.1(MSH2):c.-189T>C	MSH2	Single nucleotide variant	MSH2-related disorder +1 more	GLikely benign
Select item 142557	NM_000251.2(MSH2):c.-185C>A	MSH2	Single nucleotide variant	not provided +3 more	GBenign/Likely benign
Select item 1781300	NM_000251.1(MSH2):c.-184C>G	MSH2	Single nucleotide variant	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 184792	NM_000251.3(MSH2):c.-181G>A	MSH2	Single nucleotide variant	Lynch syndrome 1 +6 more	GUncertain significance
Select item 141069	NM_000251.1(MSH2):c.-179C>T	MSH2	Single nucleotide variant	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 90485	NM_000251.2(MSH2):c.-118T>C	MSH2	Single nucleotide variant (5 prime UTR variant)	Lynch syndrome	GBenign
Select item 142724	NM_000251.2(MSH2):c.-76G>A	MSH2	Single nucleotide variant (5 prime UTR variant)	MSH2-related disorder +2 more	GConflicting classifications of pathogenicity
Select item 141079	NM_000251.2(MSH2):c.-73G>A	MSH2	Single nucleotide variant (5 prime UTR variant)	MSH2-related disorder +3 more	GConflicting classifications of pathogenicity
Select item 422224	NM_000251.3(MSH2):c.-8G>T	MSH2	Single nucleotide variant (5 prime UTR variant +1 more)	not specified +4 more	GConflicting classifications of pathogenicity
Select item 628499	NM_000251.3(MSH2):c.-7T>A	MSH2	Single nucleotide variant (5 prime UTR variant +1 more)	MSH2-related disorder +2 more	GConflicting classifications of pathogenicity
Select item 127624	NM_000251.3(MSH2):c.-3G>C	MSH2	Single nucleotide variant (5 prime UTR variant +1 more)	MSH2-related disorder +6 more	GConflicting classifications of pathogenicity
Select item 90832	NM_000251.3(MSH2):c.1A>C (p.Met1Leu)	MSH2 (M1L)	Single nucleotide variant (missense variant +2 more)	Lynch syndrome	GUncertain significance
Select item 41650	NM_000251.3(MSH2):c.4G>A (p.Ala2Thr)	MSH2 (A2T)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome 1	GLikely benign
Select item 380128	NM_000251.3(MSH2):c.6G>C (p.Ala2=)	MSH2	Single nucleotide variant (synonymous variant +1 more)	not specified +5 more	GLikely benign
Select item 489932	NM_000251.3(MSH2):c.20A>C (p.Glu7Ala)	MSH2 (E7A)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome +4 more	GConflicting classifications of pathogenicity
Select item 90964	NM_000251.3(MSH2):c.23C>T (p.Thr8Met)	MSH2 (T8M)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome	GBenign
Select item 182595	NM_000251.3(MSH2):c.55T>C (p.Phe19Leu)	MSH2 (F19L)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +7 more	GConflicting classifications of pathogenicity
Select item 827377	NM_000251.3(MSH2):c.79C>T (p.Pro27Ser)	MSH2 (P27S)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome 1 +4 more	GConflicting classifications of pathogenicity
Select item 90560	NM_000251.3(MSH2):c.118G>A (p.Gly40Ser)	MSH2 (G40S)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +7 more	GConflicting classifications of pathogenicity
Select item 560786	NM_000251.3(MSH2):c.127T>G (p.Tyr43Asp)	MSH2 (Y43D)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +3 more	GUncertain significance
Select item 90619	NM_000251.3(MSH2):c.128A>G (p.Tyr43Cys)	MSH2 (Y43C)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +8 more	GConflicting classifications of pathogenicity
Select item 90654	NM_000251.3(MSH2):c.138C>G (p.His46Gln)	MSH2 (H46Q)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome	GLikely benign
Select item 229782	NM_000251.3(MSH2):c.160G>A (p.Ala54Thr)	MSH2 (A54T)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +3 more	GConflicting classifications of pathogenicity
Select item 483733	NM_000251.3(MSH2):c.183G>C (p.Gln61His)	MSH2 (Q61H)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 182608	NM_000251.3(MSH2):c.198C>T (p.Tyr66=)	MSH2	Single nucleotide variant (synonymous variant +2 more)	Lynch syndrome +7 more	GConflicting classifications of pathogenicity
Select item 134841	NM_000251.3(MSH2):c.208G>A (p.Ala70Thr)	MSH2 (A70T +1 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms +4 more	GConflicting classifications of pathogenicity
Select item 378154	NM_000251.3(MSH2):c.211+8C>T	MSH2	Single nucleotide variant (intron variant)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 36573	NM_000251.3(MSH2):c.211+9C>G	MSH2	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 252472	NM_000251.3(MSH2):c.212-3A>T	MSH2	Single nucleotide variant (intron variant)	Hereditary nonpolyposis colorectal neoplasms +4 more	GConflicting classifications of pathogenicity
Select item 237382	NM_000251.3(MSH2):c.213A>G (p.Gly71=)	MSH2	Single nucleotide variant (synonymous variant)	Lynch syndrome 1	GLikely benign
Select item 230705	NM_000251.3(MSH2):c.267A>C (p.Val89=)	MSH2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 91050	NM_000251.3(MSH2):c.273TCT[2] (p.Leu94del)	MSH2 (L94del +1 more)	Microsatellite (inframe_deletion)	Lynch syndrome	GBenign
Select item 36575	NM_000251.3(MSH2):c.304G>A (p.Val102Ile)	MSH2 (V102I +1 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GLikely benign
Select item 36576	NM_000251.3(MSH2):c.339G>A (p.Lys113=)	MSH2	Single nucleotide variant (synonymous variant)	Lynch syndrome	GBenign
Select item 232621	NM_000251.3(MSH2):c.366+4A>C	MSH2	Single nucleotide variant (intron variant)	not specified +3 more	GConflicting classifications of pathogenicity
Select item 36577	NM_000251.3(MSH2):c.380A>G (p.Asn127Ser)	MSH2 (N127S +1 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GBenign
Select item 91090	NM_000251.3(MSH2):c.388_389del (p.Gln130fs)	MSH2 (Q64fs)	Deletion (frameshift variant)	Lynch syndrome	GPathogenic
Select item 91092	NM_000251.3(MSH2):c.399C>T (p.Asp133=)	MSH2	Single nucleotide variant (synonymous variant)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 141500	NM_000251.3(MSH2):c.409G>C (p.Gly137Arg)	MSH2 (G137R +1 more)	Single nucleotide variant (missense variant)	Lynch syndrome +5 more	GConflicting classifications of pathogenicity
Select item 91097	NM_000251.3(MSH2):c.435T>G (p.Ile145Met)	MSH2 (I145M +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +9 more	GConflicting classifications of pathogenicity
Select item 420893	NM_000251.3(MSH2):c.440T>G (p.Val147Gly)	MSH2 (V147G +1 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms +4 more	GConflicting classifications of pathogenicity
Select item 428515	NM_000251.3(MSH2):c.471C>T (p.Gly157=)	MSH2	Single nucleotide variant (synonymous variant)	Hereditary nonpolyposis colorectal neoplasms +2 more	GConflicting classifications of pathogenicity
Select item 91101	NM_000251.3(MSH2):c.471C>A (p.Gly157=)	MSH2	Single nucleotide variant (synonymous variant)	Lynch syndrome	GLikely benign
Select item 91112	NM_000251.3(MSH2):c.499G>C (p.Asp167His)	MSH2 (D167H +1 more)	Single nucleotide variant (missense variant)	Lynch syndrome 1	GBenign
Select item 91140	NM_000251.3(MSH2):c.573C>T (p.Leu191=)	MSH2	Single nucleotide variant (synonymous variant)	Lynch syndrome	GBenign
Select item 183729	NM_000251.3(MSH2):c.606C>G (p.Pro202=)	MSH2	Single nucleotide variant (synonymous variant)	Lynch syndrome +6 more	GConflicting classifications of pathogenicity
Select item 186041	NM_000251.3(MSH2):c.624A>C (p.Gly208=)	MSH2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GLikely benign
Select item 220153	NM_000251.3(MSH2):c.646-3T>C	MSH2	Single nucleotide variant (intron variant)	not provided +7 more	GConflicting classifications of pathogenicity
Select item 91200	NM_000251.3(MSH2):c.762T>C (p.Asn254=)	MSH2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +5 more	GBenign/Likely benign
Select item 140810	NM_000251.3(MSH2):c.775C>T (p.Pro259Ser)	MSH2 (P259S +1 more)	Single nucleotide variant (missense variant)	MSH2-related disorder +6 more	GConflicting classifications of pathogenicity
Select item 408483	NM_000251.3(MSH2):c.786G>T (p.Glu262Asp)	MSH2 (E262D +1 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms +2 more	GUncertain significance
Select item 220025	NM_000251.3(MSH2):c.812C>G (p.Ser271Cys)	MSH2 (S271C +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 41651	NM_000251.3(MSH2):c.815C>T (p.Ala272Val)	MSH2 (A272V +1 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GBenign
Select item 135864	NM_000251.3(MSH2):c.819A>G (p.Val273=)	MSH2	Single nucleotide variant (synonymous variant)	Lynch syndrome 1 +4 more	GConflicting classifications of pathogenicity
Select item 187433	NM_000251.3(MSH2):c.820A>G (p.Ile274Val)	MSH2 (I274V +1 more)	Single nucleotide variant (missense variant)	Lynch syndrome 1 +6 more	GConflicting classifications of pathogenicity
Select item 237412	NM_000251.3(MSH2):c.843A>T (p.Ser281=)	MSH2	Single nucleotide variant (synonymous variant)	Lynch syndrome 1 +6 more	GConflicting classifications of pathogenicity
Select item 455623	NM_000251.3(MSH2):c.911T>C (p.Ile304Thr)	MSH2 (I304T +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 91243	NM_000251.3(MSH2):c.913G>A (p.Ala305Thr)	MSH2 (A305T +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 695772	NM_000251.3(MSH2):c.942+24_942+29del	MSH2	Deletion	Breast and/or ovarian cancer +6 more	GBenign/Likely benign
Select item 36580	NM_000251.3(MSH2):c.942+3A>T	MSH2	Single nucleotide variant (intron variant)	Lynch syndrome	GPathogenic
Select item 41652	NM_000251.3(MSH2):c.944G>T (p.Gly315Val)	MSH2 (G315V +1 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GLikely benign
Select item 1762	NM_000251.3(MSH2):c.965G>A (p.Gly322Asp)	MSH2 (G322D +1 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GBenign
Select item 187194	NM_000251.3(MSH2):c.968C>T (p.Ser323Phe)	MSH2 (S323F +1 more)	Single nucleotide variant (missense variant)	Lynch syndrome 1 +5 more	GConflicting classifications of pathogenicity
Select item 91264	NM_000251.3(MSH2):c.972G>A (p.Gln324=)	MSH2	Single nucleotide variant (synonymous variant)	Lynch syndrome	GLikely benign
Select item 91269	NM_000251.3(MSH2):c.984C>T (p.Ala328=)	MSH2	Single nucleotide variant (synonymous variant)	Lynch syndrome	GLikely benign
Select item 215677	NM_000251.3(MSH2):c.996G>A (p.Lys332=)	MSH2	Single nucleotide variant (synonymous variant)	MSH2-related disorder +4 more	GLikely benign
Select item 90502	NM_000251.3(MSH2):c.1009C>T (p.Gln337Ter)	MSH2 (Q337* +1 more)	Single nucleotide variant (nonsense)	Lynch syndrome	GPathogenic
Select item 387932	NM_000251.3(MSH2):c.1032G>A (p.Gln344=)	MSH2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GLikely benign
Select item 516283	NM_000251.3(MSH2):c.1077-15G>T	MSH2	Single nucleotide variant (intron variant)	not specified +5 more	GBenign/Likely benign
Select item 36562	NM_000251.3(MSH2):c.1077-10T>C	MSH2	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 237356	NM_000251.3(MSH2):c.1077-7A>G	MSH2	Single nucleotide variant (intron variant)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 90554	NM_000251.3(MSH2):c.1147C>T (p.Arg383Ter)	MSH2 (R383* +1 more)	Single nucleotide variant (nonsense)	Lynch syndrome	GPathogenic
Select item 491750	NM_000251.3(MSH2):c.1148G>C (p.Arg383Pro)	MSH2 (R383P +1 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms +2 more	GUncertain significance
Select item 428531	NM_000251.3(MSH2):c.1148G>A (p.Arg383Gln)	MSH2 (R383Q +1 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms +4 more	GConflicting classifications of pathogenicity
Select item 41641	NM_000251.3(MSH2):c.1168C>T (p.Leu390Phe)	MSH2 (L390F +1 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GBenign
Select item 483669	NM_000251.3(MSH2):c.1200C>G (p.Asn400Lys)	MSH2 (N400K +1 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms +3 more	GConflicting classifications of pathogenicity
Select item 216341	NM_000251.3(MSH2):c.1254A>G (p.Ile418Met)	MSH2 (I418M +1 more)	Single nucleotide variant (missense variant)	MSH2-related disorder +8 more	GConflicting classifications of pathogenicity
Select item 90589	NM_000251.3(MSH2):c.1275A>G (p.Glu425=)	MSH2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 138253	NM_000251.3(MSH2):c.1277-16T>C	MSH2	Single nucleotide variant (intron variant)	Breast and/or ovarian cancer +5 more	GBenign/Likely benign
Select item 219695	NM_000251.3(MSH2):c.1277-7C>A	MSH2	Single nucleotide variant (intron variant)	Hereditary nonpolyposis colorectal neoplasms +3 more	GLikely benign
Select item 386197	NM_000251.3(MSH2):c.1296G>A (p.Leu432=)	MSH2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 90637	NM_000251.3(MSH2):c.1356A>G (p.Glu452=)	MSH2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 560787	NM_000251.3(MSH2):c.1366A>G (p.Thr456Ala)	MSH2 (T456A +1 more)	Single nucleotide variant (missense variant)	not specified +2 more	GConflicting classifications of pathogenicity
Select item 418315	NM_000251.3(MSH2):c.1387-14_1387-11del	MSH2	Deletion (intron variant)	not specified +3 more	GConflicting classifications of pathogenicity
Select item 36565	NM_000251.3(MSH2):c.1387-8G>T	MSH2	Single nucleotide variant (intron variant)	Lynch syndrome 1	GBenign
Select item 183938	NM_000251.3(MSH2):c.1387-4G>C	MSH2	Single nucleotide variant (intron variant)	MSH2-related disorder +3 more	GConflicting classifications of pathogenicity
Select item 455490	NM_000251.3(MSH2):c.1405C>G (p.Leu469Val)	MSH2 (L469V +1 more)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 479798	NM_000251.3(MSH2):c.1424A>T (p.Asp475Val)	MSH2 (D475V +1 more)	Single nucleotide variant (missense variant)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 455494	NM_000251.3(MSH2):c.1440A>G (p.Glu480=)	MSH2	Single nucleotide variant (synonymous variant)	Lynch syndrome +3 more	GLikely benign
Select item 90674	NM_000251.3(MSH2):c.1461C>G (p.Asp487Glu)	MSH2 (D487E +1 more)	Single nucleotide variant (missense variant)	not specified +6 more	GConflicting classifications of pathogenicity
Select item 127630	NM_000251.3(MSH2):c.1505A>G (p.Asp502Gly)	MSH2 (D502G +1 more)	Single nucleotide variant (missense variant)	MSH2-related disorder +6 more	GConflicting classifications of pathogenicity
Select item 2628599	NM_000251.3(MSH2):c.1511-41G>T	MSH2	Single nucleotide variant (intron variant)	MSH2-related disorder	GUncertain significance
Select item 221162	NM_000251.3(MSH2):c.1511-41G>C	MSH2	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 36566	NM_000251.3(MSH2):c.1511-9A>T	MSH2	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 182563	NM_000251.3(MSH2):c.1530G>C (p.Gln510His)	MSH2 (Q510H +1 more)	Single nucleotide variant (missense variant)	Lynch syndrome +5 more	GConflicting classifications of pathogenicity
Select item 455506	NM_000251.3(MSH2):c.1545C>T (p.Ser515=)	MSH2	Single nucleotide variant (synonymous variant)	Hereditary nonpolyposis colorectal neoplasms +3 more	GLikely benign
Select item 138254	NM_000251.3(MSH2):c.1560A>G (p.Gly520=)	MSH2	Single nucleotide variant (synonymous variant)	not provided +7 more	GConflicting classifications of pathogenicity
Select item 489919	NM_000251.3(MSH2):c.1593A>C (p.Lys531Asn)	MSH2 (K531N +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 219420	NM_000251.3(MSH2):c.1622C>T (p.Thr541Ile)	MSH2 (T541I +1 more)	Single nucleotide variant (missense variant)	Breast and/or ovarian cancer +7 more	GConflicting classifications of pathogenicity

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