"PreventionGenetics, part of Exact Sciences"[submitter] AND "MSH3"[gen - ClinVar

Search results

Items: 79

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 650237	NM_000791.4(DHFR):c.-254G>A	DHFR, MSH3 (P6S)	Single nucleotide variant (5 prime UTR variant +2 more)	MSH3-related disorder +4 more	GUncertain significance
Select item 765859	NM_000791.4(DHFR):c.-319G>A	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	MSH3-related disorder +3 more	GLikely benign
Select item 757843	NM_000791.4(DHFR):c.-334T>G	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +3 more	GLikely benign
Select item 650057	NM_002439.5(MSH3):c.122C>T (p.Thr41Ile)	DHFR, MSH3 (T41I)	Single nucleotide variant (5 prime UTR variant +2 more)	MSH3-related disorder +3 more	GUncertain significance
Select item 651887	NM_002439.5(MSH3):c.145C>T (p.Pro49Ser)	DHFR, MSH3 (P49S)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 758975	NM_002439.5(MSH3):c.146C>G (p.Pro49Arg)	DHFR, MSH3 (P49R)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 1786716	NM_002439.5(MSH3):c.214C>T (p.Pro72Ser)	DHFR, MSH3 (P72S)	Single nucleotide variant (5 prime UTR variant +2 more)	MSH3-related disorder +3 more	GUncertain significance
Select item 2635185	NM_002439.5(MSH3):c.221A>G (p.Gln74Arg)	DHFR, MSH3 (Q74R)	Single nucleotide variant (5 prime UTR variant +2 more)	MSH3-related disorder	GUncertain significance
Select item 849773	NM_002439.5(MSH3):c.222G>C (p.Gln74His)	MSH3, DHFR (Q74H)	Single nucleotide variant (5 prime UTR variant +2 more)	MSH3-related disorder +3 more	GUncertain significance
Select item 748710	NM_002439.5(MSH3):c.225G>T (p.Leu75=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	MSH3-related disorder +2 more	GLikely benign
Select item 761175	NM_002439.5(MSH3):c.237+7T>G	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 650967	NM_002439.5(MSH3):c.287C>T (p.Pro96Leu)	MSH3 (P96L)	Single nucleotide variant (missense variant)	MSH3-related disorder +4 more	GUncertain significance
Select item 737203	NM_002439.5(MSH3):c.409T>C (p.Leu137=)	MSH3	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 838544	NM_002439.5(MSH3):c.427G>A (p.Asp143Asn)	MSH3 (D143N)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 759608	NM_002439.5(MSH3):c.558G>A (p.Ser186=)	MSH3	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 639536	NM_002439.5(MSH3):c.562C>T (p.Arg188Cys)	MSH3 (R188C)	Single nucleotide variant (missense variant)	Endometrial carcinoma +4 more	GConflicting classifications of pathogenicity
Select item 969980	NM_002439.5(MSH3):c.579+4T>C	MSH3	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 1094476	NM_002439.5(MSH3):c.663T>C (p.Ala221=)	MSH3	Single nucleotide variant (synonymous variant)	MSH3-related disorder +1 more	GLikely benign
Select item 654492	NM_002439.5(MSH3):c.692C>T (p.Pro231Leu)	MSH3 (P231L)	Single nucleotide variant (missense variant)	MSH3-related disorder +3 more	GUncertain significance
Select item 662932	NM_002439.5(MSH3):c.758G>C (p.Gly253Ala)	MSH3 (G253A)	Single nucleotide variant (missense variant)	Endometrial carcinoma +3 more	GUncertain significance
Select item 713697	NM_002439.5(MSH3):c.792+7C>T	MSH3	Single nucleotide variant (intron variant)	not provided +1 more	GLikely benign
Select item 822797	NM_002439.5(MSH3):c.888C>T (p.Arg296=)	MSH3	Single nucleotide variant (synonymous variant)	MSH3-related disorder +3 more	GLikely benign
Select item 644085	NM_002439.5(MSH3):c.1060dup (p.Val354fs)	MSH3 (V354fs)	Duplication (frameshift variant)	Hereditary cancer-predisposing syndrome +4 more	GPathogenic/Likely pathogenic
Select item 8738	NM_002439.5(MSH3):c.1148del (p.Lys383fs)	MSH3 (K383fs)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome +4 more	GPathogenic/Likely pathogenic
Select item 733688	NM_002439.5(MSH3):c.1160T>A (p.Phe387Tyr)	MSH3 (F387Y)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 759003	NM_002439.5(MSH3):c.1177G>A (p.Val393Met)	MSH3 (V393M)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 757367	NM_002439.5(MSH3):c.1194C>T (p.Gly398=)	MSH3	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 642593	NM_002439.5(MSH3):c.1249C>T (p.Arg417Trp)	MSH3 (R417W)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 758495	NM_002439.5(MSH3):c.1251G>A (p.Arg417=)	MSH3	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 647051	NM_002439.5(MSH3):c.1295T>G (p.Leu432Trp)	MSH3 (L432W)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 754900	NM_002439.5(MSH3):c.1299C>T (p.Ser433=)	MSH3	Single nucleotide variant (synonymous variant)	not provided +2 more	GLikely benign
Select item 791261	NM_002439.5(MSH3):c.1313C>T (p.Ala438Val)	MSH3 (A438V)	Single nucleotide variant (missense variant)	MSH3-related disorder +2 more	GConflicting classifications of pathogenicity
Select item 757368	NM_002439.5(MSH3):c.1314G>A (p.Ala438=)	MSH3	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 743358	NM_002439.5(MSH3):c.1469C>A (p.Ser490Tyr)	MSH3 (S490Y)	Single nucleotide variant (missense variant)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 781999	NM_002439.5(MSH3):c.1522A>G (p.Lys508Glu)	MSH3 (K508E)	Single nucleotide variant (missense variant)	MSH3-related disorder +2 more	GConflicting classifications of pathogenicity
Select item 780543	NM_002439.5(MSH3):c.1567G>A (p.Glu523Lys)	MSH3 (E523K)	Single nucleotide variant (missense variant)	MSH3-related disorder +5 more	GBenign/Likely benign
Select item 771860	NM_002439.5(MSH3):c.1764-9_1764-8del	MSH3	Deletion (intron variant)	not provided +2 more	GBenign/Likely benign
Select item 724343	NM_002439.5(MSH3):c.1887T>C (p.Tyr629=)	MSH3	Single nucleotide variant (synonymous variant)	not provided +3 more	GBenign/Likely benign
Select item 659090	NM_002439.5(MSH3):c.1896A>G (p.Lys632=)	MSH3	Single nucleotide variant (synonymous variant)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 658270	NM_002439.5(MSH3):c.1910A>C (p.Glu637Ala)	MSH3 (E637A)	Single nucleotide variant (missense variant)	Endometrial carcinoma +3 more	GUncertain significance
Select item 3045488	NM_002439.5(MSH3):c.1956T>C (p.Phe652=)	MSH3	Single nucleotide variant (synonymous variant)	MSH3-related disorder	GLikely benign
Select item 713891	NM_002439.5(MSH3):c.1992G>A (p.Gln664=)	MSH3	Single nucleotide variant (synonymous variant)	MSH3-related disorder +3 more	GBenign/Likely benign
Select item 733995	NM_002439.5(MSH3):c.2005C>T (p.Arg669Trp)	MSH3 (R669W)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 654902	NM_002439.5(MSH3):c.2006G>A (p.Arg669Gln)	MSH3 (R669Q)	Single nucleotide variant (missense variant)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 758614	NM_002439.5(MSH3):c.2010C>T (p.Thr670=)	MSH3	Single nucleotide variant (synonymous variant)	not specified +3 more	GLikely benign
Select item 641087	NM_002439.5(MSH3):c.2016T>G (p.Ile672Met)	MSH3 (I672M)	Single nucleotide variant (missense variant)	Endometrial carcinoma +4 more	GUncertain significance
Select item 656200	NM_002439.5(MSH3):c.2041C>T (p.Pro681Ser)	MSH3 (P681S)	Single nucleotide variant (missense variant)	MSH3-related disorder +4 more	GConflicting classifications of pathogenicity
Select item 3054098	NM_002439.5(MSH3):c.2068_2069dup (p.Asn690fs)	MSH3 (N690fs)	Duplication (frameshift variant)	MSH3-related disorder	GLikely pathogenic
Select item 648984	NM_002439.5(MSH3):c.2075A>G (p.Gln692Arg)	MSH3 (Q692R)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 799014	NM_002439.5(MSH3):c.2133A>G (p.Leu711=)	MSH3	Single nucleotide variant (synonymous variant)	MSH3-related disorder +2 more	GLikely benign
Select item 846548	NM_002439.5(MSH3):c.2189T>C (p.Leu730Ser)	MSH3 (L730S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 639446	NM_002439.5(MSH3):c.2218C>T (p.Pro740Ser)	MSH3 (P740S)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 658298	NM_002439.5(MSH3):c.2262A>G (p.Ile754Met)	MSH3 (I754M)	Single nucleotide variant (missense variant)	Endometrial carcinoma +4 more	GConflicting classifications of pathogenicity
Select item 639231	NM_002439.5(MSH3):c.2290A>T (p.Ile764Leu)	MSH3 (I764L)	Single nucleotide variant (missense variant)	MSH3-related disorder +3 more	GUncertain significance
Select item 2632439	NM_002439.5(MSH3):c.2297C>T (p.Thr766Ile)	MSH3 (T766I)	Single nucleotide variant (missense variant)	Endometrial carcinoma +1 more	GUncertain significance
Select item 840753	NM_002439.5(MSH3):c.2356G>A (p.Val786Ile)	MSH3 (V786I)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 1643076	NM_002439.5(MSH3):c.2436-17TGC[2]	MSH3	Microsatellite (intron variant)	MSH3-related disorder +1 more	GLikely benign
Select item 724344	NM_002439.5(MSH3):c.2480A>G (p.His827Arg)	MSH3 (H827R)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 1147255	NM_002439.5(MSH3):c.2571T>A (p.Ile857=)	MSH3	Single nucleotide variant (synonymous variant)	not provided +3 more	GLikely benign
Select item 757222	NM_002439.5(MSH3):c.2685C>T (p.Thr895=)	MSH3	Single nucleotide variant (synonymous variant)	not specified +3 more	GBenign/Likely benign
Select item 664031	NM_002439.5(MSH3):c.2695A>G (p.Met899Val)	MSH3 (M899V)	Single nucleotide variant (missense variant)	Endometrial carcinoma +4 more	GUncertain significance
Select item 757273	NM_002439.5(MSH3):c.2740A>G (p.Ile914Val)	MSH3 (I914V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 643346	NM_002439.5(MSH3):c.2774A>G (p.Glu925Gly)	MSH3 (E925G)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 757791	NM_002439.5(MSH3):c.2790G>A (p.Gly930=)	MSH3	Single nucleotide variant (synonymous variant)	not provided +2 more	GLikely benign
Select item 758308	NM_002439.5(MSH3):c.2813+9G>A	MSH3	Single nucleotide variant (intron variant)	not specified +2 more	GLikely benign
Select item 649217	NM_002439.5(MSH3):c.2917A>G (p.Ile973Val)	MSH3 (I973V)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 659866	NM_002439.5(MSH3):c.3000T>G (p.Asp1000Glu)	MSH3 (D1000E)	Single nucleotide variant (missense variant)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 757937	NM_002439.5(MSH3):c.3000+10C>T	MSH3	Single nucleotide variant (intron variant)	not provided +1 more	GLikely benign
Select item 748398	NM_002439.5(MSH3):c.3027C>G (p.Thr1009=)	MSH3	Single nucleotide variant (synonymous variant)	MSH3-related disorder +2 more	GBenign/Likely benign
Select item 757790	NM_002439.5(MSH3):c.3036G>A (p.Pro1012=)	MSH3	Single nucleotide variant (synonymous variant)	not provided +2 more	GLikely benign
Select item 665740	NM_002439.5(MSH3):c.3072G>C (p.Gln1024His)	MSH3 (Q1024H)	Single nucleotide variant (missense variant)	Endometrial carcinoma +4 more	GUncertain significance
Select item 1154418	NM_002439.5(MSH3):c.3093A>T (p.Gly1031=)	MSH3	Single nucleotide variant (synonymous variant)	not provided +1 more	GLikely benign
Select item 640499	NM_002439.5(MSH3):c.3166C>T (p.Leu1056Phe)	MSH3 (L1056F)	Single nucleotide variant (missense variant)	MSH3-related disorder +3 more	GUncertain significance
Select item 823116	NM_002439.5(MSH3):c.3184G>A (p.Gly1062Arg)	MSH3 (G1062R)	Single nucleotide variant (missense variant)	MSH3-related disorder +3 more	GUncertain significance
Select item 650997	NM_002439.5(MSH3):c.3188T>C (p.Ile1063Thr)	MSH3 (I1063T)	Single nucleotide variant (missense variant)	MSH3-related disorder +3 more	GUncertain significance
Select item 643451	NM_002439.5(MSH3):c.3198G>T (p.Arg1066Ser)	MSH3 (R1066S)	Single nucleotide variant (missense variant)	MSH3-related disorder +3 more	GUncertain significance
Select item 641483	NM_002439.5(MSH3):c.3290T>C (p.Ile1097Thr)	MSH3 (I1097T)	Single nucleotide variant (missense variant)	MSH3-related disorder +3 more	GUncertain significance
Select item 754647	NM_002439.5(MSH3):c.3302+7G>T	MSH3	Single nucleotide variant (intron variant)	not provided +1 more	GLikely benign
Select item 661863	NM_002439.5(MSH3):c.3350A>G (p.Gln1117Arg)	MSH3 (Q1117R)	Single nucleotide variant (missense variant)	Endometrial carcinoma +3 more	GUncertain significance

ClinVar

Result Filters

Classification type

Germline classification

Types of conflicts

Molecular consequence

Variation type

Variation size

Variant length

Review status

Additional filters

Search results

Items: 79