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Items: 1 to 100 of 197

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
ACMSD, AMER3
+391 more
Copy number loss
See cases
GPathogenic
ACMSD, AMER3
+336 more
Copy number loss
See cases
GPathogenic
AMMECR1L, BIN1
+125 more
Copy number gain
See cases
GUncertain significance
CCDC115, CCDC74B
+23 more
Copy number gain
See cases
GBenign
CCDC115, CCDC74B
+22 more
Copy number gain
See cases
GBenign
CCDC115, CCDC74B
+22 more
Copy number loss
See cases
GUncertain significance
CCDC115, CCDC74B
+23 more
Copy number gain
See cases
GBenign
CCDC115, CCDC74B
+19 more
Copy number loss
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GPathogenic
CCDC115, IMP4
+16 more
Copy number loss
See cases
GUncertain significance
SMPD4
(Q836H +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(K823R +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(E820K +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
Single nucleotide variant
(synonymous variant +1 more)
not provided
GLikely benign
SMPD4
(T801M +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(T801A +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GLikely benign
SMPD4
(L792P +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(L729fs +2 more)
Microsatellite
(frameshift variant +1 more)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GUncertain significance
SMPD4
(A800T +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(V799A +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(F725del +2 more)
Microsatellite
(inframe_deletion +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(F787S +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(F724V +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
Duplication
(inframe_insertion +1 more)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GUncertain significance
SMPD4
(R715Q +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
SMPD4
(R715W +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(Y777C +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
Single nucleotide variant
(synonymous variant +1 more)
not provided
GLikely benign
SMPD4
Single nucleotide variant
(synonymous variant +1 more)
not provided
GLikely benign
SMPD4
(G766D +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(G776S +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(R765C +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
Single nucleotide variant
(synonymous variant +1 more)
not provided
GBenign
SMPD4
(R694W +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
SMPD4
(S685fs +2 more)
Deletion
(frameshift variant +1 more)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GLikely pathogenic
SMPD4
(T679I +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(L743V +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(R729Q +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(R729W +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(M723T +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(M660V +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(Q761* +3 more)
Single nucleotide variant
(nonsense +1 more)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GUncertain significance
SMPD4
(R710G +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(L645P +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
SMPD4
Single nucleotide variant
(synonymous variant +1 more)
not provided
GLikely benign
SMPD4
(T644A +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GLikely benign
SMPD4
(E629* +2 more)
Single nucleotide variant
(nonsense +1 more)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GLikely pathogenic
SMPD4
(P691L +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(D627fs +2 more)
Deletion
(frameshift variant +1 more)
not provided
GLikely pathogenic
SMPD4
(Q625fs +2 more)
Deletion
(frameshift variant +1 more)
not provided
GLikely pathogenic
SMPD4
Single nucleotide variant
(intron variant)
not provided
+1 more
GBenign
SMPD4
Single nucleotide variant
(intron variant)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GLikely pathogenic
SMPD4
(R673Q +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(R610W +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(G602R +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(K591fs +2 more)
Indel
(frameshift variant +1 more)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GLikely pathogenic
SMPD4
(L652F +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(A572V +2 more)
Single nucleotide variant
(missense variant +1 more)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
+1 more
GConflicting classifications of pathogenicity
SMPD4
(L569I +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
Single nucleotide variant
(splice donor variant)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GLikely pathogenic
SMPD4
(R631P +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(R564H +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(A632V +3 more)
Single nucleotide variant
(missense variant +1 more)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GUncertain significance
SMPD4
(T552I +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
SMPD4
(R613Q +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(R623W +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(D547G +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(T532A +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
Single nucleotide variant
(synonymous variant +1 more)
not specified
GBenign
SMPD4
(A513V +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(D573H +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
Single nucleotide variant
(synonymous variant +1 more)
not provided
GLikely benign
SMPD4
(K502E +2 more)
Single nucleotide variant
(missense variant +1 more)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GUncertain significance
SMPD4
Deletion
(splice acceptor variant)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GLikely pathogenic
SMPD4
(R488H +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
SMPD4
Single nucleotide variant
(synonymous variant +1 more)
not provided
GLikely benign
SMPD4
Single nucleotide variant
(synonymous variant +1 more)
not provided
GLikely benign
SMPD4
(T505K +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(T442M +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(F514S +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(L440P +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(I433fs +2 more)
Deletion
(frameshift variant +1 more)
not provided
GPathogenic
SMPD4
(P531L +3 more)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
SMPD4
Single nucleotide variant
(splice donor variant)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GPathogenic
SMPD4
(N477I +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(N477S +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GLikely benign
SMPD4
(F467L +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(M402L +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
SMPD4
(A400T +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(H472Y +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(L390fs +3 more)
Deletion
(frameshift variant +1 more)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GPathogenic
SMPD4
(R461H +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(R451C +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
Single nucleotide variant
(intron variant)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GPathogenic
SMPD4
Single nucleotide variant
(intron variant)
not provided
+1 more
GLikely benign
SMPD4
(S427L +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(Q359H +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(P354S +2 more)
Indel
(missense variant +1 more)
not provided
GUncertain significance
SMPD4
(P354L +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(P354S +2 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
SMPD4
(P446L +3 more)
Single nucleotide variant
(missense variant +1 more)
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies
GUncertain significance
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