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Items: 1 to 100 of 122

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
TARDBP
Single nucleotide variant
(missense variant)
TARDBP-related frontotemporal dementia
+3 more
GConflicting classifications of pathogenicity
TARDBP
Single nucleotide variant
(missense variant)
TARDBP-related frontotemporal dementia
+3 more
GPathogenic/Likely pathogenic
TARDBP
(M311V)
Single nucleotide variant
(missense variant)
Amyotrophic lateral sclerosis type 10
+2 more
GLikely pathogenic
TARDBP
Single nucleotide variant
(missense variant)
TARDBP-related frontotemporal dementia
+2 more
GPathogenic/Likely pathogenic
MUTYH
(P295L +8 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+2 more
GPathogenic/Likely pathogenic
MUTYH
(A274fs +7 more)
Deletion
(frameshift variant +1 more)
Familial adenomatous polyposis 2
+2 more
GPathogenic/Likely pathogenic
MUTYH
(Y165C +8 more)
Single nucleotide variant
(missense variant +1 more)
Familial adenomatous polyposis 2
+3 more
GPathogenic/Likely pathogenic
MUTYH
Duplication
(inframe_insertion +2 more)
Familial adenomatous polyposis 2
+2 more
GPathogenic/Likely pathogenic
FPGT-TNNI3K, TNNI3K
(P786S +1 more)
Single nucleotide variant
(missense variant)
Atrial conduction disease
+1 more
GUncertain significance
ADAMTSL4, ADAMTSL4-AS2
(E382fs)
Deletion
(frameshift variant)
Ectopia lentis et pupillae
+3 more
GPathogenic/Likely pathogenic
LMNA
(Q355* +2 more)
Single nucleotide variant
(nonsense)
Dilated cardiomyopathy 1A
+1 more
GPathogenic
CASQ1
(G383fs)
Deletion
(frameshift variant)
not provided
+1 more
GUncertain significance
MPZ
(Y82H)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease, type I
+4 more
GPathogenic/Likely pathogenic
TNNT2
(K107N +2 more)
Single nucleotide variant
(missense variant +1 more)
Cardiomyopathy, familial restrictive, 3
+4 more
GConflicting classifications of pathogenicity
TNNT2
(M1I)
Single nucleotide variant
(missense variant +1 more)
not provided
+5 more
GUncertain significance
SPAST
(Y236* +3 more)
Duplication
(nonsense)
not provided
+1 more
GPathogenic/Likely pathogenic
MSH2
Single nucleotide variant
(splice donor variant)
not provided
+3 more
GPathogenic
MSH2
(L191del +1 more)
Microsatellite
(inframe_deletion)
Lynch syndrome
GPathogenic
MSH2
(Q215* +1 more)
Single nucleotide variant
(nonsense)
Lynch syndrome
GPathogenic
MSH2
(N263S +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
MSH2
(C333Y +1 more)
Single nucleotide variant
(missense variant)
Lynch syndrome 1
GPathogenic
MSH2
(P349S +1 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GLikely pathogenic
MSH2
(Q429* +1 more)
Single nucleotide variant
(nonsense)
Lynch syndrome
GPathogenic
MSH2
(R711* +1 more)
Single nucleotide variant
(nonsense)
Lynch syndrome
GPathogenic
MSH6
(S242R +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+3 more
GUncertain significance
MSH6
Microsatellite
(nonsense)
Lynch syndrome
GPathogenic
MSH6
(R495* +2 more)
Single nucleotide variant
(nonsense)
Lynch syndrome
GPathogenic
MSH6
(R1331* +2 more)
Single nucleotide variant
(nonsense)
Lynch syndrome
GPathogenic
SCN3A
(V657A)
Single nucleotide variant
(missense variant +1 more)
not provided
+2 more
GUncertain significance
SCN1A-AS1, SCN9A
(I1917T)
Single nucleotide variant
(missense variant)
Generalized epilepsy with febrile seizures plus, type 7
+3 more
GUncertain significance
ERBB4
(I481V)
Single nucleotide variant
(missense variant)
Amyotrophic lateral sclerosis type 10
+1 more
GUncertain significance
MLH1
(C77Y)
Single nucleotide variant
(missense variant +2 more)
Lynch syndrome
GPathogenic
MLH1
Single nucleotide variant
(intron variant)
Lynch syndrome
GPathogenic
MLH1
(S556T +5 more)
Single nucleotide variant
(missense variant)
Familial cancer of breast
+4 more
GConflicting classifications of pathogenicity
MLH1
(P654L +6 more)
Single nucleotide variant
(missense variant +1 more)
Lynch syndrome
GPathogenic
MLH1
(R687W +7 more)
Single nucleotide variant
(missense variant +1 more)
Lynch syndrome
GPathogenic
CTNNB1
(R661* +1 more)
Single nucleotide variant
(nonsense)
not provided
+3 more
GPathogenic/Likely pathogenic
MYLK
(R1204W +2 more)
Single nucleotide variant
(missense variant)
Megacystis-microcolon-intestinal hypoperistalsis syndrome 1
+4 more
GConflicting classifications of pathogenicity
MME
(D120N)
Single nucleotide variant
(missense variant)
See cases
+1 more
GUncertain significance
NAA15
(H80fs)
Deletion
(frameshift variant)
Inborn genetic diseases
+4 more
GPathogenic/Likely pathogenic
HEXB
(R308H +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic/Likely pathogenic
APC
(Q1004* +12 more)
Single nucleotide variant
(nonsense)
not provided
+2 more
GPathogenic/Likely pathogenic
APC
(T1273fs +12 more)
Duplication
(frameshift variant)
Hereditary cancer-predisposing syndrome
+1 more
GPathogenic
NDST1
(G611S)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal recessive 46
+3 more
GPathogenic/Likely pathogenic
SQSTM1
(P392L +1 more)
Single nucleotide variant
(missense variant)
Frontotemporal dementia and/or amyotrophic lateral sclerosis 1
+6 more
GConflicting classifications of pathogenicity
ITPR3
(T1424M)
Single nucleotide variant
(missense variant)
not provided
+1 more
GLikely pathogenic
PKHD1
(C2422G)
Single nucleotide variant
(missense variant)
Autosomal recessive polycystic kidney disease
+2 more
GConflicting classifications of pathogenicity
MICAL1
(S697* +2 more)
Single nucleotide variant
(nonsense)
not provided
+1 more
GConflicting classifications of pathogenicity
PRKN
(K211N +2 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic/Likely pathogenic
PMS2
(K647* +7 more)
Single nucleotide variant
(nonsense +1 more)
Lynch syndrome
GPathogenic
PMS2
(I476fs +7 more)
Duplication
(frameshift variant +1 more)
Lynch syndrome
GPathogenic
PMS2
(V159M +3 more)
Single nucleotide variant
(missense variant +2 more)
Lynch syndrome
+7 more
GConflicting classifications of pathogenicity
SAMD9L
(Q1381fs)
Duplication
(frameshift variant)
not provided
+1 more
GUncertain significance
KMT2E
(K961fs)
Deletion
(frameshift variant)
Global developmental delay
+1 more
GLikely pathogenic
CFTR, CFTR-AS1
Deletion
(inframe_deletion)
Cystic fibrosis
GPathogenic
CFTR
(N1303K)
Single nucleotide variant
(missense variant)
Cystic fibrosis
GPathogenic
FLNC
(T1667M)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+5 more
GConflicting classifications of pathogenicity
FLNC, FLNC-AS1
(G2118S +1 more)
Single nucleotide variant
(missense variant)
Myofibrillar myopathy 5
+5 more
GConflicting classifications of pathogenicity
WASHC5
Single nucleotide variant
(intron variant)
Hereditary spastic paraplegia 8
+2 more
GUncertain significance
COL5A1
(G1351fs)
Duplication
(frameshift variant)
Familial thoracic aortic aneurysm and aortic dissection
+3 more
GPathogenic/Likely pathogenic
OPTN
(K360fs)
Deletion
(frameshift variant)
not provided
+3 more
GPathogenic/Likely pathogenic
PTEN
Deletion
(frameshift variant)
Global developmental delay
+2 more
GPathogenic/Likely pathogenic
MYBPC3
(Q1233*)
Single nucleotide variant
(nonsense)
not provided
+8 more
GPathogenic/Likely pathogenic
GANAB
(R433Q +5 more)
Single nucleotide variant
(missense variant)
Polycystic kidney disease 3 with or without polycystic liver disease
+1 more
GUncertain significance
MYO7A
(A446T +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
ATM, C11orf65
Single nucleotide variant
(splice acceptor variant +1 more)
Familial cancer of breast
+4 more
GPathogenic
ATM, C11orf65
Indel
(missense variant +1 more)
Familial cancer of breast
+3 more
GPathogenic/Likely pathogenic
POLR3B
(V523E +1 more)
Single nucleotide variant
(missense variant)
See cases
+8 more
GPathogenic/Likely pathogenic
TRPV4
(R755fs +4 more)
Deletion
(frameshift variant)
Inborn genetic diseases
+2 more
GConflicting classifications of pathogenicity
BRCA2
(F81I)
Single nucleotide variant
(missense variant)
Hereditary breast ovarian cancer syndrome
+4 more
GConflicting classifications of pathogenicity
BRCA2
(Q1175*)
Single nucleotide variant
(nonsense)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
(Q1429fs)
Duplication
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
Deletion
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
Deletion
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
(S1982fs)
Deletion
(frameshift variant)
BRCA2-related cancer predisposition
GPathogenic
BRCA2
Deletion
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
(I2627F)
Single nucleotide variant
(missense variant)
BRCA2-related cancer predisposition
GPathogenic
BRCA2
(T3033fs)
Duplication
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
(N3124I)
Single nucleotide variant
(missense variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
ANG, EGILA
+1 more
(M1I)
Single nucleotide variant
(non-coding transcript variant +4 more)
not provided
+2 more
GConflicting classifications of pathogenicity
MYH7
Single nucleotide variant
(intron variant)
Cardiovascular phenotype
+3 more
GUncertain significance
MLH3
(M809V)
Single nucleotide variant
(missense variant)
Colorectal cancer, hereditary nonpolyposis, type 7
+2 more
GConflicting classifications of pathogenicity
FBN1
(D2607N)
Single nucleotide variant
(missense variant)
Myopathy
+2 more
GLikely pathogenic
FBN1
(R1530C)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+11 more
GPathogenic/Likely pathogenic
FBN1
(A882V)
Single nucleotide variant
(missense variant)
not specified
+11 more
GPathogenic/Likely pathogenic
JMJD8, STUB1
(P171L +1 more)
Single nucleotide variant
(missense variant +2 more)
Spinocerebellar ataxia 48
+1 more
GConflicting classifications of pathogenicity
NTHL1
(Q82*)
Single nucleotide variant
(nonsense +1 more)
not provided
+2 more
GPathogenic
PKD1
(C2370R)
Single nucleotide variant
(missense variant)
Polycystic kidney disease, adult type
+1 more
GPathogenic/Likely pathogenic
LOC126862264, MEFV
Single nucleotide variant
(missense variant +1 more)
Recurrent fever
+24 more
GPathogenic/Likely pathogenic
SRCAP
(E1890V)
Single nucleotide variant
(missense variant)
Developmental delay, hypotonia, musculoskeletal defects, and behavioral abnormalities
+1 more
GUncertain significance
SPG7
(A510V)
Single nucleotide variant
(missense variant)
Spastic paraparesis
+10 more
GPathogenic/Likely pathogenic
TP53
(F206S +3 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+4 more
GUncertain significance
NF1
Single nucleotide variant
(splice acceptor variant)
Cardiovascular phenotype
+4 more
GLikely pathogenic
NF1
(D1116fs)
Deletion
(frameshift variant)
Neurofibromatosis, type 1
+1 more
GPathogenic
NF1
(R1947* +1 more)
Single nucleotide variant
(nonsense)
NF1-related disorder
+10 more
GPathogenic
OLikely oncogenic
RAD51D, RAD51L3-RFFL
(R232* +2 more)
Single nucleotide variant
(nonsense +1 more)
Breast-ovarian cancer, familial, susceptibility to, 4
+5 more
GPathogenic/Likely pathogenic
BRCA1
(Q1756fs +3 more)
Duplication
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(R1751* +79 more)
Single nucleotide variant
(nonsense +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(S1655F +77 more)
Single nucleotide variant
(missense variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
+2 more
GPathogenic/Likely pathogenic
BRCA1, LOC126862571
(E1163fs +21 more)
Duplication
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
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