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Items: 23

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
PIK3CA
(E81K)
Single nucleotide variant
(missense variant)
not provided
+3 more
GPathogenic
PIK3CA
(N345K)
Single nucleotide variant
(missense variant)
Congenital macrodactylia
+14 more
GPathogenic
PIK3CA
(C420R)
Single nucleotide variant
(missense variant)
Cowden syndrome
+7 more
GPathogenic
OOncogenic
PIK3CA
(E453K)
Single nucleotide variant
(missense variant)
PIK3CA-related disorder
+5 more
GPathogenic
PIK3CA
(E542K)
Single nucleotide variant
(missense variant)
Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes
+1 more
GPathogenic
OOncogenic
PIK3CA
(E545K)
Single nucleotide variant
(missense variant)
Eccrine angiomatous hamartoma
+6 more
GPathogenic/Likely pathogenic
OOncogenic
PIK3CA
(E545A)
Single nucleotide variant
(missense variant)
Ovarian neoplasm
GPathogenic
PIK3CA
(Q546R)
Single nucleotide variant
(missense variant)
Ovarian neoplasm
+3 more
GPathogenic
OOncogenic
PIK3CA
(G914R)
Single nucleotide variant
(missense variant)
Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes
GPathogenic
PIK3CA
(Y1021C)
Single nucleotide variant
(missense variant)
Cowden syndrome
GPathogenic
PIK3CA
(H1047R)
Single nucleotide variant
(missense variant)
Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes
+1 more
GPathogenic
OOncogenic
TEK
(R849W +4 more)
Single nucleotide variant
(missense variant)
Multiple cutaneous and mucosal venous malformations
+2 more
GPathogenic
TEK
(Y897C +4 more)
Single nucleotide variant
(missense variant)
Multiple cutaneous and mucosal venous malformations
+1 more
GPathogenic
TEK
(L766F +4 more)
Single nucleotide variant
(missense variant)
Vascular malformation
+1 more
GPathogenic
TEK
(R767C +4 more)
Single nucleotide variant
(missense variant)
not provided
GPathogenic/Likely pathogenic
TEK
(R770C +4 more)
Single nucleotide variant
(missense variant)
Multiple cutaneous and mucosal venous malformations
GLikely pathogenic
TEK
(R918H +4 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GConflicting classifications of pathogenicity
TEK
(R1055* +4 more)
Single nucleotide variant
(nonsense)
Multiple cutaneous and mucosal venous malformations
GPathogenic
TEK
(Y1064* +4 more)
Single nucleotide variant
(nonsense)
Multiple cutaneous and mucosal venous malformations
GPathogenic
TEK
(G1071* +4 more)
Single nucleotide variant
(nonsense)
Multiple cutaneous and mucosal venous malformations
GPathogenic
GNAQ
(Q209R)
Single nucleotide variant
(missense variant)
Sturge-Weber syndrome
GPathogenic
PTEN
(R130* +1 more)
Single nucleotide variant
(nonsense +1 more)
Hereditary cancer-predisposing syndrome
+8 more
GPathogenic
OOncogenic
PTEN
(R233* +2 more)
Single nucleotide variant
(nonsense)
Cowden syndrome
+6 more
GPathogenic/Likely pathogenic
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