MEN1[gene] AND (clinsig_pathogenic[prop] OR clinsig_likely_pathogenic[ - ClinVar - NCBI

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VariationLocation		Gene(s)	Protein change	Condition(s)	Clinical significance (Last reviewed)	Review status
Select item 5727621.	NM_000244.3(MEN1):c.1366_*820del1303 (p.Val456_Ter(616_?)(?)) GRCh37: Chr11:64570986-64572288 GRCh38: Chr11:64803514-64804816	MEN1	V451fs	Multiple endocrine neoplasia, type 1	Pathogenic (Jun 23, 2018)	criteria provided, single submitter
Select item 4173172.	NC_000011.10:g.(?_64803514)_(64804816_?)del GRCh37: Chr11:64570986-64572288 GRCh38: Chr11:64803514-64804816	MEN1		Multiple endocrine neoplasia, type 1	Pathogenic (Sep 3, 2016)	criteria provided, single submitter
Select item 4173163.	NC_000011.10:g.(?_64803514)_(64810132_?)del GRCh37: Chr11:64570986-64577604 GRCh38: Chr11:64803514-64810132	MEN1		Multiple endocrine neoplasia, type 1	Pathogenic (Aug 2, 2016)	criteria provided, single submitter
Select item 4465034.	NM_001370259.2(MEN1):c.*412G>A GRCh37: Chr11:64571394 GRCh38: Chr11:64803922	MEN1		Somatotroph adenoma	Likely pathogenic (Dec 5, 2017)	criteria provided, single submitter
Select item 5806495.	NM_001370259.2(MEN1):c.1351-2_*132del GRCh37: Chr11:64571674-64572290 GRCh38: Chr11:64804202-64804818	MEN1		Multiple endocrine neoplasia, type 1	Pathogenic (Sep 14, 2021)	criteria provided, single submitter
Select item 6552186.	NC_000011.10:g.(?_64804324)_(64810716_?)del GRCh37: Chr11:64571796-64578188 GRCh38: Chr11:64804324-64810716	MEN1		Multiple endocrine neoplasia, type 1	Pathogenic (Jun 18, 2019)	criteria provided, single submitter
Select item 4465027.	NM_001370259.2(MEN1):c.1831T>A (p.Ter611Arg) GRCh37: Chr11:64571808 GRCh38: Chr11:64804336	MEN1		Somatotroph adenoma	Pathogenic (Dec 5, 2017)	criteria provided, single submitter
Select item 20958008.	NM_001370259.2(MEN1):c.1756C>T (p.Gln586Ter) GRCh37: Chr11:64571883 GRCh38: Chr11:64804411	MEN1	Q531, Q586, Q591, Q628, Q551, Q593, Q633*	Multiple endocrine neoplasia, type 1	Likely pathogenic (Feb 9, 2022)	criteria provided, single submitter
Select item 2206479.	NM_001370259.2(MEN1):c.1739del (p.Thr580fs) GRCh37: Chr11:64571900 GRCh38: Chr11:64804428	MEN1	T545fs, T622fs, T585fs, T580fs	Multiple endocrine neoplasia, type 1	Likely pathogenic (Aug 9, 2021)	criteria provided, single submitter
Select item 213713710.	NM_001370259.2(MEN1):c.1732C>T (p.Gln578Ter) GRCh37: Chr11:64571907 GRCh38: Chr11:64804435	MEN1	Q523, Q578, Q585, Q620, Q543, Q583, Q625*	Multiple endocrine neoplasia, type 1	Likely pathogenic (Aug 7, 2022)	criteria provided, single submitter
Select item 42806811.	NM_001370259.2(MEN1):c.1708_1728del (p.Ile570_Lys576del) GRCh37: Chr11:64571911-64571931 GRCh38: Chr11:64804439-64804459	MEN1		Hereditary cancer-predisposing syndrome	Likely pathogenic (Sep 15, 2015)	criteria provided, single submitter
Select item 48572712.	NM_001370259.2(MEN1):c.1725del (p.Lys576fs) GRCh37: Chr11:64571914 GRCh38: Chr11:64804442	MEN1	K541fs, K618fs, K581fs, K576fs	Hereditary cancer-predisposing syndrome	Likely pathogenic (Aug 19, 2016)	criteria provided, single submitter
Select item 42806713.	NM_001370259.2(MEN1):c.1643_1721delinsTG (p.Gly548fs) GRCh37: Chr11:64571918-64571996 GRCh38: Chr11:64804446-64804524	MEN1	G513fs, G548fs, G553fs, G590fs	Hereditary cancer-predisposing syndrome	Pathogenic (Dec 6, 2018)	criteria provided, single submitter
Select item 177855514.	NM_001370259.2(MEN1):c.1710del (p.Asn571fs) GRCh37: Chr11:64571929 GRCh38: Chr11:64804457	MEN1	N536fs, N576fs, N613fs, N571fs	Hereditary cancer-predisposing syndrome	Likely pathogenic (Sep 21, 2021)	criteria provided, single submitter
Select item 20098915.	NM_001370259.2(MEN1):c.1687G>T (p.Glu563Ter) GRCh37: Chr11:64571952 GRCh38: Chr11:64804480	MEN1	E563, E568, E528, E605	not provided	Pathogenic (Apr 24, 2017)	criteria provided, single submitter
Select item 9625116.	NM_001370259.2(MEN1):c.1685dup (p.Glu563fs) GRCh37: Chr11:64571953-64571954 GRCh38: Chr11:64804481-64804482	MEN1	E568fs, E528fs, E563fs, E605fs	not provided	Pathogenic (Jan 21, 2013)	no assertion criteria provided
Select item 177794417.	NM_001370259.2(MEN1):c.1682T>G (p.Met561Arg) GRCh37: Chr11:64571957 GRCh38: Chr11:64804485	MEN1	M506R, M526R, M566R, M561R, M608R, M603R, M568R	Hereditary cancer-predisposing syndrome	Likely pathogenic (Mar 22, 2017)	criteria provided, single submitter
Select item 85958018.	NM_001370259.2(MEN1):c.1672_1679del (p.Met558fs) GRCh37: Chr11:64571960-64571967 GRCh38: Chr11:64804488-64804495	MEN1	M563fs, M523fs, M558fs, M600fs	Multiple endocrine neoplasia, type 1	Pathogenic (Aug 27, 2021)	criteria provided, single submitter
Select item 177777319.	NM_001370259.2(MEN1):c.1675A>T (p.Lys559Ter) GRCh37: Chr11:64571964 GRCh38: Chr11:64804492	MEN1	K564, K601, K566, K606, K559, K524, K504*	Hereditary cancer-predisposing syndrome	Pathogenic (May 25, 2022)	criteria provided, single submitter
Select item 56915420.	NM_001370259.2(MEN1):c.1674dup (p.Lys559fs) GRCh37: Chr11:64571964-64571965 GRCh38: Chr11:64804492-64804493	MEN1	K524fs, K564fs, K601fs, K559fs	Multiple endocrine neoplasia, type 1	Pathogenic (Aug 9, 2021)	criteria provided, single submitter
Select item 208050521.	NM_001370259.2(MEN1):c.1642_1673delinsCC (p.Gly548_Met558delinsPro) GRCh37: Chr11:64571966-64571997 GRCh38: Chr11:64804494-64804525	MEN1		Multiple endocrine neoplasia, type 1	Pathogenic (Jan 11, 2022)	criteria provided, single submitter
Select item 66617322.	NM_001370259.2(MEN1):c.1670del (p.Lys557fs) GRCh37: Chr11:64571969 GRCh38: Chr11:64804497	MEN1	K557fs, K522fs, K562fs, K599fs	Multiple endocrine neoplasia, type 1	Pathogenic (Aug 28, 2021)	criteria provided, single submitter
Select item 42805923.	NM_001370259.2(MEN1):c.1669A>G (p.Lys557Glu) GRCh37: Chr11:64571970 GRCh38: Chr11:64804498	MEN1	K557E, K562E, K522E, K599E	Hereditary cancer-predisposing syndrome	Likely pathogenic (Jun 23, 2015)	criteria provided, single submitter
Select item 42805124.	NM_001370259.2(MEN1):c.1665_1668del (p.Ser555fs) GRCh37: Chr11:64571971-64571974 GRCh38: Chr11:64804499-64804502	MEN1	S555fs, S520fs, S560fs, S597fs	Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1	Pathogenic/Likely pathogenic (Feb 5, 2019)	criteria provided, multiple submitters, no conflicts
Select item 42804125.	NM_001370259.2(MEN1):c.1666G>T (p.Glu556Ter) GRCh37: Chr11:64571973 GRCh38: Chr11:64804501	MEN1	E556, E561, E598, E521	Hereditary cancer-predisposing syndrome	Pathogenic (Nov 22, 2015)	criteria provided, single submitter
Select item 21613426.	NM_001370259.2(MEN1):c.1664G>A (p.Ser555Asn) GRCh37: Chr11:64571975 GRCh38: Chr11:64804503	MEN1	S555N, S560N, S597N, S520N	not specified, Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1	Pathogenic/Likely pathogenic (Jul 31, 2022)	criteria provided, multiple submitters, no conflicts
Select item 138641627.	NM_001370259.2(MEN1):c.1660del (p.Gln554fs) GRCh37: Chr11:64571979 GRCh38: Chr11:64804507	MEN1	Q519fs, Q554fs, Q596fs, Q559fs	Multiple endocrine neoplasia, type 1	Pathogenic (Nov 12, 2021)	criteria provided, single submitter
Select item 20098828.	NM_001370259.2(MEN1):c.1660C>T (p.Gln554Ter) GRCh37: Chr11:64571979 GRCh38: Chr11:64804507	MEN1	Q554, Q559, Q519, Q596	Hereditary cancer-predisposing syndrome, not provided, Multiple endocrine neoplasia, type 1	Pathogenic (Aug 13, 2021)	criteria provided, multiple submitters, no conflicts
Select item 145636429.	NM_001370259.2(MEN1):c.1657_1658del (p.Phe553fs) GRCh37: Chr11:64571981-64571982 GRCh38: Chr11:64804509-64804510	MEN1	F518fs, F553fs, F558fs, F595fs	Multiple endocrine neoplasia, type 1	Pathogenic (Aug 17, 2021)	criteria provided, single submitter
Select item 1669830.	NM_001370259.2(MEN1):c.1654A>T (p.Thr552Ser) GRCh37: Chr11:64571985 GRCh38: Chr11:64804513	MEN1	T552S, T557S, T517S, T594S	Adrenocortical adenoma	Pathogenic (Dec 1, 1999)	no assertion criteria provided
Select item 20100331.	NM_001370259.2(MEN1):c.1651del (p.Leu551fs) GRCh37: Chr11:64571988 GRCh38: Chr11:64804516	MEN1	L593fs, L516fs, L551fs, L556fs	not provided	Pathogenic (May 30, 2014)	criteria provided, single submitter
Select item 42803532.	NM_001370259.2(MEN1):c.1638_1639dup (p.Glu547fs) GRCh37: Chr11:64571999-64572000 GRCh38: Chr11:64804527-64804528	MEN1	E552fs, E512fs, E589fs, E547fs	Hereditary cancer-predisposing syndrome	Pathogenic (Jul 9, 2021)	criteria provided, single submitter
Select item 20102233.	NM_001370259.2(MEN1):c.1602_1618dup (p.Pro540fs) GRCh37: Chr11:64572020-64572021 GRCh38: Chr11:64804548-64804549	MEN1	P540fs, P505fs, P545fs, P582fs	not provided	Pathogenic (Jan 31, 2014)	criteria provided, single submitter
Select item 50362734.	NM_001370259.2(MEN1):c.1602_1618del (p.Ala535fs) GRCh37: Chr11:64572021-64572037 GRCh38: Chr11:64804549-64804565	MEN1	A577fs, A500fs, A540fs, A535fs	not provided	Likely pathogenic (Apr 14, 2017)	criteria provided, single submitter
Select item 177645635.	NM_001370259.2(MEN1):c.1614dup (p.Ala539fs) GRCh37: Chr11:64572024-64572025 GRCh38: Chr11:64804552-64804553	MEN1	A504fs, A539fs, A544fs, A581fs	Hereditary cancer-predisposing syndrome, not provided	Pathogenic/Likely pathogenic (Sep 2, 2022)	criteria provided, multiple submitters, no conflicts
Select item 145960836.	NM_001370259.2(MEN1):c.1609del (p.Val537fs) GRCh37: Chr11:64572030 GRCh38: Chr11:64804558	MEN1	V542fs, V537fs, V502fs, V579fs	Hereditary cancer-predisposing syndrome, not provided, Multiple endocrine neoplasia, type 1	Pathogenic/Likely pathogenic (May 19, 2022)	criteria provided, multiple submitters, no conflicts
Select item 26524237.	NM_001370259.2(MEN1):c.1590del (p.Gly531fs) GRCh37: Chr11:64572049 GRCh38: Chr11:64804577	MEN1	G496fs, G536fs, G531fs, G573fs	not provided, Multiple endocrine neoplasia, type 1	Pathogenic (Dec 17, 2021)	criteria provided, multiple submitters, no conflicts
Select item 1668838.	NM_001370259.2(MEN1):c.1579C>T (p.Arg527Ter) GRCh37: Chr11:64572060 GRCh38: Chr11:64804588	MEN1	R527, R532, R569, R492	not provided, Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1	Pathogenic (Oct 15, 2021)	criteria provided, multiple submitters, no conflicts
Select item 42805539.	NM_001370259.2(MEN1):c.1574del (p.Thr525fs) GRCh37: Chr11:64572065 GRCh38: Chr11:64804593	MEN1	T567fs, T525fs, T490fs, T530fs	Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1	Pathogenic (Sep 1, 2021)	criteria provided, multiple submitters, no conflicts
Select item 91763940.	NM_001370259.2(MEN1):c.1564dup (p.Val522fs) GRCh37: Chr11:64572074-64572075 GRCh38: Chr11:64804602-64804603	MEN1	V487fs, V522fs, V527fs, V564fs	Multiple endocrine neoplasia, type 1	Likely pathogenic (Jan 8, 2020)	criteria provided, single submitter
Select item 107211241.	NM_001370259.2(MEN1):c.1556del (p.Pro519fs) GRCh37: Chr11:64572083 GRCh38: Chr11:64804611	MEN1	P484fs, P519fs, P524fs, P561fs	not provided, Multiple endocrine neoplasia, type 1	Pathogenic (Sep 1, 2021)	criteria provided, multiple submitters, no conflicts
Select item 98837542.	NM_001370259.2(MEN1):c.1548_1549del (p.Lys517fs) GRCh37: Chr11:64572090-64572091 GRCh38: Chr11:64804618-64804619	MEN1	K482fs, K517fs, K522fs, K559fs	not provided	Pathogenic (Jan 13, 2017)	criteria provided, single submitter
Select item 20100243.	NM_001370259.2(MEN1):c.1548dup (p.Lys517fs) GRCh37: Chr11:64572090-64572091 GRCh38: Chr11:64804618-64804619	MEN1	K517fs, K559fs, K482fs, K522fs	Hereditary cancer-predisposing syndrome, not provided, Multiple endocrine neoplasia, type 1	Pathogenic/Likely pathogenic (Sep 2, 2021)	criteria provided, multiple submitters, no conflicts
Select item 20098644.	NM_001370259.2(MEN1):c.1549A>T (p.Lys517Ter) GRCh37: Chr11:64572090 GRCh38: Chr11:64804618	MEN1	K517, K522, K482, K559	Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1	Pathogenic (Aug 12, 2021)	criteria provided, multiple submitters, no conflicts
Select item 98853145.	NM_001370259.2(MEN1):c.1548del (p.Lys517fs) GRCh37: Chr11:64572091 GRCh38: Chr11:64804619	MEN1	K482fs, K517fs, K522fs, K559fs	not provided	Pathogenic (Feb 16, 2016)	criteria provided, single submitter
Select item 98849046.	NM_001370259.2(MEN1):c.1546_1547dup (p.Lys517fs) GRCh37: Chr11:64572091-64572092 GRCh38: Chr11:64804619-64804620	MEN1	K482fs, K517fs, K522fs, K559fs	not provided	Pathogenic (Sep 20, 2016)	criteria provided, single submitter
Select item 27985247.	NM_001370259.2(MEN1):c.1546dup (p.Arg516fs) GRCh37: Chr11:64572092-64572093 GRCh38: Chr11:64804620-64804621	MEN1	R481fs, R521fs, R558fs, R516fs	not provided, Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome	Pathogenic (Jul 28, 2022)	criteria provided, multiple submitters, no conflicts
Select item 20099948.	NM_001370259.2(MEN1):c.1546del (p.Arg516fs) GRCh37: Chr11:64572093 GRCh38: Chr11:64804621	MEN1	R516fs, R481fs, R521fs, R558fs	Hereditary cancer-predisposing syndrome, not provided, Multiple endocrine neoplasia, type 1	Pathogenic (Feb 21, 2023)	criteria provided, multiple submitters, no conflicts
Select item 96023949.	NM_001370259.2(MEN1):c.1532_1541del (p.Val511fs) GRCh37: Chr11:64572098-64572107 GRCh38: Chr11:64804626-64804635	MEN1	V476fs, V511fs, V553fs, V516fs	Multiple endocrine neoplasia, type 1	Pathogenic (Aug 27, 2021)	criteria provided, single submitter
Select item 81943350.	NM_001370259.2(MEN1):c.1539del (p.Arg516fs) GRCh37: Chr11:64572100 GRCh38: Chr11:64804628	MEN1	R521fs, R558fs, R481fs, R516fs	Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome	Pathogenic/Likely pathogenic (Jul 14, 2021)	criteria provided, multiple submitters, no conflicts
Select item 45730551.	NM_001370259.2(MEN1):c.1535C>G (p.Ser512Ter) GRCh37: Chr11:64572104 GRCh38: Chr11:64804632	MEN1	S512, S517, S477, S554	Multiple endocrine neoplasia, type 1	Pathogenic (Jul 14, 2021)	criteria provided, single submitter
Select item 20102152.	NM_001370259.2(MEN1):c.1533_1534dup (p.Ser512fs) GRCh37: Chr11:64572104-64572105 GRCh38: Chr11:64804632-64804633	MEN1	S512fs, S477fs, S517fs, S554fs	Hereditary cancer-predisposing syndrome, not provided, Multiple endocrine neoplasia, type 1	Pathogenic (Apr 6, 2022)	criteria provided, multiple submitters, no conflicts
Select item 94529453.	NM_001370259.2(MEN1):c.1532dup (p.Ser512fs) GRCh37: Chr11:64572106-64572107 GRCh38: Chr11:64804634-64804635	MEN1	S554fs, S477fs, S517fs, S512fs	Multiple endocrine neoplasia, type 1	Pathogenic (Sep 2, 2021)	criteria provided, single submitter
Select item 42806454.	NM_001370259.2(MEN1):c.1529_1530del (p.Ala510fs) GRCh37: Chr11:64572109-64572110 GRCh38: Chr11:64804637-64804638	MEN1	A552fs, A510fs, A475fs, A515fs	Hereditary cancer-predisposing syndrome	Pathogenic (Jul 30, 2015)	criteria provided, single submitter
Select item 93103355.	NM_001370259.2(MEN1):c.1522C>T (p.Gln508Ter) GRCh37: Chr11:64572117 GRCh38: Chr11:64804645	MEN1	Q473, Q513, Q508, Q550	Multiple endocrine neoplasia, type 1	Pathogenic (Mar 31, 2019)	criteria provided, single submitter
Select item 42801056.	NM_001370259.2(MEN1):c.1504_1507dup (p.Gly503fs) GRCh37: Chr11:64572131-64572132 GRCh38: Chr11:64804659-64804660	MEN1	G468fs, G508fs, G545fs, G503fs	Hereditary cancer-predisposing syndrome	Pathogenic (Jan 14, 2013)	criteria provided, single submitter
Select item 41869457.	NM_001370259.2(MEN1):c.1505dup (p.Leu504fs) GRCh37: Chr11:64572133-64572134 GRCh38: Chr11:64804661-64804662	MEN1	L509fs, L546fs, L504fs, L469fs	Multiple endocrine neoplasia, type 1, not provided	Pathogenic (Sep 1, 2021)	criteria provided, multiple submitters, no conflicts
Select item 61820958.	NM_001370259.2(MEN1):c.1487del (p.Lys496fs) GRCh37: Chr11:64572152 GRCh38: Chr11:64804680	MEN1	K461fs, K496fs, K501fs, K538fs	not provided	Pathogenic (Aug 16, 2017)	criteria provided, single submitter
Select item 177349659.	NM_001370259.2(MEN1):c.1478del (p.Pro493fs) GRCh37: Chr11:64572161 GRCh38: Chr11:64804689	MEN1	P458fs, P493fs, P498fs, P535fs	Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome	Pathogenic (Aug 12, 2022)	criteria provided, multiple submitters, no conflicts
Select item 52728560.	NM_001370259.2(MEN1):c.1473del (p.Glu491fs) GRCh37: Chr11:64572166 GRCh38: Chr11:64804694	MEN1	E491fs, E533fs, E456fs, E496fs	Multiple endocrine neoplasia, type 1	Pathogenic (Aug 9, 2021)	criteria provided, single submitter
Select item 199854161.	NM_001370259.2(MEN1):c.1471G>T (p.Glu491Ter) GRCh37: Chr11:64572168 GRCh38: Chr11:64804696	MEN1	E456, E498, E491, E436, E496, E533, E538*	Multiple endocrine neoplasia, type 1	Likely pathogenic (May 25, 2022)	criteria provided, single submitter
Select item 26524162.	NM_001370259.2(MEN1):c.1464del (p.Lys488fs) GRCh37: Chr11:64572175 GRCh38: Chr11:64804703	MEN1	K453fs, K488fs, K530fs, K493fs	Hereditary cancer-predisposing syndrome, not provided	Pathogenic (Dec 2, 2015)	criteria provided, multiple submitters, no conflicts
Select item 106977663.	NM_001370259.2(MEN1):c.1456G>T (p.Glu486Ter) GRCh37: Chr11:64572183 GRCh38: Chr11:64804711	MEN1	E451, E486, E491, E528	Multiple endocrine neoplasia, type 1	Pathogenic (Jul 30, 2022)	criteria provided, single submitter
Select item 177279064.	NM_001370259.2(MEN1):c.1445del (p.Gly482fs) GRCh37: Chr11:64572194 GRCh38: Chr11:64804722	MEN1	G524fs, G447fs, G482fs, G487fs	Hereditary cancer-predisposing syndrome	Pathogenic (Aug 2, 2018)	criteria provided, single submitter
Select item 137262065.	NM_001370259.2(MEN1):c.1435_1441del (p.Arg479fs) GRCh37: Chr11:64572198-64572204 GRCh38: Chr11:64804726-64804732	MEN1	R479fs, R521fs, R444fs, R484fs	Multiple endocrine neoplasia, type 1	Pathogenic (May 16, 2022)	criteria provided, single submitter
Select item 98827866.	NM_001370259.2(MEN1):c.1394_1439del (p.Ala465fs) GRCh37: Chr11:64572200-64572245 GRCh38: Chr11:64804728-64804773	MEN1	A430fs, A465fs, A470fs, A507fs	not provided	Likely pathogenic (Aug 28, 2014)	criteria provided, single submitter
Select item 94599067.	NM_001370259.2(MEN1):c.1437del (p.Arg480fs) GRCh37: Chr11:64572202 GRCh38: Chr11:64804730	MEN1	R480fs, R485fs, R445fs, R522fs	Multiple endocrine neoplasia, type 1	Pathogenic (Aug 28, 2021)	criteria provided, single submitter
Select item 27985168.	NM_001370259.2(MEN1):c.1429dup (p.Glu477fs) GRCh37: Chr11:64572209-64572210 GRCh38: Chr11:64804737-64804738	MEN1	E442fs, E477fs, E482fs, E519fs	not provided	Pathogenic (Dec 27, 2017)	criteria provided, single submitter
Select item 177244569.	NM_001370259.2(MEN1):c.1429del (p.Glu477fs) GRCh37: Chr11:64572210 GRCh38: Chr11:64804738	MEN1	E442fs, E519fs, E477fs, E482fs	Hereditary cancer-predisposing syndrome	Pathogenic (Jul 30, 2021)	criteria provided, single submitter
Select item 21613370.	NM_001370259.2(MEN1):c.1429G>T (p.Glu477Ter) GRCh37: Chr11:64572210 GRCh38: Chr11:64804738	MEN1	E477, E482, E519, E442	not provided, Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1	Pathogenic (May 23, 2022)	criteria provided, multiple submitters, no conflicts
Select item 66380471.	NM_001370259.2(MEN1):c.1420del (p.Glu474fs) GRCh37: Chr11:64572219 GRCh38: Chr11:64804747	MEN1	E439fs, E474fs, E479fs, E516fs	Multiple endocrine neoplasia, type 1	Pathogenic (Sep 2, 2021)	criteria provided, single submitter
Select item 177216572.	NM_001370259.2(MEN1):c.1417G>T (p.Glu473Ter) GRCh37: Chr11:64572222 GRCh38: Chr11:64804750	MEN1	E473, E520, E418, E438, E480, E478, E515*	Hereditary cancer-predisposing syndrome	Pathogenic (Apr 22, 2022)	criteria provided, single submitter
Select item 42808073.	NM_001370259.2(MEN1):c.1406_1413dup (p.Gly472fs) GRCh37: Chr11:64572225-64572226 GRCh38: Chr11:64804753-64804754	MEN1	G477fs, G514fs, G437fs, G472fs	Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1	Pathogenic (Aug 9, 2021)	criteria provided, multiple submitters, no conflicts
Select item 94320374.	NM_001370259.2(MEN1):c.1413G>A (p.Trp471Ter) GRCh37: Chr11:64572226 GRCh38: Chr11:64804754	MEN1	W471, W436, W476, W513	Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1	Pathogenic (Aug 30, 2021)	criteria provided, multiple submitters, no conflicts
Select item 65717975.	NM_001370259.2(MEN1):c.1400_1413del (p.Ala467fs) GRCh37: Chr11:64572226-64572239 GRCh38: Chr11:64804754-64804767	MEN1	A432fs, A467fs, A472fs, A509fs	Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1	Pathogenic (Jun 27, 2022)	criteria provided, multiple submitters, no conflicts
Select item 40383976.	NM_001370259.2(MEN1):c.1412G>A (p.Trp471Ter) GRCh37: Chr11:64572227 GRCh38: Chr11:64804755	MEN1	W471, W476, W436, W513	Multiple endocrine neoplasia, type 1	Pathogenic (Jul 14, 2021)	criteria provided, single submitter
Select item 40384377.	NM_001370259.2(MEN1):c.1382_1404dup (p.Glu469fs) GRCh37: Chr11:64572234-64572235 GRCh38: Chr11:64804762-64804763	MEN1	E434fs, E474fs, E469fs, E511fs	Multiple endocrine neoplasia, type 1	Pathogenic (Jul 14, 2021)	criteria provided, single submitter
Select item 213714078.	NM_001370259.2(MEN1):c.1393_1396del (p.Ala465fs) GRCh37: Chr11:64572243-64572246 GRCh38: Chr11:64804771-64804774	MEN1	A470fs, A507fs, A465fs, A430fs	Multiple endocrine neoplasia, type 1	Pathogenic (Aug 27, 2022)	criteria provided, single submitter
Select item 139070179.	NM_001370259.2(MEN1):c.1393del (p.Ala465fs) GRCh37: Chr11:64572246 GRCh38: Chr11:64804774	MEN1	A470fs, A507fs, A430fs, A465fs	Multiple endocrine neoplasia, type 1	Pathogenic (Jul 14, 2021)	criteria provided, single submitter
Select item 200370780.	NM_001370259.2(MEN1):c.1391_1392insCAGAGGCCGAGGC (p.Ala465fs) GRCh37: Chr11:64572247-64572248 GRCh38: Chr11:64804775-64804776	MEN1	A465fs, A430fs, A470fs, A507fs	Multiple endocrine neoplasia, type 1	Pathogenic (Jun 9, 2022)	criteria provided, single submitter
Select item 107334781.	NM_001370259.2(MEN1):c.1391dup (p.Ala465fs) GRCh37: Chr11:64572247-64572248 GRCh38: Chr11:64804775-64804776	MEN1	A430fs, A465fs, A470fs, A507fs	Multiple endocrine neoplasia, type 1	Pathogenic (Jul 17, 2022)	criteria provided, single submitter
Select item 107095482.	NM_001370259.2(MEN1):c.1375_1391dup (p.Ala467fs) GRCh37: Chr11:64572247-64572248 GRCh38: Chr11:64804775-64804776	MEN1	A432fs, A467fs, A472fs, A509fs	Hereditary cancer-predisposing syndrome, not provided, Multiple endocrine neoplasia, type 1	Pathogenic (May 20, 2022)	criteria provided, multiple submitters, no conflicts
Select item 42806383.	NM_130799.2(MEN1):c.1391_1392ins13 (p.?) GRCh37: Chr11:64572247-64572248 GRCh38: Chr11:64804775-64804776	MEN1		Hereditary cancer-predisposing syndrome	Pathogenic (Jul 11, 2015)	criteria provided, single submitter
Select item 43989384.	NM_001370259.2(MEN1):c.1391del (p.Ala464fs) GRCh37: Chr11:64572248 GRCh38: Chr11:64804776	MEN1	A469fs, A506fs, A429fs, A464fs	not specified	Likely pathogenic (Feb 14, 2017)	criteria provided, single submitter
Select item 42807585.	NM_001370259.2(MEN1):c.1382_1389dup (p.Ala464fs) GRCh37: Chr11:64572249-64572250 GRCh38: Chr11:64804777-64804778	MEN1	A469fs, A506fs, A429fs, A464fs	Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1	Pathogenic (Jul 14, 2021)	criteria provided, multiple submitters, no conflicts
Select item 42804086.	NM_001370259.2(MEN1):c.1390delinsCCT (p.Ala464fs) GRCh37: Chr11:64572249 GRCh38: Chr11:64804777	MEN1	A506fs, A469fs, A429fs, A464fs	Hereditary cancer-predisposing syndrome	Pathogenic (Jul 16, 2014)	criteria provided, single submitter
Select item 177144387.	NM_001370259.2(MEN1):c.1387G>T (p.Glu463Ter) GRCh37: Chr11:64572252 GRCh38: Chr11:64804780	MEN1	E463, E470, E428, E468, E505, E408, E510*	Hereditary cancer-predisposing syndrome	Pathogenic (Aug 19, 2021)	criteria provided, single submitter
Select item 177126888.	NM_001370259.2(MEN1):c.1380_1383del (p.Glu461fs) GRCh37: Chr11:64572256-64572259 GRCh38: Chr11:64804784-64804787	MEN1	E503fs, E461fs, E466fs, E426fs	Hereditary cancer-predisposing syndrome	Pathogenic (Oct 12, 2022)	criteria provided, single submitter
Select item 45729089.	NM_001370259.2(MEN1):c.1375_1382del (p.Ser459fs) GRCh37: Chr11:64572257-64572264 GRCh38: Chr11:64804785-64804792	MEN1	S464fs, S424fs, S501fs, S459fs	Multiple endocrine neoplasia, type 1	Pathogenic (Aug 9, 2021)	criteria provided, single submitter
Select item 42426890.	NM_001370259.2(MEN1):c.1378delinsACATAGT (p.Arg460delinsThrTer) GRCh37: Chr11:64572261 GRCh38: Chr11:64804789	MEN1		not provided	Pathogenic (Mar 10, 2017)	criteria provided, single submitter
Select item 1669291.	NM_001370259.2(MEN1):c.1378C>T (p.Arg460Ter) GRCh37: Chr11:64572261 GRCh38: Chr11:64804789	MEN1	R460, R465, R502, R425	Hereditary cancer-predisposing syndrome, not provided, Multiple endocrine neoplasia, type 1	Pathogenic (Jul 22, 2022)	criteria provided, multiple submitters, no conflicts
Select item 1670892.	NG_008929.1:g.11484_11495del GRCh37: Chr11:64572272-64572283 GRCh38: Chr11:64804800-64804811	MEN1		Multiple endocrine neoplasia, type 1	Pathogenic (Jul 1, 2004)	no assertion criteria provided
Select item 106687393.	NM_001370259.2(MEN1):c.1351-3_1359del GRCh37: Chr11:64572280-64572291 GRCh38: Chr11:64804808-64804819	MEN1		not provided, Multiple endocrine neoplasia, type 1	Likely pathogenic (Oct 8, 2021)	criteria provided, multiple submitters, no conflicts
Select item 107320594.	NM_001370259.2(MEN1):c.1356dup (p.Gln453fs) GRCh37: Chr11:64572282-64572283 GRCh38: Chr11:64804810-64804811	MEN1	Q418fs, Q453fs, Q458fs, Q495fs	Multiple endocrine neoplasia, type 1	Pathogenic (Aug 26, 2021)	criteria provided, single submitter
Select item 107626695.	NM_001370259.2(MEN1):c.1351-1G>T GRCh37: Chr11:64572289 GRCh38: Chr11:64804817	MEN1		Multiple endocrine neoplasia, type 1	Pathogenic (Aug 20, 2022)	criteria provided, single submitter
Select item 24180196.	NM_001370259.2(MEN1):c.1351-1G>A GRCh37: Chr11:64572289 GRCh38: Chr11:64804817	MEN1		Multiple endocrine neoplasia, type 1	Pathogenic (Aug 12, 2021)	criteria provided, single submitter
Select item 20098597.	NM_001370259.2(MEN1):c.1351-1G>C GRCh37: Chr11:64572289 GRCh38: Chr11:64804817	MEN1		Multiple endocrine neoplasia, type 1	Pathogenic (Oct 15, 2019)	criteria provided, single submitter
Select item 81893398.	NM_001370259.2(MEN1):c.1351-2A>C GRCh37: Chr11:64572290 GRCh38: Chr11:64804818	MEN1		Hereditary cancer-predisposing syndrome	Likely pathogenic (Sep 5, 2019)	criteria provided, single submitter
Select item 40383299.	NM_001370259.2(MEN1):c.1351-2A>G GRCh37: Chr11:64572290 GRCh38: Chr11:64804818	MEN1		Multiple endocrine neoplasia, type 1	Pathogenic (Sep 10, 2021)	criteria provided, single submitter
Select item 844638100.	NM_001370259.2(MEN1):c.1277_1350+28del GRCh37: Chr11:64572478-64572579 GRCh38: Chr11:64805006-64805107	MEN1		Multiple endocrine neoplasia, type 1	Likely pathogenic (Nov 27, 2019)	criteria provided, single submitter

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