PALB2[gene] AND (clinsig_pathogenic[prop] OR clinsig_likely_pathogenic - ClinVar - NCBI

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VariationLocation		Gene(s)	Protein change	Condition(s)	Clinical significance (Last reviewed)	Review status
Select item 4306941.	NM_024675.3(PALB2):c.3350+1090_*1278dup GRCh37: Chr16:23613502-23618095 GRCh38: Chr16:23602181-23606774	PALB2		Familial cancer of breast	Likely pathogenic (Jun 7, 2017)	criteria provided, single submitter
Select item 4175172.	NC_000016.10:g.(?_23603162)_(23641357_?)del GRCh37: Chr16:23614483-23652678 GRCh38: Chr16:23603162-23641357	PALB2		Familial cancer of breast	Pathogenic (Jun 13, 2016)	criteria provided, single submitter
Select item 2415623.	NM_024675.3(PALB2):c.3351-?_*297del GRCh37: Chr16:23614483-23614990 GRCh38: Chr16:23603162-23603669	PALB2		Familial cancer of breast	Pathogenic (Jan 9, 2017)	criteria provided, single submitter
Select item 6607064.	NC_000016.10:g.(?_23603449)_(23614101_?)del GRCh37: Chr16:23614770-23625422 GRCh38: Chr16:23603449-23614101	PALB2		Familial cancer of breast	Pathogenic (Dec 31, 2018)	criteria provided, single submitter
Select item 5843625.	NC_000016.10:g.(?_23603449)_(23603679_?)del GRCh37: Chr16:23614770-23615000 GRCh38: Chr16:23603449-23603679	PALB2		Familial cancer of breast	Pathogenic (Jul 5, 2019)	criteria provided, single submitter
Select item 5841126.	NC_000016.10:g.(?_23603449)_(23608022_?)del GRCh37: Chr16:23614770-23619343 GRCh38: Chr16:23603449-23608022	PALB2		Familial cancer of breast	Pathogenic (Jul 2, 2019)	criteria provided, single submitter
Select item 5834377.	NC_000016.10:g.(?_23603449)_(23626407_?)del GRCh37: Chr16:23614770-23637728 GRCh38: Chr16:23603449-23626407	PALB2		Familial cancer of breast	Pathogenic (Apr 22, 2019)	criteria provided, single submitter
Select item 4606518.	NC_000016.10:g.(?_23603453)_(23614097_?)del GRCh37: Chr16:23614774-23625418 GRCh38: Chr16:23603453-23614097	PALB2		Familial cancer of breast	Pathogenic (Feb 9, 2018)	criteria provided, single submitter
Select item 10489839.	NM_024675.4(PALB2):c.3351-150_*2del GRCh37: Chr16:23614778-23615140 GRCh38: Chr16:23603457-23603819	PALB2		Malignant tumor of breast	Likely pathogenic	no assertion criteria provided
Select item 21988010.	NM_024675.3(PALB2):c.3202-?_*(1_?)del GRCh37: Chr16:23614779-23619333 GRCh38: Chr16:23603458-23608012	PALB2		Hereditary cancer-predisposing syndrome	Pathogenic (Nov 20, 2015)	criteria provided, single submitter
Select item 21981611.	NM_024675.3(PALB2):c.3114-?_*(1_?)del GRCh37: Chr16:23614779-23625412 GRCh38: Chr16:23603458-23614091	PALB2		Familial cancer of breast	Pathogenic (Aug 11, 2015)	criteria provided, single submitter
Select item 18837212.	NM_024675.3(PALB2):c.3351-?_*(1_?)del GRCh37: Chr16:23614779-23614990 GRCh38: Chr16:23603458-23603669	PALB2		Familial cancer of breast	Pathogenic (May 17, 2015)	criteria provided, single submitter
Select item 43784313.	NC_000016.10:g.(?_23603459)_(23608012_?)del GRCh37: Chr16:23614780-23619333 GRCh38: Chr16:23603459-23608012	PALB2		Familial cancer of breast	Pathogenic (Oct 3, 2016)	criteria provided, single submitter
Select item 43784014.	NC_000016.10:g.(?_23603459)_(23626397_?)del GRCh37: Chr16:23614780-23637718 GRCh38: Chr16:23603459-23626397	PALB2		Familial cancer of breast	Pathogenic (Nov 25, 2016)	criteria provided, single submitter
Select item 12814415.	NM_024675.4(PALB2):c.3549C>A (p.Tyr1183Ter) GRCh37: Chr16:23614792 GRCh38: Chr16:23603471	PALB2	Y1183*	Hereditary breast ovarian cancer syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N, Pancreatic cancer, susceptibility to, 3, not provided	Pathogenic (Oct 21, 2022)	criteria provided, multiple submitters, no conflicts
Select item 124516.	NM_024675.4(PALB2):c.3549C>G (p.Tyr1183Ter) GRCh37: Chr16:23614792 GRCh38: Chr16:23603471	PALB2	Y1183*	PALB2-Related Disorders, Hereditary cancer-predisposing syndrome, not provided, Familial cancer of breast, Fanconi anemia complementation group N	Pathogenic/Likely pathogenic (Nov 15, 2022)	criteria provided, multiple submitters, no conflicts
Select item 57943017.	NM_024675.4(PALB2):c.3542_3543dup (p.Val1182fs) GRCh37: Chr16:23614797-23614798 GRCh38: Chr16:23603476-23603477	PALB2	V1182fs	Familial cancer of breast	Pathogenic (Jul 14, 2021)	criteria provided, single submitter
Select item 94479918.	NM_024675.4(PALB2):c.3543del (p.Phe1181fs) GRCh37: Chr16:23614798 GRCh38: Chr16:23603477	PALB2	F1181fs	Familial cancer of breast	Pathogenic (Aug 13, 2021)	criteria provided, single submitter
Select item 142846119.	NM_024675.4(PALB2):c.3528_3540del (p.Lys1176fs) GRCh37: Chr16:23614801-23614813 GRCh38: Chr16:23603480-23603492	PALB2	K1176fs	Familial cancer of breast	Pathogenic (Jul 27, 2022)	criteria provided, single submitter
Select item 117287920.	NM_024675.4(PALB2):c.3523_3529delinsAAAAAAAAA (p.Gln1175fs) GRCh37: Chr16:23614812-23614818 GRCh38: Chr16:23603491-23603497	PALB2	Q1175fs	Malignant tumor of breast	Likely pathogenic (Jun 2, 2021)	criteria provided, single submitter
Select item 53007021.	NM_024675.4(PALB2):c.3523C>T (p.Gln1175Ter) GRCh37: Chr16:23614818 GRCh38: Chr16:23603497	PALB2	Q1175*	Familial cancer of breast, Hereditary cancer-predisposing syndrome	Pathogenic (Feb 7, 2022)	criteria provided, multiple submitters, no conflicts
Select item 14097822.	NM_024675.4(PALB2):c.3507_3508del (p.His1170fs) GRCh37: Chr16:23614833-23614834 GRCh38: Chr16:23603512-23603513	PALB2	H1170fs	PALB2-Related Disorders, Hereditary cancer-predisposing syndrome, not provided, Hereditary breast ovarian cancer syndrome, Familial cancer of breast, Fanconi anemia complementation group N	Pathogenic/Likely pathogenic (Oct 21, 2022)	criteria provided, multiple submitters, no conflicts
Select item 145472623.	NM_024675.4(PALB2):c.3501_3504del (p.Asp1168fs) GRCh37: Chr16:23614837-23614840 GRCh38: Chr16:23603516-23603519	PALB2	D1168fs	Familial cancer of breast	Pathogenic (Jan 27, 2022)	criteria provided, single submitter
Select item 145678924.	NM_024675.4(PALB2):c.3498_3502del (p.Thr1167fs) GRCh37: Chr16:23614839-23614843 GRCh38: Chr16:23603518-23603522	PALB2	T1167fs	Familial cancer of breast	Pathogenic (Oct 31, 2022)	criteria provided, single submitter
Select item 107184325.	NM_024675.4(PALB2):c.3501_3502insTGGCCGGGCGCGGTGGCTCACGCCTGTAGTCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCATGAGGTCAGGAGATCGAGACCATCCTGGCTAACAAGGTGAAACCCCNNNNNNNNNNAAAAAAAAAAAAAAAAAAAAGAAATGGTCGGGTACA (p.Asp1168delinsTrpProGlyAlaValAlaHisAlaCysSerProSerThrLeuGlyGlyArgGlyGlyTrpIleMetArgSerGlyAspArgAspHisProGlyTer) GRCh37: Chr16:23614839-23614840 GRCh38: Chr16:23603518-23603519	PALB2		Familial cancer of breast	Pathogenic (Feb 28, 2022)	criteria provided, single submitter
Select item 14397526.	NM_024675.4(PALB2):c.3497_3498del (p.Gly1166fs) GRCh37: Chr16:23614843-23614844 GRCh38: Chr16:23603522-23603523	PALB2	G1166fs	Familial cancer of breast, not provided	Pathogenic (May 13, 2019)	no assertion criteria provided
Select item 12674627.	NM_024675.4(PALB2):c.3497del (p.Gly1166fs) GRCh37: Chr16:23614844 GRCh38: Chr16:23603523	PALB2	G1166fs	Hereditary cancer-predisposing syndrome	Pathogenic (Oct 18, 2021)	criteria provided, single submitter
Select item 107516728.	NM_024675.4(PALB2):c.3494dup (p.Thr1167fs) GRCh37: Chr16:23614846-23614847 GRCh38: Chr16:23603525-23603526	PALB2	T1167fs	Familial cancer of breast	Pathogenic (Aug 27, 2021)	criteria provided, single submitter
Select item 53019929.	NM_024675.4(PALB2):c.3494C>A (p.Ser1165Ter) GRCh37: Chr16:23614847 GRCh38: Chr16:23603526	PALB2	S1165*	Familial cancer of breast	Pathogenic (Mar 14, 2022)	criteria provided, single submitter
Select item 24635430.	NM_024675.4(PALB2):c.3492G>A (p.Trp1164Ter) GRCh37: Chr16:23614849 GRCh38: Chr16:23603528	PALB2	W1164*	Hereditary cancer-predisposing syndrome, not provided, Familial cancer of breast	Pathogenic/Likely pathogenic (May 4, 2022)	criteria provided, multiple submitters, no conflicts
Select item 24612931.	NM_024675.4(PALB2):c.3491G>A (p.Trp1164Ter) GRCh37: Chr16:23614850 GRCh38: Chr16:23603529	PALB2	W1164*	Hereditary cancer-predisposing syndrome, not provided, Familial cancer of breast	Pathogenic/Likely pathogenic (Jul 19, 2022)	criteria provided, multiple submitters, no conflicts
Select item 125569732.	NM_024675.4(PALB2):c.3483del (p.Phe1161fs) GRCh37: Chr16:23614858 GRCh38: Chr16:23603537	PALB2	F1161fs	Breast and/or ovarian cancer, Hereditary cancer-predisposing syndrome	Likely pathogenic (Nov 2, 2020)	criteria provided, multiple submitters, no conflicts
Select item 65569633.	NM_024675.4(PALB2):c.3477G>A (p.Trp1159Ter) GRCh37: Chr16:23614864 GRCh38: Chr16:23603543	PALB2	W1159*	Familial cancer of breast	Pathogenic (Sep 1, 2021)	criteria provided, single submitter
Select item 23066434.	NM_024675.4(PALB2):c.3473_3476dup (p.Trp1159Ter) GRCh37: Chr16:23614864-23614865 GRCh38: Chr16:23603543-23603544	PALB2	W1159*	Hereditary cancer-predisposing syndrome	Pathogenic (Apr 17, 2017)	criteria provided, single submitter
Select item 14184135.	NM_024675.4(PALB2):c.3476G>A (p.Trp1159Ter) GRCh37: Chr16:23614865 GRCh38: Chr16:23603544	PALB2	W1159*	Hereditary cancer-predisposing syndrome	Pathogenic (Apr 22, 2016)	criteria provided, single submitter
Select item 145555336.	NM_024675.4(PALB2):c.3475del (p.Trp1159fs) GRCh37: Chr16:23614866 GRCh38: Chr16:23603545	PALB2	W1159fs	Familial cancer of breast	Pathogenic (May 30, 2022)	criteria provided, single submitter
Select item 82380637.	NM_024675.4(PALB2):c.3469C>T (p.Gln1157Ter) GRCh37: Chr16:23614872 GRCh38: Chr16:23603551	PALB2	Q1157*	Familial cancer of breast, Hereditary cancer-predisposing syndrome	Pathogenic (May 21, 2022)	criteria provided, multiple submitters, no conflicts
Select item 136740338.	NM_024675.4(PALB2):c.3464_3465del (p.Val1154_Ser1155insTer) GRCh37: Chr16:23614876-23614877 GRCh38: Chr16:23603555-23603556	PALB2		Familial cancer of breast, Hereditary cancer-predisposing syndrome	Pathogenic (Oct 14, 2021)	criteria provided, multiple submitters, no conflicts
Select item 173157739.	NM_024675.4(PALB2):c.3453_3459del (p.Pro1152fs) GRCh37: Chr16:23614882-23614888 GRCh38: Chr16:23603561-23603567	PALB2	P1152fs	Hereditary cancer-predisposing syndrome	Pathogenic (Oct 27, 2020)	criteria provided, single submitter
Select item 12814240.	NM_024675.4(PALB2):c.3456dup (p.Pro1153fs) GRCh37: Chr16:23614884-23614885 GRCh38: Chr16:23603563-23603564	PALB2	P1153fs	Hereditary cancer-predisposing syndrome, not provided, Familial cancer of breast	Pathogenic (Oct 26, 2022)	criteria provided, multiple submitters, no conflicts
Select item 66449041.	NM_024675.4(PALB2):c.3455del (p.Pro1152fs) GRCh37: Chr16:23614886 GRCh38: Chr16:23603565	PALB2	P1152fs	Familial cancer of breast	Pathogenic (Oct 3, 2018)	criteria provided, single submitter
Select item 173152142.	NM_024675.4(PALB2):c.3448_3450delinsTT (p.Leu1150fs) GRCh37: Chr16:23614891-23614893 GRCh38: Chr16:23603570-23603572	PALB2	L1150fs	Hereditary cancer-predisposing syndrome	Likely pathogenic (Sep 26, 2022)	criteria provided, single submitter
Select item 132002843.	NM_024675.4(PALB2):c.3446_3447insAGTACAGC (p.Leu1150fs) GRCh37: Chr16:23614894-23614895 GRCh38: Chr16:23603573-23603574	PALB2	L1150fs	Familial cancer of breast	Likely pathogenic (Jun 30, 2021)	no assertion criteria provided
Select item 54600844.	NM_024675.4(PALB2):c.3441T>A (p.Cys1147Ter) GRCh37: Chr16:23614900 GRCh38: Chr16:23603579	PALB2	C1147*	not provided, Hereditary cancer-predisposing syndrome, Familial cancer of breast	Pathogenic (Jan 11, 2022)	criteria provided, multiple submitters, no conflicts
Select item 46099445.	NM_024675.4(PALB2):c.3436C>T (p.Gln1146Ter) GRCh37: Chr16:23614905 GRCh38: Chr16:23603584	PALB2	Q1146*	Hereditary cancer-predisposing syndrome, Familial cancer of breast	Pathogenic (Oct 13, 2022)	criteria provided, multiple submitters, no conflicts
Select item 18579946.	NM_024675.4(PALB2):c.3426_3429del (p.Leu1142fs) GRCh37: Chr16:23614912-23614915 GRCh38: Chr16:23603591-23603594	PALB2	L1142fs	Hereditary cancer-predisposing syndrome, Familial cancer of breast, not provided	Pathogenic (Jan 10, 2023)	criteria provided, multiple submitters, no conflicts
Select item 14397447.	NM_024675.4(PALB2):c.3426dup (p.Leu1143fs) GRCh37: Chr16:23614914-23614915 GRCh38: Chr16:23603593-23603594	PALB2	L1143fs	Hereditary cancer-predisposing syndrome, Familial cancer of breast, not provided	Pathogenic (Sep 6, 2022)	criteria provided, multiple submitters, no conflicts
Select item 94486448.	NM_024675.4(PALB2):c.3425T>G (p.Leu1142Ter) GRCh37: Chr16:23614916 GRCh38: Chr16:23603595	PALB2	L1142*	Hereditary cancer-predisposing syndrome, Familial cancer of breast	Pathogenic (Jul 11, 2022)	criteria provided, multiple submitters, no conflicts
Select item 54601049.	NM_024675.4(PALB2):c.3425T>A (p.Leu1142Ter) GRCh37: Chr16:23614916 GRCh38: Chr16:23603595	PALB2	L1142*	not provided, Familial cancer of breast	Pathogenic (Aug 24, 2021)	criteria provided, multiple submitters, no conflicts
Select item 37184050.	NM_024675.4(PALB2):c.3425del (p.Leu1142fs) GRCh37: Chr16:23614916 GRCh38: Chr16:23603595	PALB2	L1142fs	Familial cancer of breast, Hereditary cancer-predisposing syndrome	Pathogenic/Likely pathogenic (Oct 27, 2021)	criteria provided, multiple submitters, no conflicts
Select item 24156451.	NM_024675.4(PALB2):c.3420G>A (p.Trp1140Ter) GRCh37: Chr16:23614921 GRCh38: Chr16:23603600	PALB2	W1140*	Familial cancer of breast	Pathogenic (Jul 12, 2021)	criteria provided, single submitter
Select item 169879152.	NM_024675.4(PALB2):c.3418del (p.Trp1140fs) GRCh37: Chr16:23614923 GRCh38: Chr16:23603602	PALB2	W1140fs	Familial cancer of breast	Likely pathogenic (Jul 22, 2020)	criteria provided, single submitter
Select item 210752653.	NM_024675.4(PALB2):c.3407del (p.Thr1136fs) GRCh37: Chr16:23614934 GRCh38: Chr16:23603613	PALB2	T1136fs	Familial cancer of breast	Pathogenic (Mar 8, 2022)	criteria provided, single submitter
Select item 23357054.	NM_024675.4(PALB2):c.3396_3405del (p.Thr1133fs) GRCh37: Chr16:23614936-23614945 GRCh38: Chr16:23603615-23603624	PALB2	T1133fs	Hereditary cancer-predisposing syndrome, Familial cancer of breast	Pathogenic (Aug 12, 2021)	criteria provided, multiple submitters, no conflicts
Select item 82371755.	NM_024675.4(PALB2):c.3395T>A (p.Leu1132Ter) GRCh37: Chr16:23614946 GRCh38: Chr16:23603625	PALB2	L1132*	Hereditary cancer-predisposing syndrome	Pathogenic (Mar 2, 2020)	criteria provided, multiple submitters, no conflicts
Select item 23368656.	NM_024675.4(PALB2):c.3374_3395del (p.Asp1125fs) GRCh37: Chr16:23614946-23614967 GRCh38: Chr16:23603625-23603646	PALB2		not provided, Familial cancer of breast, Hereditary cancer-predisposing syndrome	Pathogenic/Likely pathogenic (Sep 28, 2022)	criteria provided, multiple submitters, no conflicts
Select item 92326057.	NM_024675.4(PALB2):c.3392del (p.Ile1131fs) GRCh37: Chr16:23614949 GRCh38: Chr16:23603628	PALB2	I1131fs	Hereditary cancer-predisposing syndrome	Pathogenic (Jan 15, 2020)	criteria provided, single submitter
Select item 12673958.	NM_024675.4(PALB2):c.3362del (p.Gly1121fs) GRCh37: Chr16:23614979 GRCh38: Chr16:23603658	PALB2		Hereditary cancer-predisposing syndrome, Breast and/or ovarian cancer, not provided, Hereditary breast ovarian cancer syndrome, Familial cancer of breast	Pathogenic/Likely pathogenic (Jan 4, 2023)	criteria provided, multiple submitters, no conflicts
Select item 23078959.	NM_024675.4(PALB2):c.3358G>T (p.Glu1120Ter) GRCh37: Chr16:23614983 GRCh38: Chr16:23603662	PALB2	E1120*	Hereditary cancer-predisposing syndrome	Pathogenic (Aug 3, 2020)	criteria provided, multiple submitters, no conflicts
Select item 107235560.	NM_024675.4(PALB2):c.3351-1G>A GRCh37: Chr16:23614991 GRCh38: Chr16:23603670	PALB2		Familial cancer of breast	Pathogenic (Sep 1, 2021)	criteria provided, single submitter
Select item 82365061.	NM_024675.4(PALB2):c.3351-1G>C GRCh37: Chr16:23614991 GRCh38: Chr16:23603670	PALB2		Hereditary cancer-predisposing syndrome	Likely pathogenic (Oct 11, 2022)	criteria provided, single submitter
Select item 171322962.	NM_024675.4(PALB2):c.3351-2A>T GRCh37: Chr16:23614992 GRCh38: Chr16:23603671	PALB2		Hereditary cancer-predisposing syndrome	Likely pathogenic (Jan 9, 2020)	criteria provided, single submitter
Select item 41015263.	NM_024675.4(PALB2):c.3351-2A>G GRCh37: Chr16:23614992 GRCh38: Chr16:23603671	PALB2		Hereditary cancer-predisposing syndrome, Familial cancer of breast	Likely pathogenic (Nov 3, 2022)	criteria provided, multiple submitters, no conflicts
Select item 58381264.	NC_000016.9:g.(?_23619175)_(23619343_?)dup GRCh37: Chr16:23619175-23619343 GRCh38: Chr16:23607854-23608022	PALB2		Familial cancer of breast	Likely pathogenic (Jan 15, 2022)	criteria provided, single submitter
Select item 48203665.	NM_024675.4(PALB2):c.3350+4A>C GRCh37: Chr16:23619181 GRCh38: Chr16:23607860	PALB2		Hereditary cancer-predisposing syndrome, Familial cancer of breast	Likely pathogenic (Oct 1, 2021)	criteria provided, multiple submitters, no conflicts
Select item 12673766.	NM_024675.4(PALB2):c.3350+4A>G GRCh37: Chr16:23619181 GRCh38: Chr16:23607860	PALB2		PALB2-Related Disorders, Hereditary cancer-predisposing syndrome, not provided, Familial cancer of breast	Pathogenic/Likely pathogenic (Oct 20, 2022)	criteria provided, multiple submitters, no conflicts
Select item 49221867.	NM_024675.4(PALB2):c.3350+2C>G GRCh37: Chr16:23619183 GRCh38: Chr16:23607862	PALB2		Hereditary cancer-predisposing syndrome, Familial cancer of breast	Likely pathogenic (Oct 13, 2022)	criteria provided, multiple submitters, no conflicts
Select item 21964168.	NM_024675.4(PALB2):c.3350+1G>A GRCh37: Chr16:23619184 GRCh38: Chr16:23607863	PALB2		Familial cancer of breast	Pathogenic (Oct 1, 2020)	criteria provided, single submitter
Select item 18809369.	NM_024675.3(PALB2):c.3114-?_3350+?del GRCh37: Chr16:23619185-23625412 GRCh38: Chr16:23607864-23614091	PALB2		Familial cancer of breast	Likely pathogenic (Nov 24, 2016)	criteria provided, single submitter
Select item 57756470.	NM_024675.4(PALB2):c.3340C>T (p.Gln1114Ter) GRCh37: Chr16:23619195 GRCh38: Chr16:23607874	PALB2	Q1114*	Familial cancer of breast, Hereditary cancer-predisposing syndrome	Pathogenic (Jan 17, 2022)	criteria provided, multiple submitters, no conflicts
Select item 80323171.	NM_024675.4(PALB2):c.3332del (p.Pro1111fs) GRCh37: Chr16:23619203 GRCh38: Chr16:23607882	PALB2	P1111fs	Familial cancer of breast, Hereditary cancer-predisposing syndrome	Pathogenic (Jun 3, 2022)	criteria provided, multiple submitters, no conflicts
Select item 46099072.	NM_024675.4(PALB2):c.3324C>G (p.Tyr1108Ter) GRCh37: Chr16:23619211 GRCh38: Chr16:23607890	PALB2	Y1108*	Familial cancer of breast, Hereditary cancer-predisposing syndrome	Pathogenic/Likely pathogenic (Jul 12, 2022)	criteria provided, multiple submitters, no conflicts
Select item 45025673.	NM_024675.4(PALB2):c.3324C>A (p.Tyr1108Ter) GRCh37: Chr16:23619211 GRCh38: Chr16:23607890	PALB2	Y1108*	not provided	Likely pathogenic (Jun 29, 2017)	criteria provided, single submitter
Select item 12673474.	NM_024675.4(PALB2):c.3323del (p.Tyr1108fs) GRCh37: Chr16:23619212 GRCh38: Chr16:23607891	PALB2		Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N, Pancreatic cancer, susceptibility to, 3, not provided, Hereditary breast ovarian cancer syndrome, Familial cancer of breast, Fanconi anemia complementation group N	Pathogenic (Oct 24, 2022)	criteria provided, multiple submitters, no conflicts
Select item 169682175.	NM_024675.4(PALB2):c.3314_3315del (p.Val1105fs) GRCh37: Chr16:23619220-23619221 GRCh38: Chr16:23607899-23607900	PALB2	V1105fs	Lynch syndrome 1	Likely pathogenic (Nov 16, 2021)	criteria provided, single submitter
Select item 243128576.	NM_024675.4(PALB2):c.3313dup (p.Val1105fs) GRCh37: Chr16:23619221-23619222 GRCh38: Chr16:23607900-23607901	PALB2	V1105fs	Familial cancer of breast	Pathogenic (Jan 12, 2023)	criteria provided, single submitter
Select item 40230777.	NM_024675.4(PALB2):c.3311del (p.Gly1104fs) GRCh37: Chr16:23619224 GRCh38: Chr16:23607903	PALB2	G1104fs	Hereditary cancer-predisposing syndrome, not provided	Pathogenic (Apr 8, 2020)	criteria provided, multiple submitters, no conflicts
Select item 92717978.	NM_024675.4(PALB2):c.3295_3310delinsCGTGGT (p.Thr1099fs) GRCh37: Chr16:23619225-23619240 GRCh38: Chr16:23607904-23607919	PALB2	T1099fs	Hereditary cancer-predisposing syndrome, Familial cancer of breast	Pathogenic (Jan 15, 2020)	criteria provided, multiple submitters, no conflicts
Select item 208971679.	NM_024675.4(PALB2):c.3302_3306dup (p.Val1103fs) GRCh37: Chr16:23619228-23619229 GRCh38: Chr16:23607907-23607908	PALB2	V1103fs	Familial cancer of breast	Pathogenic (Jan 26, 2022)	criteria provided, single submitter
Select item 46098680.	NM_024675.4(PALB2):c.3299_3306dup (p.Val1103fs) GRCh37: Chr16:23619228-23619229 GRCh38: Chr16:23607907-23607908	PALB2	V1103fs	Hereditary cancer-predisposing syndrome, not provided, Familial cancer of breast	Pathogenic (Jan 26, 2022)	criteria provided, multiple submitters, no conflicts
Select item 145589081.	NM_024675.4(PALB2):c.3305_3306insACGCTCAG (p.Ser1102fs) GRCh37: Chr16:23619229-23619230 GRCh38: Chr16:23607908-23607909	PALB2	S1102fs	Familial cancer of breast	Pathogenic (Oct 27, 2021)	criteria provided, single submitter
Select item 57522182.	NM_024675.4(PALB2):c.3302_3303del (p.Leu1101fs) GRCh37: Chr16:23619232-23619233 GRCh38: Chr16:23607911-23607912	PALB2	L1101fs	Familial cancer of breast, Hereditary cancer-predisposing syndrome	Pathogenic (Jul 14, 2021)	criteria provided, multiple submitters, no conflicts
Select item 58077583.	NM_024675.4(PALB2):c.3297_3301del (p.Thr1100fs) GRCh37: Chr16:23619234-23619238 GRCh38: Chr16:23607913-23607917	PALB2	T1100fs	Hereditary cancer-predisposing syndrome, Familial cancer of breast	Pathogenic (Feb 18, 2022)	criteria provided, multiple submitters, no conflicts
Select item 26557284.	NM_024675.4(PALB2):c.3295_3301del (p.Thr1099fs) GRCh37: Chr16:23619234-23619240 GRCh38: Chr16:23607913-23607919	PALB2	T1099fs	not provided	Likely pathogenic (Jun 28, 2017)	criteria provided, single submitter
Select item 83020285.	NM_024675.4(PALB2):c.3294_3298del (p.Lys1098fs) GRCh37: Chr16:23619237-23619241 GRCh38: Chr16:23607916-23607920	PALB2	K1098fs	Fanconi anemia complementation group N	Pathogenic (May 13, 2019)	no assertion criteria provided
Select item 63334486.	NM_024675.4(PALB2):c.3297_3298insT (p.Thr1100fs) GRCh37: Chr16:23619237-23619238 GRCh38: Chr16:23607916-23607917	PALB2	T1100fs	Familial cancer of breast	Pathogenic/Likely pathogenic (Jan 4, 2022)	criteria provided, multiple submitters, no conflicts
Select item 202985287.	NM_024675.4(PALB2):c.3293_3296dup (p.Thr1100fs) GRCh37: Chr16:23619238-23619239 GRCh38: Chr16:23607917-23607918	PALB2	T1100fs	Familial cancer of breast	Pathogenic (Oct 31, 2022)	criteria provided, single submitter
Select item 95052988.	NM_024675.4(PALB2):c.3296del (p.Thr1099fs) GRCh37: Chr16:23619239 GRCh38: Chr16:23607918	PALB2	T1099fs	Familial cancer of breast	Pathogenic (Aug 31, 2021)	criteria provided, multiple submitters, no conflicts
Select item 172984289.	NM_024675.4(PALB2):c.3290_3292delinsAT (p.Pro1097fs) GRCh37: Chr16:23619243-23619245 GRCh38: Chr16:23607922-23607924	PALB2	P1097fs	Hereditary cancer-predisposing syndrome	Likely pathogenic (Aug 19, 2022)	criteria provided, single submitter
Select item 22031090.	NM_024675.4(PALB2):c.3286_3289delinsGTTAATGA (p.Asn1096fs) GRCh37: Chr16:23619246-23619249 GRCh38: Chr16:23607925-23607928	PALB2	N1096fs	Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome, Familial cancer of breast, not provided	Pathogenic (Jan 20, 2023)	criteria provided, multiple submitters, no conflicts
Select item 107574691.	NM_024675.4(PALB2):c.3285_3286insGTTAATG (p.Asn1096fs) GRCh37: Chr16:23619249-23619250 GRCh38: Chr16:23607928-23607929	PALB2	N1096fs	Familial cancer of breast	Pathogenic (Aug 31, 2021)	criteria provided, single submitter
Select item 209980592.	NM_024675.4(PALB2):c.3272dup (p.Leu1092fs) GRCh37: Chr16:23619262-23619263 GRCh38: Chr16:23607941-23607942	PALB2	L1092fs	Familial cancer of breast	Pathogenic (Feb 20, 2022)	criteria provided, single submitter
Select item 21951893.	NM_024675.4(PALB2):c.3271C>T (p.Gln1091Ter) GRCh37: Chr16:23619264 GRCh38: Chr16:23607943	PALB2	Q1091*	not provided, Hereditary cancer-predisposing syndrome, Familial cancer of breast	Pathogenic/Likely pathogenic (Jun 22, 2022)	criteria provided, multiple submitters, no conflicts
Select item 14162794.	NM_024675.4(PALB2):c.3267_3268del (p.Phe1090fs) GRCh37: Chr16:23619267-23619268 GRCh38: Chr16:23607946-23607947	PALB2	F1090fs	Hereditary cancer-predisposing syndrome, Familial cancer of breast	Pathogenic (Sep 21, 2022)	criteria provided, multiple submitters, no conflicts
Select item 95169895.	NM_024675.4(PALB2):c.3263del (p.Pro1088fs) GRCh37: Chr16:23619272 GRCh38: Chr16:23607951	PALB2	P1088fs	Familial cancer of breast	Pathogenic (Jun 14, 2019)	criteria provided, single submitter
Select item 145686496.	NM_024675.4(PALB2):c.3249_3258del (p.Ser1084fs) GRCh37: Chr16:23619277-23619286 GRCh38: Chr16:23607956-23607965	PALB2	S1084fs	Familial cancer of breast	Pathogenic (Jun 25, 2021)	criteria provided, single submitter
Select item 83020097.	NM_024675.4(PALB2):c.3255dup (p.Arg1086fs) GRCh37: Chr16:23619279-23619280 GRCh38: Chr16:23607958-23607959	PALB2	R1086fs	not provided	Pathogenic (Dec 23, 2019)	no assertion criteria provided
Select item 37197198.	NM_024675.4(PALB2):c.3256del (p.Arg1086fs) GRCh37: Chr16:23619279 GRCh38: Chr16:23607958	PALB2	R1086fs	Hereditary cancer-predisposing syndrome, Familial cancer of breast	Pathogenic/Likely pathogenic (May 9, 2022)	criteria provided, multiple submitters, no conflicts
Select item 12672999.	NM_024675.4(PALB2):c.3256C>T (p.Arg1086Ter) GRCh37: Chr16:23619279 GRCh38: Chr16:23607958	PALB2	R1086*	Hereditary breast ovarian cancer syndrome, Breast and/or ovarian cancer, Familial cancer of breast, PALB2-Related Disorders, Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N, Pancreatic cancer, susceptibility to, 3, not provided, Malignant tumor of breast	Pathogenic/Likely pathogenic (Jan 27, 2023)	criteria provided, multiple submitters, no conflicts
Select item 630713100.	NM_024675.3(PALB2):c.3249_3253delinsAGCC (p.Ser1084fs) GRCh37: Chr16:23619282-23619286 GRCh38: Chr16:23607961-23607965	PALB2		Hereditary cancer-predisposing syndrome	Pathogenic (Oct 23, 2017)	criteria provided, single submitter

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