WT1[gene] AND (clinsig_pathogenic[prop] OR clinsig_likely_pathogenic[p - ClinVar

Search results

Items: 73

VariationLocation		Gene(s)	Protein change	Condition(s)	Clinical significance (Last reviewed)	Review status
Select item 10770361.	NM_024426.6(WT1):c.1534C>T (p.Gln512Ter) GRCh37: Chr11:32410639 GRCh38: Chr11:32389093	WT1	Q116, Q278, Q292, Q492, Q509, Q512, Q464, Q454, Q465, Q490, Q495, Q507, Q258, Q468, Q481*	Nephrotic syndrome, type 4	Pathogenic	criteria provided, single submitter
Select item 6641132.	NM_024426.6(WT1):c.1499G>A (p.Arg500Gln) GRCh37: Chr11:32410674 GRCh38: Chr11:32389128	WT1	R480Q, R497Q, R280Q, R104Q, R266Q, R500Q, R442Q, R483Q, R495Q, R452Q, R453Q, R456Q, R469Q, R246Q, R478Q	Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome	Pathogenic (Jun 14, 2022)	criteria provided, single submitter
Select item 5623773.	NM_024426.6(WT1):c.1448G>A (p.Ser483Asn) GRCh37: Chr11:32410725 GRCh38: Chr11:32389179	WT1	G263D, S483N, G463D, S249N, S87N, G480D, S461N, S466N, G452D, G478D, S436N, G439D, S229N, G435D, S425N	not provided	Likely pathogenic (Sep 16, 2018)	no assertion criteria provided
Select item 13385324.	NM_024426.6(WT1):c.1448-20_1448-1del GRCh37: Chr11:32410726-32410745 GRCh38: Chr11:32389180-32389199	WT1		not provided	Likely pathogenic (Jul 18, 2019)	criteria provided, single submitter
Select item 34865.	NM_024426.6(WT1):c.1447+6T>A GRCh37: Chr11:32413512 GRCh38: Chr11:32391966	WT1		Frasier syndrome	Pathogenic (Dec 1, 1997)	no assertion criteria provided
Select item 34936.	NM_024426.6(WT1):c.1447+5G>A GRCh37: Chr11:32413513 GRCh38: Chr11:32391967	WT1		Wilms tumor 1, 11p partial monosomy syndrome, Frasier syndrome, Drash syndrome, Wilms tumor 1, 11p partial monosomy syndrome, Meacham syndrome, Aniridia 1, Nephrotic syndrome, type 4, Frasier syndrome, Mesothelioma, malignantDrash syndrome, Familial idiopathic steroid-resistant nephrotic syndrome, not provided, Nephrotic syndrome, type 4, Drash syndrome, Frasier syndrome, ...see more	Pathogenic (Oct 14, 2022)	criteria provided, multiple submitters, no conflicts
Select item 35007.	NM_024426.6(WT1):c.1447+4C>T GRCh37: Chr11:32413514 GRCh38: Chr11:32391968	WT1		Wilms tumor 1, 11p partial monosomy syndrome, Frasier syndrome, Drash syndrome, not provided, Nephrotic syndrome, type 4, Frasier syndrome	Pathogenic/Likely pathogenic (Dec 30, 2022)	criteria provided, multiple submitters, no conflicts
Select item 9473098.	NM_024426.6(WT1):c.1447+2T>C GRCh37: Chr11:32413516 GRCh38: Chr11:32391970	WT1		Drash syndrome, Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome	Likely pathogenic (Jun 16, 2019)	criteria provided, single submitter
Select item 6232239.	NM_024426.6(WT1):c.1421A>C (p.His474Pro) GRCh37: Chr11:32413544 GRCh38: Chr11:32391998	WT1	H257P, H474P, H240P, H457P, H78P, H427P, H220P, H433P, H472P, H416P, H452P	Drash syndrome	Likely pathogenic (Mar 28, 2017)	criteria provided, single submitter
Select item 167875110.	NM_024426.6(WT1):c.1420C>T (p.His474Tyr) GRCh37: Chr11:32413545 GRCh38: Chr11:32391999	WT1	H240Y, H257Y, H457Y, H474Y, H78Y, H220Y, H416Y, H427Y, H452Y, H433Y, H469Y, H472Y	not provided	Likely pathogenic (Jun 21, 2019)	criteria provided, single submitter
Select item 348911.	NM_024426.6(WT1):c.1406A>G (p.Asp469Gly) GRCh37: Chr11:32413559 GRCh38: Chr11:32392013	WT1	D252G, D452G, D469G, D73G, D235G, D428G, D215G, D422G, D467G, D411G	Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome, Frasier syndrome	Likely pathogenic (Jul 14, 2021)	criteria provided, single submitter
Select item 54716712.	NM_024426.6(WT1):c.1405G>T (p.Asp469Tyr) GRCh37: Chr11:32413560 GRCh38: Chr11:32392014	WT1	D252Y, D452Y, D469Y, D235Y, D73Y, D411Y, D447Y, D215Y, D422Y, D428Y, D467Y	Drash syndrome, Nephrotic syndrome, type 4	Likely pathogenic (Mar 16, 2018)	criteria provided, single submitter
Select item 349013.	NM_024426.6(WT1):c.1405G>A (p.Asp469Asn) GRCh37: Chr11:32413560 GRCh38: Chr11:32392014	WT1	D252N, D452N, D469N, D235N, D73N, D215N, D428N, D411N, D422N, D467N	Nephrotic syndrome, type 4	Pathogenic (Jan 3, 2022)	criteria provided, single submitter
Select item 41933214.	NM_024426.6(WT1):c.1400G>A (p.Arg467Gln) GRCh37: Chr11:32413565 GRCh38: Chr11:32392019	WT1	R250Q, R467Q, R450Q, R71Q, R233Q, R213Q, R465Q, R409Q, R420Q, R445Q, R426Q	Frasier syndrome, Aniridia 1, Drash syndrome, Meacham syndrome, Mesothelioma, malignant, Nephrotic syndrome, type 4, Wilms tumor 1, 11p partial monosomy syndrome, Kidney disorder, not provided, Wilms tumor 1Frasier syndrome, ...see more	Pathogenic/Likely pathogenic (Jun 21, 2022)	criteria provided, multiple submitters, no conflicts
Select item 349115.	NM_024426.6(WT1):c.1400G>C (p.Arg467Pro) GRCh37: Chr11:32413565 GRCh38: Chr11:32392019	WT1	R250P, R450P, R467P, R71P, R233P, R213P, R420P, R426P, R409P, R465P	Drash syndrome	Pathogenic (May 1, 1992)	no assertion criteria provided
Select item 348716.	NM_024426.6(WT1):c.1399C>T (p.Arg467Trp) GRCh37: Chr11:32413566 GRCh38: Chr11:32392020	WT1	R250W, R467W, R233W, R450W, R71W, R465W, R213W, R409W, R420W, R426W	Drash syndrome, Wilms tumor 1, 11p partial monosomy syndrome, Frasier syndrome, Drash syndrome, Kidney disorder, not provided, Meacham syndrome, Wilms tumor 1, 11p partial monosomy syndrome, Nephrotic syndrome, type 4Frasier syndrome, Drash syndrome, Aniridia 1, Mesothelioma, malignant, ...see more	Pathogenic (Dec 22, 2022)	criteria provided, multiple submitters, no conflicts
Select item 350417.	NM_024426.6(WT1):c.1393T>C (p.Phe465Leu) GRCh37: Chr11:32413572 GRCh38: Chr11:32392026	WT1	F248L, F231L, F448L, F465L, F69L, F211L, F407L, F418L, F424L, F463L	Frasier syndrome	Pathogenic (Jan 1, 1999)	no assertion criteria provided
Select item 349418.	NM_024426.6(WT1):c.1387C>T (p.Arg463Ter) GRCh37: Chr11:32413578 GRCh38: Chr11:32392032	WT1	R246, R229, R446, R463, R67, R209, R461, R416, R405, R422	Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome, Meacham syndrome, Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome, Nephrotic syndrome, type 4, Aniridia 1, Drash syndromeMesothelioma, malignant, not provided, Focal segmental glomerulosclerosis, ...see more	Pathogenic (Jul 11, 2022)	criteria provided, multiple submitters, no conflicts
Select item 213704919.	NM_024426.6(WT1):c.1372T>C (p.Cys458Arg) GRCh37: Chr11:32413593 GRCh38: Chr11:32392047	WT1	C400R, C436R, C411R, C241R, C441R, C458R, C204R, C224R, C417R, C453R, C456R, C62R	Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome, Frasier syndrome	Pathogenic (May 29, 2022)	criteria provided, single submitter
Select item 350220.	NM_024426.6(WT1):c.1366T>C (p.Phe456Leu) GRCh37: Chr11:32413599 GRCh38: Chr11:32392053	WT1	F239L, F439L, F456L, F222L, F60L, F398L, F415L, F409L, F454L, F202L	Nephrotic syndrome, type 4	Pathogenic (Apr 1, 1998)	no assertion criteria provided
Select item 80266721.	NM_024426.6(WT1):c.1354+4_1354+11del GRCh37: Chr11:32414201-32414208 GRCh38: Chr11:32392655-32392662	WT1		Drash syndrome	Likely pathogenic (May 28, 2019)	criteria provided, single submitter
Select item 45318322.	NM_024426.6(WT1):c.1351A>C (p.Thr451Pro) GRCh37: Chr11:32414215 GRCh38: Chr11:32392669	WT1	T234P, T55P, T217P, T434P, T451P, T393P, T410P, T429P, T197P, T449P	not provided	Likely pathogenic (Nov 3, 2017)	criteria provided, single submitter
Select item 349523.	NM_024426.6(WT1):c.1348C>T (p.His450Tyr) GRCh37: Chr11:32414218 GRCh38: Chr11:32392672	WT1	H233Y, H216Y, H450Y, H433Y, H54Y, H196Y, H392Y, H409Y, H448Y	Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome, Frasier syndrome, Drash syndrome	Pathogenic/Likely pathogenic (Oct 9, 2022)	criteria provided, multiple submitters, no conflicts
Select item 97319324.	NM_024426.6(WT1):c.1338C>A (p.His446Gln) GRCh37: Chr11:32414228 GRCh38: Chr11:32392682	WT1	H429Q, H229Q, H212Q, H446Q, H50Q, H424Q, H192Q, H405Q, H444Q, H388Q, H441Q	Drash syndrome, Frasier syndrome, Wilms tumor 1, Drash syndrome, 11p partial monosomy syndrome, Frasier syndrome	Pathogenic (Oct 13, 2022)	criteria provided, multiple submitters, no conflicts
Select item 349825.	NM_024426.6(WT1):c.1338C>G (p.His446Gln) GRCh37: Chr11:32414228 GRCh38: Chr11:32392682	WT1	H229Q, H429Q, H212Q, H446Q, H50Q, H444Q, H192Q, H388Q, H405Q	Drash syndrome	Pathogenic (Oct 18, 2016)	no assertion criteria provided
Select item 170839526.	NM_024426.6(WT1):c.1322A>T (p.Asp441Val) GRCh37: Chr11:32414244 GRCh38: Chr11:32392698	WT1	D187V, D207V, D224V, D383V, D400V, D419V, D424V, D436V, D439V, D441V, D45V	Nephrotic syndrome, type 4	Likely pathogenic (Jan 14, 2022)	criteria provided, single submitter
Select item 348827.	NM_024426.6(WT1):c.1316G>A (p.Arg439His) GRCh37: Chr11:32414250 GRCh38: Chr11:32392704	WT1	R222H, R422H, R439H, R205H, R43H, R398H, R437H, R185H, R381H	Wilms tumor 1, Drash syndrome, Nephrotic syndrome, type 4, Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome, Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome, Meacham syndromeDrash syndrome, Aniridia 1, Nephrotic syndrome, type 4, Mesothelioma, malignant, Frasier syndrome, not provided, Nephrotic syndrome, type 4, Wilms tumor 1, ...see more	Pathogenic (Jan 17, 2022)	criteria provided, multiple submitters, no conflicts
Select item 350528.	NM_024426.6(WT1):c.1315C>T (p.Arg439Cys) GRCh37: Chr11:32414251 GRCh38: Chr11:32392705	WT1	R222C, R422C, R205C, R439C, R43C, R381C, R398C, R185C, R437C	not provided	Pathogenic (Jun 18, 2020)	criteria provided, multiple submitters, no conflicts
Select item 349729.	NM_024426.6(WT1):c.1303C>T (p.Arg435Ter) GRCh37: Chr11:32414263 GRCh38: Chr11:32392717	WT1	R218, R201, R39, R418, R435, R394, R377, R181, R433*	Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome, Frasier syndrome, Nephrotic syndrome, type 4, Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome, Meacham syndrome, Mesothelioma, malignant, Frasier syndromeAniridia 1, not provided, Wilms tumor 1, ...see more	Pathogenic (May 20, 2022)	criteria provided, multiple submitters, no conflicts
Select item 203349830.	NM_024426.6(WT1):c.1299T>A (p.Cys433Ter) GRCh37: Chr11:32414267 GRCh38: Chr11:32392721	WT1	C216, C375, C433, C392, C416, C199, C179, C37, C411, C428, C431*	Drash syndrome, Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome	Pathogenic (Sep 30, 2022)	criteria provided, single submitter
Select item 349631.	NM_024426.6(WT1):c.1297T>G (p.Cys433Gly) GRCh37: Chr11:32414269 GRCh38: Chr11:32392723	WT1	C216G, C199G, C37G, C433G, C416G, C179G, C392G, C431G, C375G	Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome, Frasier syndrome	Likely pathogenic (Apr 11, 2022)	criteria provided, single submitter
Select item 81290232.	NM_024426.6(WT1):c.1281G>C (p.Gln427His) GRCh37: Chr11:32414285 GRCh38: Chr11:32392739	WT1	Q427H, Q193H, Q410H, Q210H, Q31H, Q405H, Q173H, Q386H, Q425H, Q369H, Q422H	Nephrotic range proteinuria	Likely pathogenic	no assertion criteria provided
Select item 22289033.	NM_024426.6(WT1):c.1265G>T (p.Gly422Val) GRCh37: Chr11:32414301 GRCh38: Chr11:32392755	WT1	G205V, G422V, G405V, G188V, G26V, G364V, G420V, G400V, G168V, G381V	Familial idiopathic steroid-resistant nephrotic syndrome	Likely pathogenic (Oct 22, 2015)	criteria provided, single submitter
Select item 47667234.	NC_000011.10:g.(?_32396251)_(32417660_?)del GRCh37: Chr11:32417797-32439206 GRCh38: Chr11:32396251-32417660	WT1		Wilms tumor 1, 11p partial monosomy syndrome, Frasier syndrome, Drash syndrome	Pathogenic (Aug 12, 2021)	criteria provided, single submitter
Select item 52240135.	NM_024426.6(WT1):c.1259A>C (p.His420Pro) GRCh37: Chr11:32417808 GRCh38: Chr11:32396262	WT1	H203P, H420P, H403P, H186P, H24P, H166P, H418P, H362P, H379P, H398P	Nephrotic syndrome, type 4	Likely pathogenic (Sep 18, 2017)	no assertion criteria provided
Select item 168462136.	NM_024426.6(WT1):c.1245dup (p.His416fs) GRCh37: Chr11:32417821-32417822 GRCh38: Chr11:32396275-32396276	WT1	H182fs, H199fs, H20fs, H399fs, H416fs	Wilms tumor 1	Likely pathogenic	criteria provided, single submitter
Select item 145777837.	NM_024426.6(WT1):c.1240C>T (p.Gln414Ter) GRCh37: Chr11:32417827 GRCh38: Chr11:32396281	WT1	Q18, Q414, Q197, Q397, Q180, Q160, Q392, Q409, Q373, Q356, Q412*	Drash syndrome, Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome	Pathogenic (Aug 24, 2021)	criteria provided, single submitter
Select item 349238.	NM_024426.6(WT1):c.1208G>A (p.Cys403Tyr) GRCh37: Chr11:32417859 GRCh38: Chr11:32396313	WT1	C186Y, C169Y, C386Y, C403Y, C7Y, C362Y, C401Y, C149Y, C345Y	Drash syndrome	Pathogenic (May 1, 1992)	no assertion criteria provided
Select item 244184839.	NM_024426.6(WT1):c.1207T>G (p.Cys403Gly) GRCh37: Chr11:32417860 GRCh38: Chr11:32396314	WT1	C149G, C169G, C186G, C345G, C362G, C381G, C386G, C398G, C401G, C403G, C7G	Wilms tumor 1	Likely pathogenic (Dec 10, 2022)	criteria provided, single submitter
Select item 37601340.	NM_024426.6(WT1):c.1157_1158insTGTACGGT (p.Ala387fs) GRCh37: Chr11:32417909-32417910 GRCh38: Chr11:32396363-32396364	WT1	A153fs, A170fs, A387fs, A370fs	Acute myeloid leukemia	Likely pathogenic (Oct 2, 2014)	no assertion criteria provided
Select item 54312041.	NM_024426.6(WT1):c.1149del (p.Val384fs) GRCh37: Chr11:32417918 GRCh38: Chr11:32396372	WT1	V384fs, V150fs, V167fs, V367fs	Drash syndrome, Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome	Pathogenic (Aug 20, 2021)	criteria provided, single submitter
Select item 97907242.	NM_024426.6(WT1):c.1142del (p.Pro381fs) GRCh37: Chr11:32417925 GRCh38: Chr11:32396379	WT1	P147fs, P164fs, P364fs, P381fs	Wilms tumor 1	Likely pathogenic (Oct 15, 2018)	criteria provided, single submitter
Select item 137854343.	NM_024426.6(WT1):c.1121_1122insGGGG (p.Arg375fs) GRCh37: Chr11:32417945-32417946 GRCh38: Chr11:32396399-32396400	WT1	R141fs, R358fs, R375fs, R158fs	Frasier syndrome, Drash syndrome, Wilms tumor 1, 11p partial monosomy syndrome	Pathogenic (Jul 29, 2021)	criteria provided, single submitter
Select item 44941644.	NM_024426.6(WT1):c.1120C>T (p.Arg374Ter) GRCh37: Chr11:32417947 GRCh38: Chr11:32396401	WT1	R157, R374, R357, R140, R316, R333, R372, R120, R352*	Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome, Frasier syndrome, Inborn genetic diseases, See cases, not provided, Wilms tumor 1, Drash syndrome	Pathogenic (Oct 26, 2022)	criteria provided, multiple submitters, no conflicts
Select item 106992145.	NC_000011.9:g.32417953del GRCh37: Chr11:32417953 GRCh38: Chr11:32396407	WT1		Drash syndrome, Wilms tumor 1, 11p partial monosomy syndrome, Frasier syndrome	Pathogenic (Apr 29, 2020)	criteria provided, single submitter
Select item 94361446.	NM_024426.6(WT1):c.1114-1G>T GRCh37: Chr11:32417954 GRCh38: Chr11:32396408	WT1		Drash syndrome, Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome	Likely pathogenic (May 24, 2022)	criteria provided, single submitter
Select item 348547.	NM_024426.6(WT1):c.1094del (p.Gly365fs) GRCh37: Chr11:32421513 GRCh38: Chr11:32399967	WT1	G131fs, G148fs, G348fs, G365fs	Wilms tumor 1	Pathogenic (Oct 3, 1991)	no assertion criteria provided
Select item 202895548.	NM_024426.6(WT1):c.1077C>G (p.Tyr359Ter) GRCh37: Chr11:32421530 GRCh38: Chr11:32399984	WT1	Y354, Y357, Y125, Y142, Y342, Y105, Y318, Y337, Y359, Y301	Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome	Pathogenic (Sep 4, 2022)	criteria provided, single submitter
Select item 98724849.	NM_024426.6(WT1):c.1061del (p.Leu354fs) GRCh37: Chr11:32421546 GRCh38: Chr11:32400000	WT1	L120fs, L137fs, L337fs, L354fs	not provided	Pathogenic (Oct 23, 2020)	criteria provided, single submitter
Select item 349950.	NM_024426.6(WT1):c.1036A>G (p.Ser346Gly) GRCh37: Chr11:32421571 GRCh38: Chr11:32400025	WT1	S129G, S329G, S112G, S346G, S305G, S92G, S288G, S344G	Mesothelioma	Pathogenic (Dec 1, 1993)	no assertion criteria provided
Select item 92976951.	NM_024426.6(WT1):c.1021A>G (p.Ser341Gly) GRCh37: Chr11:32421586 GRCh38: Chr11:32400040	WT1	S107G, S124G, S324G, S341G, S300G, S319G, S283G, S336G, S87G	Premature ovarian failure	Likely pathogenic (Mar 2, 2020)	criteria provided, single submitter
Select item 148992752.	NM_024426.6(WT1):c.1016+2T>G GRCh37: Chr11:32438034 GRCh38: Chr11:32416488	WT1		Wilms tumor 1, Frasier syndrome, 11p partial monosomy syndrome, Drash syndrome	Likely pathogenic (Oct 4, 2021)	criteria provided, single submitter
Select item 151849053.	NM_024426.6(WT1):c.1016+1G>A GRCh37: Chr11:32438035 GRCh38: Chr11:32416489	WT1		Wilms tumor 1, Frasier syndrome, 11p partial monosomy syndrome, Drash syndrome	Likely pathogenic (Oct 6, 2022)	criteria provided, single submitter
Select item 120259054.	NM_024426.6(WT1):c.983C>T (p.Ser328Phe) GRCh37: Chr11:32438069 GRCh38: Chr11:32416523	WT1	S111F, S328F, S287F, S323F, S74F	Disorder of sexual differentiation	Likely pathogenic (Aug 17, 2021)	no assertion criteria provided
Select item 66194255.	NM_024426.6(WT1):c.965+1G>A GRCh37: Chr11:32439122 GRCh38: Chr11:32417576	WT1		Drash syndrome, Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome, not provided	Pathogenic/Likely pathogenic (Oct 20, 2022)	criteria provided, multiple submitters, no conflicts
Select item 210028156.	NM_024426.6(WT1):c.913C>T (p.Gln305Ter) GRCh37: Chr11:32439175 GRCh38: Chr11:32417629	WT1	Q305, Q51, Q264, Q88, Q300*	Drash syndrome, Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome	Pathogenic (Mar 9, 2022)	criteria provided, single submitter
Select item 7833857.	NM_024426.6(WT1):c.911C>T (p.Ser304Phe) GRCh37: Chr11:32439177 GRCh38: Chr11:32417631	WT1	S87F, S304F, S263F, S50F	Frasier syndrome	Likely pathogenic (Jul 18, 2018)	no assertion criteria provided
Select item 348458.	NM_024426.6(WT1):c.893_909del (p.Asn298fs) GRCh37: Chr11:32439179-32439195 GRCh38: Chr11:32417633-32417649	WT1	N81fs, N298fs	Wilms tumor 1	Pathogenic (Oct 3, 1991)	no assertion criteria provided
Select item 167545659.	NM_024426.6(WT1):c.900C>G (p.Tyr300Ter) GRCh37: Chr11:32439188 GRCh38: Chr11:32417642	WT1	Y300, Y83, Y259, Y295, Y46*	not provided	Pathogenic (Mar 1, 2022)	criteria provided, single submitter
Select item 95825360.	NM_024426.6(WT1):c.897del (p.Leu299fs) GRCh37: Chr11:32439191 GRCh38: Chr11:32417645	WT1	L299fs, L82fs	Wilms tumor 1, 11p partial monosomy syndrome, Frasier syndrome, Drash syndrome	Pathogenic (Nov 7, 2019)	criteria provided, single submitter
Select item 150327861.	NM_024426.6(WT1):c.882_887+3del GRCh37: Chr11:32449499-32449507 GRCh38: Chr11:32427953-32427961	WT1		Wilms tumor 1, Frasier syndrome, 11p partial monosomy syndrome, Drash syndrome	Likely pathogenic (Aug 12, 2021)	criteria provided, single submitter
Select item 64500862.	NM_024426.6(WT1):c.882C>A (p.Tyr294Ter) GRCh37: Chr11:32449507 GRCh38: Chr11:32427961	WT1	Y294, Y77, Y253, Y289, Y40*	Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome	Pathogenic (Dec 28, 2018)	criteria provided, single submitter
Select item 43875763.	NM_024426.6(WT1):c.880_882del (p.Tyr294del) GRCh37: Chr11:32449507-32449509 GRCh38: Chr11:32427961-32427963	WT1	Y77del, Y294del, Y40del, Y253del	Wilms tumor 1	Pathogenic (Mar 23, 2013)	no assertion criteria provided
Select item 132757764.	NM_024426.6(WT1):c.834dup (p.Thr279fs) GRCh37: Chr11:32449554-32449555 GRCh38: Chr11:32428008-32428009	WT1	T279fs, T62fs	Wilms tumor 1	Pathogenic (Nov 11, 2021)	criteria provided, single submitter
Select item 40668065.	NM_024426.6(WT1):c.812del (p.Pro271fs) GRCh37: Chr11:32449577 GRCh38: Chr11:32428031	WT1	P271fs, P54fs	Wilms tumor 1, Frasier syndrome, 11p partial monosomy syndrome, Drash syndrome, Wilms tumor 1, Frasier syndrome, Drash syndrome	Pathogenic (Jun 12, 2016)	criteria provided, single submitter
Select item 107673066.	NM_024426.6(WT1):c.798C>G (p.Tyr266Ter) GRCh37: Chr11:32449591 GRCh38: Chr11:32428045	WT1	Y266, Y49, Y225, Y12, Y261*	Drash syndrome, Wilms tumor 1, Frasier syndrome, 11p partial monosomy syndrome	Pathogenic (Oct 13, 2020)	criteria provided, single submitter
Select item 169193267.	NM_024426.6(WT1):c.783_784+1del GRCh37: Chr11:32450042-32450044 GRCh38: Chr11:32428496-32428498	WT1		Hereditary cancer-predisposing syndrome	Likely pathogenic (Feb 1, 2022)	criteria provided, single submitter
Select item 44425068.	NM_024426.6(WT1):c.699C>A (p.Tyr233Ter) GRCh37: Chr11:32450128 GRCh38: Chr11:32428582	WT1	Y16, Y233	not provided	Likely pathogenic (May 1, 2019)	criteria provided, single submitter
Select item 98685169.	NM_024426.6(WT1):c.689del (p.Thr230fs) GRCh37: Chr11:32450138 GRCh38: Chr11:32428592	WT1	T13fs, T230fs	not provided	Pathogenic (Oct 23, 2020)	criteria provided, single submitter
Select item 47671370.	NM_024426.6(WT1):c.682dup (p.Asp228fs) GRCh37: Chr11:32450144-32450145 GRCh38: Chr11:32428598-32428599	WT1	D228fs, D11fs	Wilms tumor 1, 11p partial monosomy syndrome, Frasier syndrome, Drash syndrome	Pathogenic (May 31, 2017)	criteria provided, single submitter
Select item 107361671.	NC_000011.9:g.(?_32421484)_(32421600_?)del GRCh37: Chr11:32421484-32421600	WT1		Drash syndrome, Frasier syndrome, 11p partial monosomy syndrome, Wilms tumor 1	Pathogenic (Apr 26, 2022)	criteria provided, single submitter
Select item 83320272.	NC_000011.10:g.(?_32396247)_(32400054_?)del GRCh37: Chr11:32417793-32421600	WT1		Frasier syndrome, Wilms tumor 1, 11p partial monosomy syndrome, Drash syndrome	Pathogenic (Aug 4, 2021)	criteria provided, single submitter
Select item 83310773.	NC_000011.10:g.(?_32434690)_(32435345_?)del GRCh37: Chr11:32456236-32456891	WT1		Wilms tumor 1, Drash syndrome, 11p partial monosomy syndrome, Frasier syndrome	Pathogenic (Dec 23, 2019)	criteria provided, single submitter

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Items: 73