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GRCh38/hg38 17p13.3(chr17:445331-823474)x3 AND See cases

Germline classification:
Pathogenic (1 submission)
Last evaluated:
Jan 30, 2010
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of clinical impact:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of oncogenicity:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Record status:
current
Accession:
RCV000136769.5

Allele description [Variation Report for GRCh38/hg38 17p13.3(chr17:445331-823474)x3]

GRCh38/hg38 17p13.3(chr17:445331-823474)x3

Genes:
  • LOC130059861:ATAC-STARR-seq lymphoblastoid active region 11438 [Gene]
  • LOC130059865:ATAC-STARR-seq lymphoblastoid active region 11439 [Gene]
  • LOC130059868:ATAC-STARR-seq lymphoblastoid active region 11440 [Gene]
  • LOC130059869:ATAC-STARR-seq lymphoblastoid active region 11442 [Gene]
  • LOC130059859:ATAC-STARR-seq lymphoblastoid silent region 7939 [Gene]
  • LOC130059860:ATAC-STARR-seq lymphoblastoid silent region 7940 [Gene]
  • LOC130059862:ATAC-STARR-seq lymphoblastoid silent region 7941 [Gene]
  • LOC130059863:ATAC-STARR-seq lymphoblastoid silent region 7942 [Gene]
  • LOC130059864:ATAC-STARR-seq lymphoblastoid silent region 7943 [Gene]
  • LOC130059866:ATAC-STARR-seq lymphoblastoid silent region 7944 [Gene]
  • LOC130059867:ATAC-STARR-seq lymphoblastoid silent region 7945 [Gene]
  • LOC126862457:BRD4-independent group 4 enhancer GRCh37_chr17:504328-505527 [Gene]
  • LOC126862458:BRD4-independent group 4 enhancer GRCh37_chr17:560426-561625 [Gene]
  • LOC126862456:CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:463241-464440 [Gene]
  • LOC121848002:Sharpr-MPRA regulatory region 11717 [Gene]
  • LOC125177400:Sharpr-MPRA regulatory region 15051 [Gene]
  • LOC125177399:Sharpr-MPRA regulatory region 8461 [Gene]
  • LOC121587568:Sharpr-MPRA regulatory region 8532 [Gene]
  • TLCD3A:TLC domain containing 3A [Gene - OMIM - HGNC]
  • VPS53:VPS53 subunit of GARP complex [Gene - OMIM - HGNC]
  • GEMIN4:gem nuclear organelle associated protein 4 [Gene - OMIM - HGNC]
  • GLOD4:glyoxalase domain containing 4 [Gene - OMIM - HGNC]
  • MRM3:mitochondrial rRNA methyltransferase 3 [Gene - OMIM - HGNC]
  • NXN:nucleoredoxin [Gene - OMIM - HGNC]
  • RFLNB:refilin B [Gene - OMIM - HGNC]
Variant type:
copy number gain
Cytogenetic location:
17p13.3
Genomic location:
Preferred name:
GRCh38/hg38 17p13.3(chr17:445331-823474)x3
HGVS:
  • NC_000017.11:g.(?_445331)_(823474_?)dup
  • NC_000017.10:g.(?_396627)_(726714_?)dup
  • NC_000017.9:g.(?_295350)_(673464_?)dup
Links:
dbVar: nssv582147; dbVar: nsv534113
Observations:
1

Condition(s)

Name:
See cases [See the Variation display for details]
Identifiers:

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Assertion and evidence details

Help
Submission AccessionSubmitterReview Status
(Assertion method)		Clinical Significance
(Last evaluated)		OriginMethodCitations
SCV000176890ISCA site 8

See additional submitters

no assertion criteria provided
Pathogenic
(Jan 30, 2010) 		unknownclinical testing

PubMed (1)
[See all records that cite this PMID]

Help

Summary from all submissions

EthnicityOriginAffectedIndividualsFamiliesChromosomes testedNumber TestedFamily historyMethod
not providednot providedyes1not providednot providednot providednot providedclinical testing

Citations

PubMed

Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies.

Miller DT, Adam MP, Aradhya S, Biesecker LG, Brothman AR, Carter NP, Church DM, Crolla JA, Eichler EE, Epstein CJ, Faucett WA, Feuk L, Friedman JM, Hamosh A, Jackson L, Kaminsky EB, Kok K, Krantz ID, Kuhn RM, Lee C, Ostell JM, Rosenberg C, et al.

Am J Hum Genet. 2010 May 14;86(5):749-64. doi: 10.1016/j.ajhg.2010.04.006. Review.

PubMed [citation]
PMID:
20466091
PMCID:
PMC2869000

Details of each submission

From ISCA site 8, SCV000176890.3

#EthnicityIndividualsChromosomes TestedFamily HistoryMethodCitations
1not provided1not providednot providedclinical testing PubMed (1)
#SampleMethodObservation
OriginAffectedNumber testedTissuePurposeMethodIndividualsAllele frequencyFamiliesCo-occurrences
1unknownyesnot providednot providedDiscovery1not providednot providednot provided

Last Updated: May 7, 2024