ClinVar for Gene (Select 6391) - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 3356092	NM_003001.5(SDHC):c.*62G>A	SDHC	Single nucleotide variant (synonymous variant +2 more)	SDHC-related disorder	GLikely benign
Select item 3316910	NM_003001.5(SDHC):c.313T>G (p.Ser105Ala)	SDHC (S84A +7 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316909	NM_003001.5(SDHC):c.20+118G>A	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316907	NM_003001.5(SDHC):c.292T>A (p.Ser98Thr)	SDHC (S45T +7 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316906	NM_003001.5(SDHC):c.383C>T (p.Thr128Ile)	SDHC (T128I +7 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316905	NM_003001.5(SDHC):c.138A>G (p.Ile46Met)	SDHC (I46M +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3256496	NM_003001.5(SDHC):c.406-43T>G	SDHC	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3256493	NM_003001.5(SDHC):c.242-20C>T	SDHC	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3254373	NM_003001.5(SDHC):c.118dup (p.Arg40fs)	SDHC (R21fs +2 more)	Duplication (frameshift variant +2 more)	Paragangliomas 3	GPathogenic
Select item 3247759	NC_000001.10:g.(?_161326447)_(161332223_?)dup	SDHC	Duplication	Gastrointestinal stromal tumor +1 more	GUncertain significance
Select item 3247758	NC_000001.10:g.(?_161310364)_(161332223_?)dup	SDHC	Duplication	Gastrointestinal stromal tumor +1 more	GUncertain significance
Select item 3247757	NC_000001.10:g.(?_161293384)_(161293480_?)dup	SDHC	Duplication	Gastrointestinal stromal tumor +1 more	GUncertain significance
Select item 3247756	NC_000001.10:g.(?_161284196)_(161284215_?)del	SDHC	Deletion	Gastrointestinal stromal tumor +1 more	GPathogenic
Select item 3223036	NM_003001.5(SDHC):c.63G>C (p.Gln21His)	SDHC (Q21H)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223035	NM_003001.5(SDHC):c.62A>T (p.Gln21Leu)	SDHC (Q21L)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223034	NM_003001.5(SDHC):c.50A>G (p.His17Arg)	SDHC (H17R)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223033	NM_003001.5(SDHC):c.474T>C (p.Leu158=)	SDHC (Y104H +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3223032	NM_003001.5(SDHC):c.458T>C (p.Val153Ala)	SDHC (V100A +7 more)	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223031	NM_003001.5(SDHC):c.405G>C (p.Leu135Phe)	SDHC (L101F +7 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223030	NM_003001.5(SDHC):c.381T>A (p.His127Gln)	SDHC (H106Q +7 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223029	NM_003001.5(SDHC):c.293C>G (p.Ser98Cys)	SDHC (S138C +7 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223028	NM_003001.5(SDHC):c.25G>C (p.Val9Leu)	SDHC (V9L)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223027	NM_003001.5(SDHC):c.183G>A (p.Trp61Ter)	SDHC (W101* +5 more)	Single nucleotide variant (nonsense +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3223026	NM_003001.5(SDHC):c.173T>A (p.Ile58Asn)	SDHC (I21N +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223025	NM_003001.5(SDHC):c.172A>C (p.Ile58Leu)	SDHC (I21L +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3148693	NM_003001.5(SDHC):c.204dup (p.Ile69fs)	SDHC (I109fs +5 more)	Duplication (frameshift variant +1 more)	Paragangliomas 3	GPathogenic
Select item 3148630	NM_003001.5(SDHC):c.242-2_242-1insT	SDHC	Insertion (splice acceptor variant +1 more)	Paragangliomas 3	GLikely pathogenic
Select item 3074545	NM_003001.5(SDHC):c.196G>C (p.Ala66Pro)	SDHC (A106P +5 more)	Single nucleotide variant (missense variant +1 more)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3074535	NM_003001.5(SDHC):c.482T>G (p.Leu161Trp)	SDHC (L108W +7 more)	Single nucleotide variant (synonymous variant +2 more)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3074458	NM_003001.5(SDHC):c.242-7T>C	SDHC	Single nucleotide variant (intron variant)	Hereditary pheochromocytoma-paraganglioma	GLikely benign
Select item 3073891	NM_003001.5(SDHC):c.*3A>G	SDHC (K117E +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary pheochromocytoma-paraganglioma +1 more	GUncertain significance
Select item 3073349	NM_003001.5(SDHC):c.429G>A (p.Leu143=)	SDHC (E55K +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary pheochromocytoma-paraganglioma	GLikely benign
Select item 3072560	NM_003001.5(SDHC):c.-14G>T	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3072319	NM_003001.5(SDHC):c.480G>T (p.Val160=)	SDHC (V106F +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary pheochromocytoma-paraganglioma	GLikely benign
Select item 3070766	NM_003001.5(SDHC):c.-12C>G	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3070129	NM_003001.5(SDHC):c.-4C>G	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3065204	NM_003001.5(SDHC):c.371_372del (p.Leu124fs)	SDHC (L103fs +7 more)	Microsatellite (frameshift variant +2 more)	Paragangliomas 3	GLikely benign
Select item 3062766	GRCh37/hg19 1q23.3(chr1:161333263-161413937)x3	CFAP126, SDHC	Copy number gain	not specified	GUncertain significance
Select item 3062369	GRCh37/hg19 1q23.3(chr1:161224742-161415981)x3	CFAP126, MPZ +2 more	Copy number gain	not specified	GLikely pathogenic
Select item 3029816	NM_003001.5(SDHC):c.*50A>G	SDHC	Single nucleotide variant (synonymous variant +2 more)	SDHC-related disorder	GLikely benign
Select item 3029582	NM_003001.5(SDHC):c.*65A>G	SDHC	Single nucleotide variant (synonymous variant +2 more)	SDHC-related disorder	GLikely benign
Select item 2954266	NM_003001.5(SDHC):c.37T>C (p.Cys13Arg)	SDHC (C13R)	Single nucleotide variant (missense variant +3 more)	Gastrointestinal stromal tumor +1 more	GUncertain significance
Select item 2954043	NM_003001.5(SDHC):c.143_144insTGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGANNNNNNNNNNAAAAAAAAAAAAAAAAAAAAAAGAATATAGGTTC (p.Ser48_Asn49insGlyArgAlaArgTrpLeuThrProValIleProAlaLeuTrpGluAlaGluAlaGlyGlySerArgXaaXaaXaaXaaLysLysLysLysLysLysLysAsnIleGlySer)	SDHC	Insertion (inframe_insertion +2 more)	Gastrointestinal stromal tumor +1 more	GPathogenic
Select item 2953422	NM_003001.5(SDHC):c.179+2T>A	SDHC	Single nucleotide variant (splice donor variant +1 more)	Gastrointestinal stromal tumor +1 more	GLikely pathogenic
Select item 2953332	NM_003001.5(SDHC):c.399A>G (p.Arg133=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Gastrointestinal stromal tumor +1 more	GLikely benign
Select item 2953217	NM_003001.5(SDHC):c.268C>T (p.Leu90=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Gastrointestinal stromal tumor +1 more	GLikely benign
Select item 2953031	NM_003001.5(SDHC):c.441G>A (p.Gln147=)	SDHC (A59T +2 more)	Single nucleotide variant (missense variant +2 more)	Gastrointestinal stromal tumor +1 more	GLikely benign
Select item 2952842	NM_003001.5(SDHC):c.396C>A (p.Ile132=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Gastrointestinal stromal tumor +1 more	GLikely benign
Select item 2952693	NM_003001.5(SDHC):c.179+10del	SDHC	Deletion (intron variant)	Gastrointestinal stromal tumor +1 more	GLikely benign
Select item 2952356	NM_003001.5(SDHC):c.180-17T>C	SDHC	Single nucleotide variant (intron variant)	Gastrointestinal stromal tumor +1 more	GLikely benign
Select item 2951937	NM_003001.5(SDHC):c.484T>C (p.Ser162Pro)	SDHC (S126P +10 more)	Single nucleotide variant (missense variant +1 more)	Gastrointestinal stromal tumor +1 more	GUncertain significance
Select item 2951850	NM_003001.5(SDHC):c.405+6T>G	SDHC	Single nucleotide variant (intron variant)	Gastrointestinal stromal tumor +1 more	GUncertain significance
Select item 2951426	NM_003001.5(SDHC):c.332C>T (p.Ala111Val)	SDHC (A58V +7 more)	Single nucleotide variant (missense variant +2 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2951254	NM_003001.5(SDHC):c.21-5T>G	SDHC	Single nucleotide variant (intron variant)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2951094	NM_003001.5(SDHC):c.78T>C (p.Asn26=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2950992	NM_003001.5(SDHC):c.393G>A (p.Gly131=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +1 more	GLikely benign
Select item 2950878	NM_003001.5(SDHC):c.61C>T (p.Gln21Ter)	SDHC (Q21*)	Single nucleotide variant (nonsense +3 more)	Paragangliomas 3 +1 more	GPathogenic
Select item 2950649	NM_003001.5(SDHC):c.393G>T (p.Gly131=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +1 more	GLikely benign
Select item 2950017	NM_003001.5(SDHC):c.37T>A (p.Cys13Ser)	SDHC (C13S)	Single nucleotide variant (missense variant +3 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2949153	NM_003001.5(SDHC):c.20+1G>A	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	Paragangliomas 3 +1 more	GLikely pathogenic
Select item 2948959	NM_003001.5(SDHC):c.20+13G>A	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	Paragangliomas 3 +1 more	GLikely benign
Select item 2948784	NM_003001.5(SDHC):c.242-20C>G	SDHC	Single nucleotide variant (intron variant)	Paragangliomas 3 +1 more	GLikely benign
Select item 2948682	NM_003001.5(SDHC):c.501_503dup (p.Ala168_Met169insAla)	SDHC	Duplication (inframe_insertion +1 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2948110	NM_003001.5(SDHC):c.106G>A (p.Glu36Lys)	SDHC (E17K +1 more)	Single nucleotide variant (missense variant +3 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2947478	NM_003001.5(SDHC):c.258C>T (p.Gly86=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +1 more	GLikely benign
Select item 2946953	NM_003001.5(SDHC):c.7G>C (p.Ala3Pro)	SDHC (A3P)	Single nucleotide variant (missense variant +2 more)	Paragangliomas 3 +2 more	GUncertain significance
Select item 2946768	NM_003001.5(SDHC):c.296A>T (p.Tyr99Phe)	SDHC (Y65F +7 more)	Single nucleotide variant (missense variant +2 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2946701	NM_003001.5(SDHC):c.6T>A (p.Ala2=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +2 more	GLikely benign
Select item 2946341	NM_003001.5(SDHC):c.241+19A>G	SDHC	Single nucleotide variant (intron variant)	Paragangliomas 3 +1 more	GLikely benign
Select item 2946012	NM_003001.5(SDHC):c.252T>C (p.Leu84=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +1 more	GLikely benign
Select item 2945929	NM_003001.5(SDHC):c.20+14G>A	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	Paragangliomas 3 +1 more	GLikely benign
Select item 2945115	NM_003001.5(SDHC):c.154C>G (p.Leu52Val)	SDHC (L15V +2 more)	Single nucleotide variant (missense variant +2 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2944331	NM_003001.5(SDHC):c.105A>C (p.Lys35Asn)	SDHC (K16N +1 more)	Single nucleotide variant (missense variant +3 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2943401	NM_003001.5(SDHC):c.341A>C (p.His114Pro)	SDHC (H77P +7 more)	Single nucleotide variant (missense variant +2 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2943305	NM_003001.5(SDHC):c.497dup (p.Ala167fs)	SDHC (A131fs +10 more)	Duplication (frameshift variant +1 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2943261	NM_003001.5(SDHC):c.20+15A>C	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	Paragangliomas 3 +1 more	GLikely benign
Select item 2943040	NM_003001.5(SDHC):c.2T>C (p.Met1Thr)	SDHC (M1T)	Single nucleotide variant (missense variant +3 more)	Paragangliomas 3 +1 more	GPathogenic
Select item 2943036	NM_003001.5(SDHC):c.115G>C (p.Glu39Gln)	SDHC (E20Q +2 more)	Single nucleotide variant (missense variant +2 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2942866	NM_003001.5(SDHC):c.80C>T (p.Ala27Val)	SDHC (A27V +1 more)	Single nucleotide variant (missense variant +3 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2942723	NM_003001.5(SDHC):c.442C>T (p.Leu148=)	SDHC (A74V +2 more)	Single nucleotide variant (missense variant +2 more)	Paragangliomas 3 +1 more	GLikely benign
Select item 2942722	NM_003001.5(SDHC):c.441G>T (p.Gln147His)	SDHC (Q128H +10 more)	Single nucleotide variant (missense variant +1 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2942143	NM_003001.5(SDHC):c.21-4G>A	SDHC	Single nucleotide variant (intron variant)	Paragangliomas 3 +1 more	GLikely benign
Select item 2942066	NM_003001.5(SDHC):c.452C>T (p.Ser151Phe)	SDHC (S114F +7 more)	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2941678	NM_003001.5(SDHC):c.241+7A>C	SDHC	Single nucleotide variant (intron variant)	Paragangliomas 3 +1 more	GLikely benign
Select item 2940786	NM_003001.5(SDHC):c.267C>T (p.Ala89=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +1 more	GLikely benign
Select item 2940402	NM_003001.5(SDHC):c.20+11_20+12insTT	SDHC	Insertion (5 prime UTR variant +1 more)	Paragangliomas 3 +1 more	GLikely benign
Select item 2939471	NM_003001.5(SDHC):c.203C>T (p.Ser68Phe)	SDHC (S68F +5 more)	Single nucleotide variant (missense variant +1 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2939412	NM_003001.5(SDHC):c.375G>A (p.Met125Ile)	SDHC (M106I +7 more)	Single nucleotide variant (missense variant +2 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2938872	NM_003001.5(SDHC):c.348T>C (p.Ala116=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +1 more	GLikely benign
Select item 2938605	NM_003001.5(SDHC):c.78-19del	SDHC	Deletion (intron variant)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2936185	NM_003001.5(SDHC):c.500C>T (p.Ala167Val)	SDHC (A146V +7 more)	Single nucleotide variant (non-coding transcript variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 2934637	NM_003001.5(SDHC):c.406-5del	SDHC	Deletion (intron variant)	Paragangliomas 3 +1 more	GLikely benign
Select item 2934577	NM_003001.5(SDHC):c.241+4T>C	SDHC	Single nucleotide variant (intron variant)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2932501	NM_003001.5(SDHC):c.419G>A (p.Gly140Glu)	SDHC (G103E +7 more)	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +1 more	GUncertain significance
Select item 2932178	NM_003001.5(SDHC):c.237T>C (p.Ser79=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +1 more	GLikely benign
Select item 2931322	NM_003001.5(SDHC):c.21-7C>T	SDHC	Single nucleotide variant (intron variant)	Paragangliomas 3 +1 more	GLikely benign
Select item 2927356	NM_003001.5(SDHC):c.406-4A>G	SDHC	Single nucleotide variant (intron variant)	Paragangliomas 3 +1 more	GLikely benign
Select item 2926321	NM_003001.5(SDHC):c.10C>T (p.Leu4=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 2924636	NM_003001.5(SDHC):c.179+20C>G	SDHC	Single nucleotide variant (intron variant)	Paragangliomas 3 +1 more	GLikely benign
Select item 2922729	NM_003001.5(SDHC):c.417A>G (p.Leu139=)	SDHC (R85G +2 more)	Single nucleotide variant (missense variant +2 more)	Paragangliomas 3 +1 more	GLikely benign

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