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Links from MedGen

Items: 43

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
PBX1
(T231fs +1 more)
Duplication
(frameshift variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
PBX1
(M111K +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GUncertain significance
PBX1
(I53fs)
Duplication
(frameshift variant +1 more)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(V140fs +1 more)
Duplication
(frameshift variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
PBX1
(I206L +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GUncertain significance
PBX1
(Q41*)
Single nucleotide variant
(nonsense +1 more)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
PBX1
(R155W +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
Single nucleotide variant
(splice donor variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(I128fs +1 more)
Deletion
(frameshift variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
PBX1
(R205* +1 more)
Single nucleotide variant
(nonsense)
not provided
+2 more
GPathogenic
PBX1
(M111V +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GUncertain significance
PBX1
(Y170S +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(R107Q +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
+1 more
GPathogenic/Likely pathogenic
PBX1
Deletion
(inframe_deletion)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(R10* +1 more)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic/Likely pathogenic
PBX1
(R151W +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
+1 more
GConflicting classifications of pathogenicity
PBX1
(R107fs +1 more)
Duplication
(frameshift variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
PBX1
Insertion
(intron variant)
not provided
+1 more
GBenign
PBX1
Single nucleotide variant
(intron variant)
not provided
+1 more
GBenign
PBX1
(R123fs +1 more)
Deletion
(frameshift variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
Gnot provided
PBX1
Single nucleotide variant
(intron variant)
not provided
+1 more
GBenign
PBX1
(K133* +1 more)
Single nucleotide variant
(nonsense)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(S23fs)
Deletion
(frameshift variant +1 more)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
PBX1
Single nucleotide variant
(splice donor variant +1 more)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(R107P +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(C190R +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(Q129* +1 more)
Single nucleotide variant
(nonsense)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(Q196R +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
Deletion
(splice donor variant +1 more)
not provided
GLikely pathogenic
PBX1
(R152W +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(K124fs +1 more)
Duplication
(frameshift variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(E221* +1 more)
Single nucleotide variant
(nonsense)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
PBX1
(Q49*)
Single nucleotide variant
(nonsense +1 more)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(C273Y +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(R234Q +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PBX1
(S179fs +1 more)
Duplication
(frameshift variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
PBX1
(R235Q +1 more)
Single nucleotide variant
(missense variant)
not provided
GPathogenic
PBX1
(R234P +1 more)
Single nucleotide variant
(missense variant)
PBX1-related intellectual disability and pleiotropic developmental defects
GLikely pathogenic
PBX1
(R227P +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
PBX1
(G138fs +1 more)
Deletion
(frameshift variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
PBX1
Single nucleotide variant
(splice acceptor variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
PBX1
(R184* +1 more)
Single nucleotide variant
(nonsense)
Autism spectrum disorder
GPathogenic
PBX1
(N143fs +1 more)
Deletion
(frameshift variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
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