ClinVar for MedGen (Select 18073) - ClinVar - NCBI

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VariationLocation		Gene(s)	Protein change	Condition(s)	Clinical significance (Last reviewed)	Review status
Select item 24170161.	NM_006270.5(RRAS):c.572+3G>A GRCh37: Chr19:50138988 GRCh38: Chr19:49635731	RRAS		Noonan syndrome	Uncertain significance (Dec 25, 2021)	criteria provided, single submitter
Select item 22031172.	NM_006270.5(RRAS):c.50G>T (p.Gly17Val) GRCh37: Chr19:50143306 GRCh38: Chr19:49640049	RRAS	G17V	Noonan syndrome	Uncertain significance (Oct 14, 2022)	criteria provided, single submitter
Select item 21992433.	NM_006270.5(RRAS):c.337C>T (p.Arg113Trp) GRCh37: Chr19:50140088 GRCh38: Chr19:49636831	RRAS	R113W	Noonan syndrome	Uncertain significance (Apr 15, 2022)	criteria provided, single submitter
Select item 21969364.	NM_006270.5(RRAS):c.242-8C>G GRCh37: Chr19:50140191 GRCh38: Chr19:49636934	RRAS		Noonan syndrome	Likely benign (Sep 30, 2022)	criteria provided, single submitter
Select item 21947675.	NM_006270.5(RRAS):c.12_13delinsAA (p.Ala5Thr) GRCh37: Chr19:50143343-50143344 GRCh38: Chr19:49640086-49640087	RRAS	A5T	Noonan syndrome	Uncertain significance (Mar 10, 2022)	criteria provided, single submitter
Select item 21935956.	NM_006270.5(RRAS):c.288G>A (p.Gln96=) GRCh37: Chr19:50140137 GRCh38: Chr19:49636880	RRAS		Noonan syndrome	Likely benign (Feb 18, 2022)	criteria provided, single submitter
Select item 21453137.	NM_006270.5(RRAS):c.242-12_242-11del GRCh37: Chr19:50140194-50140195 GRCh38: Chr19:49636937-49636938	RRAS		Noonan syndrome	Likely benign (Apr 14, 2022)	criteria provided, single submitter
Select item 21445888.	NM_006270.5(RRAS):c.209G>A (p.Cys70Tyr) GRCh37: Chr19:50140332 GRCh38: Chr19:49637075	RRAS	C70Y	Inborn genetic diseases, Noonan syndrome	Uncertain significance (Jun 22, 2023)	criteria provided, multiple submitters, no conflicts
Select item 21441729.	NM_006270.5(RRAS):c.493C>G (p.His165Asp) GRCh37: Chr19:50139070 GRCh38: Chr19:49635813	RRAS	H165D	Noonan syndrome	Uncertain significance (Apr 11, 2022)	criteria provided, single submitter
Select item 213743910.	NM_006270.5(RRAS):c.1A>T (p.Met1Leu) GRCh37: Chr19:50143355 GRCh38: Chr19:49640098	RRAS	M1L	Noonan syndrome	Uncertain significance (Sep 10, 2022)	criteria provided, single submitter
Select item 213290111.	NM_006270.5(RRAS):c.572+13C>A GRCh37: Chr19:50138978 GRCh38: Chr19:49635721	RRAS		Noonan syndrome	Likely benign (May 3, 2022)	criteria provided, single submitter
Select item 213189912.	NM_006270.5(RRAS):c.643T>C (p.Cys215Arg) GRCh37: Chr19:50138847 GRCh38: Chr19:49635590	RRAS	C215R	Noonan syndrome	Uncertain significance (Jul 13, 2022)	criteria provided, single submitter
Select item 211881513.	NM_006270.5(RRAS):c.572+5G>A GRCh37: Chr19:50138986 GRCh38: Chr19:49635729	RRAS		Noonan syndrome	Uncertain significance (Jun 8, 2022)	criteria provided, single submitter
Select item 208784314.	NM_006270.5(RRAS):c.453+17T>C GRCh37: Chr19:50139859 GRCh38: Chr19:49636602	RRAS		Noonan syndrome	Likely benign (Jan 19, 2022)	criteria provided, single submitter
Select item 208307615.	NM_006270.5(RRAS):c.571C>T (p.Arg191Trp) GRCh37: Chr19:50138992 GRCh38: Chr19:49635735	RRAS	R191W	not specified, Inborn genetic diseases, Noonan syndrome	Uncertain significance (Sep 26, 2023)	criteria provided, multiple submitters, no conflicts
Select item 207233516.	NM_006270.5(RRAS):c.84G>C (p.Glu28Asp) GRCh37: Chr19:50143272 GRCh38: Chr19:49640015	RRAS	E28D	Noonan syndrome	Uncertain significance (Jun 8, 2022)	criteria provided, single submitter
Select item 205983217.	NM_006270.5(RRAS):c.599C>T (p.Pro200Leu) GRCh37: Chr19:50138891 GRCh38: Chr19:49635634	RRAS	P200L	Noonan syndrome	Uncertain significance (May 12, 2022)	criteria provided, single submitter
Select item 205767218.	NM_006270.5(RRAS):c.345-14G>A GRCh37: Chr19:50139998 GRCh38: Chr19:49636741	RRAS		Noonan syndrome	Uncertain significance (Jun 22, 2022)	criteria provided, single submitter
Select item 205189119.	NM_006270.5(RRAS):c.454-4C>T GRCh37: Chr19:50139113 GRCh38: Chr19:49635856	RRAS		Noonan syndrome	Likely benign (Mar 26, 2022)	criteria provided, single submitter
Select item 205158620.	NM_006270.5(RRAS):c.541G>A (p.Glu181Lys) GRCh37: Chr19:50139022 GRCh38: Chr19:49635765	RRAS	E181K	Noonan syndrome	Uncertain significance (Jul 1, 2022)	criteria provided, single submitter
Select item 203998921.	NM_006270.5(RRAS):c.573-15G>A GRCh37: Chr19:50138932 GRCh38: Chr19:49635675	RRAS		Noonan syndrome	Likely benign (May 26, 2022)	criteria provided, single submitter
Select item 203975222.	NM_006270.5(RRAS):c.610A>G (p.Ser204Gly) GRCh37: Chr19:50138880 GRCh38: Chr19:49635623	RRAS	S204G	Noonan syndrome	Uncertain significance (Aug 5, 2022)	criteria provided, single submitter
Select item 203811623.	NM_006270.5(RRAS):c.44G>C (p.Arg15Pro) GRCh37: Chr19:50143312 GRCh38: Chr19:49640055	RRAS	R15P	Noonan syndrome	Uncertain significance (Mar 16, 2022)	criteria provided, single submitter
Select item 201583324.	NM_006270.5(RRAS):c.292A>G (p.Met98Val) GRCh37: Chr19:50140133 GRCh38: Chr19:49636876	RRAS	M98V	Noonan syndrome	Uncertain significance (Jul 21, 2022)	criteria provided, single submitter
Select item 199559825.	NM_006270.5(RRAS):c.44G>A (p.Arg15Gln) GRCh37: Chr19:50143312 GRCh38: Chr19:49640055	RRAS	R15Q	Noonan syndrome	Uncertain significance (Sep 6, 2022)	criteria provided, single submitter
Select item 197785726.	NM_006270.5(RRAS):c.153+10C>A GRCh37: Chr19:50143193 GRCh38: Chr19:49639936	RRAS		Noonan syndrome	Likely benign (May 12, 2022)	criteria provided, single submitter
Select item 196646927.	NM_006270.5(RRAS):c.436C>A (p.Leu146Met) GRCh37: Chr19:50139893 GRCh38: Chr19:49636636	RRAS	L146M	Noonan syndrome	Uncertain significance (Dec 10, 2021)	criteria provided, single submitter
Select item 196493928.	NM_006270.5(RRAS):c.480C>T (p.Phe160=) GRCh37: Chr19:50139083 GRCh38: Chr19:49635826	RRAS		Inborn genetic diseases, Noonan syndrome	Likely benign (Mar 26, 2023)	criteria provided, multiple submitters, no conflicts
Select item 196449029.	NM_006270.5(RRAS):c.1A>G (p.Met1Val) GRCh37: Chr19:50143355 GRCh38: Chr19:49640098	RRAS	M1V	Noonan syndrome	Uncertain significance (Jun 14, 2022)	criteria provided, single submitter
Select item 194682030.	NM_006270.5(RRAS):c.454-10dup GRCh37: Chr19:50139118-50139119 GRCh38: Chr19:49635861-49635862	RRAS		Noonan syndrome	Benign (Mar 17, 2022)	criteria provided, single submitter
Select item 194363231.	NM_006270.5(RRAS):c.295C>T (p.Arg99Cys) GRCh37: Chr19:50140130 GRCh38: Chr19:49636873	RRAS	R99C	Inborn genetic diseases, Noonan syndrome	Uncertain significance (Jun 5, 2023)	criteria provided, multiple submitters, no conflicts
Select item 190671332.	NM_006270.5(RRAS):c.454G>A (p.Val152Ile) GRCh37: Chr19:50139109 GRCh38: Chr19:49635852	RRAS	V152I	Noonan syndrome	Uncertain significance (Apr 13, 2022)	criteria provided, single submitter
Select item 180532033.	NM_006270.5(RRAS):c.43C>T (p.Arg15Trp) GRCh37: Chr19:50143313 GRCh38: Chr19:49640056	RRAS	R15W	Noonan syndrome	Uncertain significance (May 21, 2020)	criteria provided, single submitter
Select item 180328134.	NM_006767.4(LZTR1):c.401-1G>A GRCh37: Chr22:21342298 GRCh38: Chr22:20988009	LZTR1		Schwannomatosis 2, Noonan syndrome	Pathogenic (May 25, 2022)	criteria provided, multiple submitters, no conflicts
Select item 179265935.	NM_006270.5(RRAS):c.252C>T (p.Thr84=) GRCh37: Chr19:50140173 GRCh38: Chr19:49636916	RRAS		Inborn genetic diseases, Noonan syndrome	Likely benign (Feb 22, 2022)	criteria provided, multiple submitters, no conflicts
Select item 177679036.	NM_006270.5(RRAS):c.162C>T (p.Phe54=) GRCh37: Chr19:50140379 GRCh38: Chr19:49637122	RRAS		Noonan syndrome, Inborn genetic diseases	Likely benign (Oct 21, 2022)	criteria provided, multiple submitters, no conflicts
Select item 175347237.	NM_006270.5(RRAS):c.642C>T (p.Pro214=) GRCh37: Chr19:50138848 GRCh38: Chr19:49635591	RRAS		Inborn genetic diseases, Noonan syndrome	Likely benign (May 17, 2022)	criteria provided, multiple submitters, no conflicts
Select item 175278238.	NM_006270.5(RRAS):c.630C>T (p.Gly210=) GRCh37: Chr19:50138860 GRCh38: Chr19:49635603	RRAS		Inborn genetic diseases, Noonan syndrome	Likely benign (Oct 17, 2022)	criteria provided, multiple submitters, no conflicts
Select item 174458039.	NM_006270.5(RRAS):c.498G>A (p.Val166=) GRCh37: Chr19:50139065 GRCh38: Chr19:49635808	RRAS		Noonan syndrome, Inborn genetic diseases	Conflicting interpretations of pathogenicity (Jan 11, 2022)	criteria provided, conflicting interpretations
Select item 173650840.	NM_006270.5(RRAS):c.395G>A (p.Arg132His) GRCh37: Chr19:50139934 GRCh38: Chr19:49636677	RRAS	R132H	Inborn genetic diseases, Noonan syndrome	Uncertain significance (Apr 7, 2022)	criteria provided, multiple submitters, no conflicts
Select item 171728641.	NM_006270.5(RRAS):c.77C>T (p.Pro26Leu) GRCh37: Chr19:50143279 GRCh38: Chr19:49640022	RRAS	P26L	Noonan syndrome	Uncertain significance (Aug 21, 2022)	criteria provided, single submitter
Select item 171338442.	NM_006270.5(RRAS):c.475G>C (p.Ala159Pro) GRCh37: Chr19:50139088 GRCh38: Chr19:49635831	RRAS	A159P	Noonan syndrome	Uncertain significance (Aug 3, 2022)	criteria provided, single submitter
Select item 169154743.	NM_005633.4(SOS1):c.4C>A (p.Gln2Lys) GRCh37: Chr2:39347560 GRCh38: Chr2:39120419	LOC129933535, SOS1	Q2K	Noonan syndrome	Uncertain significance (Jan 6, 2022)	criteria provided, single submitter
Select item 166596244.	NM_006270.5(RRAS):c.241+13A>G GRCh37: Chr19:50140287 GRCh38: Chr19:49637030	RRAS		Noonan syndrome	Likely benign (Oct 7, 2021)	criteria provided, single submitter
Select item 166591445.	NM_006270.5(RRAS):c.645C>T (p.Cys215=) GRCh37: Chr19:50138845 GRCh38: Chr19:49635588	RRAS		Noonan syndrome, Inborn genetic diseases	Likely benign (Jun 14, 2022)	criteria provided, multiple submitters, no conflicts
Select item 166351246.	NM_006270.5(RRAS):c.453+18T>C GRCh37: Chr19:50139858 GRCh38: Chr19:49636601	RRAS		Noonan syndrome	Likely benign (Jul 19, 2022)	criteria provided, single submitter
Select item 166149047.	NM_006270.5(RRAS):c.454-7C>T GRCh37: Chr19:50139116 GRCh38: Chr19:49635859	RRAS		Noonan syndrome	Likely benign (Jul 13, 2021)	criteria provided, single submitter
Select item 165848448.	NM_006270.5(RRAS):c.66G>A (p.Gly22=) GRCh37: Chr19:50143290 GRCh38: Chr19:49640033	RRAS		Noonan syndrome	Likely benign (Feb 28, 2021)	criteria provided, single submitter
Select item 165690549.	NM_006270.5(RRAS):c.42C>T (p.Pro14=) GRCh37: Chr19:50143314 GRCh38: Chr19:49640057	RRAS		Noonan syndrome	Likely benign (Jul 22, 2022)	criteria provided, single submitter
Select item 164777350.	NM_006270.5(RRAS):c.75G>C (p.Pro25=) GRCh37: Chr19:50143281 GRCh38: Chr19:49640024	RRAS		Noonan syndrome	Likely benign (May 13, 2022)	criteria provided, single submitter
Select item 164612151.	NM_006270.5(RRAS):c.43C>A (p.Arg15=) GRCh37: Chr19:50143313 GRCh38: Chr19:49640056	RRAS		Inborn genetic diseases, Noonan syndrome	Likely benign (Jul 29, 2022)	criteria provided, multiple submitters, no conflicts
Select item 162941052.	NM_006270.5(RRAS):c.573-13C>T GRCh37: Chr19:50138930 GRCh38: Chr19:49635673	RRAS		Noonan syndrome	Likely benign (Jul 25, 2022)	criteria provided, single submitter
Select item 162900053.	NM_006270.5(RRAS):c.624G>A (p.Lys208=) GRCh37: Chr19:50138866 GRCh38: Chr19:49635609	RRAS		Noonan syndrome	Likely benign (Nov 1, 2021)	criteria provided, single submitter
Select item 162837154.	NM_006270.5(RRAS):c.345-19C>G GRCh37: Chr19:50140003 GRCh38: Chr19:49636746	RRAS		Noonan syndrome	Likely benign (Aug 20, 2022)	criteria provided, single submitter
Select item 162249955.	NM_006270.5(RRAS):c.291C>T (p.Tyr97=) GRCh37: Chr19:50140134 GRCh38: Chr19:49636877	RRAS		Noonan syndrome	Likely benign (Jun 1, 2022)	criteria provided, single submitter
Select item 160316956.	NM_006270.5(RRAS):c.345-19_345-18del GRCh37: Chr19:50140002-50140003 GRCh38: Chr19:49636745-49636746	RRAS		Noonan syndrome	Likely benign (Sep 9, 2021)	criteria provided, single submitter
Select item 157467657.	NM_006270.5(RRAS):c.572+20T>G GRCh37: Chr19:50138971 GRCh38: Chr19:49635714	RRAS		Noonan syndrome	Likely benign (Sep 25, 2021)	criteria provided, single submitter
Select item 156912558.	NM_006270.5(RRAS):c.102C>T (p.Val34=) GRCh37: Chr19:50143254 GRCh38: Chr19:49639997	RRAS		Noonan syndrome	Likely benign (Apr 12, 2022)	criteria provided, single submitter
Select item 155757059.	NM_006270.5(RRAS):c.652C>T (p.Leu218=) GRCh37: Chr19:50138838 GRCh38: Chr19:49635581	RRAS		Noonan syndrome, Inborn genetic diseases	Likely benign (Feb 5, 2023)	criteria provided, multiple submitters, no conflicts
Select item 155453660.	NM_006270.5(RRAS):c.516G>A (p.Ser172=) GRCh37: Chr19:50139047 GRCh38: Chr19:49635790	RRAS		Noonan syndrome	Likely benign (Mar 13, 2022)	criteria provided, single submitter
Select item 154272161.	NM_006270.5(RRAS):c.573-19C>G GRCh37: Chr19:50138936 GRCh38: Chr19:49635679	RRAS		Noonan syndrome	Likely benign (Jul 19, 2022)	criteria provided, single submitter
Select item 152099062.	NM_006270.5(RRAS):c.449G>C (p.Arg150Pro) GRCh37: Chr19:50139880 GRCh38: Chr19:49636623	RRAS	R150P	Noonan syndrome	Uncertain significance (Aug 28, 2021)	criteria provided, single submitter
Select item 151226363.	NM_006270.5(RRAS):c.453+5G>A GRCh37: Chr19:50139871 GRCh38: Chr19:49636614	RRAS		Noonan syndrome	Uncertain significance (Aug 9, 2021)	criteria provided, single submitter
Select item 150848164.	NM_006270.5(RRAS):c.535G>A (p.Val179Met) GRCh37: Chr19:50139028 GRCh38: Chr19:49635771	RRAS	V179M	Noonan syndrome	Uncertain significance (Oct 1, 2022)	criteria provided, single submitter
Select item 150338965.	NM_006270.5(RRAS):c.81C>T (p.Ser27=) GRCh37: Chr19:50143275 GRCh38: Chr19:49640018	RRAS		Noonan syndrome, RRAS-related condition, Inborn genetic diseases	Conflicting interpretations of pathogenicity (Nov 16, 2022)	criteria provided, conflicting interpretations
Select item 149873066.	NM_006270.5(RRAS):c.363G>A (p.Lys121=) GRCh37: Chr19:50139966 GRCh38: Chr19:49636709	RRAS		Noonan syndrome, Inborn genetic diseases	Likely benign (May 16, 2022)	criteria provided, multiple submitters, no conflicts
Select item 149655767.	NM_006270.5(RRAS):c.2T>A (p.Met1Lys) GRCh37: Chr19:50143354 GRCh38: Chr19:49640097	RRAS	M1K	Noonan syndrome	Uncertain significance (Jul 6, 2021)	criteria provided, single submitter
Select item 149290068.	NM_006270.5(RRAS):c.70C>T (p.Pro24Ser) GRCh37: Chr19:50143286 GRCh38: Chr19:49640029	RRAS	P24S	Noonan syndrome	Uncertain significance (Sep 1, 2021)	criteria provided, single submitter
Select item 148994069.	NM_006270.5(RRAS):c.74dup (p.Pro26fs) GRCh37: Chr19:50143281-50143282 GRCh38: Chr19:49640024-49640025	RRAS	P26fs	Noonan syndrome	Uncertain significance (Aug 22, 2022)	criteria provided, single submitter
Select item 148838570.	NM_006270.5(RRAS):c.115G>T (p.Gly39Cys) GRCh37: Chr19:50143241 GRCh38: Chr19:49639984	RRAS	G39C	Noonan syndrome	Uncertain significance (Aug 27, 2021)	criteria provided, single submitter
Select item 148745871.	NM_006270.5(RRAS):c.573-16T>A GRCh37: Chr19:50138933 GRCh38: Chr19:49635676	RRAS		Noonan syndrome	Uncertain significance (Sep 29, 2021)	criteria provided, single submitter
Select item 147179272.	NM_006270.5(RRAS):c.541G>C (p.Glu181Gln) GRCh37: Chr19:50139022 GRCh38: Chr19:49635765	RRAS	E181Q	Noonan syndrome	Uncertain significance (Jul 6, 2022)	criteria provided, single submitter
Select item 147147473.	NM_006270.5(RRAS):c.527G>A (p.Arg176His) GRCh37: Chr19:50139036 GRCh38: Chr19:49635779	RRAS	R176H	Inborn genetic diseases, Noonan syndrome	Uncertain significance (Oct 29, 2021)	criteria provided, multiple submitters, no conflicts
Select item 145355174.	NM_006270.5(RRAS):c.30G>C (p.Gly10=) GRCh37: Chr19:50143326 GRCh38: Chr19:49640069	RRAS		Noonan syndrome	Likely benign (Jul 25, 2022)	criteria provided, single submitter
Select item 144757975.	NM_006270.5(RRAS):c.227C>T (p.Pro76Leu) GRCh37: Chr19:50140314 GRCh38: Chr19:49637057	RRAS	P76L	Noonan syndrome	Uncertain significance (Mar 18, 2022)	criteria provided, single submitter
Select item 144660476.	NM_006270.5(RRAS):c.356T>G (p.Val119Gly) GRCh37: Chr19:50139973 GRCh38: Chr19:49636716	RRAS	V119G	Noonan syndrome	Uncertain significance (Sep 21, 2021)	criteria provided, single submitter
Select item 144610077.	NM_006270.5(RRAS):c.153+17C>A GRCh37: Chr19:50143186 GRCh38: Chr19:49639929	RRAS		Noonan syndrome	Uncertain significance (Nov 22, 2021)	criteria provided, single submitter
Select item 143237378.	NM_006270.5(RRAS):c.422G>C (p.Gly141Ala) GRCh37: Chr19:50139907 GRCh38: Chr19:49636650	RRAS	G141A	Noonan syndrome	Uncertain significance (Aug 27, 2021)	criteria provided, single submitter
Select item 142899379.	NM_006270.5(RRAS):c.296G>A (p.Arg99His) GRCh37: Chr19:50140129 GRCh38: Chr19:49636872	RRAS	R99H	Noonan syndrome	Uncertain significance (Aug 31, 2021)	criteria provided, single submitter
Select item 141891280.	NM_006270.5(RRAS):c.200C>T (p.Thr67Met) GRCh37: Chr19:50140341 GRCh38: Chr19:49637084	RRAS	T67M	Noonan syndrome	Uncertain significance (Sep 9, 2021)	criteria provided, single submitter
Select item 140988581.	NM_006270.5(RRAS):c.382C>T (p.Arg128Trp) GRCh37: Chr19:50139947 GRCh38: Chr19:49636690	RRAS	R128W	Noonan syndrome	Uncertain significance (Jul 31, 2021)	criteria provided, single submitter
Select item 140687082.	NM_006270.5(RRAS):c.232C>T (p.Arg78Trp) GRCh37: Chr19:50140309 GRCh38: Chr19:49637052	RRAS	R78W	Inborn genetic diseases, Noonan syndrome	Uncertain significance (Apr 19, 2023)	criteria provided, multiple submitters, no conflicts
Select item 140623183.	NM_006270.5(RRAS):c.53G>A (p.Gly18Glu) GRCh37: Chr19:50143303 GRCh38: Chr19:49640046	RRAS	G18E	Noonan syndrome	Uncertain significance (Mar 26, 2022)	criteria provided, single submitter
Select item 139849484.	NM_006270.5(RRAS):c.453+4C>T GRCh37: Chr19:50139872 GRCh38: Chr19:49636615	RRAS		Noonan syndrome	Uncertain significance (Oct 3, 2021)	criteria provided, single submitter
Select item 139700985.	NM_006270.5(RRAS):c.412G>T (p.Val138Leu) GRCh37: Chr19:50139917 GRCh38: Chr19:49636660	RRAS	V138L	Noonan syndrome	Uncertain significance (Dec 14, 2021)	criteria provided, single submitter
Select item 139608686.	NM_006270.5(RRAS):c.481G>A (p.Gly161Ser) GRCh37: Chr19:50139082 GRCh38: Chr19:49635825	RRAS	G161S	Noonan syndrome	Uncertain significance (Feb 18, 2022)	criteria provided, single submitter
Select item 139441787.	NM_006270.5(RRAS):c.487T>C (p.Ser163Pro) GRCh37: Chr19:50139076 GRCh38: Chr19:49635819	RRAS	S163P	Inborn genetic diseases, Noonan syndrome	Uncertain significance (Mar 19, 2022)	criteria provided, multiple submitters, no conflicts
Select item 139257888.	NM_006270.5(RRAS):c.29G>C (p.Gly10Ala) GRCh37: Chr19:50143327 GRCh38: Chr19:49640070	RRAS	G10A	Noonan syndrome	Uncertain significance (Jul 6, 2022)	criteria provided, single submitter
Select item 138386289.	NM_006270.5(RRAS):c.241+6G>C GRCh37: Chr19:50140294 GRCh38: Chr19:49637037	RRAS		Noonan syndrome	Uncertain significance (Mar 18, 2022)	criteria provided, single submitter
Select item 138041490.	NM_006270.5(RRAS):c.163G>A (p.Val55Met) GRCh37: Chr19:50140378 GRCh38: Chr19:49637121	RRAS	V55M	Noonan syndrome	Uncertain significance (Aug 14, 2021)	criteria provided, single submitter
Select item 138032091.	NM_006270.5(RRAS):c.560T>C (p.Val187Ala) GRCh37: Chr19:50139003 GRCh38: Chr19:49635746	RRAS	V187A	Noonan syndrome	Uncertain significance (Sep 17, 2021)	criteria provided, single submitter
Select item 137271892.	NM_006270.5(RRAS):c.461G>A (p.Arg154Gln) GRCh37: Chr19:50139102 GRCh38: Chr19:49635845	RRAS	R154Q	Noonan syndrome, Inborn genetic diseases	Uncertain significance (Aug 22, 2022)	criteria provided, multiple submitters, no conflicts
Select item 136658893.	NM_006270.5(RRAS):c.646G>A (p.Val216Ile) GRCh37: Chr19:50138844 GRCh38: Chr19:49635587	RRAS	V216I	Inborn genetic diseases, Noonan syndrome	Uncertain significance (Dec 15, 2022)	criteria provided, multiple submitters, no conflicts
Select item 136544294.	NM_006270.5(RRAS):c.153+3A>G GRCh37: Chr19:50143200 GRCh38: Chr19:49639943	RRAS		Noonan syndrome	Uncertain significance (Oct 14, 2021)	criteria provided, single submitter
Select item 135963995.	NM_006270.5(RRAS):c.98T>C (p.Val33Ala) GRCh37: Chr19:50143258 GRCh38: Chr19:49640001	RRAS	V33A	Noonan syndrome	Uncertain significance (Aug 27, 2021)	criteria provided, single submitter
Select item 135875196.	NM_006270.5(RRAS):c.233G>A (p.Arg78Gln) GRCh37: Chr19:50140308 GRCh38: Chr19:49637051	RRAS	R78Q	Noonan syndrome	Uncertain significance (Aug 27, 2021)	criteria provided, single submitter
Select item 135456597.	NM_006270.5(RRAS):c.38G>A (p.Arg13Gln) GRCh37: Chr19:50143318 GRCh38: Chr19:49640061	RRAS	R13Q	Noonan syndrome	Uncertain significance (Sep 1, 2021)	criteria provided, single submitter
Select item 134489498.	NM_006767.4(LZTR1):c.743G>A (p.Gly248Glu) GRCh37: Chr22:21344766 GRCh38: Chr22:20990477	LZTR1	G248E	Noonan syndrome	Likely pathogenic	no assertion criteria provided
Select item 134209299.	NM_012250.6(RRAS2):c.67G>T (p.Gly23Cys) GRCh37: Chr11:14380350 GRCh38: Chr11:14358804	LOC130005368, RRAS2	G23C	not provided, Noonan syndrome	Pathogenic/Likely pathogenic (Oct 31, 2023)	criteria provided, multiple submitters, no conflicts
Select item 1339463100.	NM_007373.4(SHOC2):c.520C>T (p.Leu174Phe) GRCh37: Chr10:112724636 GRCh38: Chr10:110964878	SHOC2	L174F	Noonan syndrome	Likely pathogenic (May 22, 2020)	no assertion criteria provided

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