ClinVar for MedGen (Select 342428) - ClinVar - NCBI

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VariationLocation		Gene(s)	Protein change	Condition(s)	Clinical significance (Last reviewed)	Review status
Select item 16859501.	NM_004530.6(MMP2):c.691G>T (p.Glu231Ter) GRCh37: Chr16:55519548 GRCh38: Chr16:55485636	MMP2	E155, E181, E231*	Multicentric osteolysis nodulosis arthropathy spectrum	Pathogenic (May 4, 2022)	criteria provided, single submitter
Select item 14269932.	NM_004530.6(MMP2):c.1453A>T (p.Ile485Phe) GRCh37: Chr16:55527186 GRCh38: Chr16:55493274	MMP2	I409F, I485F, I435F	Multicentric osteolysis nodulosis arthropathy spectrum, not provided	Uncertain significance (Nov 16, 2021)	criteria provided, multiple submitters, no conflicts
Select item 13419943.	NM_004530.6(MMP2):c.301C>T (p.Arg101Cys) GRCh37: Chr16:55516968 GRCh38: Chr16:55483056	MMP2	R101C, R25C, R51C	Multicentric osteolysis nodulosis arthropathy spectrum	Pathogenic	no assertion criteria provided
Select item 13328654.	NM_004530.6(MMP2):c.789C>A (p.Tyr263Ter) GRCh37: Chr16:55519646 GRCh38: Chr16:55485734	MMP2	Y187, Y213, Y263*	Multicentric osteolysis nodulosis arthropathy spectrum	Pathogenic	criteria provided, single submitter
Select item 13328565.	NM_004530.6(MMP2):c.306C>A (p.Cys102Ter) GRCh37: Chr16:55516973 GRCh38: Chr16:55483061	MMP2	C102, C26, C52*	Multicentric osteolysis nodulosis arthropathy spectrum	Likely pathogenic	criteria provided, single submitter
Select item 13326966.	NM_004530.6(MMP2):c.1229G>T (p.Gly410Val) GRCh37: Chr16:55525761 GRCh38: Chr16:55491849	MMP2	G334V, G360V, G410V	Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance	criteria provided, single submitter
Select item 13326897.	NM_004530.6(MMP2):c.910_916del (p.Ser304fs) GRCh37: Chr16:55522532-55522538 GRCh38: Chr16:55488620-55488626	MMP2	S228fs, S254fs, S304fs	Multicentric osteolysis nodulosis arthropathy spectrum	Pathogenic	criteria provided, single submitter
Select item 13016668.	NM_004530.6(MMP2):c.1013C>T (p.Ser338Phe) GRCh37: Chr16:55523569 GRCh38: Chr16:55489657	MMP2	S262F, S288F, S338F	Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Mar 25, 2020)	criteria provided, single submitter
Select item 12995519.	NM_004530.6(MMP2):c.1456TTC[2] (p.Phe488del) GRCh37: Chr16:55527187-55527189 GRCh38: Chr16:55493275-55493277	MMP2	F412del, F438del, F488del	Multicentric osteolysis nodulosis arthropathy spectrum	Likely pathogenic (Aug 10, 2021)	criteria provided, single submitter
Select item 129955010.	NM_004530.6(MMP2):c.529G>A (p.Glu177Lys) GRCh37: Chr16:55518076 GRCh38: Chr16:55484164	MMP2	E101K, E127K, E177K	Multicentric osteolysis nodulosis arthropathy spectrum	Likely pathogenic (Aug 10, 2021)	criteria provided, single submitter
Select item 103222611.	NM_004530.6(MMP2):c.380+6G>A GRCh37: Chr16:55517053 GRCh38: Chr16:55483141	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jul 28, 2021)	criteria provided, multiple submitters, no conflicts
Select item 102986012.	NM_004530.6(MMP2):c.628G>T (p.Asp210Tyr) GRCh37: Chr16:55519309 GRCh38: Chr16:55485397	MMP2	D160Y, D210Y, D134Y	Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Sep 19, 2020)	criteria provided, single submitter
Select item 91543013.	NM_004530.6(MMP2):c.1648C>T (p.Arg550Ter) GRCh37: Chr16:55532239 GRCh38: Chr16:55498327	MMP2	R550, R474, R500*	Multicentric osteolysis nodulosis arthropathy spectrum	Pathogenic (May 3, 2020)	criteria provided, single submitter
Select item 88837314.	NM_004530.6(MMP2):c.*277G>A GRCh37: Chr16:55539631 GRCh38: Chr16:55505719	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 88837215.	NM_004530.6(MMP2):c.*250C>T GRCh37: Chr16:55539604 GRCh38: Chr16:55505692	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 88837116.	NM_004530.6(MMP2):c.*183A>G GRCh37: Chr16:55539537 GRCh38: Chr16:55505625	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Jan 13, 2018)	criteria provided, single submitter
Select item 88830717.	NM_004530.6(MMP2):c.1493C>T (p.Thr498Met) GRCh37: Chr16:55530858 GRCh38: Chr16:55496946	MMP2	T422M, T448M, T498M	Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (May 2, 2017)	criteria provided, single submitter
Select item 88830618.	NM_004530.6(MMP2):c.1484G>A (p.Arg495Gln) GRCh37: Chr16:55530849 GRCh38: Chr16:55496937	MMP2	R445Q, R495Q, R419Q	not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jun 24, 2022)	criteria provided, multiple submitters, no conflicts
Select item 88830519.	NM_004530.6(MMP2):c.1276A>C (p.Thr426Pro) GRCh37: Chr16:55525808 GRCh38: Chr16:55491896	MMP2	T426P, T350P, T376P	Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 88824320.	NM_004530.6(MMP2):c.115G>A (p.Gly39Ser) GRCh37: Chr16:55513506 GRCh38: Chr16:55479594	MMP2	G39S	Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Apr 27, 2017)	criteria provided, single submitter
Select item 88824221.	NM_004530.6(MMP2):c.38C>G (p.Pro13Arg) GRCh37: Chr16:55513429 GRCh38: Chr16:55479517	MMP2	P13R	not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Aug 27, 2021)	criteria provided, multiple submitters, no conflicts
Select item 88717622.	NM_004530.6(MMP2):c.*1204A>G GRCh37: Chr16:55540558 GRCh38: Chr16:55506646	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 88710523.	NM_004530.6(MMP2):c.*111G>A GRCh37: Chr16:55539465 GRCh38: Chr16:55505553	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Jan 13, 2018)	criteria provided, single submitter
Select item 88710424.	NM_004530.6(MMP2):c.*93C>T GRCh37: Chr16:55539447 GRCh38: Chr16:55505535	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Jan 12, 2018)	criteria provided, single submitter
Select item 88710325.	NM_004530.6(MMP2):c.*43G>A GRCh37: Chr16:55539397 GRCh38: Chr16:55505485	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 88703626.	NM_004530.6(MMP2):c.969C>T (p.Tyr323=) GRCh37: Chr16:55522591 GRCh38: Chr16:55488679	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Conflicting interpretations of pathogenicity (May 3, 2022)	criteria provided, conflicting interpretations
Select item 88697527.	NM_004530.6(MMP2):c.-147T>A GRCh37: Chr16:55513245 GRCh38: Chr16:55479333	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 88616428.	NM_004530.6(MMP2):c.*1048C>T GRCh37: Chr16:55540402 GRCh38: Chr16:55506490	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 88616329.	NM_004530.6(MMP2):c.*1029G>A GRCh37: Chr16:55540383 GRCh38: Chr16:55506471	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 88616230.	NM_004530.6(MMP2):c.*1012T>A GRCh37: Chr16:55540366 GRCh38: Chr16:55506454	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 88616131.	NM_004530.6(MMP2):c.*799G>A GRCh37: Chr16:55540153 GRCh38: Chr16:55506241	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 88604432.	NM_004530.6(MMP2):c.920C>T (p.Thr307Ile) GRCh37: Chr16:55522542 GRCh38: Chr16:55488630	MMP2	T307I, T257I, T231I	Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Mar 16, 2018)	criteria provided, single submitter
Select item 88604333.	NM_004530.6(MMP2):c.890T>A (p.Phe297Tyr) GRCh37: Chr16:55522512 GRCh38: Chr16:55488600	MMP2	F247Y, F221Y, F297Y	Multicentric osteolysis nodulosis arthropathy spectrum, not provided	Uncertain significance (Dec 27, 2021)	criteria provided, multiple submitters, no conflicts
Select item 88604234.	NM_004530.6(MMP2):c.887G>A (p.Arg296His) GRCh37: Chr16:55522509 GRCh38: Chr16:55488597	MMP2	R246H, R220H, R296H	Inborn genetic diseases, not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Apr 8, 2023)	criteria provided, multiple submitters, no conflicts
Select item 88604135.	NM_004530.6(MMP2):c.813C>T (p.Tyr271=) GRCh37: Chr16:55519670 GRCh38: Chr16:55485758	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Conflicting interpretations of pathogenicity (Nov 21, 2020)	criteria provided, conflicting interpretations
Select item 88526836.	NM_004530.6(MMP2):c.*642T>C GRCh37: Chr16:55539996 GRCh38: Chr16:55506084	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 88526737.	NM_004530.6(MMP2):c.*523T>C GRCh37: Chr16:55539877 GRCh38: Chr16:55505965	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Likely benign (Jan 13, 2018)	criteria provided, single submitter
Select item 88526638.	NM_004530.6(MMP2):c.*505T>G GRCh37: Chr16:55539859 GRCh38: Chr16:55505947	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 88520439.	NM_004530.6(MMP2):c.1685C>T (p.Pro562Leu) GRCh37: Chr16:55532276 GRCh38: Chr16:55498364	MMP2	P562L, P486L, P512L	not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Oct 24, 2022)	criteria provided, multiple submitters, no conflicts
Select item 88520340.	NM_004530.6(MMP2):c.1634C>T (p.Ala545Val) GRCh37: Chr16:55532225 GRCh38: Chr16:55498313	MMP2	A495V, A545V, A469V	not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Oct 17, 2022)	criteria provided, multiple submitters, no conflicts
Select item 88520241.	NM_004530.6(MMP2):c.1627T>C (p.Tyr543His) GRCh37: Chr16:55532218 GRCh38: Chr16:55498306	MMP2	Y493H, Y543H, Y467H	not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Oct 10, 2022)	criteria provided, multiple submitters, no conflicts
Select item 88520142.	NM_004530.6(MMP2):c.1560T>C (p.Ile520=) GRCh37: Chr16:55530925 GRCh38: Chr16:55497013	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 88520043.	NM_004530.6(MMP2):c.1551G>A (p.Pro517=) GRCh37: Chr16:55530916 GRCh38: Chr16:55497004	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Conflicting interpretations of pathogenicity (Jun 19, 2022)	criteria provided, conflicting interpretations
Select item 88513744.	NM_004530.6(MMP2):c.474G>A (p.Arg158=) GRCh37: Chr16:55518021 GRCh38: Chr16:55484109	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 88513645.	NM_004530.6(MMP2):c.344G>T (p.Arg115Leu) GRCh37: Chr16:55517011 GRCh38: Chr16:55483099	MMP2	R65L, R39L, R115L	Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 88513546.	NM_004530.6(MMP2):c.306C>T (p.Cys102=) GRCh37: Chr16:55516973 GRCh38: Chr16:55483061	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum, not provided	Conflicting interpretations of pathogenicity (Aug 29, 2022)	criteria provided, conflicting interpretations
Select item 88513447.	NM_004530.6(MMP2):c.153+12C>T GRCh37: Chr16:55513556 GRCh38: Chr16:55479644	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 78908548.	NM_004530.6(MMP2):c.1861G>C (p.Val621Leu) GRCh37: Chr16:55536782 GRCh38: Chr16:55502870	MMP2	V571L, V621L, V545L	not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Nov 1, 2022)	criteria provided, multiple submitters, no conflicts
Select item 73693649.	NM_004530.6(MMP2):c.1499G>A (p.Arg500His) GRCh37: Chr16:55530864 GRCh38: Chr16:55496952	MMP2	R500H, R424H, R450H	Multicentric osteolysis nodulosis arthropathy spectrum, not provided	Benign (Oct 17, 2022)	criteria provided, multiple submitters, no conflicts
Select item 73230350.	NM_004530.6(MMP2):c.1842C>T (p.Pro614=) GRCh37: Chr16:55536763 GRCh38: Chr16:55502851	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Conflicting interpretations of pathogenicity (Jan 3, 2018)	criteria provided, conflicting interpretations
Select item 72936151.	NM_004530.6(MMP2):c.96G>T (p.Ser32=) GRCh37: Chr16:55513487 GRCh38: Chr16:55479575	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum, not provided	Conflicting interpretations of pathogenicity (Nov 1, 2022)	criteria provided, conflicting interpretations
Select item 72050852.	NM_004530.6(MMP2):c.1227G>A (p.Met409Ile) GRCh37: Chr16:55525759 GRCh38: Chr16:55491847	MMP2	M359I, M409I, M333I	not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Oct 21, 2022)	criteria provided, multiple submitters, no conflicts
Select item 71402153.	NM_004530.6(MMP2):c.1860C>T (p.Val620=) GRCh37: Chr16:55536781 GRCh38: Chr16:55502869	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Conflicting interpretations of pathogenicity (Oct 30, 2022)	criteria provided, conflicting interpretations
Select item 69037554.	NM_004530.6(MMP2):c.377A>G (p.Tyr126Cys) GRCh37: Chr16:55517044 GRCh38: Chr16:55483132	MMP2	Y126C, Y50C, Y76C	Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Dec 20, 2018)	criteria provided, single submitter
Select item 62585355.	NM_017839.5(LPCAT2):c.172-6188G>A GRCh37: Chr16:55553232 GRCh38: Chr16:55519320	LPCAT2		Multicentric osteolysis nodulosis arthropathy spectrum	Pathogenic	no assertion criteria provided
Select item 49945856.	NM_004530.6(MMP2):c.1802G>T (p.Gly601Val) GRCh37: Chr16:55536723 GRCh38: Chr16:55502811	MMP2	G601V, G551V, G525V	not specified, not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Likely benign (Sep 24, 2022)	criteria provided, multiple submitters, no conflicts
Select item 49852757.	NM_004530.6(MMP2):c.496G>A (p.Glu166Lys) GRCh37: Chr16:55518043 GRCh38: Chr16:55484131	MMP2	E166K, E116K, E90K	not specified, not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Benign/Likely benign (Oct 5, 2022)	criteria provided, multiple submitters, no conflicts
Select item 37434558.	NM_004530.6(MMP2):c.539A>T (p.Asp180Val) GRCh37: Chr16:55519220 GRCh38: Chr16:55485308	MMP2	D180V, D104V, D130V	Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jun 10, 2015)	no assertion criteria provided
Select item 31978759.	NM_004530.6(MMP2):c.*1204A>T GRCh37: Chr16:55540558 GRCh38: Chr16:55506646	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 31978660.	NM_004530.6(MMP2):c.*1062C>T GRCh37: Chr16:55540416 GRCh38: Chr16:55506504	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Jan 13, 2018)	criteria provided, single submitter
Select item 31978561.	NM_004530.6(MMP2):c.*930C>T GRCh37: Chr16:55540284 GRCh38: Chr16:55506372	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 31978462.	NM_004530.6(MMP2):c.*872C>T GRCh37: Chr16:55540226 GRCh38: Chr16:55506314	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Jan 13, 2018)	criteria provided, single submitter
Select item 31978363.	NM_004530.6(MMP2):c.*853A>G GRCh37: Chr16:55540207 GRCh38: Chr16:55506295	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 31978264.	NM_004530.6(MMP2):c.*669C>G GRCh37: Chr16:55540023 GRCh38: Chr16:55506111	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Jan 13, 2018)	criteria provided, single submitter
Select item 31978165.	NM_004530.6(MMP2):c.*627T>C GRCh37: Chr16:55539981 GRCh38: Chr16:55506069	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 31977966.	NM_004530.6(MMP2):c.*498A>G GRCh37: Chr16:55539852 GRCh38: Chr16:55505940	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 31977867.	NM_004530.6(MMP2):c.*453C>G GRCh37: Chr16:55539807 GRCh38: Chr16:55505895	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Likely benign (Jan 13, 2018)	criteria provided, single submitter
Select item 31977768.	NM_004530.6(MMP2):c.*400G>A GRCh37: Chr16:55539754 GRCh38: Chr16:55505842	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Jan 13, 2018)	criteria provided, single submitter
Select item 31977669.	NM_004530.6(MMP2):c.*260A>C GRCh37: Chr16:55539614 GRCh38: Chr16:55505702	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum, not provided	Benign (Oct 31, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31977570.	NM_004530.6(MMP2):c.*228C>T GRCh37: Chr16:55539582 GRCh38: Chr16:55505670	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 31977471.	NM_004530.6(MMP2):c.*212C>T GRCh37: Chr16:55539566 GRCh38: Chr16:55505654	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Likely benign (Jan 13, 2018)	criteria provided, single submitter
Select item 31977372.	NM_004530.6(MMP2):c.*170G>A GRCh37: Chr16:55539524 GRCh38: Chr16:55505612	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Jan 13, 2018)	criteria provided, single submitter
Select item 31977273.	NM_004530.6(MMP2):c.*159T>C GRCh37: Chr16:55539513 GRCh38: Chr16:55505601	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Jan 13, 2018)	criteria provided, single submitter
Select item 31977174.	NM_004530.6(MMP2):c.*132T>A GRCh37: Chr16:55539486 GRCh38: Chr16:55505574	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 31977075.	NM_004530.6(MMP2):c.*51G>A GRCh37: Chr16:55539405 GRCh38: Chr16:55505493	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 31976976.	NM_004530.6(MMP2):c.1842C>G (p.Pro614=) GRCh37: Chr16:55536763 GRCh38: Chr16:55502851	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Nov 3, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31976877.	NM_004530.6(MMP2):c.1806C>T (p.Phe602=) GRCh37: Chr16:55536727 GRCh38: Chr16:55502815	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Nov 4, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31976778.	NM_004530.6(MMP2):c.1779G>A (p.Glu593=) GRCh37: Chr16:55536700 GRCh38: Chr16:55502788	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum, not provided	Conflicting interpretations of pathogenicity (May 29, 2022)	criteria provided, conflicting interpretations
Select item 31976679.	NM_004530.6(MMP2):c.1770-4A>G GRCh37: Chr16:55536687 GRCh38: Chr16:55502775	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum, not provided	Benign (Nov 4, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31976580.	NM_004530.6(MMP2):c.1769+10G>A GRCh37: Chr16:55532370 GRCh38: Chr16:55498458	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum, not provided	Benign/Likely benign (Mar 18, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31976481.	NM_004530.6(MMP2):c.1758C>A (p.Asp586Glu) GRCh37: Chr16:55532349 GRCh38: Chr16:55498437	MMP2	D586E, D536E, D510E	Multicentric osteolysis nodulosis arthropathy spectrum, Inborn genetic diseases	Uncertain significance (Oct 6, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31976382.	NM_004530.6(MMP2):c.1572C>T (p.Tyr524=) GRCh37: Chr16:55530937 GRCh38: Chr16:55497025	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Conflicting interpretations of pathogenicity (Dec 1, 2022)	criteria provided, conflicting interpretations
Select item 31976283.	NM_004530.6(MMP2):c.1567G>T (p.Val523Leu) GRCh37: Chr16:55530932 GRCh38: Chr16:55497020	MMP2	V523L, V473L, V447L	Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 31976184.	NM_004530.6(MMP2):c.1380G>A (p.Thr460=) GRCh37: Chr16:55527113 GRCh38: Chr16:55493201	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum, not provided	Benign (Nov 4, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31976085.	NM_004530.6(MMP2):c.1340C>T (p.Ala447Val) GRCh37: Chr16:55527073 GRCh38: Chr16:55493161	MMP2	A447V, A371V, A397V	Multicentric osteolysis nodulosis arthropathy spectrum, not provided	Benign (Oct 31, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31975986.	NM_004530.6(MMP2):c.1337-7T>C GRCh37: Chr16:55527063 GRCh38: Chr16:55493151	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum, not provided	Benign/Likely benign (Oct 23, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31975887.	NM_004530.6(MMP2):c.1336+11G>A GRCh37: Chr16:55525879 GRCh38: Chr16:55491967	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Conflicting interpretations of pathogenicity (Oct 13, 2022)	criteria provided, conflicting interpretations
Select item 31975788.	NM_004530.6(MMP2):c.1233G>A (p.Leu411=) GRCh37: Chr16:55525765 GRCh38: Chr16:55491853	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Conflicting interpretations of pathogenicity (Sep 7, 2022)	criteria provided, conflicting interpretations
Select item 31975689.	NM_004530.6(MMP2):c.1149T>C (p.Asp383=) GRCh37: Chr16:55523705 GRCh38: Chr16:55489793	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Nov 4, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31975590.	NM_004530.6(MMP2):c.1144G>A (p.Asp382Asn) GRCh37: Chr16:55523700 GRCh38: Chr16:55489788	MMP2	D382N, D306N, D332N	not provided, Multicentric osteolysis nodulosis arthropathy spectrum, Inborn genetic diseases	Uncertain significance (Jul 12, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31975491.	NM_004530.6(MMP2):c.1098C>T (p.Ala366=) GRCh37: Chr16:55523654 GRCh38: Chr16:55489742	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Nov 3, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31975392.	NM_004530.6(MMP2):c.1066C>T (p.Leu356=) GRCh37: Chr16:55523622 GRCh38: Chr16:55489710	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Nov 1, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31975293.	NM_004530.6(MMP2):c.832+12C>T GRCh37: Chr16:55519701 GRCh38: Chr16:55485789	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Oct 30, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31975194.	NM_004530.6(MMP2):c.750C>T (p.Thr250=) GRCh37: Chr16:55519607 GRCh38: Chr16:55485695	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Nov 1, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31975095.	NM_004530.6(MMP2):c.678G>C (p.Gly226=) GRCh37: Chr16:55519535 GRCh38: Chr16:55485623	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Benign (Nov 4, 2022)	criteria provided, multiple submitters, no conflicts
Select item 31974996.	NM_004530.6(MMP2):c.658+13C>T GRCh37: Chr16:55519352 GRCh38: Chr16:55485440	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Conflicting interpretations of pathogenicity (Jan 3, 2022)	criteria provided, conflicting interpretations
Select item 31974897.	NM_004530.6(MMP2):c.658+10G>A GRCh37: Chr16:55519349 GRCh38: Chr16:55485437	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Conflicting interpretations of pathogenicity (Nov 2, 2022)	criteria provided, conflicting interpretations
Select item 31974798.	NM_004530.6(MMP2):c.588C>T (p.Ala196=) GRCh37: Chr16:55519269 GRCh38: Chr16:55485357	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 31974699.	NM_004530.6(MMP2):c.51C>T (p.Leu17=) GRCh37: Chr16:55513442 GRCh38: Chr16:55479530	MMP2		not provided, Multicentric osteolysis nodulosis arthropathy spectrum	Benign/Likely benign (Jun 28, 2022)	criteria provided, multiple submitters, no conflicts
Select item 319745100.	NM_004530.6(MMP2):c.-2C>A GRCh37: Chr16:55513390 GRCh38: Chr16:55479478	MMP2		Multicentric osteolysis nodulosis arthropathy spectrum	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter

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