ClinVar for MedGen (Select 413312) - ClinVar - NCBI

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VariationLocation		Gene(s)	Protein change	Condition(s)	Clinical significance (Last reviewed)	Review status
Select item 25021551.	NM_014000.3(VCL):c.1360G>A (p.Gly454Arg) GRCh37: Chr10:75854036 GRCh38: Chr10:74094278	VCL	G454R	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15	Uncertain significance (Apr 20, 2022)	criteria provided, single submitter
Select item 25001092.	NM_014000.3(VCL):c.2607G>C (p.Glu869Asp) GRCh37: Chr10:75868776 GRCh38: Chr10:74109018	VCL	E869D	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Mar 30, 2021)	criteria provided, single submitter
Select item 18038263.	NM_014000.3(VCL):c.1343T>C (p.Leu448Pro) GRCh37: Chr10:75849947 GRCh38: Chr10:74090189	VCL	L448P	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15	Uncertain significance (Jun 11, 2021)	criteria provided, single submitter
Select item 15501874.	NM_014000.3(VCL):c.2001G>A (p.Thr667=) GRCh37: Chr10:75860834 GRCh38: Chr10:74101076	VCL		Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Likely benign (Oct 4, 2021)	criteria provided, multiple submitters, no conflicts
Select item 14837725.	NM_014000.3(VCL):c.1132A>G (p.Thr378Ala) GRCh37: Chr10:75849063 GRCh38: Chr10:74089305	VCL	T378A	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Sep 1, 2021)	criteria provided, multiple submitters, no conflicts
Select item 14377566.	NM_014000.3(VCL):c.2305A>G (p.Arg769Gly) GRCh37: Chr10:75864982 GRCh38: Chr10:74105224	VCL	R769G	Cardiovascular phenotype, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Apr 19, 2022)	criteria provided, multiple submitters, no conflicts
Select item 13827287.	NM_014000.3(VCL):c.1225C>G (p.Arg409Gly) GRCh37: Chr10:75849829 GRCh38: Chr10:74090071	VCL	R409G	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Aug 31, 2021)	criteria provided, multiple submitters, no conflicts
Select item 13726008.	NM_014000.3(VCL):c.806C>G (p.Ala269Gly) GRCh37: Chr10:75842234 GRCh38: Chr10:74082476	VCL	A269G	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Feb 22, 2022)	criteria provided, multiple submitters, no conflicts
Select item 13126129.	NM_014000.3(VCL):c.482C>G (p.Thr161Arg) GRCh37: Chr10:75830824 GRCh38: Chr10:74071066	VCL	T161R	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided	Uncertain significance (Feb 2, 2022)	criteria provided, multiple submitters, no conflicts
Select item 130983010.	NM_014000.3(VCL):c.686dup (p.Asn229fs) GRCh37: Chr10:75834558-75834559 GRCh38: Chr10:74074800-74074801	VCL	N229fs	Dilated cardiomyopathy 1W, not provided, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Dec 11, 2021)	criteria provided, multiple submitters, no conflicts
Select item 130874111.	NM_014000.3(VCL):c.1465G>A (p.Ala489Thr) GRCh37: Chr10:75854141 GRCh38: Chr10:74094383	VCL	A489T	Dilated cardiomyopathy 1W, not provided, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (May 18, 2022)	criteria provided, multiple submitters, no conflicts
Select item 130660512.	NM_014000.3(VCL):c.844G>T (p.Gly282Cys) GRCh37: Chr10:75842272 GRCh38: Chr10:74082514	VCL	G282C	Dilated cardiomyopathy 1W, not provided, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Cardiovascular phenotype	Uncertain significance (Apr 22, 2022)	criteria provided, multiple submitters, no conflicts
Select item 126403913.	NM_014000.3(VCL):c.3153+47T>C GRCh37: Chr10:75874192 GRCh38: Chr10:74114434	VCL		not provided, Hypertrophic cardiomyopathy 15	Benign (Dec 5, 2021)	criteria provided, multiple submitters, no conflicts
Select item 117480614.	NM_014000.3(VCL):c.1558C>T (p.Arg520Trp) GRCh37: Chr10:75855428 GRCh38: Chr10:74095670	VCL	R520W	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Cardiovascular phenotype, Dilated cardiomyopathy 1W	Uncertain significance (Oct 17, 2022)	criteria provided, multiple submitters, no conflicts
Select item 102202215.	NM_014000.3(VCL):c.2023-1G>C GRCh37: Chr10:75863577 GRCh38: Chr10:74103819	VCL		Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Sep 10, 2021)	criteria provided, multiple submitters, no conflicts
Select item 101662516.	NM_014000.3(VCL):c.1503G>C (p.Gln501His) GRCh37: Chr10:75854179 GRCh38: Chr10:74094421	VCL	Q501H	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Jul 22, 2022)	criteria provided, multiple submitters, no conflicts
Select item 100619017.	NM_014000.3(VCL):c.625A>G (p.Met209Val) GRCh37: Chr10:75834503 GRCh38: Chr10:74074745	VCL	M209V	Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15	Uncertain significance (Oct 9, 2021)	criteria provided, multiple submitters, no conflicts
Select item 96815618.	NM_014000.3(VCL):c.2579del (p.Pro860fs) GRCh37: Chr10:75868747 GRCh38: Chr10:74108989	VCL	P860fs	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Sep 19, 2022)	criteria provided, multiple submitters, no conflicts
Select item 96035519.	NM_014000.3(VCL):c.1606C>A (p.Pro536Thr) GRCh37: Chr10:75855476 GRCh38: Chr10:74095718	VCL	P536T	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W, Cardiovascular phenotype	Uncertain significance (Nov 2, 2022)	criteria provided, multiple submitters, no conflicts
Select item 94415920.	NM_014000.3(VCL):c.1246C>T (p.Arg416Trp) GRCh37: Chr10:75849850 GRCh38: Chr10:74090092	VCL	R416W	Cardiovascular phenotype, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (May 19, 2022)	criteria provided, multiple submitters, no conflicts
Select item 94347021.	NM_014000.3(VCL):c.1354G>A (p.Gly452Arg) GRCh37: Chr10:75854030 GRCh38: Chr10:74094272	VCL	G452R	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Cardiovascular phenotype, Dilated cardiomyopathy 1W	Uncertain significance (Jan 25, 2023)	criteria provided, multiple submitters, no conflicts
Select item 94311822.	NM_014000.3(VCL):c.1640G>A (p.Arg547Gln) GRCh37: Chr10:75855510 GRCh38: Chr10:74095752	VCL	R547Q	Dilated cardiomyopathy 1W, Cardiovascular phenotype, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15	Uncertain significance (Jan 6, 2022)	criteria provided, multiple submitters, no conflicts
Select item 93398323.	NM_014000.3(VCL):c.739G>A (p.Val247Met) GRCh37: Chr10:75834617 GRCh38: Chr10:74074859	VCL	V247M	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Cardiovascular phenotype, Dilated cardiomyopathy 1W	Uncertain significance (Sep 3, 2022)	criteria provided, multiple submitters, no conflicts
Select item 91577224.	NM_014000.3(VCL):c.2407G>A (p.Ala803Thr) GRCh37: Chr10:75865084 GRCh38: Chr10:74105326	VCL	A803T	Cardiomyopathy, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Cardiovascular phenotype	Uncertain significance (Jan 12, 2022)	criteria provided, multiple submitters, no conflicts
Select item 87971725.	NM_014000.3(VCL):c.*646C>G GRCh37: Chr10:75878573 GRCh38: Chr10:74118815	VCL		Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15	Uncertain significance (Aug 24, 2021)	criteria provided, multiple submitters, no conflicts
Select item 87880826.	NM_014000.3(VCL):c.*1794G>A GRCh37: Chr10:75879721 GRCh38: Chr10:74119963	VCL		Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Jul 16, 2021)	criteria provided, multiple submitters, no conflicts
Select item 85637927.	NM_014000.3(VCL):c.2775_2780del (p.Gly926_Val927del) GRCh37: Chr10:75871695-75871700 GRCh38: Chr10:74111937-74111942	VCL		not specified, Cardiovascular phenotype, not provided, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Oct 27, 2022)	criteria provided, multiple submitters, no conflicts
Select item 85319828.	NM_014000.3(VCL):c.1457C>T (p.Pro486Leu) GRCh37: Chr10:75854133 GRCh38: Chr10:74094375	VCL	P486L	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Mar 23, 2022)	criteria provided, multiple submitters, no conflicts
Select item 84721129.	NM_014000.3(VCL):c.1435C>T (p.Arg479Trp) GRCh37: Chr10:75854111 GRCh38: Chr10:74094353	VCL	R479W	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Feb 10, 2022)	criteria provided, multiple submitters, no conflicts
Select item 84498230.	NM_014000.3(VCL):c.2747C>T (p.Pro916Leu) GRCh37: Chr10:75871668 GRCh38: Chr10:74111910	VCL	P916L	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Aug 13, 2022)	criteria provided, multiple submitters, no conflicts
Select item 84333631.	NM_014000.3(VCL):c.2558G>A (p.Arg853Gln) GRCh37: Chr10:75867111 GRCh38: Chr10:74107353	VCL	R853Q	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Sep 1, 2021)	criteria provided, multiple submitters, no conflicts
Select item 84123032.	NM_014000.3(VCL):c.527A>G (p.Asp176Gly) GRCh37: Chr10:75832515 GRCh38: Chr10:74072757	VCL	D176G	Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15	Uncertain significance (Sep 19, 2022)	criteria provided, multiple submitters, no conflicts
Select item 83776733.	NM_014000.3(VCL):c.2030C>T (p.Ser677Leu) GRCh37: Chr10:75863585 GRCh38: Chr10:74103827	VCL	S677L	not provided, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15	Uncertain significance (Aug 9, 2022)	criteria provided, multiple submitters, no conflicts
Select item 83467434.	NM_014000.3(VCL):c.1879G>A (p.Asp627Asn) GRCh37: Chr10:75860712 GRCh38: Chr10:74100954	VCL	D627N	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Aug 31, 2021)	criteria provided, multiple submitters, no conflicts
Select item 80651335.	NM_014000.3(VCL):c.2038C>T (p.Arg680Cys) GRCh37: Chr10:75863593 GRCh38: Chr10:74103835	VCL	R680C	not provided, Cardiovascular phenotype, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Aug 19, 2022)	criteria provided, multiple submitters, no conflicts
Select item 80650936.	NM_014000.3(VCL):c.239+6T>G GRCh37: Chr10:75802917 GRCh38: Chr10:74043159	VCL		Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided, Dilated cardiomyopathy 1W	Uncertain significance (Apr 12, 2022)	criteria provided, multiple submitters, no conflicts
Select item 66554337.	NM_014000.3(VCL):c.1620T>A (p.Asp540Glu) GRCh37: Chr10:75855490 GRCh38: Chr10:74095732	VCL	D540E	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Sep 1, 2021)	criteria provided, multiple submitters, no conflicts
Select item 66329638.	NM_014000.3(VCL):c.1743+6A>G GRCh37: Chr10:75855619 GRCh38: Chr10:74095861	VCL		Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Sep 20, 2022)	criteria provided, multiple submitters, no conflicts
Select item 65794839.	NM_014000.3(VCL):c.1039C>T (p.Pro347Ser) GRCh37: Chr10:75848970 GRCh38: Chr10:74089212	VCL	P347S	not provided, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Cardiomyopathy	Uncertain significance (Dec 27, 2022)	criteria provided, multiple submitters, no conflicts
Select item 64096740.	NM_014000.3(VCL):c.20G>T (p.Arg7Leu) GRCh37: Chr10:75757985 GRCh38: Chr10:73998227	VCL	R7L	Inborn genetic diseases, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Jan 20, 2023)	criteria provided, multiple submitters, no conflicts
Select item 64017241.	NM_014000.3(VCL):c.2285G>A (p.Arg762Gln) GRCh37: Chr10:75864962 GRCh38: Chr10:74105204	VCL	R762Q	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Oct 30, 2022)	criteria provided, multiple submitters, no conflicts
Select item 61848342.	NM_014000.3(VCL):c.2905G>A (p.Ala969Thr) GRCh37: Chr10:75871826 GRCh38: Chr10:74112068	VCL	A969T	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, not provided, Dilated cardiomyopathy 1W	Uncertain significance (Apr 18, 2022)	criteria provided, multiple submitters, no conflicts
Select item 57544843.	NM_014000.3(VCL):c.1046C>T (p.Ala349Val) GRCh37: Chr10:75848977 GRCh38: Chr10:74089219	VCL	A349V	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Cardiovascular phenotype, Dilated cardiomyopathy 1W	Uncertain significance (Jul 15, 2022)	criteria provided, multiple submitters, no conflicts
Select item 56007144.	Single allele GRCh37: Chr10:75802539-75896413	AP3M1, VCL		Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Oct 30, 2015)	criteria provided, single submitter
Select item 53671145.	NM_014000.3(VCL):c.853C>T (p.Arg285Cys) GRCh37: Chr10:75842281 GRCh38: Chr10:74082523	VCL	R285C	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy	Uncertain significance (Jan 28, 2022)	criteria provided, multiple submitters, no conflicts
Select item 53671046.	NM_014000.3(VCL):c.2443A>G (p.Lys815Glu) GRCh37: Chr10:75866996 GRCh38: Chr10:74107238	VCL	K815E	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Jul 26, 2022)	criteria provided, multiple submitters, no conflicts
Select item 53670647.	NM_014000.3(VCL):c.768T>A (p.Asp256Glu) GRCh37: Chr10:75834646 GRCh38: Chr10:74074888	VCL	D256E	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Oct 24, 2022)	criteria provided, multiple submitters, no conflicts
Select item 53670448.	NM_014000.3(VCL):c.2531C>T (p.Pro844Leu) GRCh37: Chr10:75867084 GRCh38: Chr10:74107326	VCL	P844L	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided, Cardiovascular phenotype	Uncertain significance (Aug 15, 2023)	criteria provided, multiple submitters, no conflicts
Select item 51877049.	NM_014000.3(VCL):c.2399A>T (p.Asp800Val) GRCh37: Chr10:75865076 GRCh38: Chr10:74105318	VCL	D800V	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided, Dilated cardiomyopathy 1W	Uncertain significance (Sep 27, 2022)	criteria provided, multiple submitters, no conflicts
Select item 50639150.	NM_014000.3(VCL):c.169-11del GRCh37: Chr10:75802823 GRCh38: Chr10:74043065	VCL		Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not specified	Benign/Likely benign (Sep 25, 2022)	criteria provided, multiple submitters, no conflicts
Select item 50502451.	NM_014000.3(VCL):c.1490T>C (p.Ile497Thr) GRCh37: Chr10:75854166 GRCh38: Chr10:74094408	VCL	I497T	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W, not specified, not provided	Uncertain significance (May 9, 2023)	criteria provided, multiple submitters, no conflicts
Select item 49845752.	NM_014000.3(VCL):c.875-24T>A GRCh37: Chr10:75843100 GRCh38: Chr10:74083342	VCL		not specified, not provided, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15	Benign (Nov 4, 2022)	criteria provided, multiple submitters, no conflicts
Select item 49642353.	NM_014000.3(VCL):c.238A>C (p.Lys80Gln) GRCh37: Chr10:75802910 GRCh38: Chr10:74043152	VCL	K80Q	Cardiovascular phenotype, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, not provided	Uncertain significance (Apr 26, 2022)	criteria provided, multiple submitters, no conflicts
Select item 48817454.	NM_014000.3(VCL):c.625A>T (p.Met209Leu) GRCh37: Chr10:75834503 GRCh38: Chr10:74074745	VCL	M209L	Hypertrophic cardiomyopathy 15, Cardiomyopathy, Dilated cardiomyopathy 1W, not specified	Uncertain significance (May 16, 2023)	criteria provided, multiple submitters, no conflicts
Select item 48763055.	NM_014000.3(VCL):c.550C>T (p.His184Tyr) GRCh37: Chr10:75832538 GRCh38: Chr10:74072780	VCL	H184Y	Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, not provided	Uncertain significance (Mar 19, 2022)	criteria provided, multiple submitters, no conflicts
Select item 48762756.	NM_014000.3(VCL):c.1928C>T (p.Thr643Met) GRCh37: Chr10:75860761 GRCh38: Chr10:74101003	VCL	T643M	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided, Dilated cardiomyopathy 1W	Uncertain significance (Oct 19, 2022)	criteria provided, multiple submitters, no conflicts
Select item 46882457.	NM_014000.3(VCL):c.787A>T (p.Thr263Ser) GRCh37: Chr10:75842215 GRCh38: Chr10:74082457	VCL	T263S	Cardiovascular phenotype, not provided, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Conflicting interpretations of pathogenicity (Oct 24, 2022)	criteria provided, conflicting interpretations
Select item 46882258.	NM_014000.3(VCL):c.458C>T (p.Thr153Ile) GRCh37: Chr10:75830800 GRCh38: Chr10:74071042	VCL	T153I	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Aug 28, 2021)	criteria provided, multiple submitters, no conflicts
Select item 46881259.	NM_014000.3(VCL):c.1814C>G (p.Pro605Arg) GRCh37: Chr10:75857032 GRCh38: Chr10:74097274	VCL	P605R	Dilated cardiomyopathy 1W, Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Mar 20, 2023)	criteria provided, multiple submitters, no conflicts
Select item 46880560.	NM_014000.3(VCL):c.1296_1297inv (p.Arg433Cys) GRCh37: Chr10:75849900-75849901 GRCh38: Chr10:74090142-74090143	VCL	R433C	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided, Dilated cardiomyopathy 1W	Conflicting interpretations of pathogenicity (Sep 12, 2022)	criteria provided, conflicting interpretations
Select item 45229661.	NM_014000.3(VCL):c.1940C>T (p.Ala647Val) GRCh37: Chr10:75860773 GRCh38: Chr10:74101015	VCL	A647V	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided, Cardiovascular phenotype, Dilated cardiomyopathy 1W	Uncertain significance (Aug 8, 2022)	criteria provided, multiple submitters, no conflicts
Select item 45085062.	NM_014000.3(VCL):c.565G>T (p.Val189Leu) GRCh37: Chr10:75832553 GRCh38: Chr10:74072795	VCL	V189L	Cardiovascular phenotype, not provided, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15	Uncertain significance (Oct 26, 2022)	criteria provided, multiple submitters, no conflicts
Select item 42421963.	NM_014000.3(VCL):c.2528C>T (p.Pro843Leu) GRCh37: Chr10:75867081 GRCh38: Chr10:74107323	VCL	P843L	Dilated cardiomyopathy 1W, not provided, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15	Uncertain significance (Aug 9, 2022)	criteria provided, multiple submitters, no conflicts
Select item 41795064.	NM_014000.3(VCL):c.158A>G (p.Asn53Ser) GRCh37: Chr10:75758123 GRCh38: Chr10:73998365	VCL	N53S	Cardiovascular phenotype, Dilated cardiomyopathy 1W	Uncertain significance (Aug 31, 2021)	criteria provided, multiple submitters, no conflicts
Select item 40895565.	NM_014000.3(VCL):c.2022+5G>T GRCh37: Chr10:75860860 GRCh38: Chr10:74101102	VCL		Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Mar 13, 2022)	criteria provided, multiple submitters, no conflicts
Select item 40895366.	NM_014000.3(VCL):c.2866A>G (p.Met956Val) GRCh37: Chr10:75871787 GRCh38: Chr10:74112029	VCL	M956V	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Oct 10, 2022)	criteria provided, multiple submitters, no conflicts
Select item 40894967.	NM_014000.3(VCL):c.1195A>C (p.Asn399His) GRCh37: Chr10:75849799 GRCh38: Chr10:74090041	VCL	N399H	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Dec 1, 2022)	criteria provided, multiple submitters, no conflicts
Select item 40894868.	NM_014000.3(VCL):c.2823_2824delinsGT (p.Pro942Ser) GRCh37: Chr10:75871744-75871745 GRCh38: Chr10:74111986-74111987	VCL	P942S	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (May 29, 2022)	criteria provided, multiple submitters, no conflicts
Select item 40894669.	NM_014000.3(VCL):c.1865G>A (p.Arg622Lys) GRCh37: Chr10:75857083 GRCh38: Chr10:74097325	VCL	R622K	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Mar 19, 2022)	criteria provided, multiple submitters, no conflicts
Select item 40894570.	NM_014000.3(VCL):c.2649A>C (p.Glu883Asp) GRCh37: Chr10:75868818 GRCh38: Chr10:74109060	VCL	E883D	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Jul 1, 2022)	criteria provided, multiple submitters, no conflicts
Select item 40894471.	NM_014000.3(VCL):c.1031G>C (p.Gly344Ala) GRCh37: Chr10:75848962 GRCh38: Chr10:74089204	VCL	G344A	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, not provided, Dilated cardiomyopathy 1W	Uncertain significance (Sep 3, 2022)	criteria provided, multiple submitters, no conflicts
Select item 40894272.	NM_014000.3(VCL):c.1511T>C (p.Ile504Thr) GRCh37: Chr10:75854187 GRCh38: Chr10:74094429	VCL	I504T	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided, Dilated cardiomyopathy 1W	Uncertain significance (Dec 6, 2022)	criteria provided, multiple submitters, no conflicts
Select item 39283773.	NM_014000.3(VCL):c.1744-1G>T GRCh37: Chr10:75856961 GRCh38: Chr10:74097203	VCL		Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W, not provided	Uncertain significance (Oct 18, 2022)	criteria provided, multiple submitters, no conflicts
Select item 37885074.	NM_014000.3(VCL):c.3381T>C (p.Val1127=) GRCh37: Chr10:75877903 GRCh38: Chr10:74118145	VCL		not specified, Cardiovascular phenotype, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Likely benign (Oct 17, 2022)	criteria provided, multiple submitters, no conflicts
Select item 37884875.	NM_014000.3(VCL):c.239+11G>A GRCh37: Chr10:75802922 GRCh38: Chr10:74043164	VCL		Dilated cardiomyopathy 1W, not specified, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Likely benign (Oct 1, 2022)	criteria provided, multiple submitters, no conflicts
Select item 30082876.	NM_014000.3(VCL):c.*1854A>C GRCh37: Chr10:75879781 GRCh38: Chr10:74120023	VCL		Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Benign/Likely benign (Sep 18, 2021)	criteria provided, multiple submitters, no conflicts
Select item 30082777.	NM_014000.3(VCL):c.*1853A>C GRCh37: Chr10:75879780 GRCh38: Chr10:74120022	VCL		Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Benign/Likely benign (Aug 12, 2021)	criteria provided, multiple submitters, no conflicts
Select item 30082078.	NM_014000.3(VCL):c.*1761A>G GRCh37: Chr10:75879688 GRCh38: Chr10:74119930	VCL		Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Jul 8, 2021)	criteria provided, multiple submitters, no conflicts
Select item 30081679.	NM_014000.3(VCL):c.*1659C>T GRCh37: Chr10:75879586 GRCh38: Chr10:74119828	VCL		Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Aug 12, 2021)	criteria provided, multiple submitters, no conflicts
Select item 30081280.	NM_014000.3(VCL):c.*1285C>T GRCh37: Chr10:75879212 GRCh38: Chr10:74119454	VCL		Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Sep 14, 2021)	criteria provided, multiple submitters, no conflicts
Select item 30081181.	NM_014000.3(VCL):c.*1282C>T GRCh37: Chr10:75879209 GRCh38: Chr10:74119451	VCL		Dilated Cardiomyopathy, Dominant, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Aug 24, 2021)	criteria provided, multiple submitters, no conflicts
Select item 30080182.	NM_014000.3(VCL):c.*212C>A GRCh37: Chr10:75878139 GRCh38: Chr10:74118381	VCL		Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Jul 20, 2021)	criteria provided, multiple submitters, no conflicts
Select item 30079783.	NM_014000.3(VCL):c.2807C>T (p.Ala936Val) GRCh37: Chr10:75871728 GRCh38: Chr10:74111970	VCL	A936V	not provided, Cardiovascular phenotype, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15	Uncertain significance (Jan 11, 2023)	criteria provided, multiple submitters, no conflicts
Select item 30079384.	NM_014000.3(VCL):c.2006G>A (p.Arg669Gln) GRCh37: Chr10:75860839 GRCh38: Chr10:74101081	VCL	R669Q	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided, Long QT syndrome, Cardiovascular phenotype, Dilated cardiomyopathy 1W	Uncertain significance (Jul 24, 2023)	criteria provided, multiple submitters, no conflicts
Select item 30078785.	NM_014000.3(VCL):c.1287T>A (p.Asp429Glu) GRCh37: Chr10:75849891 GRCh38: Chr10:74090133	VCL	D429E	Cardiovascular phenotype, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided	Uncertain significance (May 25, 2022)	criteria provided, multiple submitters, no conflicts
Select item 30078686.	NM_014000.3(VCL):c.1040C>T (p.Pro347Leu) GRCh37: Chr10:75848971 GRCh38: Chr10:74089213	VCL	P347L	Cardiovascular phenotype, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, not provided, Dilated cardiomyopathy 1W	Uncertain significance (Sep 26, 2022)	criteria provided, multiple submitters, no conflicts
Select item 30078387.	NM_014000.3(VCL):c.592G>A (p.Val198Met) GRCh37: Chr10:75832580 GRCh38: Chr10:74072822	VCL	V198M	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W	Uncertain significance (Mar 16, 2022)	criteria provided, multiple submitters, no conflicts
Select item 26334588.	NM_014000.3(VCL):c.1621C>G (p.Leu541Val) GRCh37: Chr10:75855491 GRCh38: Chr10:74095733	VCL	L541V	Primary familial dilated cardiomyopathy, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not specified, Dilated cardiomyopathy 1W, Cardiovascular phenotype, not provided, Cardiomyopathy	Uncertain significance (Feb 24, 2023)	criteria provided, multiple submitters, no conflicts
Select item 22288989.	NM_014000.3(VCL):c.2468G>A (p.Arg823Gln) GRCh37: Chr10:75867021 GRCh38: Chr10:74107263	VCL	R823Q	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, Dilated cardiomyopathy 1W, not provided, Primary familial hypertrophic cardiomyopathy	Uncertain significance (Oct 7, 2022)	criteria provided, multiple submitters, no conflicts
Select item 21749790.	NM_014000.3(VCL):c.1531G>T (p.Asp511Tyr) GRCh37: Chr10:75854207 GRCh38: Chr10:74094449	VCL	D511Y	Hypertrophic cardiomyopathy 15	Likely pathogenic	criteria provided, single submitter
Select item 20216391.	NM_014000.3(VCL):c.2828_2829del (p.Pro943fs) GRCh37: Chr10:75871749-75871750 GRCh38: Chr10:74111991-74111992	VCL		Cardiovascular phenotype, not provided, Primary dilated cardiomyopathy, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15	Conflicting interpretations of pathogenicity (Nov 11, 2022)	criteria provided, conflicting interpretations
Select item 20216292.	NM_014000.3(VCL):c.1819A>C (p.Lys607Gln) GRCh37: Chr10:75857037 GRCh38: Chr10:74097279	VCL	K607Q	Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided, Dilated cardiomyopathy 1W	Uncertain significance (Aug 23, 2022)	criteria provided, multiple submitters, no conflicts
Select item 20216093.	NM_014000.3(VCL):c.1583G>A (p.Arg528His) GRCh37: Chr10:75855453 GRCh38: Chr10:74095695	VCL	R528H	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided, Dilated cardiomyopathy 1W	Uncertain significance (Jul 30, 2022)	criteria provided, multiple submitters, no conflicts
Select item 20215894.	NM_014000.3(VCL):c.1298G>A (p.Arg433His) GRCh37: Chr10:75849902 GRCh38: Chr10:74090144	VCL	R433H	Cardiovascular phenotype, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, not provided, Dilated cardiomyopathy 1W	Uncertain significance (Sep 26, 2022)	criteria provided, multiple submitters, no conflicts
Select item 19210795.	NM_014000.3(VCL):c.2893C>T (p.Pro965Ser) GRCh37: Chr10:75871814 GRCh38: Chr10:74112056	VCL	P965S	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not provided, Dilated cardiomyopathy 1W	Uncertain significance (Aug 7, 2023)	criteria provided, multiple submitters, no conflicts
Select item 19210396.	NM_014000.3(VCL):c.1192C>T (p.Pro398Ser) GRCh37: Chr10:75849796 GRCh38: Chr10:74090038	VCL	P398S	Cardiovascular phenotype, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, not provided, Dilated cardiomyopathy 1W	Conflicting interpretations of pathogenicity (Jun 27, 2023)	criteria provided, conflicting interpretations
Select item 19100297.	NM_014000.3(VCL):c.2924G>A (p.Arg975Gln) GRCh37: Chr10:75871845 GRCh38: Chr10:74112087	VCL	R975Q	Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W	Uncertain significance (Jun 27, 2022)	criteria provided, multiple submitters, no conflicts
Select item 17828198.	NM_014000.3(VCL):c.1348A>C (p.Arg450=) GRCh37: Chr10:75849952 GRCh38: Chr10:74090194	VCL		Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, not provided, Dilated cardiomyopathy 1W, Cardiovascular phenotype, not specified	Benign/Likely benign (Nov 3, 2022)	criteria provided, multiple submitters, no conflicts
Select item 16655199.	NM_014000.3(VCL):c.2046A>T (p.Leu682Phe) GRCh37: Chr10:75863601 GRCh38: Chr10:74103843	VCL	L682F	Cardiovascular phenotype, Hypertrophic cardiomyopathy 15, Dilated cardiomyopathy 1W, not specified, not provided, Cardiomyopathy, Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy	Uncertain significance (Apr 4, 2023)	criteria provided, multiple submitters, no conflicts
Select item 137903100.	NM_014000.3(VCL):c.1353-19G>A GRCh37: Chr10:75854010 GRCh38: Chr10:74094252	VCL		Dilated cardiomyopathy 1W, Hypertrophic cardiomyopathy 15, not specified, not provided, Dilated cardiomyopathy 1W	Benign/Likely benign (Oct 26, 2022)	criteria provided, multiple submitters, no conflicts

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