ClinVar for MedGen (Select 460728) - ClinVar - NCBI

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VariationLocation		Gene(s)	Protein change	Condition(s)	Clinical significance (Last reviewed)	Review status
Select item 24248411.	NM_012092.4(ICOS):c.477A>G (p.Ile159Met) GRCh37: Chr2:204821464 GRCh38: Chr2:203956741	ICOS	I159M	Immunodeficiency, common variable, 1	Uncertain significance (Apr 29, 2022)	criteria provided, single submitter
Select item 24239822.	NC_000002.11:g.(?_201943606)_(204824322_?)dup GRCh37: Chr2:201943606-204824322	ALS2, CD28, CTLA4, CYP20A1, FAM117B, FLACC1, FZD7, CDK15, CFLAR, ABI2, BMPR2, C2CD6, CARF, CASP10, CASP8, ICA1L, ICOS, MPP4, NBEAL1, NDUFB3, NOP58, RAPH1, STRADB, SUMO1, TMEM237, TRAK2, WDR12		Autoimmune lymphoproliferative syndrome type 2B, Immunodeficiency, common variable, 1	Uncertain significance (Aug 19, 2022)	criteria provided, single submitter
Select item 24171913.	NM_012092.4(ICOS):c.190G>A (p.Asp64Asn) GRCh37: Chr2:204820490 GRCh38: Chr2:203955767	ICOS	D64N	Immunodeficiency, common variable, 1	Uncertain significance (Mar 19, 2022)	criteria provided, single submitter
Select item 21806994.	NM_012092.4(ICOS):c.578G>A (p.Arg193Lys) GRCh37: Chr2:204822598 GRCh38: Chr2:203957875	ICOS	R193K	Immunodeficiency, common variable, 1	Uncertain significance (Oct 5, 2022)	criteria provided, single submitter
Select item 21806985.	NM_012092.4(ICOS):c.576T>C (p.Ser192=) GRCh37: Chr2:204822596 GRCh38: Chr2:203957873	ICOS		Immunodeficiency, common variable, 1	Likely benign (Oct 5, 2022)	criteria provided, single submitter
Select item 21390216.	NM_012092.4(ICOS):c.24C>A (p.Phe8Leu) GRCh37: Chr2:204801561 GRCh38: Chr2:203936838	ICOS	F8L	Immunodeficiency, common variable, 1	Uncertain significance (Jun 10, 2022)	criteria provided, single submitter
Select item 21274307.	NM_012092.4(ICOS):c.395-19A>G GRCh37: Chr2:204821363 GRCh38: Chr2:203956640	ICOS		Immunodeficiency, common variable, 1	Likely benign (Apr 17, 2022)	criteria provided, single submitter
Select item 21088358.	NM_012092.4(ICOS):c.395-4C>A GRCh37: Chr2:204821378 GRCh38: Chr2:203956655	ICOS		Immunodeficiency, common variable, 1	Likely benign (Mar 11, 2022)	criteria provided, single submitter
Select item 20968569.	NM_012092.4(ICOS):c.595C>T (p.Leu199=) GRCh37: Chr2:204824317 GRCh38: Chr2:203959594	ICOS		Immunodeficiency, common variable, 1	Likely benign (Feb 22, 2022)	criteria provided, single submitter
Select item 207578310.	NM_012092.4(ICOS):c.394+14T>G GRCh37: Chr2:204820708 GRCh38: Chr2:203955985	ICOS		Immunodeficiency, common variable, 1	Likely benign (Aug 17, 2022)	criteria provided, single submitter
Select item 206220811.	NM_012092.4(ICOS):c.586+11A>G GRCh37: Chr2:204822617 GRCh38: Chr2:203957894	ICOS		Immunodeficiency, common variable, 1	Likely benign (Dec 27, 2021)	criteria provided, single submitter
Select item 202885612.	NM_012092.4(ICOS):c.427T>C (p.Leu143=) GRCh37: Chr2:204821414 GRCh38: Chr2:203956691	ICOS		Immunodeficiency, common variable, 1	Likely benign (Sep 3, 2022)	criteria provided, single submitter
Select item 200563413.	NM_012092.4(ICOS):c.394+19C>T GRCh37: Chr2:204820713 GRCh38: Chr2:203955990	ICOS		Immunodeficiency, common variable, 1	Likely benign (Aug 3, 2022)	criteria provided, single submitter
Select item 200384114.	NM_012092.4(ICOS):c.357del (p.Phe119fs) GRCh37: Chr2:204820654 GRCh38: Chr2:203955931	ICOS	F119fs	Immunodeficiency, common variable, 1	Pathogenic (Jun 9, 2022)	criteria provided, single submitter
Select item 200281715.	NM_012092.4(ICOS):c.17G>A (p.Trp6Ter) GRCh37: Chr2:204801554 GRCh38: Chr2:203936831	ICOS	W6*	Immunodeficiency, common variable, 1	Pathogenic (Jun 8, 2022)	criteria provided, single submitter
Select item 197845316.	NM_012092.4(ICOS):c.43A>G (p.Ile15Val) GRCh37: Chr2:204801580 GRCh38: Chr2:203936857	ICOS	I15V	Immunodeficiency, common variable, 1	Uncertain significance (Jul 10, 2022)	criteria provided, single submitter
Select item 196973417.	NM_012092.4(ICOS):c.416T>G (p.Leu139Arg) GRCh37: Chr2:204821403 GRCh38: Chr2:203956680	ICOS	L139R	Immunodeficiency, common variable, 1	Uncertain significance (Jul 17, 2022)	criteria provided, single submitter
Select item 196275118.	NM_012092.4(ICOS):c.451G>A (p.Val151Ile) GRCh37: Chr2:204821438 GRCh38: Chr2:203956715	ICOS	V151I	Immunodeficiency, common variable, 1	Uncertain significance (Dec 19, 2021)	criteria provided, single submitter
Select item 192755419.	NM_012092.4(ICOS):c.395-17del GRCh37: Chr2:204821364 GRCh38: Chr2:203956641	ICOS		Immunodeficiency, common variable, 1	Likely benign (Jan 7, 2022)	criteria provided, single submitter
Select item 180148720.	NM_005214.5(CTLA4):c.231_297delinsA (p.Gln80_Ser101del) GRCh37: Chr2:204735430-204735496 GRCh38: Chr2:203870707-203870773	CTLA4		Immunodeficiency, common variable, 1	Likely pathogenic (Mar 11, 2021)	criteria provided, single submitter
Select item 171549221.	NM_012092.4(ICOS):c.523G>C (p.Asp175His) GRCh37: Chr2:204822543 GRCh38: Chr2:203957820	ICOS	D175H	Immunodeficiency, common variable, 1	Uncertain significance (Aug 16, 2022)	criteria provided, single submitter
Select item 167202322.	NM_012092.4(ICOS):c.552A>G (p.Arg184=) GRCh37: Chr2:204822572 GRCh38: Chr2:203957849	ICOS		Immunodeficiency, common variable, 1	Likely benign (Mar 2, 2022)	criteria provided, single submitter
Select item 162384423.	NM_012092.4(ICOS):c.522C>T (p.His174=) GRCh37: Chr2:204822542 GRCh38: Chr2:203957819	ICOS		Immunodeficiency, common variable, 1	Likely benign (Jul 20, 2021)	criteria provided, single submitter
Select item 160720824.	NM_012092.4(ICOS):c.411C>T (p.Cys137=) GRCh37: Chr2:204821398 GRCh38: Chr2:203956675	ICOS		Immunodeficiency, common variable, 1	Likely benign (Aug 22, 2022)	criteria provided, single submitter
Select item 160085325.	NM_012092.4(ICOS):c.395-10dup GRCh37: Chr2:204821365-204821366 GRCh38: Chr2:203956642-203956643	ICOS		Immunodeficiency, common variable, 1	Benign (Mar 31, 2021)	criteria provided, single submitter
Select item 157067926.	NM_012092.4(ICOS):c.586+20T>G GRCh37: Chr2:204822626 GRCh38: Chr2:203957903	ICOS		Immunodeficiency, common variable, 1	Likely benign (Mar 10, 2021)	criteria provided, single submitter
Select item 155423627.	NM_012092.4(ICOS):c.394+9T>C GRCh37: Chr2:204820703 GRCh38: Chr2:203955980	ICOS		Immunodeficiency, common variable, 1	Likely benign (Apr 25, 2021)	criteria provided, single submitter
Select item 154942828.	NM_012092.4(ICOS):c.59-16C>A GRCh37: Chr2:204820343 GRCh38: Chr2:203955620	ICOS		Immunodeficiency, common variable, 1	Likely benign (Nov 3, 2021)	criteria provided, single submitter
Select item 154222029.	NM_012092.4(ICOS):c.395-15T>C GRCh37: Chr2:204821367 GRCh38: Chr2:203956644	ICOS		Immunodeficiency, common variable, 1	Likely benign (Aug 31, 2022)	criteria provided, single submitter
Select item 153662330.	NM_012092.4(ICOS):c.186C>G (p.Leu62=) GRCh37: Chr2:204820486 GRCh38: Chr2:203955763	ICOS		Immunodeficiency, common variable, 1	Likely benign (Jul 19, 2022)	criteria provided, single submitter
Select item 153342431.	NM_012092.4(ICOS):c.586+12T>C GRCh37: Chr2:204822618 GRCh38: Chr2:203957895	ICOS		Immunodeficiency, common variable, 1	Likely benign (Feb 4, 2022)	criteria provided, single submitter
Select item 151375932.	NM_012092.4(ICOS):c.406T>C (p.Cys136Arg) GRCh37: Chr2:204821393 GRCh38: Chr2:203956670	ICOS	C136R	Immunodeficiency, common variable, 1	Uncertain significance (Aug 20, 2021)	criteria provided, single submitter
Select item 151043633.	NM_012092.4(ICOS):c.562_573del (p.Thr188_Lys191del) GRCh37: Chr2:204822582-204822593 GRCh38: Chr2:203957859-203957870	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Aug 5, 2021)	criteria provided, single submitter
Select item 145605734.	NC_000002.11:g.(?_201943606)_(204824322_?)del GRCh37: Chr2:201943606-204824322	ALS2, BMPR2, CYP20A1, FAM117B, FLACC1, C2CD6, CARF, ABI2, CASP10, CASP8, CD28, CDK15, CFLAR, CTLA4, FZD7, ICA1L, ICOS, MPP4, NBEAL1, NDUFB3, NOP58, RAPH1, STRADB, SUMO1, TMEM237, TRAK2, WDR12		Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency, Immunodeficiency, common variable, 1, Autoimmune lymphoproliferative syndrome type 2B	Pathogenic (Jun 20, 2022)	criteria provided, single submitter
Select item 144957635.	NM_012092.4(ICOS):c.318T>G (p.Tyr106Ter) GRCh37: Chr2:204820618 GRCh38: Chr2:203955895	ICOS	Y106*	Immunodeficiency, common variable, 1	Pathogenic (Mar 15, 2022)	criteria provided, single submitter
Select item 142782936.	NM_012092.4(ICOS):c.547A>G (p.Met183Val) GRCh37: Chr2:204822567 GRCh38: Chr2:203957844	ICOS	M183V	Immunodeficiency, common variable, 1	Uncertain significance (Sep 18, 2021)	criteria provided, single submitter
Select item 141613937.	NM_012092.4(ICOS):c.235A>C (p.Ser79Arg) GRCh37: Chr2:204820535 GRCh38: Chr2:203955812	ICOS	S79R	Immunodeficiency, common variable, 1	Uncertain significance (Aug 30, 2021)	criteria provided, single submitter
Select item 141012338.	NM_012092.4(ICOS):c.59-3C>T GRCh37: Chr2:204820356 GRCh38: Chr2:203955633	ICOS		not provided, Immunodeficiency, common variable, 1	Uncertain significance (Jan 1, 2023)	criteria provided, multiple submitters, no conflicts
Select item 140104239.	NC_000002.11:g.(?_204820339)_(204824322_?)del GRCh37: Chr2:204820339-204824322	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Sep 27, 2022)	criteria provided, single submitter
Select item 139363140.	NM_012092.4(ICOS):c.58+4A>C GRCh37: Chr2:204801599 GRCh38: Chr2:203936876	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Nov 16, 2021)	criteria provided, single submitter
Select item 138263341.	NM_012092.4(ICOS):c.41G>A (p.Arg14His) GRCh37: Chr2:204801578 GRCh38: Chr2:203936855	ICOS	R14H	Immunodeficiency, common variable, 1	Uncertain significance (Oct 18, 2022)	criteria provided, single submitter
Select item 138232542.	NM_012092.4(ICOS):c.509C>T (p.Ser170Leu) GRCh37: Chr2:204822529 GRCh38: Chr2:203957806	ICOS	S170L	Immunodeficiency, common variable, 1	Uncertain significance (Sep 19, 2021)	criteria provided, single submitter
Select item 138006143.	NM_012092.4(ICOS):c.85G>A (p.Glu29Lys) GRCh37: Chr2:204820385 GRCh38: Chr2:203955662	ICOS	E29K	Immunodeficiency, common variable, 1	Uncertain significance (Dec 18, 2021)	criteria provided, single submitter
Select item 137457844.	NM_012092.4(ICOS):c.496A>G (p.Lys166Glu) GRCh37: Chr2:204821483 GRCh38: Chr2:203956760	ICOS	K166E	Immunodeficiency, common variable, 1	Uncertain significance (Apr 6, 2022)	criteria provided, single submitter
Select item 136018745.	NM_012092.4(ICOS):c.514A>G (p.Ser172Gly) GRCh37: Chr2:204822534 GRCh38: Chr2:203957811	ICOS	S172G	Immunodeficiency, common variable, 1	Uncertain significance (Sep 1, 2021)	criteria provided, single submitter
Select item 135900846.	NM_012092.4(ICOS):c.61G>T (p.Glu21Ter) GRCh37: Chr2:204820361 GRCh38: Chr2:203955638	ICOS	E21*	Immunodeficiency, common variable, 1	Pathogenic (Oct 24, 2022)	criteria provided, single submitter
Select item 135623947.	NM_012092.4(ICOS):c.584C>T (p.Thr195Ile) GRCh37: Chr2:204822604 GRCh38: Chr2:203957881	ICOS	T195I	Immunodeficiency, common variable, 1	Uncertain significance (Aug 27, 2021)	criteria provided, single submitter
Select item 128524948.	NM_012092.4(ICOS):c.587-26T>G GRCh37: Chr2:204824283 GRCh38: Chr2:203959560	ICOS		Immunodeficiency, common variable, 1, not provided	Benign (Aug 10, 2021)	criteria provided, multiple submitters, no conflicts
Select item 115986249.	NM_012092.4(ICOS):c.438A>T (p.Gly146=) GRCh37: Chr2:204821425 GRCh38: Chr2:203956702	ICOS		Immunodeficiency, common variable, 1	Likely benign (Oct 28, 2022)	criteria provided, single submitter
Select item 115664250.	NM_012092.4(ICOS):c.599A>G (p.Ter200=) GRCh37: Chr2:204824321 GRCh38: Chr2:203959598	ICOS		Immunodeficiency, common variable, 1	Likely benign (Jul 5, 2022)	criteria provided, single submitter
Select item 115057351.	NM_012092.4(ICOS):c.336A>G (p.Ser112=) GRCh37: Chr2:204820636 GRCh38: Chr2:203955913	ICOS		Immunodeficiency, common variable, 1	Likely benign (Jan 25, 2020)	criteria provided, single submitter
Select item 114755552.	NM_012092.4(ICOS):c.390T>A (p.Ile130=) GRCh37: Chr2:204820690 GRCh38: Chr2:203955967	ICOS		Immunodeficiency, common variable, 1	Likely benign (Jun 17, 2022)	criteria provided, single submitter
Select item 114731553.	NM_012092.4(ICOS):c.177G>A (p.Gly59=) GRCh37: Chr2:204820477 GRCh38: Chr2:203955754	ICOS		Immunodeficiency, common variable, 1	Likely benign (Oct 7, 2020)	criteria provided, single submitter
Select item 112633954.	NM_012092.4(ICOS):c.471A>G (p.Gly157=) GRCh37: Chr2:204821458 GRCh38: Chr2:203956735	ICOS		Immunodeficiency, common variable, 1	Likely benign (May 1, 2019)	criteria provided, single submitter
Select item 112543155.	NM_012092.4(ICOS):c.402A>G (p.Gln134=) GRCh37: Chr2:204821389 GRCh38: Chr2:203956666	ICOS		Immunodeficiency, common variable, 1	Likely benign (May 15, 2020)	criteria provided, single submitter
Select item 110907756.	NM_012092.4(ICOS):c.294C>T (p.Asn98=) GRCh37: Chr2:204820594 GRCh38: Chr2:203955871	ICOS		Immunodeficiency, common variable, 1	Likely benign (May 15, 2020)	criteria provided, single submitter
Select item 110712857.	NM_012092.4(ICOS):c.394+7C>T GRCh37: Chr2:204820701 GRCh38: Chr2:203955978	ICOS		Immunodeficiency, common variable, 1	Likely benign (Dec 31, 2019)	criteria provided, single submitter
Select item 109479058.	NM_012092.4(ICOS):c.9A>C (p.Ser3=) GRCh37: Chr2:204801546 GRCh38: Chr2:203936823	ICOS		Immunodeficiency, common variable, 1	Likely benign (Sep 23, 2022)	criteria provided, single submitter
Select item 109437759.	NM_012092.4(ICOS):c.516T>C (p.Ser172=) GRCh37: Chr2:204822536 GRCh38: Chr2:203957813	ICOS		Immunodeficiency, common variable, 1	Likely benign (Dec 20, 2021)	criteria provided, single submitter
Select item 109382460.	NM_012092.4(ICOS):c.567C>G (p.Ala189=) GRCh37: Chr2:204822587 GRCh38: Chr2:203957864	ICOS		Immunodeficiency, common variable, 1	Likely benign (Aug 31, 2022)	criteria provided, single submitter
Select item 105805361.	NM_012092.4(ICOS):c.502-6_502-5insG GRCh37: Chr2:204822516-204822517 GRCh38: Chr2:203957793-203957794	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Aug 28, 2021)	criteria provided, single submitter
Select item 105337962.	NM_012092.4(ICOS):c.376G>A (p.Gly126Arg) GRCh37: Chr2:204820676 GRCh38: Chr2:203955953	ICOS	G126R	Immunodeficiency, common variable, 1	Uncertain significance (Aug 20, 2021)	criteria provided, single submitter
Select item 103599563.	NM_012092.4(ICOS):c.580C>A (p.Leu194Ile) GRCh37: Chr2:204822600 GRCh38: Chr2:203957877	ICOS	L194I	Immunodeficiency, common variable, 1	Uncertain significance (Nov 29, 2021)	criteria provided, single submitter
Select item 103117664.	NM_012092.4(ICOS):c.129A>T (p.Lys43Asn) GRCh37: Chr2:204820429 GRCh38: Chr2:203955706	ICOS	K43N	Immunodeficiency, common variable, 1	Uncertain significance (Dec 19, 2019)	criteria provided, single submitter
Select item 100248465.	NM_012092.4(ICOS):c.466T>G (p.Leu156Val) GRCh37: Chr2:204821453 GRCh38: Chr2:203956730	ICOS	L156V	Immunodeficiency, common variable, 1	Uncertain significance (Aug 31, 2021)	criteria provided, single submitter
Select item 96983166.	NM_012092.4(ICOS):c.45T>G (p.Ile15Met) GRCh37: Chr2:204801582 GRCh38: Chr2:203936859	ICOS	I15M	Immunodeficiency, common variable, 1	Uncertain significance (Aug 9, 2022)	criteria provided, single submitter
Select item 96944667.	NM_012092.4(ICOS):c.271A>G (p.Ser91Gly) GRCh37: Chr2:204820571 GRCh38: Chr2:203955848	ICOS	S91G	Immunodeficiency, common variable, 1	Uncertain significance (Sep 1, 2021)	criteria provided, single submitter
Select item 96074868.	NM_012092.4(ICOS):c.128A>G (p.Lys43Arg) GRCh37: Chr2:204820428 GRCh38: Chr2:203955705	ICOS	K43R	Immunodeficiency, common variable, 1	Uncertain significance (Nov 6, 2019)	criteria provided, single submitter
Select item 95589469.	NM_001322934.2(NFKB2):c.1972C>T (p.Arg658Trp) GRCh37: Chr10:104160707 GRCh38: Chr10:102400950	NFKB2	R616W, R658W	Immunodeficiency, common variable, 10	Uncertain significance (Oct 30, 2022)	criteria provided, single submitter
Select item 94908570.	NM_012092.4(ICOS):c.71G>T (p.Gly24Val) GRCh37: Chr2:204820371 GRCh38: Chr2:203955648	ICOS	G24V	Inborn genetic diseases, Immunodeficiency, common variable, 1	Uncertain significance (Nov 21, 2022)	criteria provided, multiple submitters, no conflicts
Select item 94052971.	NM_012092.4(ICOS):c.13C>T (p.Leu5Phe) GRCh37: Chr2:204801550 GRCh38: Chr2:203936827	ICOS	L5F	Immunodeficiency, common variable, 1	Uncertain significance (Aug 28, 2021)	criteria provided, single submitter
Select item 94039772.	NM_012092.4(ICOS):c.181del (p.Ile61fs) GRCh37: Chr2:204820479 GRCh38: Chr2:203955756	ICOS	I61fs	Immunodeficiency, common variable, 1	Pathogenic (Jun 26, 2019)	criteria provided, single submitter
Select item 93630573.	NM_012092.4(ICOS):c.512C>A (p.Ser171Tyr) GRCh37: Chr2:204822532 GRCh38: Chr2:203957809	ICOS	S171Y	Immunodeficiency, common variable, 1	Uncertain significance (Aug 31, 2021)	criteria provided, single submitter
Select item 89880674.	NM_012092.4(ICOS):c.*1025A>T GRCh37: Chr2:204825347 GRCh38: Chr2:203960624	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 89880575.	NM_012092.4(ICOS):c.*939A>G GRCh37: Chr2:204825261 GRCh38: Chr2:203960538	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 89873976.	NM_012092.4(ICOS):c.42C>A (p.Arg14=) GRCh37: Chr2:204801579 GRCh38: Chr2:203936856	ICOS		Immunodeficiency, common variable, 1	Conflicting interpretations of pathogenicity (Jun 27, 2022)	criteria provided, conflicting interpretations
Select item 89873877.	NM_012092.4(ICOS):c.-24G>T GRCh37: Chr2:204801514 GRCh38: Chr2:203936791	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 15, 2018)	criteria provided, single submitter
Select item 89771678.	NM_012092.4(ICOS):c.*1948G>T GRCh37: Chr2:204826270 GRCh38: Chr2:203961547	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 89771579.	NM_012092.4(ICOS):c.*1901A>G GRCh37: Chr2:204826223 GRCh38: Chr2:203961500	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 89764180.	NM_012092.4(ICOS):c.*594C>T GRCh37: Chr2:204824916 GRCh38: Chr2:203960193	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 89764081.	NM_012092.4(ICOS):c.*512T>C GRCh37: Chr2:204824834 GRCh38: Chr2:203960111	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 89763982.	NM_012092.4(ICOS):c.*474G>T GRCh37: Chr2:204824796 GRCh38: Chr2:203960073	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 89763883.	NM_012092.4(ICOS):c.*399G>A GRCh37: Chr2:204824721 GRCh38: Chr2:203959998	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 89612184.	NM_012092.4(ICOS):c.*1869A>C GRCh37: Chr2:204826191 GRCh38: Chr2:203961468	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 89612085.	NM_012092.4(ICOS):c.*1457A>G GRCh37: Chr2:204825779 GRCh38: Chr2:203961056	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 89611986.	NM_012092.4(ICOS):c.*1416G>T GRCh37: Chr2:204825738 GRCh38: Chr2:203961015	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 89611887.	NM_012092.4(ICOS):c.*1300C>T GRCh37: Chr2:204825622 GRCh38: Chr2:203960899	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 89605388.	NM_012092.4(ICOS):c.*73T>C GRCh37: Chr2:204824395 GRCh38: Chr2:203959672	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 89605289.	NM_012092.4(ICOS):c.510A>G (p.Ser170=) GRCh37: Chr2:204822530 GRCh38: Chr2:203957807	ICOS		Immunodeficiency, common variable, 1	Conflicting interpretations of pathogenicity (Oct 18, 2021)	criteria provided, conflicting interpretations
Select item 89584590.	NM_012092.4(ICOS):c.*1269A>C GRCh37: Chr2:204825591 GRCh38: Chr2:203960868	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 13, 2018)	criteria provided, single submitter
Select item 89584491.	NM_012092.4(ICOS):c.*1172G>A GRCh37: Chr2:204825494 GRCh38: Chr2:203960771	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 89584392.	NM_012092.4(ICOS):c.*1137C>T GRCh37: Chr2:204825459 GRCh38: Chr2:203960736	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 89577393.	NM_012092.4(ICOS):c.495A>C (p.Thr165=) GRCh37: Chr2:204821482 GRCh38: Chr2:203956759	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Jan 12, 2018)	criteria provided, single submitter
Select item 85876694.	NM_012092.4(ICOS):c.106G>A (p.Gly36Arg) GRCh37: Chr2:204820406 GRCh38: Chr2:203955683	ICOS	G36R	not provided, Immunodeficiency, common variable, 1	Uncertain significance (Jul 6, 2022)	criteria provided, multiple submitters, no conflicts
Select item 85345095.	NM_012092.4(ICOS):c.523G>A (p.Asp175Asn) GRCh37: Chr2:204822543 GRCh38: Chr2:203957820	ICOS	D175N	Immunodeficiency, common variable, 1	Uncertain significance (Dec 31, 2019)	criteria provided, single submitter
Select item 84774696.	NM_012092.4(ICOS):c.229A>G (p.Ile77Val) GRCh37: Chr2:204820529 GRCh38: Chr2:203955806	ICOS	I77V	Inborn genetic diseases, Immunodeficiency, common variable, 1	Uncertain significance (Dec 15, 2022)	criteria provided, multiple submitters, no conflicts
Select item 84139697.	NM_012092.4(ICOS):c.77C>A (p.Ala26Asp) GRCh37: Chr2:204820377 GRCh38: Chr2:203955654	ICOS	A26D	Immunodeficiency, common variable, 1	Uncertain significance (Sep 15, 2021)	criteria provided, single submitter
Select item 83516298.	NM_012092.4(ICOS):c.586+3A>G GRCh37: Chr2:204822609 GRCh38: Chr2:203957886	ICOS		Immunodeficiency, common variable, 1	Uncertain significance (Dec 20, 2019)	criteria provided, single submitter
Select item 83045499.	NC_000002.12:g.(?_203866796)_(203959619_?)del GRCh37: Chr2:204731519-204824342	CTLA4, ICOS		Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency, Immunodeficiency, common variable, 1	Pathogenic (Jun 26, 2020)	criteria provided, single submitter
Select item 827707100.	NM_012092.4(ICOS):c.356T>C (p.Phe119Ser) GRCh37: Chr2:204820656 GRCh38: Chr2:203955933	ICOS	F119S	Inherited Immunodeficiency Diseases, Immunodeficiency, common variable, 1	Conflicting interpretations of pathogenicity (May 19, 2022)	criteria provided, conflicting interpretations

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