ClinVar for MedGen (Select 887211) - ClinVar - NCBI

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VariationLocation		Gene(s)	Protein change	Condition(s)	Clinical significance (Last reviewed)	Review status
Select item 24266381.	NC_000010.10:g.(?_43620311)_(43623717_?)dup GRCh37: Chr10:43620311-43623717	RET		Multiple endocrine neoplasia, type 2	Uncertain significance (Mar 1, 2022)	criteria provided, single submitter
Select item 24213202.	NM_020975.6(RET):c.1301G>A (p.Ser434Asn) GRCh37: Chr10:43606692 GRCh38: Chr10:43111244	RET	S259N, S288N, S302N, S338N, S391N, S434N, S104N, S180N, S192N	Multiple endocrine neoplasia, type 2	Uncertain significance (Aug 18, 2022)	criteria provided, single submitter
Select item 24187583.	NM_020975.6(RET):c.1068G>T (p.Leu356=) GRCh37: Chr10:43604483 GRCh38: Chr10:43109035	RET		Multiple endocrine neoplasia, type 2	Likely benign (Jan 6, 2022)	criteria provided, single submitter
Select item 24182214.	NM_020975.6(RET):c.1064-9T>G GRCh37: Chr10:43604470 GRCh38: Chr10:43109022	RET		Multiple endocrine neoplasia, type 2	Likely benign (Oct 24, 2022)	criteria provided, single submitter
Select item 24145625.	NM_020975.6(RET):c.2136+7G>A GRCh37: Chr10:43610191 GRCh38: Chr10:43114743	RET		Multiple endocrine neoplasia, type 2	Likely benign (Jan 18, 2022)	criteria provided, single submitter
Select item 24134066.	NM_020975.6(RET):c.483G>T (p.Lys161Asn) GRCh37: Chr10:43597935 GRCh38: Chr10:43102487	RET	K118N, K161N	Multiple endocrine neoplasia, type 2	Uncertain significance (Aug 23, 2022)	criteria provided, single submitter
Select item 22013477.	NM_020975.6(RET):c.3312A>G (p.Ser1104=) GRCh37: Chr10:43623684 GRCh38: Chr10:43128236	RET		Multiple endocrine neoplasia, type 2	Likely benign (Feb 27, 2022)	criteria provided, single submitter
Select item 22004258.	NM_020975.6(RET):c.375C>T (p.Val125=) GRCh37: Chr10:43597827 GRCh38: Chr10:43102379	RET		Multiple endocrine neoplasia, type 2	Likely benign (Sep 17, 2022)	criteria provided, single submitter
Select item 21980619.	NM_020975.6(RET):c.3040-10T>C GRCh37: Chr10:43622013 GRCh38: Chr10:43126565	RET		Multiple endocrine neoplasia, type 2	Likely benign (Jun 29, 2022)	criteria provided, single submitter
Select item 219765110.	NM_020975.6(RET):c.868-15C>T GRCh37: Chr10:43601809 GRCh38: Chr10:43106361	RET		Multiple endocrine neoplasia, type 2	Likely benign (Apr 21, 2022)	criteria provided, single submitter
Select item 219681211.	NM_020975.6(RET):c.3325A>G (p.Met1109Val) GRCh37: Chr10:43623697 GRCh38: Chr10:43128249	RET	M1013V, M1064V, M1089V, M963V, M1109V, M626V, M714V, M810V, M847V, M1066V, M606V, M767V, M867V, M977V	Multiple endocrine neoplasia, type 2	Uncertain significance (Aug 8, 2022)	criteria provided, single submitter
Select item 219626812.	NM_020975.6(RET):c.868-20A>G GRCh37: Chr10:43601804 GRCh38: Chr10:43106356	RET		Multiple endocrine neoplasia, type 2	Likely benign (Jul 22, 2022)	criteria provided, single submitter
Select item 219414013.	NM_020975.6(RET):c.626-18T>C GRCh37: Chr10:43600382 GRCh38: Chr10:43104934	RET		Multiple endocrine neoplasia, type 2	Likely benign (Dec 22, 2021)	criteria provided, single submitter
Select item 219350314.	NM_020975.6(RET):c.723C>G (p.Ala241=) GRCh37: Chr10:43600497 GRCh38: Chr10:43105049	RET		Multiple endocrine neoplasia, type 2	Likely benign (Jul 6, 2022)	criteria provided, single submitter
Select item 219176515.	NM_020975.6(RET):c.1626G>A (p.Glu542=) GRCh37: Chr10:43607650 GRCh38: Chr10:43112202	RET		Multiple endocrine neoplasia, type 2	Likely benign (Mar 12, 2022)	criteria provided, single submitter
Select item 219049616.	NM_020975.6(RET):c.1215C>G (p.Pro405=) GRCh37: Chr10:43604630 GRCh38: Chr10:43109182	RET		Multiple endocrine neoplasia, type 2	Likely benign (May 21, 2022)	criteria provided, single submitter
Select item 219001017.	NM_020975.6(RET):c.1733T>C (p.Ile578Thr) GRCh37: Chr10:43608385 GRCh38: Chr10:43112937	RET	I236T, I336T, I432T, I482T, I535T, I578T, I183T, I279T, I324T, I95T, I248T, I403T, I446T	Multiple endocrine neoplasia, type 2	Uncertain significance (Feb 28, 2022)	criteria provided, single submitter
Select item 218493818.	NM_020975.6(RET):c.626-19_626-18del GRCh37: Chr10:43600381-43600382 GRCh38: Chr10:43104933-43104934	RET		Multiple endocrine neoplasia, type 2	Likely benign (Sep 20, 2022)	criteria provided, single submitter
Select item 218450419.	NM_020975.6(RET):c.1760_1761delinsAA (p.Arg587Gln) GRCh37: Chr10:43609004-43609005 GRCh38: Chr10:43113556-43113557	RET	R104Q, R288Q, R192Q, R245Q, R257Q, R412Q, R441Q, R455Q, R587Q, R333Q, R345Q, R491Q, R544Q	Multiple endocrine neoplasia, type 2	Uncertain significance (Sep 21, 2022)	criteria provided, single submitter
Select item 218105220.	NM_020975.6(RET):c.486C>G (p.Pro162=) GRCh37: Chr10:43597938 GRCh38: Chr10:43102490	RET		Multiple endocrine neoplasia, type 2	Likely benign (Dec 14, 2021)	criteria provided, single submitter
Select item 218040721.	NM_020975.6(RET):c.2393-16del GRCh37: Chr10:43614959 GRCh38: Chr10:43119511	RET		Multiple endocrine neoplasia, type 2	Benign (Jan 27, 2022)	criteria provided, single submitter
Select item 218016422.	NM_020975.6(RET):c.1965C>G (p.Phe655Leu) GRCh37: Chr10:43610013 GRCh38: Chr10:43114565	RET	F260L, F413L, F480L, F559L, F509L, F523L, F316L, F612L, F172L, F220L, F313L, F325L, F356L, F401L, F655L	Multiple endocrine neoplasia, type 2	Uncertain significance (Dec 18, 2021)	criteria provided, single submitter
Select item 217954023.	NM_020975.6(RET):c.2940-6C>T GRCh37: Chr10:43620325 GRCh38: Chr10:43124877	RET		Multiple endocrine neoplasia, type 2	Likely benign (Jan 2, 2022)	criteria provided, single submitter
Select item 217909524.	NM_020975.6(RET):c.3116C>G (p.Pro1039Arg) GRCh37: Chr10:43622099 GRCh38: Chr10:43126651	RET	P695R, P556R, P709R, P785R, P943R, P951R, P996R, P1039R, P700R, P740R, P797R, P864R, P893R, P907R, P604R, P644R, P697R, P994R	Multiple endocrine neoplasia, type 2	Uncertain significance (Oct 3, 2022)	criteria provided, single submitter
Select item 217807025.	NM_020975.6(RET):c.1142T>G (p.Phe381Cys) GRCh37: Chr10:43604557 GRCh38: Chr10:43109109	RET	F127C, F139C, F381C, F338C, F235C, F285C, F51C	Multiple endocrine neoplasia, type 2	Uncertain significance (Sep 15, 2022)	criteria provided, single submitter
Select item 217387626.	NM_020975.6(RET):c.867+20G>A GRCh37: Chr10:43600661 GRCh38: Chr10:43105213	RET		Multiple endocrine neoplasia, type 2	Likely benign (Jun 13, 2022)	criteria provided, single submitter
Select item 217170527.	NM_020975.6(RET):c.1523-6C>T GRCh37: Chr10:43607541 GRCh38: Chr10:43112093	RET		Multiple endocrine neoplasia, type 2	Likely benign (Mar 19, 2022)	criteria provided, single submitter
Select item 217153228.	NM_020975.6(RET):c.1076A>G (p.Asn359Ser) GRCh37: Chr10:43604491 GRCh38: Chr10:43109043	RET	N105S, N29S, N359S, N117S, N263S, N316S, N213S	Multiple endocrine neoplasia, type 2	Uncertain significance (Jun 30, 2022)	criteria provided, single submitter
Select item 217104129.	NM_020975.6(RET):c.2866C>T (p.Pro956Ser) GRCh37: Chr10:43619183 GRCh38: Chr10:43123735	RET	P521S, P617S, P824S, P956S, P473S, P612S, P626S, P657S, P781S, P868S, P911S, P561S, P614S, P702S, P714S, P810S, P860S, P913S	Multiple endocrine neoplasia, type 2	Uncertain significance (Jun 4, 2022)	criteria provided, single submitter
Select item 217018230.	NM_020975.6(RET):c.910G>A (p.Val304Ile) GRCh37: Chr10:43601866 GRCh38: Chr10:43106418	RET	V261I, V208I, V304I, V50I	Multiple endocrine neoplasia, type 2	Uncertain significance (Aug 26, 2022)	criteria provided, single submitter
Select item 216999031.	NM_020975.6(RET):c.2608-14A>G GRCh37: Chr10:43615515 GRCh38: Chr10:43120067	RET		Multiple endocrine neoplasia, type 2	Likely benign (Aug 16, 2022)	criteria provided, single submitter
Select item 216909532.	NM_020975.6(RET):c.337+6G>A GRCh37: Chr10:43596176 GRCh38: Chr10:43100728	RET		Multiple endocrine neoplasia, type 2	Uncertain significance (Apr 22, 2022)	criteria provided, single submitter
Select item 216754633.	NM_020975.6(RET):c.1285A>G (p.Asn429Asp) GRCh37: Chr10:43606676 GRCh38: Chr10:43111228	RET	N254D, N333D, N187D, N297D, N175D, N386D, N99D, N283D, N429D	Multiple endocrine neoplasia, type 2	Uncertain significance (Apr 24, 2022)	criteria provided, single submitter
Select item 216734934.	NM_020975.6(RET):c.3188-16C>G GRCh37: Chr10:43623544 GRCh38: Chr10:43128096	RET		Multiple endocrine neoplasia, type 2	Likely benign (Oct 30, 2022)	criteria provided, single submitter
Select item 216728035.	NM_020975.6(RET):c.616C>T (p.Leu206Phe) GRCh37: Chr10:43598068 GRCh38: Chr10:43102620	RET	L206F, L163F	Multiple endocrine neoplasia, type 2	Uncertain significance (Sep 18, 2022)	criteria provided, single submitter
Select item 216600636.	NM_020975.6(RET):c.1834T>C (p.Phe612Leu) GRCh37: Chr10:43609078 GRCh38: Chr10:43113630	RET	F313L, F437L, F569L, F282L, F358L, F129L, F466L, F612L, F217L, F270L, F370L, F480L, F516L	Multiple endocrine neoplasia, type 2	Uncertain significance (Sep 1, 2022)	criteria provided, single submitter
Select item 216510837.	NM_020975.6(RET):c.1998G>A (p.Lys666=) GRCh37: Chr10:43610046 GRCh38: Chr10:43114598	RET		Multiple endocrine neoplasia, type 2	Likely benign (Sep 24, 2021)	criteria provided, single submitter
Select item 216268538.	NM_020975.6(RET):c.2136+17G>A GRCh37: Chr10:43610201 GRCh38: Chr10:43114753	RET		Multiple endocrine neoplasia, type 2	Likely benign (Sep 26, 2022)	criteria provided, single submitter
Select item 216242739.	NM_020975.6(RET):c.2533G>T (p.Ala845Ser) GRCh37: Chr10:43615119 GRCh38: Chr10:43119671	RET	A501S, A603S, A699S, A713S, A749S, A845S, A362S, A515S, A670S, A757S, A450S, A503S, A591S, A800S, A802S, A410S, A506S, A546S	Multiple endocrine neoplasia, type 2	Uncertain significance (Sep 20, 2022)	criteria provided, single submitter
Select item 216225640.	NM_020975.6(RET):c.2136+14C>G GRCh37: Chr10:43610198 GRCh38: Chr10:43114750	RET		Multiple endocrine neoplasia, type 2	Likely benign (May 12, 2022)	criteria provided, single submitter
Select item 216225541.	NM_020975.6(RET):c.338-4G>A GRCh37: Chr10:43597786 GRCh38: Chr10:43102338	RET		Multiple endocrine neoplasia, type 2	Likely benign (Aug 24, 2022)	criteria provided, single submitter
Select item 216174642.	NM_020975.6(RET):c.1129A>G (p.Asn377Asp) GRCh37: Chr10:43604544 GRCh38: Chr10:43109096	RET	N281D, N135D, N231D, N123D, N334D, N377D, N47D	Multiple endocrine neoplasia, type 2	Uncertain significance (Aug 6, 2022)	criteria provided, single submitter
Select item 216144143.	NM_020975.6(RET):c.1065G>T (p.Arg355Ser) GRCh37: Chr10:43604480 GRCh38: Chr10:43109032	RET	R101S, R259S, R355S, R113S, R312S	Multiple endocrine neoplasia, type 2	Uncertain significance (Feb 22, 2022)	criteria provided, single submitter
Select item 216095344.	NM_020975.6(RET):c.868-17C>T GRCh37: Chr10:43601807 GRCh38: Chr10:43106359	RET		Multiple endocrine neoplasia, type 2	Likely benign (Apr 29, 2022)	criteria provided, single submitter
Select item 216062545.	NM_020975.6(RET):c.3187+16C>T GRCh37: Chr10:43622186 GRCh38: Chr10:43126738	RET	A922V, A972V, A1025V, A729V, A814V, A893V, A1068V, A585V, A633V, A673V, A769V, A980V, A1023V, A724V, A726V, A738V, A826V, A936V	Multiple endocrine neoplasia, type 2	Likely benign (Aug 2, 2022)	criteria provided, single submitter
Select item 216018346.	NM_020975.6(RET):c.1861G>A (p.Glu621Lys) GRCh37: Chr10:43609105 GRCh38: Chr10:43113657	RET	E291K, E367K, E379K, E446K, E525K, E578K, E322K, E138K, E226K, E279K, E475K, E489K, E621K	Multiple endocrine neoplasia, type 2	Uncertain significance (Feb 19, 2022)	criteria provided, single submitter
Select item 215754547.	NM_020975.6(RET):c.1880-17A>C GRCh37: Chr10:43609911 GRCh38: Chr10:43114463	RET		Multiple endocrine neoplasia, type 2	Likely benign (Sep 25, 2022)	criteria provided, single submitter
Select item 215362748.	NM_020975.6(RET):c.2801+19C>G GRCh37: Chr10:43617483 GRCh38: Chr10:43122035	RET		Multiple endocrine neoplasia, type 2	Likely benign (Sep 16, 2022)	criteria provided, single submitter
Select item 215144449.	NM_020975.6(RET):c.153G>C (p.Leu51=) GRCh37: Chr10:43595986 GRCh38: Chr10:43100538	RET		Multiple endocrine neoplasia, type 2	Likely benign (Oct 12, 2022)	criteria provided, single submitter
Select item 215073050.	NM_020975.6(RET):c.555C>A (p.Phe185Leu) GRCh37: Chr10:43598007 GRCh38: Chr10:43102559	RET	F185L, F142L	Multiple endocrine neoplasia, type 2	Uncertain significance (Jun 1, 2022)	criteria provided, single submitter
Select item 214793651.	NM_020975.6(RET):c.1632G>A (p.Arg544=) GRCh37: Chr10:43607656 GRCh38: Chr10:43112208	RET		Multiple endocrine neoplasia, type 2	Likely benign (Aug 31, 2022)	criteria provided, single submitter
Select item 214670652.	NM_020975.6(RET):c.1363G>T (p.Val455Phe) GRCh37: Chr10:43606754 GRCh38: Chr10:43111306	RET	V323F, V412F, V125F, V201F, V213F, V359F, V455F, V280F, V309F	Multiple endocrine neoplasia, type 2	Uncertain significance (Apr 11, 2022)	criteria provided, single submitter
Select item 214623953.	NM_020975.6(RET):c.3118C>T (p.Leu1040=) GRCh37: Chr10:43622101 GRCh38: Chr10:43126653	RET		Multiple endocrine neoplasia, type 2	Likely benign (Dec 24, 2021)	criteria provided, single submitter
Select item 214615554.	NM_020975.6(RET):c.1082A>T (p.Asn361Ile) GRCh37: Chr10:43604497 GRCh38: Chr10:43109049	RET	N318I, N107I, N119I, N215I, N361I, N265I, N31I	Multiple endocrine neoplasia, type 2	Uncertain significance (Apr 1, 2022)	criteria provided, single submitter
Select item 214543355.	NM_020975.6(RET):c.279C>T (p.Gly93=) GRCh37: Chr10:43596112 GRCh38: Chr10:43100664	RET		Multiple endocrine neoplasia, type 2	Likely benign (Aug 19, 2022)	criteria provided, single submitter
Select item 214364256.	NM_020975.6(RET):c.338-13C>T GRCh37: Chr10:43597777 GRCh38: Chr10:43102329	RET		Multiple endocrine neoplasia, type 2	Likely benign (Jan 10, 2022)	criteria provided, single submitter
Select item 214238857.	NM_020975.6(RET):c.1760-19G>A GRCh37: Chr10:43608985 GRCh38: Chr10:43113537	RET		Multiple endocrine neoplasia, type 2	Likely benign (Oct 12, 2022)	criteria provided, single submitter
Select item 214107258.	NM_020975.6(RET):c.1453G>T (p.Val485Leu) GRCh37: Chr10:43606844 GRCh38: Chr10:43111396	RET	V155L, V310L, V339L, V231L, V389L, V442L, V485L, V353L, V243L	Multiple endocrine neoplasia, type 2	Uncertain significance (Sep 3, 2022)	criteria provided, single submitter
Select item 214062059.	NM_020975.6(RET):c.2534C>T (p.Ala845Val) GRCh37: Chr10:43615120 GRCh38: Chr10:43119672	RET	A362V, A591V, A749V, A800V, A501V, A503V, A699V, A757V, A802V, A515V, A546V, A603V, A410V, A450V, A506V, A670V, A713V, A845V	Multiple endocrine neoplasia, type 2	Uncertain significance (Oct 9, 2022)	criteria provided, single submitter
Select item 214043060.	NM_020975.6(RET):c.546A>G (p.Pro182=) GRCh37: Chr10:43597998 GRCh38: Chr10:43102550	RET		Multiple endocrine neoplasia, type 2	Likely benign (Jul 5, 2022)	criteria provided, single submitter
Select item 213923361.	NM_020975.6(RET):c.3040-3C>T GRCh37: Chr10:43622020 GRCh38: Chr10:43126572	RET		Multiple endocrine neoplasia, type 2	Uncertain significance (Oct 27, 2022)	criteria provided, single submitter
Select item 213884862.	NM_020975.6(RET):c.485C>G (p.Pro162Arg) GRCh37: Chr10:43597937 GRCh38: Chr10:43102489	RET	P162R, P119R	Multiple endocrine neoplasia, type 2	Uncertain significance (Sep 27, 2022)	criteria provided, single submitter
Select item 213685863.	NM_020975.6(RET):c.1832_1833delinsAT (p.Cys611Tyr) GRCh37: Chr10:43609076-43609077 GRCh38: Chr10:43113628-43113629	RET	C611Y, C357Y, C216Y, C281Y, C515Y, C128Y, C269Y, C479Y, C568Y, C312Y, C369Y, C436Y, C465Y	Multiple endocrine neoplasia, type 2	Pathogenic (Apr 12, 2022)	criteria provided, single submitter
Select item 213685664.	NM_020975.6(RET):c.1078C>T (p.Arg360Trp) GRCh37: Chr10:43604493 GRCh38: Chr10:43109045	RET	R106W, R30W, R118W, R264W, R360W, R214W, R317W	Multiple endocrine neoplasia, type 2	Uncertain significance (Sep 2, 2022)	criteria provided, single submitter
Select item 213685565.	NM_020975.6(RET):c.360C>T (p.Thr120=) GRCh37: Chr10:43597812 GRCh38: Chr10:43102364	RET		Multiple endocrine neoplasia, type 2	Likely benign (Oct 13, 2022)	criteria provided, single submitter
Select item 213576466.	NM_020975.6(RET):c.1491G>C (p.Gln497His) GRCh37: Chr10:43606882 GRCh38: Chr10:43111434	RET	Q351H, Q243H, Q322H, Q365H, Q255H, Q401H, Q167H, Q454H, Q497H	Multiple endocrine neoplasia, type 2	Uncertain significance (May 9, 2022)	criteria provided, single submitter
Select item 213496767.	NM_020975.6(RET):c.915T>A (p.Pro305=) GRCh37: Chr10:43601871 GRCh38: Chr10:43106423	RET		Multiple endocrine neoplasia, type 2	Likely benign (May 7, 2022)	criteria provided, single submitter
Select item 213496068.	NM_020975.6(RET):c.2401C>T (p.Leu801Phe) GRCh37: Chr10:43614987 GRCh38: Chr10:43119539	RET	L462F, L626F, L756F, L406F, L471F, L547F, L559F, L669F, L366F, L713F, L801F, L318F, L457F, L459F, L502F, L655F, L705F, L758F	Multiple endocrine neoplasia, type 2	Uncertain significance (May 7, 2022)	criteria provided, single submitter
Select item 213366569.	NM_020975.6(RET):c.1622G>A (p.Cys541Tyr) GRCh37: Chr10:43607646 GRCh38: Chr10:43112198	RET	C498Y, C211Y, C242Y, C395Y, C409Y, C199Y, C287Y, C445Y, C58Y, C146Y, C299Y, C366Y, C541Y	Multiple endocrine neoplasia, type 2	Likely pathogenic (May 20, 2022)	criteria provided, single submitter
Select item 213338870.	NM_020975.6(RET):c.395T>G (p.Leu132Arg) GRCh37: Chr10:43597847 GRCh38: Chr10:43102399	RET	L132R	Multiple endocrine neoplasia, type 2	Uncertain significance (May 4, 2022)	criteria provided, single submitter
Select item 213329871.	NM_020975.6(RET):c.2802-13del GRCh37: Chr10:43619104 GRCh38: Chr10:43123656	RET		Multiple endocrine neoplasia, type 2	Likely benign (Jun 3, 2022)	criteria provided, single submitter
Select item 213300872.	NM_020975.6(RET):c.1463C>A (p.Thr488Asn) GRCh37: Chr10:43606854 GRCh38: Chr10:43111406	RET	T392N, T488N, T234N, T313N, T342N, T445N, T158N, T246N, T356N	Multiple endocrine neoplasia, type 2	Uncertain significance (Dec 2, 2021)	criteria provided, single submitter
Select item 213190473.	NM_020975.6(RET):c.2940-9T>G GRCh37: Chr10:43620322 GRCh38: Chr10:43124874	RET		Multiple endocrine neoplasia, type 2	Likely benign (May 3, 2022)	criteria provided, single submitter
Select item 213186674.	NM_020975.6(RET):c.890G>C (p.Arg297Pro) GRCh37: Chr10:43601846 GRCh38: Chr10:43106398	RET	R254P, R297P, R201P, R43P	Multiple endocrine neoplasia, type 2	Uncertain significance (May 22, 2022)	criteria provided, single submitter
Select item 213158775.	NM_020975.6(RET):c.1147G>A (p.Gly383Ser) GRCh37: Chr10:43604562 GRCh38: Chr10:43109114	RET	G53S, G237S, G287S, G340S, G129S, G141S, G383S	Multiple endocrine neoplasia, type 2	Uncertain significance (Apr 28, 2022)	criteria provided, single submitter
Select item 213151176.	NM_020975.6(RET):c.1116G>C (p.Leu372=) GRCh37: Chr10:43604531 GRCh38: Chr10:43109083	RET		Multiple endocrine neoplasia, type 2	Likely benign (Apr 28, 2022)	criteria provided, single submitter
Select item 213110677.	NM_020975.6(RET):c.1014C>G (p.Thr338=) GRCh37: Chr10:43601970 GRCh38: Chr10:43106522	RET		Multiple endocrine neoplasia, type 2	Likely benign (Apr 28, 2022)	criteria provided, single submitter
Select item 213100078.	NM_020975.6(RET):c.278G>A (p.Gly93Asp) GRCh37: Chr10:43596111 GRCh38: Chr10:43100663	RET	G93D	Multiple endocrine neoplasia, type 2	Uncertain significance (Apr 28, 2022)	criteria provided, single submitter
Select item 212826579.	NM_020975.6(RET):c.793G>A (p.Glu265Lys) GRCh37: Chr10:43600567 GRCh38: Chr10:43105119	RET	E222K, E265K, E11K, E169K	Multiple endocrine neoplasia, type 2	Uncertain significance (Apr 20, 2022)	criteria provided, single submitter
Select item 212752080.	NM_020975.6(RET):c.889C>A (p.Arg297Ser) GRCh37: Chr10:43601845 GRCh38: Chr10:43106397	RET	R254S, R297S, R201S, R43S	Multiple endocrine neoplasia, type 2	Uncertain significance (Apr 18, 2022)	criteria provided, single submitter
Select item 212454981.	NM_020975.6(RET):c.252C>T (p.Asn84=) GRCh37: Chr10:43596085 GRCh38: Chr10:43100637	RET		Multiple endocrine neoplasia, type 2	Likely benign (Apr 11, 2022)	criteria provided, single submitter
Select item 212454482.	NM_020975.6(RET):c.3030T>C (p.Val1010=) GRCh37: Chr10:43620421 GRCh38: Chr10:43124973	RET		Multiple endocrine neoplasia, type 2	Likely benign (Apr 11, 2022)	criteria provided, single submitter
Select item 212326683.	NM_020975.6(RET):c.1044_1051dup (p.Val351fs) GRCh37: Chr10:43601997-43601998 GRCh38: Chr10:43106549-43106550	RET	V351fs, V97fs	Multiple endocrine neoplasia, type 2	Pathogenic (Jun 9, 2022)	criteria provided, single submitter
Select item 212305384.	NM_020975.6(RET):c.1893C>G (p.Asp631Glu) GRCh37: Chr10:43609941 GRCh38: Chr10:43114493	RET	D289E, D377E, D535E, D148E, D292E, D456E, D631E, D236E, D301E, D485E, D499E, D196E, D332E, D389E, D588E	Multiple endocrine neoplasia, type 2	Uncertain significance (May 9, 2022)	criteria provided, single submitter
Select item 212244285.	NM_020975.6(RET):c.974C>T (p.Ala325Val) GRCh37: Chr10:43601930 GRCh38: Chr10:43106482	RET	A71V, A325V, A229V, A282V	Multiple endocrine neoplasia, type 2	Uncertain significance (Apr 10, 2022)	criteria provided, single submitter
Select item 212179586.	NM_020975.6(RET):c.1927_1929del (p.Leu643del) GRCh37: Chr10:43609973-43609975 GRCh38: Chr10:43114525-43114527	RET	L208del, L389del, L600del, L160del, L468del, L248del, L301del, L304del, L344del, L401del, L547del, L313del, L497del, L511del, L643del	Multiple endocrine neoplasia, type 2	Uncertain significance (Apr 6, 2022)	criteria provided, single submitter
Select item 212046287.	NM_020975.6(RET):c.2730+16G>T GRCh37: Chr10:43615667 GRCh38: Chr10:43120219	RET		Multiple endocrine neoplasia, type 2	Uncertain significance (Apr 22, 2022)	criteria provided, single submitter
Select item 211987488.	NM_020975.6(RET):c.2318T>G (p.Leu773Arg) GRCh37: Chr10:43613854 GRCh38: Chr10:43118406	RET	L434R, L677R, L685R, L290R, L338R, L378R, L429R, L730R, L773R, L443R, L474R, L627R, L641R, L728R, L431R, L519R, L531R, L598R	Multiple endocrine neoplasia, type 2	Uncertain significance (Mar 31, 2022)	criteria provided, single submitter
Select item 211928189.	NM_020975.6(RET):c.2872G>C (p.Glu958Gln) GRCh37: Chr10:43619189 GRCh38: Chr10:43123741	RET	E619Q, E628Q, E704Q, E870Q, E913Q, E523Q, E812Q, E862Q, E958Q, E475Q, E563Q, E616Q, E716Q, E783Q, E826Q, E614Q, E659Q, E915Q	Multiple endocrine neoplasia, type 2	Uncertain significance (Mar 29, 2022)	criteria provided, single submitter
Select item 211808090.	NM_020975.6(RET):c.1481G>A (p.Arg494Lys) GRCh37: Chr10:43606872 GRCh38: Chr10:43111424	RET	R252K, R348K, R319K, R451K, R494K, R164K, R240K, R362K, R398K	Multiple endocrine neoplasia, type 2	Uncertain significance (Jun 9, 2022)	criteria provided, single submitter
Select item 211735991.	NM_020975.6(RET):c.867+8T>A GRCh37: Chr10:43600649 GRCh38: Chr10:43105201	RET		Multiple endocrine neoplasia, type 2	Likely benign (Mar 26, 2022)	criteria provided, single submitter
Select item 211450192.	NM_020975.6(RET):c.1027A>C (p.Asn343His) GRCh37: Chr10:43601983 GRCh38: Chr10:43106535	RET	N300H, N89H, N247H, N343H	Multiple endocrine neoplasia, type 2	Uncertain significance (Mar 19, 2022)	criteria provided, single submitter
Select item 211364793.	NM_020975.6(RET):c.524G>T (p.Arg175Leu) GRCh37: Chr10:43597976 GRCh38: Chr10:43102528	RET	R132L, R175L	Multiple endocrine neoplasia, type 2	Uncertain significance (Mar 18, 2022)	criteria provided, single submitter
Select item 211202594.	NM_020975.6(RET):c.1932C>T (p.Phe644=) GRCh37: Chr10:43609980 GRCh38: Chr10:43114532	RET		Multiple endocrine neoplasia, type 2	Likely benign (Mar 14, 2022)	criteria provided, single submitter
Select item 211137195.	NM_020975.6(RET):c.2130G>A (p.Lys710=) GRCh37: Chr10:43610178 GRCh38: Chr10:43114730	RET		Multiple endocrine neoplasia, type 2	Likely benign (Mar 14, 2022)	criteria provided, single submitter
Select item 210902896.	NM_020975.6(RET):c.2731-7T>C GRCh37: Chr10:43617387 GRCh38: Chr10:43121939	RET		Multiple endocrine neoplasia, type 2	Likely benign (May 4, 2022)	criteria provided, single submitter
Select item 210844897.	NM_020975.6(RET):c.2989G>T (p.Val997Leu) GRCh37: Chr10:43620380 GRCh38: Chr10:43124932	RET	V562L, V698L, V997L, V514L, V655L, V667L, V743L, V851L, V909L, V653L, V755L, V901L, V602L, V658L, V822L, V865L, V952L, V954L	Multiple endocrine neoplasia, type 2	Uncertain significance (Jun 19, 2022)	criteria provided, single submitter
Select item 210809898.	NM_020975.6(RET):c.3048G>C (p.Leu1016Phe) GRCh37: Chr10:43622031 GRCh38: Chr10:43126583	RET	L686F, L717F, L762F, L774F, L920F, L581F, L672F, L677F, L971F, L533F, L870F, L928F, L1016F, L621F, L674F, L841F, L884F, L973F	Multiple endocrine neoplasia, type 2	Uncertain significance (Mar 16, 2022)	criteria provided, single submitter
Select item 210765799.	NM_020975.6(RET):c.56T>C (p.Leu19Pro) GRCh37: Chr10:43572762 GRCh38: Chr10:43077314	RET	L19P	Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 2	Uncertain significance (Dec 18, 2022)	criteria provided, multiple submitters, no conflicts
Select item 2107354100.	NM_020975.6(RET):c.2519A>T (p.His840Leu) GRCh37: Chr10:43615105 GRCh38: Chr10:43119657	RET	H501L, H510L, H708L, H744L, H795L, H498L, H541L, H586L, H797L, H840L, H357L, H405L, H445L, H665L, H694L, H496L, H598L, H752L	Multiple endocrine neoplasia, type 2	Uncertain significance (Aug 7, 2022)	criteria provided, single submitter

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