Literature
PubMed
PubMed® comprises more than 37 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.
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Literature databases
Books and reports
Ontology used for PubMed indexing
Books, journals and more in the NLM Collections
Scientific and medical abstracts/citations
Full-text journal articles
Data
Genes
Gene sequences and annotations used as references for the study of orthologs structure, expression, and evolution
Collected information about gene loci
Functional genomics studies
Gene expression and molecular abundance profiles
Sequence sets from phylogenetic and population studies
Proteins
Protein sequences, 3-D structures, and tools for the study of functional protein domains and active sites
Conserved protein domains
Protein sequences grouped by identity
Protein sequences
Models representing homologous proteins with a common function
Experimentally-determined biomolecular structures
BLAST
A tool to find regions of similarity between biological sequences
Search nucleotide sequence databases
Search protein sequence databases
Search protein databases using a translated nucleotide query
Search translated nucleotide databases using a protein query
Find primers specific to your PCR template
Genomes
Genome sequence assemblies, large-scale functional genomics data, and source biological samples
Genome assembly information
Museum, herbaria, and other biorepository collections
Biological projects providing data to NCBI
Descriptions of biological source materials
Genome sequencing projects by organism
DNA and RNA sequences
High-throughput sequence reads
Taxonomic classification and nomenclature
Clinical
Heritable DNA variations, associations with human pathologies, and clinical diagnostics and treatments
Privately and publicly funded clinical studies conducted around the world
Human variations of clinical significance
Genotype/phenotype interaction studies
Short genetic variations
Genome structural variation studies
Genetic testing registry
Medical genetics literature and links
Online mendelian inheritance in man
PubChem
Repository of chemical information, molecular pathways, and tools for bioactivity screening
Bioactivity screening studies
Chemical information with structures, information and links
Molecular pathways with links to genes, proteins and chemicals
Deposited substance and chemical information
News
Research news
Getting to the Root of the Plant Microbiota
In plants, sugar transport and microbial community composition go hand in hand.
Chad eliminates tropical disease targeted by WHO program
Human African trypanosomiasis (HAT) is caused by parasites and spread through the bite of the tsetse fly.
MOBE: A Base Editor That Multitasks without Mix-ups
A new system for simultaneous genomic edits could unlock better models of complex diseases.
Recent blog posts
Sequencing Technique Detects Earliest Signs of Genetic Mutations Underlying Cancer, Aging, and More
Every day, billions of cells in your body divide, each producing two daughter cells. It’s an essential process for your tissues and organs to renew themselves and remain healthy. To do it, cells must first duplicate their DNA to ensure that each daughter cell gets an accurate copy. In this process, mistakes are inevitably made. Most DNA errors are accurately fixed and do not lead to mutations. But when small errors akin to single-letter typos aren’t corrected, they can become permanent in a cell and multiplied with each subsequent cell division. Even cells that don’t divide, such as neurons in your brain, acquire damage and mutations in their DNA with age. As a result, your tissues contain collections of cells with distinct mutations that accumulate over time. While many of these small errors will show no obvious consequences, others can lead to cancer and other health conditions. Now, a new DNA sequencing technique, described in Nature and developed through research supported by NIH, promises to detect early DNA changes before they become permanent mutations in a cell’s genome. The method, called Hairpin Duplex Enhanced Fidelity Sequencing (HiDEF-seq), could advance our understanding of how and why mutations arise, with potentially important implications for our health. For example, the ability to identify signs that precede mutations may help predict a person’s health risks based on genetic predispositions, environmental exposures, or other factors.
Universal Reference Numbers for Ig Domains Now Available in NCBI’s iCn3D Structure Viewer
The Immunoglobulin (Ig) fold is the most common protein structure unit in the human proteome and is involved in many cellular signaling pathways. NCBI along with researchers at the National Cancer Institute and California State University, Northridge have developed a universal reference numbering scheme for Ig folds, now available in the iCn3D structure viewer, to … Continue reading Universal Reference Numbers for Ig Domains Now Available in NCBI’s iCn3D Structure Viewer
From Telehealth to Zombies: Stories from Season Two of the NNLM Discovery Podcast
The Network of the National Library of Medicine (NNLM) is back with season two of the NNLM Discovery Podcast Series! Featuring inspiring stories from NNLM's seven regions, this season covers telehealth kiosks, food insecurity, public health during a fictional zombie apocalypse, and so much more.