Literature
PubMed
PubMed® comprises more than 37 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.
Featured Bookshelf titles
Clinical and Research Information on Drug-Induced Liver Injury
Literature databases
Books and reports
Ontology used for PubMed indexing
Books, journals and more in the NLM Collections
Scientific and medical abstracts/citations
Full-text journal articles
Data
Genes
Gene sequences and annotations used as references for the study of orthologs structure, expression, and evolution
Collected information about gene loci
Functional genomics studies
Gene expression and molecular abundance profiles
Sequence sets from phylogenetic and population studies
Proteins
Protein sequences, 3-D structures, and tools for the study of functional protein domains and active sites
Conserved protein domains
Protein sequences grouped by identity
Protein sequences
Models representing homologous proteins with a common function
Experimentally-determined biomolecular structures
BLAST
A tool to find regions of similarity between biological sequences
Search nucleotide sequence databases
Search protein sequence databases
Search protein databases using a translated nucleotide query
Search translated nucleotide databases using a protein query
Find primers specific to your PCR template
Genomes
Genome sequence assemblies, large-scale functional genomics data, and source biological samples
Genome assembly information
Museum, herbaria, and other biorepository collections
Biological projects providing data to NCBI
Descriptions of biological source materials
Genome sequencing projects by organism
DNA and RNA sequences
High-throughput sequence reads
Taxonomic classification and nomenclature
Clinical
Heritable DNA variations, associations with human pathologies, and clinical diagnostics and treatments
Privately and publicly funded clinical studies conducted around the world
Human variations of clinical significance
Genotype/phenotype interaction studies
Short genetic variations
Genome structural variation studies
Genetic testing registry
Medical genetics literature and links
Online mendelian inheritance in man
PubChem
Repository of chemical information, molecular pathways, and tools for bioactivity screening
Bioactivity screening studies
Chemical information with structures, information and links
Molecular pathways with links to genes, proteins and chemicals
Deposited substance and chemical information
News
Research news
Debunking the Dopamine Detox Trend
The fad of temporarily fasting from pleasurable activities likely won’t “reset” dopamine levels and doesn’t accurately reflect this molecule’s nuanced functions.
Study examines link between family incarceration, children’s health
The study sheds light on the ripple effects of mass incarceration.
I avoided plastic for a week. Here is what I learned about a plastic-free life
Plastic is everywhere, but we ditched it for a week. Here are some tips from our experiment that you can use to cut back your own plastic use.
Recent blog posts
Maternal Brain Hormone Key to Strengthening Bones Could Help Treat Osteoporosis, Bone Fractures
More than 200 million people around the world have osteoporosis, a condition that weakens bones to the point that they break easily. Women are at especially high risk after menopause due to declining levels of the hormone estrogen, which helps keep bones strong. While osteoporosis rarely has noticeable symptoms, it can lead to serious injuries when otherwise minor slips and falls cause broken bones that in turn can lead to further fracture risk and fracture-related mortality. So, I’m pleased to share NIH-supported research suggesting a surprising candidate for strengthening bones: a maternal hormone produced in the brain. The study in mice reported in Nature shows that this newly discovered hormone maintains and rebuilds bone strength in lactating females, even as estrogen levels dip and calcium is lost to the demands of milk production. The findings suggest this hormone—or a drug that acts similarly—could be key to treating osteoporosis and preventing and healing broken bones.
NCBI Taxonomy Updates to Birds (Aves)
Recent molecular comparisons have better defined relationships among high-level taxonomic groups in birds. To reflect new data and classification changes, NCBI is improving our Taxonomy resource. As previously announced, we updated the higher-level classification of birds (Aves) with the introduction of a new major taxonomic group (clade). What’s new? The new clade, Neoaves, comprises about … Continue reading NCBI Taxonomy Updates to Birds (Aves)
Epigenetic Editor Silences Toxic Proteins in the Mouse Brain, Offering Promising Path to Treat Deadly Prion Diseases
Prion diseases are fatal neurodegenerative disorders caused by a malfunction of the prion protein in the brain. Exposure to a misfolded version of the protein triggers normal proteins of the same type in the brain to misfold, forming clumps that produce infectious disease and fatal brain damage over time. There are currently no treatments, preventive vaccines, or cures for prion diseases, which can be acquired, like mad cow disease, or inherited, like fatal familial insomnia. But an encouraging new study in mice suggests a potentially promising path for developing a treatment for people with these deadly conditions. Findings from an NIH-supported study reported in Science show that the key to this approach is a molecular tool capable of silencing prion protein throughout the brain using epigenetic editing. Unlike gene editing approaches, which change the sequence of genes, epigenetic editing can turn gene expression off with the addition of a chemical tag that prevents genes from being translated into proteins. Such a strategy may be able to deliver modifying tools to the brain or other parts of the body to silence specific toxic or disease-causing genes, including the one encoding the prion protein, without the risks associated with altering DNA sequences.