GEO DataSets

(Submitter supplied) Calorie restriction (CR) is known to decrease not only spontaneous but also chemical carcinogen and radiation-induced carcinogenesis. However, the biological mechanisms for the anti-cancer effect of CR remain unclear. In this study, analyzed and compared with genomic alterations in thymic lymphoma (TL) arising after irradiation between with or without CR. The frequency of point mutations at Pten locus on chromosome 19 was not different between 95 kcal and 65 kcal groups, but the frequency of LOH with DNA copy number change in 65 kcal group tended to be higher than 95 kcal group. more...

Organism:

Mus musculus

Type:

Genome variation profiling by genome tiling array

Platform:

GPL19767

48 Samples

Download data: TXT

(Submitter supplied) To investigate DNA copy number changes in mouse B-cell lymphoma induced by ionizing radiation.

Organism:

Mus musculus

Type:

Genome variation profiling by array

Platform:

GPL19767

9 Samples

Download data: TXT, XLSX

(Submitter supplied) Children are considered more sensitive to radiation-induced cancer than adults, yet any differences in genomic alterations associated with age at exposure and their underlying mechanisms remain unclear. We analyzed the mutation of key tumor suppressor genes in T-cell lymphomas arising after weekly irradiation of female B6C3F1 mice with 1.2 Gy X-rays for 4 consecutive weeks starting during infancy (1 week old), adolescence (4 weeks old) or as young adults (8 weeks old). more...

Organism:

Mus musculus

Type:

Genome variation profiling by genome tiling array

Platforms:

GPL19767 GPL19421

38 Samples

Download data: TXT

(Submitter supplied) Here, male and female B6C3F1 mice were given single or fractionated whole-body exposure(s) to a monoenergetic carbon ion radiotherapy beam at the Heavy Ion Medical Accelerator in Chiba, Japan, matching the radiation quality delivered to the normal tissue ahead of the tumour volume. These mice were then monitored for the remainder of their lifespan and a large number of T cell lymphomas were analysed, alongside those arising in mice exposed to equivalent doses of standard Cs137 gamma ray-irradiation. more...

Organism:

Mus musculus

Type:

Genome variation profiling by genome tiling array

Platform:

GPL19767

32 Samples

Download data: TXT

(Submitter supplied) Genomic tiling plus high density coverage of key TL loci. Arrays of this design have barcodes that begin with 16046808 or 2546808. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. The ID column represents the Agilent Feature Extraction feature number. more...

Organism:

Mus musculus

3 Series

1 Related Platform

33 Samples

Download data: TXT

(Submitter supplied) Genomic tiling plus high density coverage of key TL loci. Arrays of this design have barcodes that begin with 16046808 or 2546808. Protocol: see manufacturer's web site at http://www.agilent.com/

Organism:

Mus musculus

4 Series

1 Related Platform

91 Samples

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