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Items: 1 to 20 of 44006

1.

RNAseq in Acly wild-type or conditional KO mouse T-ALLs

(Submitter supplied) C57BL6 mice harboring Acly conditional knockout NOTCH1-ΔE-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of Acly. Here we report the gene expression profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice, either in an acute setting (72h post-tamoxifen) or in long-term survival setting
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
20 Samples
Download data: CSV
Series
Accession:
GSE270579
ID:
200270579
2.

Wild-Type vs ORAI 1/2/3 TKO_Pathogenic Th17 cells_ 6h vs 24h

(Submitter supplied) Time-Course Transicriptome comparison between murine WT and ORAI TKO pTH17cells at 6 hours and 24 hours following differentiation
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
12 Samples
Download data: CSV
Series
Accession:
GSE288624
ID:
200288624
3.

Non-CG DNA methylation and MeCP2 stabilize repeated tuning of long genes that distinguish closely related neuron types.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
synthetic construct; Mus musculus
Type:
Other; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
4 related Platforms
108 Samples
Download data: BW, CSV
Series
Accession:
GSE237089
ID:
200237089
4.

Non-CG DNA methylation and MeCP2 stabilize repeated tuning of long genes that distinguish closely related neuron types [ChIP-seq]

(Submitter supplied) The extraordinary diversity of neuron types in the mammalian brain is delineated at the highest resolution by subtle gene expression differences that may require specialized molecular mechanisms to be maintained. Neurons uniquely express the longest genes in the genome and utilize neuron-enriched non-CG DNA methylation (mCA) together with the Rett syndrome protein, MeCP2, to control gene expression, but the function of these unique gene structures and machinery in regulating finely resolved neuron type-specific gene programs has not been explored. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21493
36 Samples
Download data: BW
Series
Accession:
GSE237085
ID:
200237085
5.

Non-CG DNA methylation and MeCP2 stabilize repeated tuning of long genes that distinguish closely related neuron types [RNA-seq]

(Submitter supplied) The extraordinary diversity of neuron types in the mammalian brain is delineated at the highest resolution by subtle gene expression differences that may require specialized molecular mechanisms to be maintained. Neurons uniquely express the longest genes in the genome and utilize neuron-enriched non-CG DNA methylation (mCA) together with the Rett syndrome protein, MeCP2, to control gene expression, but the function of these unique gene structures and machinery in regulating finely resolved neuron type-specific gene programs has not been explored. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19057 GPL21493
38 Samples
Download data: TSV, TXT
Series
Accession:
GSE237084
ID:
200237084
6.

Single-nuclei RNA sequencing of the locus coeruleus and pericoerulear brain regions

(Submitter supplied) As the primary source of norepinephrine (NE) in the brain, the locus coeruleus (LC) regulates both arousal and stress responses, but how neuromodulatory inputs contribute to LC modulation remains incompletely understood. In this study, we isolated a network of transcriptionally diverse inhibitory pericoerulear (peri-LC) GABAergic neurons that integrate distant stimuli and modulate modes of LC firing. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
4 Samples
Download data: MTX, TSV
Series
Accession:
GSE201998
ID:
200201998
7.

Wild-Type vs ORAI 2/3 DKO vs ORAI 1/2/3 TKO_Pathogenic Th17 cells_ 48h

(Submitter supplied) Transicriptome comparison between murine WT, ORAI 2/3 DKO, and ORAI TKO pTH17cells at 48 hours following differentiation
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
9 Samples
Download data: CSV
Series
Accession:
GSE287414
ID:
200287414
8.

Combination adjuvant improves influenza virus immunity by downregulation of immune homeostasis genes in lymphocytes

(Submitter supplied) Adjuvants play a central role in enhancing the immunogenicity of otherwise poorly immunogenic vaccine antigens. Combining adjuvants has the potential to enhance vaccine immunogenicity compared with single adjuvants, although the cellular and molecular mechanisms of combination adjuvants are not well understood. Using the influenza virus hemagglutinin H5 antigen, we define the immunological landscape of combining CpG and MPLA (TLR-9 and TLR-4 agonists, respectively) with a squalene nanoemulsion (AddaVax) using immunologic and transcriptomic profiling. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
15 Samples
Download data: H5AD
Series
Accession:
GSE287619
ID:
200287619
9.

Wild-Type vs Orai1KO pTH17 and npTh17 cells_ 48h

(Submitter supplied) Transicriptome comparison between WT and ORAI1 KO pTH17cells at 48 hours during differentiation
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
12 Samples
Download data: CSV
Series
Accession:
GSE286880
ID:
200286880
10.

Transcription inhibition in early mouse embryos impacts transcriptome at 4-cell stage

(Submitter supplied) Mouse zygotes were treated with DRB to inhibit transcription activity, and early embryos were collected at 4-cell stage to examine transcriptome alteration by RNA-seq.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
6 Samples
Download data: TXT
Series
Accession:
GSE282667
ID:
200282667
11.

Transcriptome analysis of oocytes and early embryos to demonstrate trancriptional regulation during mouse oocyte-to-embryo transition

(Submitter supplied) In this study, we performed RNA-seq to elucidate how transcriptional activities of mouse oocytes and preimplantation embryos are regulated to control oocyte-to-embryo transition. Through analyzing transcriptome alterations of transgenically-modified growing oocytes, early embryos from aged female, early embryos treated with drugs disturbing proteostasis, and embryonic stem cells treated with drugs disturbing proteostasis, we identified critical roles of proteostasis in transcriptional regulation of mouse oocytes and early embryos.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
32 Samples
Download data: TXT
Series
Accession:
GSE241388
ID:
200241388
12.

Epigenetic and transcriptional regulation of mouse oocytes and early embryos

(Submitter supplied) In this study, we performed ChIP-seq of RNA polymerase II, phosphorylated RNA polymerase II and related epigenetic modifications to elucidate transcriptional activities of mouse oocytes and preimplantation embryos. Through analyzing epigenetic alterations of transgenically-modified growing oocytes, early embryos from aged female, and early embryos treated with drugs disturbing proteostasis, we identified critical roles of proteostasis in transcriptional regulation of mouse oocytes and early embryos.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21493
51 Samples
Download data: BW
Series
Accession:
GSE241246
ID:
200241246
13.

Deciphering transcriptional activities in mouse early embryo

(Submitter supplied) Through analyzing elongating RNA polymerase II in different stages of mouse early embryos, we identified transcriptional activities at various stages and characterized principles of transcriptional transition between adjacent stages.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21493
26 Samples
Download data: BW
Series
Accession:
GSE241197
ID:
200241197
14.

FGFR2 Directs Inhibition of WNT Signaling to Regulate Anterior Fontanelle Closure during Skull Development

(Submitter supplied) The calvarial bones of the infant skull are linked by transient fibrous joints known as sutures and fontanelles, which are essential for skull compression during birth and expansion during postnatal brain growth. Genetic conditions caused by pathogenic variants in FGFR2, such as Apert, Pfeiffer, Crouzon syndromes, result in calvarial deformities due to premature suture fusion and a persistently open anterior fontanelle (AF). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
10 Samples
Download data: TXT
Series
Accession:
GSE286314
ID:
200286314
15.

Dynamics of γδ TCR repertoire during the de-differentiation and treatment course of thyroid cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24676 GPL21493
5 Samples
Download data: RDS
Series
Accession:
GSE224721
ID:
200224721
16.

Dynamics of γδ TCR repertoire during the de-differentiation and treatment course of thyroid cancer [mouse scRNA]

(Submitter supplied) Although the de-differentiation process of thyroid cancer has been studied, it remains unclear how T cell antigen receptor (TCR) dynamically changes during the cancer progression and treatment. Here we characterized the γδ TCR repertoire along the de-differentiation of thyroid cancers cross-sectionally and investigated the longitudinal changes of TCR components over time in thyroid cancer patients receiving different treatment. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
4 Samples
Download data: RDS
Series
Accession:
GSE224720
ID:
200224720
17.

RNA sequencing of Naive CD8 T cells isolated from Brca1 wildtype and Brca1 het splenocytes

(Submitter supplied) To determine the impact of Brca1 gene heterozygosity on transcriptomics of CD8+ T cells, we carried out bulk RNA-sequencing (RNA-seq) using naive CD8+ T cells isolated from WT and Het mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
8 Samples
Download data: TXT
Series
Accession:
GSE191217
ID:
200191217
18.

PIEZO-dependent mechano-sensing of the niche is essential for intestinal stem cell fate decision and maintenance

(Submitter supplied) Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. Here, we investigated the roles of PIEZO mechanosensitive channels in intestinal stem cell (ISC) niche. By employing mouse genetics and single-cell RNAseq analysis, we revealed the requirement for PIEZO channels in ISC maintenance. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
2 Samples
Download data: R, RDATA
Series
Accession:
GSE277223
ID:
200277223
19.

The pivotal role of the Hes1–Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosis

(Submitter supplied) Glucocorticoid-induced osteoporosis (GIOP) lacks fully effective treatments. This study investigated the role of Piezo1, a mechanosensitive ion channel component 1, in GIOP. We found reduced Piezo1 expression in cortical bone osteocytes from patients with GIOP and a GIOP mouse model. Yoda1, a Piezo1 agonist, enhanced the mechanical stress response and bone mass and strength, which were diminished by dexamethasone (DEX) administration in GIOP mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
20 Samples
Download data: TSV
Series
Accession:
GSE276391
ID:
200276391
20.

RNA-seq analysis of WT and Tmem11 KO Th1 cells

(Submitter supplied) Loss of TMEM11 did not influence T cell differentiation but selectively impaired effector functions of Th1 cells, resulting in reduced severity of symptoms in an animal model of autoimmunity. To find out genes influenced by Tmem11 knockout, we conducted RNA-seq analysis using Th1 cells after re-stimulation.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
6 Samples
Download data: CSV
Series
Accession:
GSE283950
ID:
200283950
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