GEO DataSets

(Submitter supplied) The goal of the study was to test whether CBD103 genotype of North American gray wolves impacts the gene expression response to polyI:C or to live canine distemper virus. We established 24 primary cultures of epidermal keratinocytes from skin punches of North American gray wolves, and also generated an immortalized keratinocyte line and a CRISPR/Cas9 edited cell line. We evaluated the gene expression response of cells to either 24 hours challenge with 1 ug/ml polyI:C or to five days challenge with live canine distemper virus (100 TCID50/ml). more...

Organism:

Canis lupus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26727

68 Samples

Download data: TXT

(Submitter supplied) We analyzed the transcriptomic profile of neoplastic CD5-CD21+ B cells isolated ex vivo from the enlarged lymph node of dogs with B cell lymphoma

Organism:

Canis lupus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26727

11 Samples

Download data: TXT

(Submitter supplied) Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been identified in humans and mice on the basis of their extensive portfolios of monoclonal antibodies (mAb) against Treg surface antigens. As an important veterinary species, dogs are increasingly recognised as an excellent model for many human diseases. more...

Organism:

Canis lupus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26727

10 Samples

Download data: TXT