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Items: 1 to 20 of 27

1.

Impaired fatty acid import and metabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis

(Submitter supplied) Mycobacterium tuberculosis (Mtb) infection of macrophages reprograms cellular lipid metabolism to promote the formation of cytosolic lipid droplets. While it is clearly known that intracellular Mtb utilize host derived fatty acids and cholesterol to fuel a majority of its biosynthetic demands, the role of macrophage lipid metabolism on the bacteria’s ability to access the intracellular lipid pool remains controversial. more...
Organism:
Mycobacterium tuberculosis; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL34461
12 Samples
Download data: TXT
Series
Accession:
GSE270571
ID:
200270571
2.

Genome-wide screening of Mycobacterium tuberculosis-infected macrophages identified the GID/CTLH complex as a determinant of intracellular bacterial growth

(Submitter supplied) The eukaryotic GID/CTLH complex is a highly conserved E3 ubiquitin ligase involved in a broad range of biological processes. However, a role of this complex in host antimicrobial defenses has not been described. We exploited Mycobacterium tuberculosis (Mtb) induced cytotoxicity in macrophages in a FACS based CRISPR genetic screen to identify host determinants of intracellular Mtb growth restriction. more...
Organism:
Mycobacterium tuberculosis; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL34461
12 Samples
Download data: TXT
Series
Accession:
GSE267063
ID:
200267063
3.

Illumina NovaSeq 6000 (Mus musculus; Mycobacterium tuberculosis)

Organism:
Mycobacterium tuberculosis; Mus musculus
2 Series
24 Samples
Download data
Platform
Accession:
GPL34461
ID:
100034461
4.

Mtb infected CPT2 knockdown macrophages 4 days post infection_rep3

Organism:
Mus musculus; Mycobacterium tuberculosis
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE270571
Download data
Sample
Accession:
GSM8347608
ID:
308347608
5.

Mtb infected CPT2 knockdown macrophages 4 days post infection_rep2

Organism:
Mycobacterium tuberculosis; Mus musculus
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE270571
Download data
Sample
Accession:
GSM8347607
ID:
308347607
6.

Mtb infected CPT2 knockdown macrophages 4 days post infection_rep1

Organism:
Mycobacterium tuberculosis; Mus musculus
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE270571
Download data
Sample
Accession:
GSM8347606
ID:
308347606
7.

Mtb infected FATP1 knockdown macrophages 4 days post infection_rep3

Organism:
Mycobacterium tuberculosis; Mus musculus
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE270571
Download data
Sample
Accession:
GSM8347605
ID:
308347605
8.

Mtb infected FATP1 knockdown macrophages 4 days post infection_rep2

Organism:
Mycobacterium tuberculosis; Mus musculus
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE270571
Download data
Sample
Accession:
GSM8347604
ID:
308347604
9.

Mtb infected FATP1 knockdown macrophages 4 days post infection_rep1

Organism:
Mycobacterium tuberculosis; Mus musculus
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE270571
Download data
Sample
Accession:
GSM8347603
ID:
308347603
10.

Mtb infected PLIN2 knockdown macrophages 4 days post infection_rep3

Organism:
Mus musculus; Mycobacterium tuberculosis
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE270571
Download data
Sample
Accession:
GSM8347602
ID:
308347602
11.

Mtb infected PLIN2 knockdown macrophages 4 days post infection_rep2

Organism:
Mus musculus; Mycobacterium tuberculosis
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE270571
Download data
Sample
Accession:
GSM8347601
ID:
308347601
12.

Mtb infected PLIN2 knockdown macrophages 4 days post infection_rep1

Organism:
Mycobacterium tuberculosis; Mus musculus
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE270571
Download data
Sample
Accession:
GSM8347600
ID:
308347600
13.

Mtb infected Scramble sgRNA macrophages 4 days post infection_rep3

Organism:
Mus musculus; Mycobacterium tuberculosis
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE270571
Download data
Sample
Accession:
GSM8347599
ID:
308347599
14.

Mtb infected Scramble sgRNA macrophages 4 days post infection_rep2

Organism:
Mycobacterium tuberculosis; Mus musculus
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE270571
Download data
Sample
Accession:
GSM8347598
ID:
308347598
15.

Mtb infected Scramble sgRNA macrophages 4 days post infection_rep1

Organism:
Mycobacterium tuberculosis; Mus musculus
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE270571
Download data
Sample
Accession:
GSM8347597
ID:
308347597
16.

Mtb infected MAEA knockdown macrophages 4 days post infection_3

Organism:
Mus musculus; Mycobacterium tuberculosis
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE267063
Download data
Sample
Accession:
GSM8259168
ID:
308259168
17.

Mtb infected MAEA knockdown macrophages 4 days post infection_2

Organism:
Mus musculus; Mycobacterium tuberculosis
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE267063
Download data
Sample
Accession:
GSM8259167
ID:
308259167
18.

Mtb infected MAEA knockdown macrophages 4 days post infection_1

Organism:
Mus musculus; Mycobacterium tuberculosis
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE267063
Download data
Sample
Accession:
GSM8259166
ID:
308259166
19.

Mtb infected WDR26 knockdown macrophages 4 days post infection_3

Organism:
Mycobacterium tuberculosis; Mus musculus
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE267063
Download data
Sample
Accession:
GSM8259165
ID:
308259165
20.

Mtb infected WDR26 knockdown macrophages 4 days post infection_2

Organism:
Mus musculus; Mycobacterium tuberculosis
Source name:
Bone marrow macrophages
Platform:
GPL34461
Series:
GSE267063
Download data
Sample
Accession:
GSM8259164
ID:
308259164
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