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Items: 1 to 20 of 39

1.

Context-dependent role of type 3 innate lymphoid cells in mucosal protection

(Submitter supplied) How group 3 innate lymphoid cells (ILC3) regulate mucosal protection in the presence of T cells remains poorly understood. Here, we examined ILC3 function in intestinal immunity using ILC3-deficient mice that maintain endogenous T cells, Th17 cells, and secondary lymphoid organs. ILC3 were dispensable for generation of Th17 and Th22 cell responses to commensal and pathogenic bacteria, and absence of ILC3 did not affect IL-22-production by CD4 T cells before or during infection. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL34475 GPL24247
50 Samples
Download data: TSV
Series
Accession:
GSE270398
ID:
200270398
2.

PanethcellTNF-signalinginducesbacterialsepsis: PC transcriptome 15h ater TNF in IFNARKO mice

(Submitter supplied) Paneth Cells (PCs) are secretory cells located in the crypts of Lieberkühn of the small intestine. They produce antimicrobial peptides (AMPs) and are thought to keep the microbiome under control. The cytokine TNF, which functions mainly via its TNF receptor 1 (TNFR1 or P55), is a driving force in many inflammatory bowel disease (IBD) patients, but its impact on PCs is poorly known. We have generated PC-specific P55 knockout mice (P55Paneth KO) and found that these mice are protected against lethal TNF-induced systemic inflammatory response syndrome (SIRS). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL34475
6 Samples
Download data: TXT
Series
Accession:
GSE267927
ID:
200267927
3.

PanethcellTNF-signalinginducesbacterialsepsis: PC transcriptome 15h ater TNF

(Submitter supplied) Paneth Cells (PCs) are secretory cells located in the crypts of Lieberkühn of the small intestine. They produce antimicrobial peptides (AMPs) and are thought to keep the microbiome under control. The cytokine TNF, which functions mainly via its TNF receptor 1 (TNFR1 or P55), is a driving force in many inflammatory bowel disease (IBD) patients, but its impact on PCs is poorly known. We have generated PC-specific P55 knockout mice (P55Paneth KO) and found that these mice are protected against lethal TNF-induced systemic inflammatory response syndrome (SIRS). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL34475
7 Samples
Download data: TXT
Series
Accession:
GSE267790
ID:
200267790
4.

Element AVITI (Mus musculus)

Organism:
Mus musculus
3 Series
35 Samples
Download data
Platform
Accession:
GPL34475
ID:
100034475
5.

SI_LN_PP_Residual_ILC3_steady_rep1

Organism:
Mus musculus
Source name:
SI
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341956
ID:
308341956
6.

SI_LN_PP_Residual_ILC3_steady_rep2

Organism:
Mus musculus
Source name:
SI
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341955
ID:
308341955
7.

Colon_LN_PP_uninfected_WT_rep1

Organism:
Mus musculus
Source name:
Colon
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341952
ID:
308341952
8.

Colon_LN_PP_uninfected_WT_rep2

Organism:
Mus musculus
Source name:
Colon
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341951
ID:
308341951
9.

Colon_LN_PP_Citro_infected_WT_D4_rep1

Organism:
Mus musculus
Source name:
Colon
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341950
ID:
308341950
10.

Colon_LN_PP_Citro_infected_WT_D4_rep2

Organism:
Mus musculus
Source name:
Colon
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341949
ID:
308341949
11.

Colon_LN_PP_Citro_infected_WT_D4_rep3

Organism:
Mus musculus
Source name:
Colon
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341947
ID:
308341947
12.

Colon_LN_PP_Citro_infected_CD4_D4_rep1

Organism:
Mus musculus
Source name:
Colon
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341946
ID:
308341946
13.

Colon_LN_PP_Citro_infected_CD4_D4_rep2

Organism:
Mus musculus
Source name:
Colon
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341945
ID:
308341945
14.

Colon_LN_PP_Citro_infected_CD4_D4_rep3

Organism:
Mus musculus
Source name:
Colon
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341944
ID:
308341944
15.

SI_LN_PP_uninfected_WT_rep1

Organism:
Mus musculus
Source name:
SI
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341943
ID:
308341943
16.

SI_LN_PP_uninfected_WT_rep2

Organism:
Mus musculus
Source name:
SI
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341942
ID:
308341942
17.

SI_LN_PP_Citro_infected_WT_D4_rep1

Organism:
Mus musculus
Source name:
SI
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341941
ID:
308341941
18.

SI_LN_PP_Citro_infected_WT_D4_rep2

Organism:
Mus musculus
Source name:
SI
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341940
ID:
308341940
19.

SI_LN_PP_Citro_infected_WT_D4_rep3

Organism:
Mus musculus
Source name:
SI
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341939
ID:
308341939
20.

SI_LN_PP_Citro_infected_CD4_D4_rep1

Organism:
Mus musculus
Source name:
SI
Platform:
GPL34475
Series:
GSE270398
Download data: TSV
Sample
Accession:
GSM8341938
ID:
308341938
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