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Items: 20

1.

Nuclear Receptor NR2F6 as an Alternative Cancer Immune Checkpoint in the T Cell Compartment

(Submitter supplied) Analyzing mouse tumor models in vivo, human T cells ex vivo and human lung cancer samples, we provide direct evidence that NR2F6 acts as novel immune checkpoint. Genetic ablation of Nr2f6, particularly in combination with blockade of the established PD-L1 cancer immune checkpoint, efficiently delayed tumor progression and improved survival in experimental mouse models. The target genes deregulated in intratumoral T lymphocytes upon genetic ablation of Nr2f6 alone or together with PD-L1 blockade, revealed multiple advantageous transcriptional alterations for effective tumor rejection. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18635
18 Samples
Download data: TXT
Series
Accession:
GSE111796
ID:
200111796
2.

Ion Torrent Proton (Mus musculus)

Platform
Accession:
GPL18635
ID:
100018635
3.

rep6_wt_aPDL1 [Lexogen_48]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039873
ID:
303039873
4.

rep5_wt_aPDL1 [Lexogen_47]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039872
ID:
303039872
5.

rep4_wt_aPDL1 [Lexogen_46]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039871
ID:
303039871
6.

rep6_Nr2f6_aPDL1 [Lexogen_45]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039870
ID:
303039870
7.

rep5_Nr2f6_aPDL1 [Lexogen_44]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039869
ID:
303039869
8.

rep4_Nr2f6_aPDL1 [Lexogen_43]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039868
ID:
303039868
9.

rep3_wt_aPDL1 [Lexogen_39]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039867
ID:
303039867
10.

rep2_wt_aPDL1 [Lexogen_38]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039866
ID:
303039866
11.

rep1_wt_aPDL1 [Lexogen_37]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039865
ID:
303039865
12.

rep3_wt_IgG2b [Lexogen_36]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039864
ID:
303039864
13.

rep2_wt_IgG2b [Lexogen_35]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039863
ID:
303039863
14.

rep1_wt_IgG2b [Lexogen_34]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039862
ID:
303039862
15.

rep3_Nr2f6_aPDL1 [Lexogen_33]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039861
ID:
303039861
16.

rep2_Nr2f6_aPDL1 [Lexogen_32]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039860
ID:
303039860
17.

rep1_Nr2f6_aPDL1 [Lexogen_31]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039859
ID:
303039859
18.

rep3_Nr2f6_IgG2b [Lexogen_30]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039858
ID:
303039858
19.

rep2_Nr2f6_IgG2b [Lexogen_29]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039857
ID:
303039857
20.

rep1_Nr2f6_IgG2b [Lexogen_28]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039856
ID:
303039856
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Supplemental Content

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