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Items: 12

1.

The SS18-SSX fusion oncoprotein hijacks BAF complex targeting and function to drive synovial sarcoma [ATAC-seq]

(Submitter supplied) Synovial sarcoma (SS) is defined by the hallmark SS18-SSX fusion oncoprotein, which renders BAF complexes aberrant in two manners: gain of SSX to the SS18 subunit and concomitant loss of BAF47 subunit assembly. Here we demonstrate that SS18-SSX globally hijacks BAF complexes on chromatin to activate a SS transcriptional signature we define using primary tumors and cell lines. Specifically, SS18-SSX retargets BAF complexes from enhancers to broad polycomb domains to oppose PRC2-mediated repression and activate bivalent genes. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
10 Samples
Download data: BW
Series
Accession:
GSE114487
ID:
200114487

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
12652 Series
344618 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

3.

CRL7250 SS18-SSX ATAC

Organism:
Homo sapiens
Source name:
CRL7250 SS18-SSX ATAC
Platform:
GPL18573
Series:
GSE108028 GSE114487
Download data: BW
Sample
Accession:
GSM3142826
ID:
303142826

SRA Run Selector

4.

CRL7250 SS18 ATAC

Organism:
Homo sapiens
Source name:
CRL7250 SS18 ATAC
Platform:
GPL18573
Series:
GSE108028 GSE114487
Download data: BW
Sample
Accession:
GSM3142825
ID:
303142825

SRA Run Selector

5.

Aska-Del47 shSSX ATAC rep2

Organism:
Homo sapiens
Source name:
Aska-Del47 shSSX ATAC-seq
Platform:
GPL18573
Series:
GSE108028 GSE114487
Download data
Sample
Accession:
GSM3142824
ID:
303142824

SRA Run Selector

6.

Aska-Del47 shSSX ATAC rep1

Organism:
Homo sapiens
Source name:
Aska-Del47 shSSX ATAC-seq
Platform:
GPL18573
Series:
GSE108028 GSE114487
Download data: BW
Sample
Accession:
GSM3142823
ID:
303142823

SRA Run Selector

7.

Aska-Del47 shCt ATAC rep2

Organism:
Homo sapiens
Source name:
Aska-Del47 shCt ATAC-seq
Platform:
GPL18573
Series:
GSE108028 GSE114487
Download data
Sample
Accession:
GSM3142822
ID:
303142822

SRA Run Selector

8.

Aska-Del47 shCt ATAC rep1

Organism:
Homo sapiens
Source name:
Aska-Del47 shCt ATAC-seq
Platform:
GPL18573
Series:
GSE108028 GSE114487
Download data: BW
Sample
Accession:
GSM3142821
ID:
303142821

SRA Run Selector

9.

Aska shSSX ATAC rep2

Organism:
Homo sapiens
Source name:
Aska shSSX ATAC-seq
Platform:
GPL18573
Series:
GSE108028 GSE114487
Download data
Sample
Accession:
GSM3142820
ID:
303142820

SRA Run Selector

10.

Aska shSSX ATAC rep1

Organism:
Homo sapiens
Source name:
Aska shSSX ATAC-seq
Platform:
GPL18573
Series:
GSE108028 GSE114487
Download data: BW
Sample
Accession:
GSM3142819
ID:
303142819

SRA Run Selector

11.

Aska shCt ATAC rep2

Organism:
Homo sapiens
Source name:
Aska shCt ATAC-seq
Platform:
GPL18573
Series:
GSE108028 GSE114487
Download data
Sample
Accession:
GSM3142818
ID:
303142818

SRA Run Selector

12.

Aska shCt ATAC rep1

Organism:
Homo sapiens
Source name:
Aska shCt ATAC-seq
Platform:
GPL18573
Series:
GSE108028 GSE114487
Download data: BW
Sample
Accession:
GSM3142817
ID:
303142817

SRA Run Selector

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